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| 1 | Bartter's syndrome:clinical findings,genetic causes and therapeutic approach显示文摘Backgound Bartter's syndrome(BS)is a rare group of salt losing tubulopathies due to the impairment of transport mecha-nisms at the thick ascending limb of the Henle's loop.Data sources Literature reviews and original research articles were collected from database,including PubMed and Scopus.Results According to the time of onset and symptoms,BS can be classified into antenatal and classic BS.Molecular studies have identified different subtypes of BS.BS types Ⅰ,Ⅱ and Ⅲ are caused by mutations on genes encoding the luminal Na^(+)-K^(+)-2Cl^(-) co-transporter,the luminal K+ channel ROMK,and the basolateral chloride channel ClC-Kb(CLCNKB),respectively.Loss-of-function mutations of Barttin CLCNK type accessory beta subunit cause BS type Ⅳa.Simultaneous mutations of CLCNKB and CLCNKA cause BS type Ⅳb.BS type Ⅴ consists in a novel transient form characterized by antenatal presentation due to mutations in the MAGE family member D2.Severe gain-of-function mutations of the extracellular calcium sensing receptor gene can result in an autosomal dominant condition of BS.Main clinical and biochemical alterations in BS include polyuria,dehydration,hypokalemia,hypochloremic metabolic alka-losis,hyperreninemia,high levels of prostaglandins,normal or low blood pressure,hypercalciuria and failure to thrive.Treatment focuses mainly at correcting dehydration and electrolyte disturbances and in measures to reduce polyuria,including the use of nonsteroidal anti-inflammatory medications to control excessive renal prostaglandin E2 production.Conclusions Early diagnosis and treatment of BS may prevent long-term consequences such as growth failure,nephrocal-cinosis and end-stage renal disease. | Flavia Cristina Carvalho Mrad Sílvia Bouissou Morais Soares Luiz Alberto Wanderley de Menezes Silva Pedro Versiani dos Anjos Menezes Ana Cristina Simoes-e-Silva | 2021 | World Journal of Pediatrics2021，17，1： | 10 |
| 2 | Use of rifaximin in gastrointestinal and liver diseases显示文摘Rifaximin is a broad spectrum oral antibiotic with antimicrobial activity against Gram-positive and Gramnegative aerobic and anaerobic bacteria. It is poorly absorbed and thus has a highly favorable safety profile. Rifaximin has been shown to be effective in the treatment of traveler's diarrhea, functional bloating and irritable bowel syndrome, small bowel bacterial overgrowth and in the prevention of recurrent overt hepatic encephalopathy. In addition, there is emerging evidence for a possible beneficial effect of rifaximin in the treatment of uncomplicated diverticular disease and in the prevention of recurrent diverticulitis. The use of rifaximin is associated with a low incidence of development, or persistence of spontaneous bacterial mutants. Moreover, the development of important drug resistance among extra-intestinal flora during rifaximin therapy is unlikely because of minimal systemic absorption and limited cross-resistance of rifaximin with other antimicrobials. This review addresses the current and emerging role of rifaximin in the treatment of gastrointestinal and liver disorders. | Rani H Shayto Rachel Abou Mrad Ala I Sharara | 2016 | World Journal of Gastroenterology2016，22，29： | 10 |
| 3 | A reliability study of springback on the sheet metal forming process under probabilistic variation of prestrain and blank holder force显示文摘This work deals with a reliability assessment of springback problem during the sheet metal forming process. The effects of operative parameters and material properties, blank holder force and plastic prestrain, on springback are investigated. A generic reliability approach was developed to control springback. Subsequently, the Monte Carlo simulation technique in conjunction with the Latin hypercube sampling method was adopted to study the probabilistic springback. Finite element method based on implicit/explicit algorithms was used to model the springback problem. The proposed constitutive law for sheet metal takes into account the adaptation of plastic parameters of the hardening law for each prestrain level considered. Rackwitz-Fiessler algorithm is used to find reliability properties from response surfaces of chosen springback geometrical parameters. The obtained results were analyzed using a multi-state limit reliability functions based on geometry compensations. | Hatem Mrad Mohamed Bouazara Gholamreza Aryanpour | 2013 | Acta Mechanica Sinica2013，29，4： | 4 |
| 4 | Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells显示文摘 | A. M. Madec R. Mallone G. Afonso E. Abou Mrad A. Mesnier A. Eljaafari C. Thivolet | 2009 | Diabetologia2009，，7： | 3 |
| 5 | ACTIVE VIBRATION SUPPRESSION VIA LINEARIZING HYSTERESIS OF PIEZOCERAMIC ACTUATORS显示文摘一种新奇活跃颤动控制技术根据线性化的压电的致动器被介绍。由到哪个是的一根伸臂横梁组成的一台试验性的仪器依附种类补丁和 piezoceramic 致动器被用于活跃颤动抑制被描述。伸臂的一个动态模型用 Lagrange 的方程微笑,二个坐标系统被介绍。基于 Lyapunov 的直接方法,有磁滞现象赔偿的一个活跃颤动控制器被设计。控制器被设计以便它保证全面系统的全球稳定性。开发的控制器试验性地被估计。 | HU Hong SHI Hongyan BEN MRAD Ridha | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 3 |
| 6 | The Modern Bowel Preparation in Colonoscopy显示文摘 | Ala I. Sharara Rachel Abou Mrad | 2013 | Gastroenterology Clinics of North America2013，，： | 2 |
| 7 | Primary broad ligament cystadenocarcinoma with mutinous component: a case report with immunohistochemical study显示文摘 | Mrad K Driss M Abdelmoula S | 2005 | Arch Pathol Lab Med2005，129，2： | 1 |
| 8 | Primary CD30/ALK-1 positive anaplastic large cell lymphoma of the skeletal muscle in a child显示文摘 | Driss M Abbes I Mrad K | | 0，，02： | 1 |
| 9 | Juvenile fibroadenoma of the breast: treatment and literature review 显示文摘 | Ng W K Mrad M A Brown M H | 2011 | Can J Plast Surg2011，19，3： | 1 |
| 10 | Design,modeling,and demonstration of a mems repulsive-force out-of-plane electrostatic micro actuator显示文摘 | HE S MRAD R B | 2008 | J Microelectromech Syst2008，17，3： | 1 |
| 11 | On amplification in inch- worm precision positioners显示文摘 | TENZER P E MRAD R B | 2004 | Mechatronics2004，14，5： | 1 |
| 12 | A Systematic Procedure for the Design of Pi-ezoelectric Inchworm Precision Positioners显示文摘 | PE Tenzer R B Mrad | 2004 | IEEE/ASME Trans-actions on Mechatronics2004，，9： | 1 |
| 13 | Methylenetetrahy-drofo- late reductase (C677T and A1298C) polymorphisms, hyperhomo- cysteinemia, and ischemic stroke in Tunisian patients显示文摘 | Fekih-Mrissa N Mrad M Klai S | 2013 | J Stroke Cerebrovasc Dis2013，22，4： | 1 |
| 14 | Experimental and numerical studies of the hydromechanical behaviour of a natural unsaturated swelling soil显示文摘 | NOWAMOOZ H MRAD M ABDALLAH A | 2009 | Canadian Geotechnical Journal2009，46，4： | 1 |
| 15 | Dynamic response of a horizontal axis wind turbine blade under aerodynamic, gravity and gyroscopic effects显示文摘 | HAMDI H MRAD C HAMDI A | 2014 | Applied Acoustics2014，86，： | 1 |
| 16 | Bilateral cystosarcoma phyllodes of the breast : a case report of malignant form with contralateral benign form 显示文摘 | Mrad K Driss M Maalej M | 2000 | Ann Diagn Pathol2000，4，6： | 1 |
| 17 | Discrete-time Compensation for Hysteresis in Piezoceramic Actuators显示文摘 | Mrad A | 2004 | Mechanical Syst Signal Processing2004，18，6： | 1 |
| 18 | Fiber optic sensors for structural health monitoring of air platforms显示文摘 | Guo H Xiao G Mrad N | 2010 | Sensors2010，11，： | 1 |
| 19 | On amplification in inchworm precision positioners显示文摘 | Mrad R Ben | 2004 | Mechatronics2004，14，： | 1 |
| 20 | Coronary angioplasty in small vessel disease: should all coronary small vessel lesions be stented 显示文摘 | De la Fuente LM Mrad JA | 1999 | J lnvasive Cardiol1999，11，6： | 1 |
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