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| 1 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 2 | Wilms Tumor显示文摘 | Andrew M Davidoff | 2012 | Advance In Pediatrics2012，59，1： | 1 |
| 3 | Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions显示文摘 | Schilling R Ijaz S Davidoff M | 2003 | J Viol2003，77，16： | 1 |
| 4 | Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions显示文摘 | Schilling R Ijaz S Davidoff M | 2003 | J Virol2003，77，16： | 1 |
| 5 | Neuroblastoma显示文摘 | Davidoff A M | | 0，，1： | 1 |
| 6 | Genetic basis for P53 expression in human breast cancer显示文摘 | Davidoff A M Humphrey P A Iglehart J D | 1991 | Proc Natl Acad Sci U S A1991，88，11： | 1 |
| 7 | Chemotherapy and survival benefit in elderly patients with advanced non small -cell lung cancer显示文摘 | Davidoff AJ Tang M Seal 13 | 2010 | J Clin Oncol2010，28，： | 1 |
| 8 | Neural tube defect -specific infant mortality in the United States 显示文摘 | Davidoff M J Petrini J Damus K | 2002 | Teratology2002，66，1： | 1 |
| 9 | Bone marrow - derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth inmice 显示文摘 | Davidoff A M Ng C Y Brown P | 2001 | Clin Canc Res2001，7，9： | 1 |
| 10 | Relation between P53 overepression and established prognostic factors in breast cancer显示文摘 | DAVIDOFF A M HERNDOM J E GLOVER N S | 1991 | Surgery1991，110，： | 1 |
| 11 | Immunocytochemical expres-sion of p75LNGFR and trkA in Leydig cells of the human testis显示文摘 | Koeva Y Davidoff M Popova L | 1999 | Folia Med(Plovdiv)1999，41，4： | 1 |
| 12 | Chemotherapy and aurvival benefit in elderly patients with advanced non-small cell lung cancer显示文摘 | Davidoff AJ Tang M Seal B | 2010 | J Clin Oncol2010，28，： | 1 |
| 13 | Correlation of Freundlich Kd, and n retention parameters with soils and elements 显示文摘 | Davidoff B Amacher M C | 1989 | Soil Sci1989，148，： | 1 |
| 14 | The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma 显示文摘 | Azuhata T Scott D Takamizawa S Wen J Davidoff A Fukuzawa M | 2001 | J Pediatr Surg2001，36，12： | 1 |
| 15 | The revised CONSORT statement for reporting randomized trials:explanation and elaboration显示文摘 | Altman DG Schulz KF Moher D Egger M Davidoff F Elbourne D Gotzsche PC Lang T CONSORT GROUP (Consolidated Standards of Reporting Trials) | | 0，，08： | 1 |
| 16 | hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cell s and during immortalization 显示文摘 | Counter CM Eaton EN Ellisen LW Steiner P Caddl e SD Ziaugra L Beijersbergen RL Davidoff MJ Liu Q Bacchetti S Haber DA Weinberg RA | 1997 | Cell1997，90，4： | 1 |
| 17 | Chemotherapy and survival benefit in elderly patients with advanced non-small-cell lung cancer显示文摘 | Davidoff AJ Tang M Seal B | 2010 | J Clin Oncol2010，28，： | 1 |
| 18 | Capillaries in the lamina propria of human seminiferous tubules are partly fenestrated显示文摘 | Erguen S Davidoff M Holstein AF | 1996 | Cell and Tissue Research1996，286，1： | 1 |
| 19 | Chemotherapy and survival benefit in elderly patients with advanced non-small-cell lung cancer显示文摘 | DAVIDOFF A J TANG M SEAL B | | 0，，13： | 1 |
| 20 | Diabetic cardiomyocyte dysfunction and myocyte insulin resistance:role of glucose-induced PKC activity显示文摘 | DAVIDOFF A J DAVIDSON M B CARMODY M W | 2004 | Mol Cell Biochem2004，262，12： | 1 |
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