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| 1 | Endoscopic management of esophageal stenosis in children:New and traditional treatments显示文摘Post-esophageal atresia anastomotic strictures and postcorrosive esophagitis are the most frequent types of cicatricial esophageal stricture. Congenital esophageal stenosis has been reported to be a rare but typical disease in children; other pediatric conditions are peptic, eosinophilic esophagitis and dystrophic recessive epidermolysis bullosa strictures. The conservative treatment of esophageal stenosis and strictures(ES) rather than surgery is a well-known strategy for children. Before planning esophageal dilation, the esophageal morphology should be assessed in detail for its length, aspect, number and level, and different conservative strategies should be chosen accordingly. Endoscopic dilators and techniques that involve different adjuvant treatment strategies have been reported and depend on the stricture's etiology, the availability of different tools and the operator's experience and preferences. Balloon and semirigid dilators are the most frequently used tools. No high-quality studies have reported on the differences in the efficacies and rates of complications associated with these two types of dilators. There is no consensus in the literature regarding the frequency of dilations or the diameter that should be achieved. The use of adjuvant treatments has been reported in cases of recalcitrant stenosis or strictures with evidence of dysphagic symptoms. Corticosteroids(either systemically or locally injected), the local application of mitomycin C, diathermy and laser ES sectioning have been reported. Some authors have suggested that stenting can reduce both the number of dilations and the treatment length. In many cases, this strategy is effective when either metallic or plastic stents are utilized. Treatment complications, such esophageal perforations, can be conservatively managed, considering surgery only in cases with severe pleural cavity involvement. In cases of stricture relapse,even if such relapses occur following the execution of well-conducted conservative strategies, surgical stricture resection and anastomosis or esophageal substitution are the only remaining options. | Luigi Dall rsquo Oglio Tamara Caldaro Francesca Foschia Simona Faraci Giovanni Federici di Abriola Francesca Rea Erminia Romeo Filippo Torroni Giulia Angelino Paola De Angelis | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 16 |
| 2 | Adjuvant chemotherapy for resected colorectal cancermetastases:literature review and meta-analysis显示文摘Surgical resection is the only option of cure for patients with metastatic colorectal cancer(CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence(based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials. | Giovanni Brandi Stefania De Lorenzo Margherita Nannini Stefania Curti Marta Ottone Filippo Gustavo Dall’Olio Maria Aurelia Barbera Maria Abbondanza Pantaleo Guido Biasco | 2016 | World Journal of Gastroenterology2016，22，2： | 13 |
| 3 | Enhanced Photoprotection by Protein-Bound vs Free Xanthophyll Pools: A Comparative Analysis of Chlorophyll b and Xanthophyll Biosynthesis Mutants显示文摘当植物吸收的光超过光合作用的能力时,黄色色素 violaxanthin 是 reversibly de-epoxidized 到在所谓的黄色色素周期的玉米黄质。玉米黄质迎着过量光在光合的有机体的保护起一个关键作用,由支持很快可逆(qE ) 并且长期(qI ) 激动的叶绿素熄灭,并且阻止类脂化合物氧化。玉米黄质,免费的任何一个或到轻收获的建筑群(Lhcs ) 的界限的 photoprotective 角色,被使用缺乏 Chl b (ch1 ) 或特定的黄色色素种类的异种调查了(npq, lut2 ) 。ch1 变化原因(1 ) Lhcb 蛋白质的缺席;(2 ) 反馈 de 刺激(qE ) 的强壮的减小;并且(3 ) 是的黄色色素的累积免费颜料进 thylakoids。Ch1 异种在高光显示出极端敏感到相片氧化的应力,由于更高的汗衫氧(1O2 ) 版本。双变异的 ch1npq1 比 ch1 对相片氧化更敏感,证明甚至当时,那玉米黄质确实保护类脂化合物在膜免费。不过,玉米黄质的缺乏在包含 Lhcs 植物(WT 对 npq1 ) 有类脂化合物 peroxidation 诚实的强壮得多的影响关于 Lhc 少些种(ch1 对 ch1npq1 ) ,暗示它的保护的效果被和天线蛋白质的相互作用提高。玉米黄质的抗氧化剂能力面对 PSIILHCsZea 建筑群被授权,这被建议,当它 qE 的改进上的效果仅仅提供次要的贡献时。到外长的 1O2 的 WT 对 npq1 植物的敏感的比较建议除 1O2 清除以外,至少一另外的机制涉及叶绿体 photoprotection。 | Luca Dall'Osto Stefano Cazzaniga Michel Havaux Roberto Bassi | 2010 | Molecular Plant2010，3，3： | 8 |
| 4 | ConservativeapproachinPeutz-JeghersSyndrome:Single-balloon enteroscopyandsmallbowelpolypectomy显示文摘AIM: To assess the usefulness of the balloon assisted enteroscopy in preventing surgical intervention in pa-tients with Peutz-Jeghers syndrome (PJS) having a small bowel large polyps. METHODS: Seven consecutive asymptomatic pts(age 15-38 years) with PJS have been collected; six under-went polypectomy using single balloon enteroscopy(Olympus SIF Q180) with antegrade approach using push and pull technique. SBE system consists of the SIF-Q180 enteroscope, an overtube balloon control unit(OBCU Olympus Balloon Control Unit) and a dispos-able silicone splinting tube with balloon(ST-SB1). All procedures were performed under general anesthesia. Previously all pts received wireless capsule endos-copy(WCE). Prophylactic polypectomy was reservedmainly in pts who had polyps > 15 mm in diameter. The balloon is inflated and deflated by a balloon control unit with a safety pressure setting range from-6.0 kPa to +5.4 kPa. Informed consent has been obtained from pts or parents for each procedure.RESULTS: Six pts underwent polypectomy of small bowel polyps; in 5 pts a large polyp > 15 mm(range 20-50 mm in diameter) was resected; in 1 patient with WCE negative, SBE was performed for previous surgi-cal resection of gastrointestinal stromal tumors. In 2 pts endoscopic clips were placed due to a polypectomy. No surgical complication have been reported. SBE with resection of small bowel large polyps in PJS pts was useful to avoid gastrointestinal bleeding and emergency laparotomy due to intestinal intussuscep-tions. No gastrointestinal tumors were found in sub-sequent enteroscopic surveillance in all seven pts. In order surveillance, all pts received WCE, upper en-doscopy, ileocolonoscopy every 2 years. No pts had extraintestinal malignant lesions. SBE was performed when WCE was positive for significant polyps(> 15 mm).CONCLUSION: The effective of prophylactic polyp-ectomy of small bowel large polyps(> 15 mm) could be the first line treatment for conservative approach in management of PJS patients. | Torroni F Romeo E Rea F De Angelis P Foschia F Faraci S Federici di Abriola G Contini AC Caldaro T Dall’Oglio L | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 5 | Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children显示文摘AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in children.METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was needed.CONCLUSION: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in | Sabrina Cardile Massimo Martinelli Arrigo Barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 6 | Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease显示文摘 | Elena Centis Simona Moscatiello Elisabetta Bugianesi Stefano Bellentani Anna Ludovica Fracanzani Simona Calugi Salvo Petta Riccardo Dalle Grave Giulio Marchesini | 2012 | Journal of Hepatology2012，，： | 5 |
| 7 | Plant community and ecological analysis of woodland vegetation in Metema Area,Amhara National Regional State,Northwestern Ethiopia显示文摘We studied woodland vegetation in broad-leaved deciduous woodlands of Metema in northwestern Amhara regional state,Ethiopia to determine plant community types and species distribution patterns and their relationships with environmental variables,including altitude,pH,cation exchange capacity,electrical conductivity(EC),and moisture.We used a selective approach with a systematic sampling design.A total of 74 quadrats,each 25m × 25m at intervals of 150 200 m were sampled along the established transect lines.For herbaceous vegetation and soil data collection,five subquadrats each 1m × 1m were established at the four corners and the center of each quadrat.Three community types were identified using TWINSPAN analysis.All three community types showed high diversity(Shannon-Weiner index),the highest in community type II at 3.55.The highest similarity coefficient was 0.49(49%) between community types II and III,reflecting 0.51(51%) dissimilarity in their species richness.The canonical correspondence ordination diagram revealed that the distribution pattern of community type I was explained by moisture while that of community types III and II was explained by EC and altitude and moisture,respectively.Altitude was the most statistically significant environmental variable,followed by moisture and EC in determining the total variation in species composition and distribution patterns while pH and cation exchange capacity were non significant.In conclusion,we recommend that any intervention should take into account these three discrete community types and their environmental settings to make the intervention more successful. | Haile Adamu Wale Tamrat Bekele Gemedo Dalle | 2012 | Journal of Forestry Research2012，23，4： | 5 |
| 8 | Floristic diversity, regeneration status, and vegetation structure of woodlands in Metema Area, Amhara National Regional State, North-western Ethiopia显示文摘We studied woodland vegetation in broad-leaved deciduous woodlands of Metema in northwestern Amhara regional state, Ethiopia Our objective was to describe plant species composition, diversity, regeneration status, and population structure by a selective approach with asystematic sampling design. A total of 74 quadrats (each for 25 m × 25 m,spaced at intervals of 150 200 m) were sampled along established transect lines following the homogeneity of the vegetation. Vegetation data including cover-abundance, height, diameter at breast height (DBH), and numbers of seedlings and saplings of woody species were analyzed using Excel spreadsheet, Shannon Weiner diversity index, and PAST version 1.62. A total of 87 vascular plant species of 74 genera and 36 families were recorded. The dominant family was Fabaceae represented by 16(18.39 %) species of 13 genera. Shannon Weiner diversity and evenness were 3.67 and 0.82, respectively, which showed that the area was endowed with rich floral diversity evenly distributed. The vegetation structure, as quantified by cumulative diameter class frequency distribution,plotted as an interrupted inverted-J-shape pattern with a sharp decreasein the 2nd diameter class. This indicated poor vegetation structure. The diameter classes frequency distributions of selected species plotted infour general patterns i.e., interrupted Inverted-J-shape, J-shape,Bell-shape and Irregular-shape. In conclusion, although the area showedhigh floral diversity and evenness, woody species including Sterculea setigera, Boswellia papyrifera, and Pterocarpus lucens showed lowest recruitment of seedlings and saplings. | Haile Adamu Wale Tamrat Bekele Gemedo Dalle | 2012 | Journal of Forestry Research2012，23，3： | 4 |
| 9 | Hepatitis C virus reinfection after liver transplantation: Is there a role for direct antiviral agents?显示文摘Recurrence of hepatitis C virus(HCV)infection following liver transplantation(LT)is almost universal and can accelerate graft cirrhosis in up to 30%of patients.The development of effective strategies to treat or prevent HCV recurrence after LT remains a major challenge,considering the shortage of donor organs and the accelerated progression of HCV in LT recipients.Standard antiviral therapy with pegylated-interferon plus ribavirin is the current treatment of choice for HCV LT recipients,even though the combination is not as effective as it is in immunocompetent patients.A sustained virological response in the setting of LT improves patient and graft survival,but this is only achieved in 30%-45%of patients and the treatment is poorly tolerated.To improve the efficacy of pre-and post-transplant antiviral therapy,a new class of potent direct-acting antiviral agents (DAAs)has been developed.The aim of this review is to summarize the use of DAAs in LT HCV patients.PubMed,Cochrane Library,MEDLINE,EMBASE,Web of Science and clinical trial databases were searched for this purpose.To date,only three clinical studies on the topic have been published and most of the available data are in abstract form.Although a moderately successful early virological response has been reported,DAA treatment regimens were associated with severe toxicity mitigating their potential usefulness.Moreover,the ongoing nature of data,the lack of randomized studies,the small number of enrolled patients and the heterogeneity of these studies make the results largely anecdotal and questionable.In conclusion,large welldesigned clinical studies on DAAs in HCV LT patients are required before these drugs can be recommended after transplantation. | Marco Dall’Agata Annagiulia Gramenzi Maurizio Biselli Mauro Bernardi | 2014 | World Journal of Gastroenterology2014，20，28： | 4 |
| 10 | Incorporating spatial variation in housing attribute prices: a comparison of geographically weighted regression and the spatial expansion method显示文摘 | Christopher Bitter Gordon F. Mulligan Sandy Dall’erba | 2007 | Journal of Geographical Systems2007，，1： | 3 |
| 11 | 在胰腺的 pseudocyst 的管理的 Miniprobe EUS显示文摘 Pancreatic pseudocysts(PP) arise from trauma and pancreatitis;endoscopic gastro-cyst drainage(EGCD) under endoscopic ultrasonography(EUS) in symptomatic PP is the treatment of choice.Miniprobe EUS(MEUS) allows EGCD in children.We report our experience on MEUS-EGCD in PP,reviewing 13 patients(12 children;male:female = 9:3;mean age:10 years,4 mo;one 27 years,malnourished male Belardinelli-syndrome;PP:10 post-pancreatitis,3 post-traumatic).All patients underwent ultrasonography,computed tomography and magnetic resonance imaging.Conservative treatment was the first option.MEUS EGCD was indicated for retrogastric cysts larger than 5 cm,diameter increase,symptoms or infection.EGCD(stent and/or nasogastrocystic tube) was performed after MEUS(20-MHz-miniprobe) identification of place for diathermy puncture and wire insertion.In 8 cases(61.5%),there was PP disappearance;one,surgical duodenotomy and marsupialization of retro-duodenal PP.In 4 cases(31%),there was successful MEUS-EGCD;stent removal after 3 mo.No complications and no PP relapse in 4 years of mean followup.MEUS EGCD represents an option for PP,allowing a safe and effective procedure. | Paola De Angelis Erminia Romeo Francesca Rea Filippo Torroni Tamara Caldaro Giovanni Federici di Abriola Francesca Foschia Claudia Caloisi Vincenzina Lucidi Luigi Dall’Oglio | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 12 | Effect of housing conditions on production, carcass and meat quality traits of growing rabbits显示文摘 | Zs. Matics Zs. Szendr? M. Odermatt Zs. Gerencsér I. Nagy I. Radnai A. Dalle Zotte | 2013 | Meat Science2013，，： | 2 |
| 13 | Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy显示文摘 | Francesco S. Loffredo Matthew L. Steinhauser Steven M. Jay Joseph Gannon James R. Pancoast Pratyusha Yalamanchi Manisha Sinha Claudia Dall’Osso Danika Khong Jennifer L. Shadrach Christine M. Miller Britta S. Singer Alex Stewart Nikolaos Psychogios Robert | 2013 | Cell2013，，4： | 2 |
| 14 | The Role of Lifestyle Change in the Prevention and Treatment of NAFLD显示文摘 | Elena Centis Rebecca Marzocchi Alessandro Suppini Riccardo Dalle Grave Nicola Villanova Ingrid J Hickman Giulio Marchesini | 2013 | Current Pharmaceutical Design2013，，29： | 2 |
| 15 | Chronic pancreatitis as presentation of Crohn's disease in a child显示文摘It is reported that a pancreatic disease may precede the diagnosis of inflammatory bowel disease(IBD) both in children and in adults.Idiopathic chronic pancreatitis,however,occasionally co-exists with the IBD,mainly at pediatric age.We report a case of a patient who progressively developed the features of a chronic pancreatitis,before the diagnosis of Crohn's Disease(CD).Ten months after the onset of the first episode of pancreatitis the patient developed bloody diarrhea,mucus stools and biochemical findings of inflammation.The colonoscopy revealed a diffuse colitis without involvement of the last loop and the gastroscopy showed inflammation of the iuxta-papillary area.The histological findings confirmed the diagnosis of CD that involved the colon and the duodenum.In conclusion,in children the idiopathic chronic pancreatitis may be an unusual presentation of CD.Thus,if other known cause of chronic pancreatitis are not found,a not invasive work up to exclude the IBD should be warranted.An early coincidental diagnosis of the IBD may delay the progression of the pancreatic disease. | Daniela Knafelz Fabio Panetta Lidia Monti Fiammetta Bracci Bronislava Papadatou Giuliano Torre Luigi Dall'Oglio Antonella Diamanti | 2013 | World Journal of Gastroenterology2013，19，31： | 2 |
| 16 | Ectopic expression of the osteogenic master gene RUNX2 in melanoma显示文摘The transcription factor RUNX2 is the osteogenic master gene expressed in mesenchymal stem cells during osteogenic commitment as well as in pre-osteoblasts and early osteoblasts.However,RUNX2 is also ectopically expressed in melanoma and other cancers.Malignant melanoma(MM)is a highly metastatic skin cancer.The incidence of MM has increased considerably in the past half-century.The expression levels and mutation rates of genes such as BRAF,KIT,NRAS,PTEN,P53,TERT and MITF are higher in melanoma than in other solid malignancies.Additionally,transcription factors can affect cellular processes and induce cellular transformation since they control gene expression.Recently,several studies have identified alterations in RUNX2 expression.In particular,the regulation of KIT by RUNX2 and the increased expression of RUNX2 in melanoma specimens have been shown.Melanocytes,whose transformation results in melanoma,arise from the neural crest and therefore show'stemness'features.RUNX2 plays an important role in the re-activation of the MAPK and PI-3K/AKT pathways,thus endowing melanoma cells with a high metastatic potential.In melanoma,the most frequent metastatic sites are the lung,liver,brain and lymph nodes.In addition,bone metastatic melanoma has been described.Notably,studies focusing on RUNX2may contribute to the identification of an appropriate oncotarget in melanoma. | Maria Teresa Valenti Luca Dalle Carbonare Monica Mottes | 2018 | World Journal of Stem Cells2018，10，7： | 2 |
| 17 | T-lymphoblastic lymphoma with cutaneous involvement显示文摘To study dermatological manifestation of T-lymphoblastic lymphoma and to help clinicians in the diagnosis, we report here the case of a 75-year-old patient who presented with violaceous nodules acquired during the last 4 wk and affecting the scalp and right arm. The diagnosis of systemic lymphoma was suggested upon the appearance of cutaneous tumors, palpable lymph nodes and general symptoms including asthenia and weight-loss. The pathology features: positive immunostaining for CD3 and terminal deoxynucleotidyl transferase(Td T) and staging, led us to the final diagnosis of T-lymphoblastic lymphoma(T-LBL) with cutaneous involvement. He received a CHOP regimen as first-line treatment. Unfortunately, the patient relapsed and died 8 mo after the treatment initiation. T-LBL may be diagnosed by skin lesions. Additional immunostaining including Td T and experienced histopathologists are needed to correctly classify this aggressive disease and discuss the correct management including bone-marrow transplantation where appropriate. | Emmanuelle Ginoux Fanny Julia Brigitte Balme Luc Thomas Stéphane Dalle | 2015 | World Journal of Clinical Cases2015，3，8： | 2 |
| 18 | Effects of chronic administration of PPAR gamma ligand rosiglitazone in Cushing's disease显示文摘 | Ambrosi BM Dall A Asta C | 2004 | Eur J Endocrinol2004，151，2： | 1 |
| 19 | Relationship between water mobility and distribution and sensory attributes in pork slaughtered at an age between 90 and 180 days 显示文摘 | Hanne Christine Bertram Ida K Straadt Jens A Jensen Margit Dall Aaslyng | 2007 | Meat Science2007，77，： | 1 |
| 20 | Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts 显示文摘 | Lunghi PA Tabilio PP Dall' Aglio | 2003 | Leukemia2003，17，9： | 1 |
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