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| 1 | Staging accuracy of esophageal cancer by endoscopic ultrasound:A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in the staging of esophageal cancer. METHODS: Only EUS studies confirmed by surgery were selected. Articles were searched in Medline and Pubmed. Two reviewers independently searched and extracted data. Meta-analysis of the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Forty-nine studies (n = 2558) which met the inclusion criteria were included in this analysis. Pooled sensitivity and specificity of EUS to diagnose T1 was 81.6% (95% CI: 77.8-84.9) and 99.4% (95% CI: 99.0-99.7), respectively. To diagnose T4, EUS had a pooled sensitivity of 92.4% (95% CI: 89.2-95.0) and specificity of 97.4% (95% CI: 96.6-98.0). With Fine Needle Aspiration (FNA), sensitivity of EUS to diagnose N stage improved from 84.7% (95% CI: 82.9-86.4) to 96.7% (95% CI: 92.4-98.9). The P value for the χ2 test of heterogeneity for all pooled estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity in accurately diagnosing the TN stage of esophageal cancer. EUS performs better with advanced (T4) than early (T1) disease. FNA substantially improves the sensitivity and specificity of EUS in evaluating N stage disease. EUS should be strongly considered for staging esophageal cancer. | Srinivas R Puli Jyotsna BK Reddy Matthew L Bechtold Daphne Antillon Jamal A Ibdah Mainor R Antillon | 2008 | World Journal of Gastroenterology2008，14，10： | 55 |
| 2 | Current status and perspectives of immune-based therapiesfor hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a frequent cancer with a high mortality.For early stage cancer there are potentially curative treatments including local ablation,resection and liver transplantation.However,for more advanced stage disease,there is no optimal treatment available.Even in the case of a'curative'treatment,recurrence or development of a new cancer in the precancerous liver is common.Thus,there is an urgent need for novel and effective(adjuvant)therapies to treat HCC and to prevent recurrence after local treatment in patients with HCC.The unique immune response in the liver favors tolerance,which remains a genuine challenge for conventional immunotherapy in patients with HCC.However,even in this'immunotolerant'organ,spontaneous immune responses against tumor antigens have been detected,although they are insufficient to achieve significant tumor death.Local ablation therapy leads to immunogenic tumor cell death by inducing the release of massive amounts of antigens,which enhances spontaneous immune response.New immune therapies such as dendritic cell vaccination and immune checkpoint inhibition are under investigation.Immunotherapy for cancer has made huge progress in the last few years and clinical trials examining the use of immunotherapy to treat hepatocellular carcinoma have shown some success.In this review,we discuss the current status of and offer some perspectives on immunotherapy for hepatocellular carcinoma,which could change disease progression in the near future. | Maridi Aerts DaphnéBenteyn Hans Van Vlierberghe Kris Thielemans Hendrik Reynaert | 2016 | World Journal of Gastroenterology2016，22，1： | 24 |
| 3 | Chloroplast Proteomics and the Compartmentation of Plastidial Isoprenoid Biosynthetic Pathways显示文摘proteomic 地里的最近的进展允许高产量的实验在叶绿体样品上被进行。许多 proteomic 调查集中了于整个叶绿体或 sub-plastidial 部分。迄今为止,植物蛋白质数据库(PPDB,阳光等, 2009 ) 介绍在网上可得到的最彻底的叶绿体 proteome。然而,在不同 sub-plastidial 分隔空间被识别的许多蛋白质的精确本地化仍然保持假想。为西班牙耶劳岛之旧称等。(2009 ) 去了进关于他们在由使用作为光谱的数知道的一条半量的 proteomic 途径的叶绿体以内的精确本地化的 Arabidopsis thaliana 叶绿体蛋白质的知识进一步的步。他们的 proteomic 策略基于精确的团和时间标签(AMT ) 数据库途径,他们建立了 AT_CHLORO,有 sub-plastidial 本地化的一个全面叶绿体 proteome 数据库和信封蛋白质的 curated 信息。比较这二个广泛的数据库,我们这里集中于涉及叶绿体特定的 isoprenoids 的合成的大约 100 酶。众所周知的小径(即甲基赤藻糖醇磷酸盐 biosynthetic 小径的分隔,在叶绿体以内的 tetrapyrroles 和叶绿素生合成和故障) 验证光谱基于计数的策略。一样的策略然后被用来在叶绿体以内识别类胡萝卜素和 prenylquinones 的生合成的精确本地化(即在信封膜,基质,或 thylakoids ) 那仍然保持不清楚直到现在。 | Jacques Joyard Myriam Ferro Christophe Masselon Daphne Seigneurin-Berny Daniel Salvi Jerome Garin Norbert Rolland | 2009 | Molecular Plant2009，2，6： | 15 |
| 4 | Endoscopic ultrasound:It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review显示文摘AIM:To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS:Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS:Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI:82.9-86.4) to 88.0% (95% CI:85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI:83.2-85.9) to 96.4% (95% CI:95.3-97.4). The P forchi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION:EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy. | Srinivas R Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Jamal A Ibdah Daphne Antillon Shailender Singh Mojtaba Olyaee Mainor R Antillon | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 5 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 6 | Efficacy of small-volume simethicone given at least 30 min before gastroscopy显示文摘AIM To evaluate the efficacy of 5 m L simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy.METHODS This was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior sur-gical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score(TMVS) which was evaluated using Mc Nally score. The sample size was calculated to be 24 per group(SD 2.4, 80% power, P < 0.05, 2-sample t test). RESULTS Fifty-four patients were randomised to receive either simethicone [1 m L liquid simethicone(100 mg) in 5 m L of water] or placebo(5 m L of water) at least 30 min before their gastroscopy. Six accredited consultants conductedthe gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo(5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P < 0.001). The improvement was statistically significant for the duodenum and the gastric antrum, angularis, body, and fundus. Percent 51.9 of patients in the simethicone group had a TMVS of 4(no bubbles at all) to 5(only 1 area with minimal bubbles), while in the placebo group 3.7% of patients had TMVS of 4 or 5. The number needed to treat was 2.1 to avoid a TMVS of 6 and more. The simethicone group also had a significantly shorter procedure time with less volume of additional flushes required during gastroscopy to clear away obscuring gastric foam.CONCLUSION With a premedication time of at least 30 min, 5 m L simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time. | Mingjun Song Andrew Boon Eu Kwek Ngai Moh Law Jeannie Peng Lan Ong Jessica Yi-Lyn Tan Prem Harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 10 |
| 7 | Meta-analysis and systematic review of colorectal endoscopic mucosal resection显示文摘AIM:To evaluate the proportion of successful complete cure en-bloc resections of large colorectal polyps achieved by endoscopic mucosal resection(EMR). METHODS:Studies using the EMR technique to resect large colorectal polyps were selected.Successful complete cure en-bloc resection was defined as one piece margin-free polyp resection.Articles were searched for in Medline,Pubmed,and the Cochrane Control Trial Registry,among other sources. RESULTS:An initial search identified 2620 reference articles,from which 429 relevant articles were selected and reviewed.Data was extracted from 25 studies(n =5221)which met the inclusion criteria.All the studies used snares to perform EMR.Pooled proportion of en-bloc resections using a random effect model was 62.85%(95%CI:51.50-73.52).The pooled proportion for complete cure en-bloc resections using a random effect model was 58.66%(95%CI:47.14-69.71).With higher patient load(>200 patients),this complete cure en-bloc resection rate improves from 44.19%(95%CI: 24.31-65.09)to 69.17%(95%CI:51.11-84.61). CONCLUSION:EMR is an effective technique for the resection of large colorectal polyps and offers an alternative to surgery. | Srinivas R Puli Yasuo Kakugawa Takuji Gotoda Daphne Antillon Yutaka Saito Mainor R Antillon | 2009 | World Journal of Gastroenterology2009，15，34： | 7 |
| 8 | 桡骨头骨折以及植入物重建后的运动学与稳定性(下)显示文摘二、桡骨头切除的影响
对于MasonⅢ型骨折,特别是不伴韧带损伤时,如何进行外科治疗还没有得到彻底解决。桡骨头切除对肘部运动及稳定的影响已有大量研究。可以明确的是,桡骨头的缺失将导致肘部的外翻稳定性降低,是仅次于MCL的一个重要约束。我们的内翻一外翻松弛测试显示,桡骨头的缺失导致松弛显著增加.然而,相对于MCL,桡骨头的作用要低得多,对最大内翻一外翻松弛起24%的作用(先切除桡骨头)。对于内翻一外翻松弛而言,桡骨头上升为第二位的稳定装置(图3,韧带的作用将在稍后进行进一步的详细讨论)。除外翻稳定外,桡骨头对肘的内翻稳定也起一定的作用。这可能归因于LCL复合体的松弛。 | James A. Johnson | 2009 | 中华骨科杂志2009，29，1： | 7 |
| 9 | 桡骨头骨折以及植入物重建后的运动学与稳定性(上)显示文摘桡骨头骨折是肘部最常见的骨折。单纯桡骨头骨折为无移位骨折,若伴内侧和外侧副韧带和(或)骨间韧带损伤时,则骨折会发生移位。在更严重的损伤中,桡骨头骨折可能伴随着肘和前臂的脱位。桡骨头骨折中经常可以见到冠状突和肱骨小头骨折,这进一步削弱了肘关节的稳定性。 | James A. Johnson | 2008 | 中华骨科杂志2008，28，12： | 7 |
| 10 | 溴甲烷对松木木质包装穿透性研究显示文摘25℃、48g/m3起始剂量条件下,溴甲烷熏蒸12h,熏蒸箱内溴甲烷浓度衰减率超过40%,而12h后到48h熏蒸结束时,溴甲烷衰减率小于5%。箱内溴甲烷CT值在6h达到200g.h/m3。溴甲烷对松木的穿透是顺着木纹进行的。在熏蒸48h内,无虫害木块内部各采样孔的溴甲烷浓度与箱内浓度无法达到平衡,15cm处CT值不足200g.h/m3;有虫害木块内部各采样孔溴甲烷浓度在20h与箱内浓度基本平衡,15cm处的溴甲烷CT值达到200g.h/m3需13h。 | 王跃进 任永林 刘波 张广平 Daphne Mahon 詹国平 徐亮 | 2008 | 植物检疫2008，22，1： | 6 |
| 11 | Urinary biomarkers for prostate cancer: a review显示文摘尽管测试的前列腺特定的抗原(PSA ) 无疑增加了的浆液的平淡的使用前列腺癌症(PCa ) 察觉,它的主要缺点之一是它特性的缺乏。作为后果,许多人为懒惰的瘤经历不必要的活体检视或治疗。PCa 特定的标记为疾病和一个前列腺瘤的攻击性的预言的早察觉被需要。因为 PCa 是异构的疾病,瘤标记的一块面板为更精确的诊断是基本的。几 biomarkers 由于他们为在组织的疾病的特性是有希望的。然而,织物是象一个可能的屏蔽工具不合适。因为尿能容易以一种非侵略的方式被获得,它是为测试的 biomarker 的有希望的底层。这篇文章为在尿的 PCa 的非侵略的测试考察 biomarkers。 | Daphne Hessels Jack A Schalken | 2013 | Asian Journal of Andrology2013，15，3： | 5 |
| 12 | 白沙蒿粘液瘦果萌发中聚糖内切水解酶的活动特性(英文)显示文摘对白沙蒿 (ArtemisiasphaerocephahaKrasch .)种子萌发不同阶段的种胚提取物中几种可能降解果皮外层粘液物质的多糖内切酶进行了检测。研究结果表明 :多聚半乳糖醛酸酶在干燥胚中已存在并具较高的活性 ,但其活性随着种子吸涨及萌发而降低。此酶并不释放到种胚外。β 甘露聚糖内切酶随着种子的吸涨而增加并被萌发的种胚释放到种子外。纤维素酶在种子萌发的过程中不表现出活性。提取物中的所有多糖内切酶都无法降解果皮外层的粘液物质。 | 黄振英 Daphne J.OSBORNE | 2002 | Acta Botanica Sinica2002，44，6： | 4 |
| 13 | 乌司奴单抗改善中、重度斑块状银屑病患者健康相关生活质量和临床疗效观察显示文摘目的:评估乌司奴单抗对中国3期、双盲、安慰剂对照临床(LOTUS)研究患者健康相关生活质量(HRQoL)的影响。方法:共322例患者,在第0周和第4周随机接受乌司奴单抗45mg(n=160)或安慰剂(n=162);第12周和第16周安慰剂组交叉使用乌司奴单抗,而乌司奴单抗组则在第16周继续使用乌司奴单抗。第12周HRQoL终点包括皮肤病生活质量指数(DLQI)评分较基线的变化、单个DLQI域的变化、DLQI评分为0分或1分的患者比例以及获得有临床意义DLQI改善(评分降低≥5分)的患者比例。结果:乌司奴单抗治疗患者12周时DLQI评分较基线的改善(-9.3分)显著优于安慰剂组(-1.9分)(P<0.001)。同样,乌司奴单抗治疗后DLQI≤1分的患者比例显著高于安慰剂组(42.6%vs 10.7%,P<0.001),乌司奴单抗组和安慰剂组治疗后分别有71.5%和29.6%的患者DLQI降低≥5分(P均<0.001)。乌司奴单抗治疗患者12周时单个DLQI域与安慰剂相比显著改善(P<0.001)。乌司奴单抗组DLQI的改善在治疗28周内持续存在。交叉接受乌司奴单抗的安慰剂组患者,与最初随机接受乌司奴单抗治疗的患者相比,HRQoL改善程度类似。结论:乌司奴单抗显著改善了中国中至重度斑块状银屑病患者的HRQoL。 | 朱学骏 郑敏 Michael Song Chenglong Han Daphne Chan Y.K.Shen 王宝玺 | 2014 | 临床皮肤科杂志2014，43，9： | 4 |
| 14 | Disease impact on the quality of life of children with inflammatory bowel disease显示文摘AIM To assess the impact of disease characteristics on the quality of life (QOL) in children with inflammatory bowel diseases(IBD).METHODS This was a cross-sectional study conducted at the First Department of Pediatrics of the University of Athens at the 'Aghia Sophia' Children's Hospital. Children diagnosed with Crohn's disease (CD) or ulcerative colitis (UC), who were followed as outpatients or during a hospitalization, participated, after informed consent was obtained from their legal representative. QOL was assessed by the IMPACT-III questionnaire. Demographic data and disease characteristics were also collected. Statistical analyses included parametric(Student's t-test and Pearson's r) and non-parametric(Mann-Whitney test, Fisher's test and Spearman's rho) procedures.RESULTS Ninety-nine patients (UC: 37, 73.0% females, CD: 62, 51.6% females), aged 12.8±2.6 years were included.Overall, as well as, sub-domain scores did not differ between UC and CD(overall score: 73.9±13.3 vs 77.5±11.2, respectively, P=0.16). In the entire sample, total score was related to physician's global assessment(PGA, patients classified as 'mild/moderate' active disease had, on average, 14.8±2.7 points lower total scores compared to those 'in remission', P<0.001) and age at IMPACT completion (Pearson's r=0.29, P=0.05). Disease activity assessed by the indices Pediatric Ulcerative Colitis activity index, Pediatric Crohn's disease activity index or PGA was significantly associated with all subdomains scores. Presence of extraintestinal manifestations had a negative impact on emotional and social functioning domains.CONCLUSION Disease activity is the main correlate of QOL in children with IBD, underlining the importance of achieving and sustaining clinical | Giorgos Chouliaras Daphne Margoni Konstantina Dimakou Smaragdi Fessatou Ioanna Panayiotou Eleftheria Roma-Giannikou | 2017 | World Journal of Gastroenterology2017，23，6： | 4 |
| 15 | The Treatment of Peritoneal Carcinomatosis of Colorectal Cancer with Complete Cytoreductive Surgery and Hyperthermic Intraperitoneal Peroperative Chemotherapy (HIPEC) with Oxaliplatin: A Belgian Multicentre Prospective Phase II Clinical Study显示文摘 | Daphne Hompes André D’Hoore Eric Cutsem Steffen Fieuws Wim Ceelen Marc Peeters Kurt Speeten Claude Bertrand Hugues Legendre Joseph Kerger | 2012 | Annals of Surgical Oncology2012，，7： | 3 |
| 16 | 儿童扩张型心肌病的发病率、病因及预后显示文摘背景:扩张型心肌病(dilated cardiomyopathy,DCM)是儿童心肌病最常见的类型,也是小儿心脏移植最常见的原因。但是,目前尚不清楚儿童DCM的流行病学特点和临床过程。
目的:详细描述儿童DCM的发病率、病因、预后及相关危险因素。
设计及地点:本项以人群为基础的前瞻性纵向队列研究入选1996年1月至2003年2月在89个儿科心脏中心诊断为DCM的儿童以及1990年1月至1995年12月在北美大型三级治疗中心诊断的患儿。
参试者:共入选1426例来自美国和加拿大的18岁以下DCM患儿。通过严格的超声心动图和/或病理学标准来诊断原发性DCM。因内分泌、免疫、药物中毒及其他原因患病者除外。
主要观测指标:每年每10万儿童的发病率、死亡率和心脏移植率。
结果:18岁以下儿童DCM每年的总发病率为0.57/10万,男孩的年发病率高于女孩(分别为0.66/10万和0.47/10万;P〈0.001),黑人的年发病率高于白人(分别为0.98/10万和0.46/10万;P〈0.001),婴儿(〈1岁)的年发病率高于儿童(分别为4.40/10万和0.34/10万;P〈0.001)。绝大部分属特发性,最常见的病因为心肌炎(46%)和神经肌肉性疾病(26%)。1年和5年死亡/移植率分别为31%和46%。死亡/移植的独立危险因素包括患儿诊断DCM时年龄较大、伴有充血性心力衰竭、左室收缩期Z评分较低以及DCM的病因(P均〈0.001)。
结论:儿童DCM有其多样性。患儿预后主要取决于病因、年龄和心力衰竭状况。人种、性别和年龄对发病率有一定影响。大部分患儿无明确病因,限制了特异性治疗。 | Jeffrey A. Towbin April M. Lowe Steven D. Colan Lynn A. Sleeper E. John Orav Sarah Clunie Jane Messere Gerald F. Cox Paul R. Lurie Daphne Hsu Charles Canter James D. Wilkinson Steven E. Lipshultz 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 3 |
| 17 | 白沙蒿粘液瘦果萌发中外切糖苷酶活动特性(英文)显示文摘白沙蒿 (ArtemisiasphaerocephalaKrasch .)是中国西北沙区分布的多年生植物。瘦果遇湿后其粘液层开始膨胀。对其种子萌发不同阶段的种胚提取物中几种可能降解果皮外层粘液物质的外切糖苷酶进行了检测。结果表明 :β 吡喃半乳糖苷酶在干种子中的活性很高 ,但是随着种子的吸涨而逐渐降低 ,在已萌发的种子中无法探测到。α和 β 吡喃阿拉伯糖苷酶、β 吡喃葡萄糖苷酶以及 β 吡喃甘露糖苷酶在种子萌发过程的胚提取物中也显示出了一些活性 ,但是这些活性在种胚外却无法探测到。所有胚提取物中的外切糖苷酶都无法降解果皮粘液物质。所有的证据都表明果皮外层的粘液物质无法在种子萌发的早期被水解。因此果皮粘液物质在干旱沙质条件下的生态功能被限制在吸收水分以及延长胚吸水的时间。 | 黄振英 Daphne J.OSBORNE | 2002 | Acta Botanica Sinica2002，44，11： | 3 |
| 18 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 19 | Cancer Incidence Trends Among Asian American Populations in the United States, 1990–2008显示文摘 | Scarlett Lin Gomez Anne-Michelle Noone Daphne Y. Lichtensztajn Steve Scoppa James T. Gibson Lihua Liu Cyllene Morris Sandy Kwong Kari Fish Lynne R. Wilkens Marc T. Goodman Dennis Deapen Barry A. Miller | 2013 | JNCI Journal of the National Cancer Institute2013，，15： | 2 |
| 20 | L1 use during L2 writing: An empirical study of a complex phenomenon显示文摘 | Daphne van Weijen Huub van den Bergh Gert Rijlaarsdam Ted Sanders | 2009 | Journal of Second Language Writing2009，，4： | 2 |
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