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| 1 | Characterisation and seasonal variations of particles in the atmosphere of rural, urban and industrial areas:Organic compounds显示文摘Atmospheric aerosol samples(PM_(2.5–0.3), i.e., atmospheric particles ranging from 0.3 to2.5 μm) were collected during two periods: spring–summer 2008 and autumn–winter 2008–2009, using high volume samplers equipped with cascade impactors. Two sites located in the Northern France were compared in this study: a highly industrialised city(Dunkirk) and a rural site(Rubrouck). Physicochemical analysis of particulate matter(PM) was undertaken to propose parameters that could be used to distinguish the various sources and to exhibit seasonal variations but also to provide knowledge of chemical element composition for the interpretation of future toxicological studies. The study showed that PM2.5–0.3concentration in the atmosphere of the rural area remains stable along the year and was significantly lower than in the urban or industrial ones, for which concentrations increase during winter.High concentrations of polycyclic aromatic hydrocarbons(PAHs), dioxins, furans and dioxin like polychlorinated biphenyls(DL-PCBs), generated by industrial activities, traffic and municipal wastes incineration were detected in the samples. Specific criteria like Carbon Preference Index(CPI) and Combustion PAHs/Total PAHs ratio(CPAHs/TPAHs) were used to identify the possible sources of atmospheric pollution. They revealed that paraffins are mainly emitted by biogenic sources in spring–summer whereas as in the case of PAHs, they have numerous anthropogenic emission sources in autumn-winter(mainly from traffic and domestic heating). | Fabrice Cazier Paul Genevray Dorothée Dewaele Habiba Nouali Anthony Verdin Frédéric Ledoux Adam Hachimi Lucie Courcot Sylvain Billet Saad Bouhsina Pirouz Shirali Guillaume Garcon Dominique Courcot | 2016 | Journal of Environmental Sciences2016，28，6： | 4 |
| 2 | PM_(2.5) source apportionment in a French urban coastal site under steelworks emission influences using constrained non-negative matrix factorization receptor model显示文摘The constrained weighted-non-negative matrix factorization(CW-NMF) hybrid receptor model was applied to study the influence of steelmaking activities on PM_(2.5)(particulate matter with equivalent aerodynamic diameter less than 2.5 μm) composition in Dunkerque,Northern France. Semi-diurnal PM_(2.5)samples were collected using a high volume sampler in winter 2010 and spring 2011 and were analyzed for trace metals, water-soluble ions, and total carbon using inductively coupled plasma – atomic emission spectrometry(ICP-AES),ICP- mass spectrometry(ICP-MS), ionic chromatography and micro elemental carbon analyzer. The elemental composition shows that NO_3^-, SO_4^(2-), NH_4^+and total carbon are the main PM_(2.5)constituents. Trace metals data were interpreted using concentration roses and both influences of integrated steelworks and electric steel plant were evidenced. The distinction between the two sources is made possible by the use Zn/Fe and Zn/Mn diagnostic ratios. Moreover Rb/Cr, Pb/Cr and Cu/Cd combination ratio are proposed to distinguish the ISW-sintering stack from the ISW-fugitive emissions. The a priori knowledge on the influencing source was introduced in the CW-NMF to guide the calculation. Eleven source profiles with various contributions were identified: 8 are characteristics of coastal urban background site profiles and 3 are related to the steelmaking activities. Between them,secondary nitrates, secondary sulfates and combustion profiles give the highest contributions and account for 93% of the PM_(2.5)concentration. The steelwork facilities contribute in about 2%of the total PM_(2.5)concentration and appear to be the main source of Cr, Cu, Fe, Mn, Zn. | Adib Kfoury Frederic Ledoux Cloe Roche Gilles Delmaire Gilles Roussel Dominique Courcot | 2016 | Journal of Environmental Sciences2016，28，2： | 3 |
| 3 | Influence of ship emissions on NOx, SO2, O3 and PM concentrations in a North-Sea harbor in France显示文摘The influence of in-port ship emissions on gases and PM_(10) concentrations has been estimated in the port city of Calais, northern France, one of the busiest harbor in Europe,with numerous rotations of ferries or roll-on/roll-off cargo in average per day. NO_x, SO_2, O_3 and PM_(10) concentrations were continuously measured over a three-month period, as well as real-time particle size distribution. A rural site located at Cape Gris-Nez, 20km from Calais, was considered to deduce intrinsic contribution of ship emissions at the harbor city.The average concentrations of the studied species as well as the pattern of the conditional bivariate probability function at the two sites evidenced that in-port shipping, especially during the maneuvering operations, has an important influence on the NO_xand SO_2 concentrations. The impact of shipping in the harbor of Calais on average concentrations was estimated to 51% for SO_2, 35% for NO, 15% for NO_2 and 2% for PM_(10) in the studied period.Concentration peaks of SO_2 and NO_x associated with an O_3 depletion appeared synchronized with departures and arrivals of ferries. For winds blowing from the harbor,when compared to the background level, the number of particles appeared 10 times higher,with the highest differences in the 30–67nm and the 109–167 nm size ranges. The average impact of in-port ships on PM310 concentrations was estimated to + 28.9 μg/mand concerned mainly the PM1 size fraction(40%). Punctually, PM_(10) can potentially reach a concentration value close to 100 μg/m^3. | Frederic Ledoux Cloe Rochet Fabrice Cazier Charles Beaugard Dominique Courcot | 2018 | Journal of Environmental Sciences2018，30，9： | 2 |
| 4 | miR-199a-5p is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibrohlast activation by tar- geting caveolin-l显示文摘 | Lino Cardenas CL Henaoui IS Courcot E | 2013 | PLoS Genet2013，9，10： | 1 |
| 5 | Potential of Supported Copper and Potassium Oxide Catalysts in the Combustion of Carbonaceous Particles显示文摘 | D. Courcot C. Pruvost E. A. Zhilinskaya A. Abouka?s | 2004 | Kinetics and Catalysis2004，，4： | 1 |
| 6 | TEMPORAL-SPATIAL VARIATIONS OF THE PHYSICOCHEMICAL CHARACTERISTICS OF AIR POLLUTION PARTICULATE MATTER (PM 2.5-0.3 ) AND TOXICOLOGICAL EFFECTS IN HUMAN BRONCHIAL EPITHELIAL CELLS (BEAS-2B)显示文摘 | Mona Dergham Capucine Lepers Anthony Verdin Fabrice Cazier Sylvain Billet Dominique Courcot Pirouz Shirali Guillaume Gar?on | 2014 | Environmental Research2014，，： | 1 |
| 7 | MiR-199a-5p is upregulated during fibrogenicresponse to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targetingcaveolin-1显示文摘 | Lino Cardenas CL Henaoui IS Courcot E | 2013 | PLoS Genet2013，9，10： | 1 |
| 8 | PM_(2.5)characterization of primary and secondary organic aerosols in two urban-industrial areas in the East Mediterranean显示文摘Primary and secondary organic aerosols in PM_(2.5)were investigated over a one-year campaign at Zouk Mikael and Fiaa,Lebanon.The n-alkanes concentrations were quite similar at both sites(26-29 ng/m^(3))and mainly explained by anthropogenic emissions rather than natural ones.The concentrations of total Polycyclic Aromatic Hydrocarbons(PAHs)were nearly three times higher at Zouk Mikael(2.56 ng/m^(3))compared to Fiaa(0.95 ng/m^(3)),especially for indeno[1,2,3-c,d]pyrene linked to the presence of the power plant.A characteristic indeno[1,2,3-c,d]pyrene/(indeno[1,2,3-c,d]pyrene+benzo[g,h,i]perylene)ratio in the range0.8-1.0 was determined for heavy fuel oil combustion from the power plant.Fatty acids and hopanes were also investigated and were assigned to cooking activities and vehicular emissions respectively.Phthalates were identified for the first time in Lebanon with high concentrations at Zouk and Fiaa(106.88 and 97.68 ng/m^(3) respectively).Moreover,the biogenic secondary aerosols revealed higher concentrations in summer.The total terpene concentration varied between 131 ng/m^(3) at Zouk Mikael in winter to 469 ng/m3 at Fiaa in summer.Additionnally,the concentrations of the dicarboxylic acids especially for adipic and phthalic acids were more influenced by anthropogenic sources.The analysis of molecular markers and diagnostic ratios indicated that the sites were strongly affected by anthropogenic sources such as waste open burning,diesel private generators,cooking activities,road transport,power plant,and industrial emissions.Moreover,results showed different pattern during winter and summer seasons.Whereas,higher concentrations of biogenic markers were clearly encountered during the summer period. | Marc Fadel Frédéric Ledoux Mariana Farhat Adib Kfoury Dominique Courcot Charbel Afif | 2021 | Journal of Environmental Sciences2021，33，3： | 1 |
| 9 | miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1显示文摘 | LINO CARDENAS C L HENAOUI I S COURCOTE | 2013 | PLoS Genet2013，9，10： | 1 |
| 10 | Identification of vanadium oxide species and trapped single electrons in interaction with the CeVO4 phase in vanadium?cerium oxide systems:51V MAS NMR,EPR,Raman,and thermal analysis studies显示文摘 | MATTA J COURCOT D ABI-AAD E ABOUKAIS A | 2002 | Chem Mater2002，14，10： | 1 |
| 11 | Structural and vibrational study of 6-and 6-显示文摘 | COURCOT B BRIDGEMAN A J | 2009 | The Journal of Physical Chemistry A2009，113，10： | 1 |
| 12 | Crystal and electronicstructures of magnesium(II),copper(II),and mixed magnesium(II)-copper(II)complexes of the quinoline half of styrylquinoline-type HIV-1integrase inhibitors显示文摘 | Courcot B Firley D Fraisse B | 2007 | J Phys Chem B2007，111，21： | 1 |
| 13 | Chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells显示文摘Particulate matter in ambient air constitutes a complex mixture of fine and ultrafine particles composed of various chemical compounds including metals, ions, and organics. A multidisciplinary approach was developed by studying physico-chemical characteristics and mechanisms involved in the toxicity of particulate atmospheric pollution. PM_(0.3–2.5) and PM_(2.5) including ultrafine particles were sampled in Dunkerque, a French industrialized seaside city. PM samples were characterized from a chemical and toxicological point of view. Physicochemical characterization evidenced that PM_(2.5) comes from several sources: natural ones, such as soil resuspension and marine sea-salt emissions, as well as anthropogenic ones, such as shipping traffic, road traffic, and industrial activities. Human BEAS-2 B lung cells were exposed to PM_(0.3–2.5), or to the Extractable Organic Matter(EOM) of PM_(0.3–2.5) and PM_(2.5). These exposures induced several mechanisms of action implied in the genotoxicity, such as oxidative DNA adducts and DNA Damage Response. The toxicity of PM-EOM was higher for the sample including the ultrafine fraction(PM_(2.5)) containing also higher concentrations of polycyclic aromatic hydrocarbons. These results evidenced the major role of organic compounds in the toxicity of PM. | Sylvain Billet Yann Landkocz Perrine J. Martin Anthony Verdin Frederic Ledoux Capucine Lepers Veronique Andre Fabrice Cazier Francois Sichel Pirouz Shirali Pierre Gosset Dominique Courcot | 2018 | Journal of Environmental Sciences2018，30，9： | 1 |
| 14 | Heavy metals in four fish species from the French coast of the Eastern English Channel and Southern Bight of the North Sea 显示文摘 | Henry F Amara R Courcot L | 2004 | Environment Inemational2004，30，： | 1 |
| 15 | Heavy metals in four fish species feom the French coast of the eastern English Channel and Southern Bight of the North Sea显示文摘 | Henry F Amara R Courcot L | 2004 | Environmental International2004，30，5： | 1 |
| 16 | miR-199a-5p is upregulated during fibrogenic response to tissueinjury and mediates TGFg-induced lung fibroblast activationby targeting caveolin-l显示文摘 | Lino Cardenas C L Henaoui I S Courcot E | 2013 | PLoS Genet2013，9，10： | 1 |
| 17 | Catalysts for NOx Selective Catalytic Reduction by hydrocarbons (HC-SCR)显示文摘 | Raya Mrad Aissa Aissat Renaud Cousin Dominique Courcot Stéphane Siffert | 2014 | Applied Catalysis A, General2014，，： | 1 |
| 18 | Electronic Properties of 3, 3' - Dimethyl - 5, 5' - bis (1, 2, 4 - triazine): Towards Design of Supramolecular Arrangements of N - Hetero- cyclic CuI Complexes 显示文摘 | Courcot B Tran D N Fraisse B | 2007 | Chemistry-A European Journal2007，13，12： | 1 |
| 19 | miR-199a-5p Is upregulated during fibrogcnic response to tissue injury and medi- ates TGFbeta-induced lung fibroblast activation by targeting caveo- lin-1 显示文摘 | Lino Cardenas CL Henaoui IS Courcot E | 2013 | PLoS Genet2013，9，10： | 1 |
| 20 | miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1显示文摘 | Lino CC Henaoui IS Courcot E | 2013 | PLoS Genet2013，9，10： | 1 |
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