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2篇 您的检索式:作者名="Fabio Turco"
    题名 作者 年代 出处 被引量
1S100B protein in the gut:The evidence for enteroglial-sustained intestinal inflammation显示文摘Glial cells in the gut represent the morphological and functional equivalent of astrocytes and microglia in the central nervous system (CNS). In recent years, the role of enteric glial cells (EGCs) has extended from that of simple nutritive support for enteric neurons to that of being pivotal participants in the regulation of inflammatory events in the gut. Similar to the CNS astrocytes, the EGCs physiologically express the S100B protein that exerts either trophic or toxic effects depending on its concentration in the extracellular milieu. In the CNS, S100B overexpression is responsible for the initiation of a gliotic reaction by the release of pro-inflammatory mediators, which may have a deleterious effect on neighboring cells. S100B-mediated pro-inflammatory effects are not limited to the brain: S100B overexpression is associated with the onset and maintenance of inflammation in the human gut too. In this review we describe the major features of EGCs and S100B protein occurring in intestinal inflammation deriving from such.Carla Cirillo Giovanni Sarnelli Giuseppe Esposito Fabio Turco Luca Steardo Rosario Cuomo 2011World Journal of Gastroenterology2011,17,10:16
2Treatment intensification for metastatic prostate cancer: New treatment landscapes in androgen deprivation-based therapy显示文摘1|BACKGROUND Since 2004,the treatment landscape of metastatic prostate cancer(mPC)has significantly changed.When added to androgen deprivation therapy(ADT),many treatments demonstrated to improve overall survival(OS)of mPC patients both in hormone-sensitive(mHSPC)[1]and castration-resistant(mCRPC)setting[2].With multiple available options,therapy selection and the optimal treatment sequence are currently crucial clinical challenges.Fabio Turco Marcello Tucci Marco Donatello Delcuratolo Rosario Francesco Di Stefano Chiara Pisano Alessandro Audisio Marco Audisio Antonio Ungaro Cinzia Ortega Massimo Di Maio Giorgio Vittorio Scagliotti Consuelo Buttigliero 2022Cancer Communications2022,42,8:0
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