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38篇 您的检索式:作者名="Crofts F"
    题名 作者 年代 出处 被引量
1p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson 2011Cell Research2011,21,4:3
2Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) path- way: yon Hippel-Lindau disease and HIF-2alpha gain-of-function mutation显示文摘Fonnenti F Beer PA Croft QP 2011Faseb J2011,25,6:1
3The Protein-sparing effect of carbohydrate 显示文摘Fuller M F Crofts R M J 1977British J Nutr1977,38,03:1
4Functional significance of different human CYP1A1 genotypes显示文摘CROFTS F TAIOLI E TRACHMAN J 1994Carcinogenesis1994,15,12:1
5Relationship between genotype and function of the human CYP1A1 gene 显示文摘COSMA G CROFTS F TAIOLI E 1993J Toxicol Environ Health1993,40,23:1
6Ac-celerated high - yield generation of limb - innervating 显示文摘Mackenzie W Amoroso Gist F Croft Damian J Williams 2013J Neuros-ci2013,33,2:1
7Clinical targeting of the TNF and TNFR superfamilies 显示文摘Croft M Benedict C A Ware C F 2013Nat Rev Drug Discov2013,12,2:1
8A novel CYP1A1 gene polymorphism in African-Americans 显示文摘Crofts F Cosma GN Currie D 1993Carcinogenesis1993,14,9:1
9Formulation and biopharmaceutical issues in the development of drug delivery systerns for antiparasitic drugs显示文摘 Olbrich C Croft SL Kiderlen A F 2003Parasitol Res2003,90,2:1
10Racial differences in CYP1A1 genotype and function 显示文摘Taioli E Crofts F Trachman J 1995Toxicol Lett1995,77,1:1
11Maturation of spinalmotor neurons derived from human embryonic stemcells显示文摘Takazawa T Croft G F Amoroso M W Studer L Wichterle H Macdermott A B 2012PLoS One2012,7,:1
12Natural products as potential antiparasitic drugs 显示文摘KAYSER O KIDERLEN A F CROFT S L 2002Stud Nat Prod Chem2002,26,:1
13An Mrican-American specific CYPIAI polymorphism is associated with adenocarcinoma of the lung显示文摘Taioli E Crofts F Demopoulos R 1995Cancer Res1995,55,:1
14A novel CYP1A1 gene polymorphisms in African-Americans显示文摘Crofts F Casma GN Currie D 1993Carcinogenesis1993,14,9:1
15On the correction of residual stress measurement obtained using the center-hole method显示文摘Scaramangas A Poter Croft F D 1982strain1982,18,3:1
16Racial differences in CYP1A1 genotype and function显示文摘Taioli E Crofts F tranchman J 1995Toxicol Lett1995,77,1:1
17Validation of a PETE timing model for the oriental fruit moth in Michigan and central California (Lepidoptera: Oleth- reutidae) 显示文摘Croft B A Michels M F Rice R E 1980Great Lakes Entomologist1980,13,4:1
18Functional significance of different human CYP1A1 genotypes显示文摘Crofts F Taioli E Trachman J 1994Cancinogenesis1994,15,12:1
19The Chlamydomonas genome reveals the evolution of key animal and plant functions 显示文摘Merchant S S Prochnik S E Vallon O Harris E H Karpowicz S J Witman G B Terry A Salamov A Fritz-Laylin L K Marechal- Drouard L Marshall W F Qu L H Nelson D R Sanderfoot A A Spalding M H Kapitonov V V Ren Q Ferris P Lindquist E Shapiro H Lucas S M Grimwood J Schmutz J Cardol P Cerutti H Chanfreau G Chen C L Cognat V Croft M T Dent R Dutcher S Fernandez E Fukuzawa H Gonzalez-Ballester D Gonzalez-Halphen D Hallmann A Hanikenne M Hippler M Inwood W Jabbari K Kalanon M Kuras R Lefebvre P A Lemaire S D Lobanov A V Lohr M Manuell A Meier I Mets L Mittag M Mittelmeier T Moroney J V Moseley J Napoli C Nedelcu A M Niyogi K Novoselov S V Paulsen I T Pazour G Purton S Ral J P Riano-Pachon D M Riekhof W Rymarquis L Schroda M Stern D Umen J Willows R Wilson N Zimmer S LAllmer J Balk J Bisova K Chen C J Elias M Gendler K Hauser C Lamb M R Ledford H Long J C Minagawa J Page M D Pan J Pootakham W Roje S Rose A Stahlberg E Terauchi A M Yang P Ball S Bowler C Dieckmann C L GIadyshev V N Green P Jorgensen R Mayfield S Mueller-Roeber B Rajamani S Sayre R T Brokstein P Dubchak I Goodstein D Hornick L Huang Y W Jhaveri J Luo Y Martinez D Ngau W C Otillar B Poliakov A Porter A Szajkowski L Werner G Zhou K Grigoriev I V Rokhsar D S Grossman A R 2007Science2007,318,5848:1
20Functional significance of different human CYP1A1 genotypes显示文摘 Taioli E Trachman J 1994Carcinogenesis1994,15,15:1
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