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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Effect of training systemrootstock, and cultivar on sweet cherry powdery mildew foliarinfections显示文摘 | Calabro J M Sports R A Grove G G | 2009 | HortScience2009，44，2： | 1 |
| 3 | Brain natriuretic peptide and other risk markers for outcome assessment in patients with non-ST elevation coronary syndromes and preserved systolic function显示文摘 | Calabro A | 2006 | AM J Cardiol2006，98，： | 1 |
| 4 | Dynamic Strain Measurements by Fiber Bragg Grating Sensor显示文摘 | Cusano A Cutolo A Nasser J Giordano M Calabro A | 2004 | Sensors and Actuators2004，110，： | 1 |
| 5 | Silk-based biomaterials显示文摘 | Ahman GH Diaz F JAKUBA C Calabro T Horan RL Chen J | 2003 | Biomaterials2003，24，3： | 1 |
| 6 | Resistin promotes smooth muscle cell proliferation through activation of extracellular signal -regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways 显示文摘 | CALABRO P SAMUDIO I WILLERSON J T | 2004 | Circulation2004，110，： | 1 |
| 7 | Scab resistance in Pyrus germplasm 显示文摘 | Postman J D Spotts R A Calabro J | 2005 | Acta Horticultural2005，671，： | 1 |
| 8 | On the synthesis of two-di- mensional arrays with desirable correlation properties 显示文摘 | CALABRO D WOLF J K | 1968 | IEEE Information And Control1968，，11： | 1 |
| 9 | Androgenic and estrogenic activity in water bodies receiving cattle feedlot effluent in easternnebraska,USA显示文摘 | Soto A M Calabro J M Preehtl N V | 2004 | Environmental Health Perspectives2004，112，： | 1 |
| 10 | Brain natriuretic peptide and other risk markers for out come assessment in patients with non-ST elevation coronary syn- dromes and preserved systolic function显示文摘 | Palazzuoli Adeckers J Calabro A | 2006 | AN1 J Cardiol2006，98，： | 1 |
| 11 | The role of platium in hexane isomerization over Pt/FeOy/WOx/ZO2显示文摘 | SANTIESTEBAN J G CALABRO D C VARTULI J C | 2001 | Journal of Catalysis2001，202，1： | 1 |
| 12 | On the synthesis of two-dimensional arrays with desirable correlation properties 显示文摘 | Calabro D Wolf J K | 1968 | IEEE Information and Control1968，，11： | 1 |
| 13 | Investigation of a novel cross-linked hyaluronan hydrogel for use as a sofrtissue filler显示文摘 | Chan J Darr A Alam D Calabro A | 2005 | Am J Cosmetic Surg2005，22，： | 1 |
| 14 | Accuracy of Armband Monitors for Measuring Daily Energy Expenditure in Healthy Adults显示文摘 | Johannsen D L Calabro M A Stewart J | 2010 | Medicine & Science in Sports & Exercise2010，42，11： | 1 |
| 15 | Resis- tin promotes smooth muscle cell proliferation through activa- tion of extracellular signal - regulated kinase 112 and phos- phatidylinodtol 3-kinase pathways显示文摘 | CALABRO P SAMUDIO I Wit LRSON J T | 2004 | Circulation2004，110，21： | 1 |
| 16 | Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronanmediated transformation of epithelium to mesenchyme 显示文摘 | Camenisch TD Spicer AP Brehm-Gibson T Biestedeldt J Auqustine ML Calabro A Jr | 2000 | J Clin Invest2000，106，3： | 1 |
| 17 | Scab resistance in Pyrus germplasm 显示文摘 | Postman JD Spotts RA Calabro J | 2000 | Acta Hort2000，671，： | 1 |
| 18 | Brain natri- uretic pep tideand other risk markers for outcome assessment in pa- tients with non - ST - elevation coronary syndromes and preserved systolic function显示文摘 | PALAZZUOLI A DECKERS J CALABRO A | 2006 | Am J Cardiol2006，28，10： | 1 |
| 19 | On the synthesis of two-dimensional arrays with desirable correlation properties显示文摘 | D Calabro J K Wolf | 1968 | IEEE Information and Control1968，11，56： | 1 |
| 20 | Brain natriuretic peptide and other risk markers for outcome assessment in patients with non-ST elevation coronary syndromes and preserved systolic function 显示文摘 | Palazzuoli Adeckers J Calabro A | 2006 | AM J Cardiol2006，98，： | 1 |
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