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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 2 |
| 3 | The hypothalamic-neurohypophyseal system:current and future treatment of vasopressin and oxytocyn related disorders显示文摘 | Calabro RS Italiano D Ferrara D | 2012 | Recent Pat Endocr Metab Immune Drug Discov2012，6，3： | 1 |
| 4 | Scab resistance in Pyrus germplasm 显示文摘 | Postman J D Spotts R A Calabro J | 2005 | Acta Horticultural2005，671，： | 1 |
| 5 | On the synthesis of two-di- mensional arrays with desirable correlation properties 显示文摘 | CALABRO D WOLF J K | 1968 | IEEE Information And Control1968，，11： | 1 |
| 6 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 1 |
| 7 | The role of platium in hexane isomerization over Pt/FeOy/WOx/ZO2显示文摘 | SANTIESTEBAN J G CALABRO D C VARTULI J C | 2001 | Journal of Catalysis2001，202，1： | 1 |
| 8 | On the synthesis of two-dimensional arrays with desirable correlation properties 显示文摘 | Calabro D Wolf J K | 1968 | IEEE Information and Control1968，，11： | 1 |
| 9 | Investigation of a novel cross-linked hyaluronan hydrogel for use as a sofrtissue filler显示文摘 | Chan J Darr A Alam D Calabro A | 2005 | Am J Cosmetic Surg2005，22，： | 1 |
| 10 | Accuracy of Armband Monitors for Measuring Daily Energy Expenditure in Healthy Adults显示文摘 | Johannsen D L Calabro M A Stewart J | 2010 | Medicine & Science in Sports & Exercise2010，42，11： | 1 |
| 11 | Coumarin anticoagulation during pregnancy in patients with mechanical valve prostheses显示文摘 | COTRUFOM D E LUCA T S CALABRO R | 1991 | Eur J Cardiothorac Surg1991，5，16： | 1 |
| 12 | Studies of synergistic and antagonisticcombinations of conventional cytotoxic agents with the multipleeicosanoid pathway modulator LY 293111显示文摘 | Budman D R Calabro A | 2004 | Anticancer Drugs2004，15，9： | 1 |
| 13 | Release of Protein in re- sponse to inflammatory Cytokines by human adipocytes显示文摘 | Calabro P Chang D Willerson JT | 2005 | J Am Coil Cardio2005，46，1： | 1 |
| 14 | On the synthesis of two-dimensional arrays with desirable correlation properties显示文摘 | D Calabro J K Wolf | 1968 | IEEE Information and Control1968，11，56： | 1 |
| 15 | No- vel methods for the preparation and characterization of hyaluronan oligosaccharides of defined length 显示文摘 | MAHONEY D J APLIN R T CALABRO A | 2001 | Gly- cobiology2001，11，12： | 1 |
| 16 | An RNA-binding chameleon显示文摘 | Smith C A Calabro V Frankel A D | 2000 | Mol Cell2000，6，5： | 1 |
| 17 | An acoustic-emission characterization of the failure modes in polymer-composite materials显示文摘 | M Giordano A Calabro C Esposito A D’Amore L Nicolais | 1998 | Composites Science and Technology1998，，12： | 1 |
| 18 | Release of Protein in response to inflammatory Cytokines by human adipocytes显示文摘 | Calabro P Chang D Willerson JT | | 0，，： | 1 |
| 19 | Release of C-reactive protein in re-sponse to inflammatory cytokines by human adipocytes显示文摘 | Calabro P Chang D Willerson JT | 2005 | J Am Coll Cardiol2005，46，： | 1 |
| 20 | Scab Resistance in Pyrus Germplasm显示文摘 | Postman J D Spotts R A Calabro J | 2005 | Acta Hort2005，671，： | 1 |
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