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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 2 |
| 3 | Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells显示文摘 | CALABRO P WILLERSON JT YEH ET | 2003 | Circulation2003，108，16： | 1 |
| 4 | The pleiotropic effects of statins显示文摘 | Calabro P Yeh ET | 2005 | Curr Opin Cardiol2005，20，6： | 1 |
| 5 | resist promotes smooth muscle cell proliferation through activation of extracelluar signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathway显示文摘 | Calabro P Samudio I Willerson JT | 2004 | Circulation2004，110，21： | 1 |
| 6 | Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase phosphstidylinositol 3-kinase pathways 显示文摘 | Calabro P Samudio I Willerson JT | 2004 | Circulation2004，110，21： | 1 |
| 7 | Obesity,inflammation,and vascular disease:the role of the adipose tissue as an endocrine organ显示文摘 | Calabro P Yeh ET | 2007 | Subcell Biochem2007，42，： | 1 |
| 8 | Greenhouse gases emission from municipal waste management: The role of separate collection 显示文摘 | Calabro P S | 2009 | Waste management2009，29，21： | 1 |
| 9 | Resistin promotes smooth muscle cell proliferation through activation of extracellular signal -regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways 显示文摘 | CALABRO P SAMUDIO I WILLERSON J T | 2004 | Circulation2004，110，： | 1 |
| 10 | Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells显示文摘 | Calabro P Willerson JT Yeh ET | 2003 | Circulation2003，108，16： | 1 |
| 11 | Release of C reactive protein in response to inflammatory cytokines by human adipo-cytes slinking obesity to vascular inflammation显示文摘 | Calabro P Chang DW Willerson JT | 2005 | J Am Coll Car-diol2005，46，10： | 1 |
| 12 | Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways显示文摘 | Calabro P Samudio I Willerson JT | 2004 | Circulation2004，110，： | 1 |
| 13 | Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells 显示文摘 | Calabro P Willerson JT Yeh ET | 2003 | Circulation2003，108，： | 1 |
| 14 | Resistin promotes smooth muscle cell proliferation through activation of extracellular signal- regulated kinasel/2 and phosphatidylinositol kinase path- ways显示文摘 | Calabro P Samudio I Willerson JT | 2004 | Circulation2004，110，21： | 1 |
| 15 | Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways显示文摘 | Calabro P Samudio I Willerson JT | 2004 | Circulation2004，110，： | 1 |
| 16 | Use and efficacy of saline hydration and N-acetyl cysteine to prevent contrast-induced ne- phropathy in low-risk populations undergoing coronary artery angi- ography显示文摘 | Calabro P Bianchi R Crisci M | 2011 | Intern Emerg Med2011，6，6： | 1 |
| 17 | The rutin/β- cyclodextrin interactions in fully aqueous solution:spectroscopic studies and biological assays显示文摘 | Calabro M L Tommasini S Donato P | 2005 | J Pharm Biomed Anal2005，36，5： | 1 |
| 18 | The pleiotropic effects of statins 显示文摘 | Calabro P Yeh ET | 2005 | Curr Opin Cardiol2005，20，6： | 1 |
| 19 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 1 |
| 20 | Clinical and economic ef- fects of central venous catheters on oncology patient care 显示文摘 | Console G Calabro C Nardulli P | 2007 | J Chemother2007，19，3： | 1 |
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