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| 1 | Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors显示文摘Cysteine proteases continue to provide validated targets for treatment of human diseases.In neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhibitors,notably caspases,calpains,and cathepsins.The reactive,active-site cysteine provides specificity for many inhibitor designs over other families of proteases,such as aspartate and serine;however,a)inhibitor strategies often use covalent enzyme modification,and b)obtaining selectivity within families of cysteine proteases and their isozymes is problematic.This review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversible,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy. | Marton Siklos Manel Ben Aissa Gregory R.J.Thatcher | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 11 |
| 2 | Effective capacity for interference and delay constrained cognitive radio relay chan- nels 显示文摘 | L Musavian S S Aissa S Lambotharan | 2010 | IEEE Trans Wireless Commun2010，9，5： | 1 |
| 3 | Effects of Sur- face Treatments on Photoelectric Work Function of Sil- ver-nickel Alloys显示文摘 | Mohamed A Aissa B Mahdjoub F T | 2014 | Vacuum2014，101，： | 1 |
| 4 | The use of acetylcholinesterase activity in Ruditapes decussatus and Mytilus galloprovincialis in the biomonitoring of Bizerta lagoon显示文摘 | Mohamed Dellali Mauricette Gnassia Barelli Michèle Romeo Patricia Aissa | 2001 | Comparative Biochemistry and Physiology, Part C2001，，2： | 1 |
| 5 | Resource Management in Spectrum-Sharing Cognitive Radio Broadcast Channels: Adaptive Time and Power AIlocation显示文摘 | ASGHARI V AISSA S S | 2011 | IEEE Transactions on Communications2011，59，5： | 1 |
| 6 | Cooperative Dual-hop Relaying Systems with Beamforming over Nakagami - m Fading Channels 显示文摘 | Costa D B da Aissa S | 2009 | IEEE Transactions on Wireless Communications2009，8，8： | 1 |
| 7 | Insulin-like growth factor-binding protein 1 and blood rheology in athletes显示文摘 | AISSA BENHADDAD A MONNIER J F | 2002 | Clin Hemorheol Microcirc2002，26，3： | 1 |
| 8 | Leakage based precoding for multi-user MIMO-OFDM systems 显示文摘 | SADEK U M AISSA S | 2010 | IEEE Transaction on Wireless Communication2010，8，： | 1 |
| 9 | On the BER performance of space-frequency block coded OFDM systems in fading MIMO channels显示文摘 | TORABI M AISSA S SOLEYMANI M R | 2007 | IEEE Trans Wireless Commun2007，6，4： | 1 |
| 10 | On the BER performance of space-frequency block coded OFDM systems in fading MIMO channels 显示文摘 | TORABI M~ AISSA S SOLEYMANI M R | 2008 | IEEE Transac- tions on Wireless Communications2008，6，4： | 1 |
| 11 | Preparation and mechanical characterization of laser ablated single-walled carbon-nanotubes/polyurethane nanocomposite microbeams显示文摘 | Lebel L L Aissa B Khakani M A E | 2010 | Composites Science and Technology2010，70，3： | 1 |
| 12 | Soil microbial growth and biofilm expansion assessment under wastewater infiltration percolation treatment process: Column experiments 显示文摘 | Rajeb A B Kallali H Aissa N B et ol | 2009 | Desalination2009，246，： | 1 |
| 13 | Information-guided transmission in de- code-and-forward relaying systems: spatial exploitation and throughput enhancement显示文摘 | YANG Y AISSA S | 2011 | IEEE Trans Wirel Common2011，10，7： | 1 |
| 14 | Evaluation of a model for efficient sceening of tuberculosis contact subject s显示文摘 | Khaoula Aissa Fouad Madhi Nathalie Ronsin | | Am J Respir Crit Care Med0，177，： | 1 |
| 15 | Closed - Form Expressions for the Outage and Ergodic Shannon Capacity of MIMO MRC Systems显示文摘 | Maaref A Aissa S | 2005 | IEEE Transactions on Communications2005，53，7： | 1 |
| 16 | Carriage by the housefly (Musca domestica ) of multiple - antibiotic - resistant bacteria that are potentially pathogenic to humans, in hospital and other urban environments in Misurata, Libya显示文摘 | Rahuma N Ghenghesh K S Ben Aissa R | 2005 | Ann Trop Med Parasitol2005，99，8： | 1 |
| 17 | Equal gain combining for co- operative spectrum sensing in cognitive radio networks 显示文摘 | Hamza D Aissa S Aniba G | 2014 | IEEE Transactions on Wireless Communications2014，13，8： | 1 |
| 18 | Methionine concentration in the diet has a tissue-specific effect on chromosomal stability in female mice显示文摘 | Aissa A F Uraula H G T D Mara R | 2013 | Food and Chemical Toxicology2013，62，： | 1 |
| 19 | Removal of hazardous chlorinated VOCs over Mn-Cu mixed oxide based catalyst显示文摘 | Van H V Jamal B Aissa O D | 2009 | Journal of Hazardous Materials2009，169，： | 1 |
| 20 | Estimation of the Shape and Scale Pa- rameters of Pareto Distribution Using Ranked Set Sampling显示文摘 | WALID ABU-DAYYEH AISSA ASSRHANI KAMARUL ZAMAN IBRAHIM | 2013 | Statistical Papers2013，54，1： | 1 |
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