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| 1 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 2 | Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes显示文摘 | REN J DAVIDOFF A J | 1997 | Am J Physiol1997，272，： | 1 |
| 3 | Alpha2 - Heremans Schmidt glycoprotein, a putative inhibitor of tyrosine kinase, prevents glucose toxicity associated with cardiomyocyte dysfunction 显示文摘 | Ren J Davidoff A J | 2002 | Diabetes Metab Rev2002，18，4： | 1 |
| 4 | Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function 显示文摘 | ELLINGSEN O DAVIDOFF A J PRASAD S K | 1993 | AmJ Physiol1993，265，： | 1 |
| 5 | The value of noncon-trast enhanced CT in abdominal trauma显示文摘 | Kelly J Raptopoulos V Davidoff A | 1989 | AJR1989，152，： | 1 |
| 6 | A choice theory of planning显示文摘 | Davidoff P Reiner T A | 1962 | Journal of the American Institute of Planners1962，28，2： | 1 |
| 7 | Neuroblastoma显示文摘 | Davidoff A M | | 0，，1： | 1 |
| 8 | Genetic basis for P53 expression in human breast cancer显示文摘 | Davidoff A M Humphrey P A Iglehart J D | 1991 | Proc Natl Acad Sci U S A1991，88，11： | 1 |
| 9 | Unexpected cytokinetic effects induced by puromycin include a G2-arrest, ametaphase-mitoticarrest, and apoptosis 显示文摘 | Davidoff A N Mendelow B V | 1992 | Leuk Res1992，16，11： | 1 |
| 10 | Annuities and individual welfare显示文摘 | Davidoff T Brown J R Diamond P A | 2005 | American Economic Review2005，95，5： | 1 |
| 11 | Bone marrow - derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth inmice 显示文摘 | Davidoff A M Ng C Y Brown P | 2001 | Clin Canc Res2001，7，9： | 1 |
| 12 | Relation between P53 overepression and established prognostic factors in breast cancer显示文摘 | DAVIDOFF A M HERNDOM J E GLOVER N S | 1991 | Surgery1991，110，： | 1 |
| 13 | The normal diameter of the fetal aorta and pulmonary artery :echocardiographic evaluation in utero 显示文摘 | Cartier MS Davidoff A Warneke LA | 1987 | Am J Roentgenol1987，149，5： | 1 |
| 14 | Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes 显示文摘 | Davidoff A J Ren J | 1997 | AM J Physiol1997，272，12： | 1 |
| 15 | Congestive heart failure after myocardial infarction in the rat:cardiac force and spontaneous sarcomere activity 显示文摘 | Davidoff A W Boyden P A Schwartz K | 2004 | Ann N Y Acad Sci2004，10，15： | 1 |
| 16 | Whole gut transit scintigraphy in the clinical evaluation of patients with upper and lower gastrointestinal symptoms显示文摘 | Bonapace E S Maurer A H Davidoff S | 2000 | The American journal of gas- troenterology2000，95，10： | 1 |
| 17 | Assessment of PI-3 kinase and Akt in ischemic heart diseases in diabetes显示文摘 | MATSUI T DAVIDOFF A J | 2007 | Methods Mol Med2007，139，： | 1 |
| 18 | Effect of age on survival benefit of adjuvant chemotherapy in elderly stage Ⅲ colon cancer patients:a population-based analysis显示文摘 | ZUCKERMAN IH DAVIDOFF AJ ONULWAGHA E | 2008 | J Clin Oncol2008，26，15： | 1 |
| 19 | The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma 显示文摘 | Azuhata T Scott D Takamizawa S Wen J Davidoff A Fukuzawa M | 2001 | J Pediatr Surg2001，36，12： | 1 |
| 20 | Interplay between im- pajred calcium regulation and insulin signaling abnomali- ties in diabetic cardiomyopathy 显示文摘 | Lebeche D Davidoff A J Hajjar RJ | 2008 | Nat clin Pract Cardio- vase Med2008，5，11： | 1 |
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