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| 1 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 2 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 3 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 4 | TNFalpha and its receptors in psoriatic skin,before and after treatment with etanercept显示文摘 | Caldarola G De Simone C Carbone A Tulli A Amerio P Feliciani C | 2009 | Int J Immunopathol Pharmacol2009，22，4： | 1 |
| 5 | Insulin resistance in epileptic girls who gain weight after therapy with valproic acid显示文摘 | Verrotti A Basciani F De Simone M | 2002 | J Child Neurol2002，17，4： | 1 |
| 6 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 7 | The effect of a levonorgestrel-releasing intrauterine device in the treatment of myoma-related menorrhagia显示文摘 | Mercorio F De Simone R Di Zpiezio Sardo A | 2003 | Contraception2003，67，4： | 1 |
| 8 | Photodynamic therapy and the immune system in experimental oncology显示文摘 | Canti G De Simone A Korbelik M | 2002 | Photochem Photobiol Sci2002，1，： | 1 |
| 9 | Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: A randomized phase II trial 显示文摘 | Pascher A De Simone P Pratschke J | 2015 | Am J Transplantation2015，15，5： | 1 |
| 10 | Gut liver axis:a new point of attack to treat chronic liver damage? 显示文摘 | Loguereio C De Simone T Federico A | 2002 | Am J Gastroenterol2002，97，8： | 1 |
| 11 | A functional role forSmad7 in sustaining colon cancer cell growth and survival 显示文摘 | Stolfi C De Simone V Colantoni A | 2014 | Cell Death Dis2014，5，： | 1 |
| 12 | Activation of alpha7 nicotinic acetylcholine re- ceptor by nicotine selectively up-regulates cyclooxyge- nase-2 and prostaglandin E2 in rat microglial cultures 显示文摘 | DE SIMONE R AJMONE-CAT M A CARNEVALE D | 2005 | J Neuroinflammation2005，2，： | 1 |
| 13 | A functional role for smad 7 in sustaining colon cancer cell growth and survival 显示文摘 | Stolfi C De simone V Colantoni A | 2014 | Cell Death Dis2014，20，5： | 1 |
| 14 | Removal of a protruded thoracic disc using microsurgical显示文摘 | Rosenthal D Rosenthal R DE Simone A | 1994 | Spine1994，19，： | 1 |
| 15 | Treatment of antibody-mediated rejection with high-dose immunoglobulins in ABO-incompatible liver transplant recipient显示文摘 | Urbani L Mazzoni A De Simone P | | 0，，05： | 1 |
| 16 | Granular cell tumor of the breast : Clinical and pathologic characteristics of a rare case in a 14-year-old girl显示文摘 | De Simone N Aggon A Christy C | 2011 | J Clin Oncol2011，29，22： | 1 |
| 17 | Photodynamic therapy and the immune system in experimental oncology 显示文摘 | Canti G De Simone A Korbelik M | 2002 | Photochem Photobiol Sci2002，1，1： | 1 |
| 18 | Photodynamic therapy and the immune system in experimental oncology 显示文摘 | Canti G De Simone A Korbelik M | 2002 | Photochem Photobiol Sci2002，1，： | 1 |
| 19 | Does catheter ablation cure atrial fibrillation? Single-procedure outcome of drug-refractory atrial fibrillation ablation:a 6-year multicentre experience显示文摘 | Bertaglia E Tondo C De Simone A | 2010 | Europace2010，12，2： | 1 |
| 20 | Itch/AlP4 associates with and promotes p63 protein degradation显示文摘 | Rossi M De Simone M Pollice A | 2006 | Cell Cycle2006，5，16： | 1 |
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