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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | A contrast-enhanced ultrasound study of benign and malignant breast tissue 显示文摘 | Barnard S Leen E Cooke T | 2008 | S Mr Med J2008，98，5： | 1 |
| 3 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Science1999，41，3： | 1 |
| 4 | Mechanism of friction in rotating carbon nanotube bearings 显示文摘 | Cook E H Buehler M J Spakovszky Z S | 2013 | Journal of the Mechanics and Physics of Solids2013，61，2： | 1 |
| 5 | The effects of hardpan layers on the water chemistry, from the leaching of pyrrhotite-rich tailings material 显示文摘 | GILBERT S E COOKE D R HOLLINGS P | 2003 | Environmental Geology2003，44，： | 1 |
| 6 | The Effect of time Delay and Growth Rate Inhibition in the Bacterial Treatment of Wastewater显示文摘 | Bush A W Cook S E | 1975 | J Thoo- ret Biol1975，63，： | 1 |
| 7 | Incompetent perforating veins are associated with recurrent varicose veins显示文摘 | Rutherford E E Kianifard B Cook S J | | 0，，05： | 1 |
| 8 | Neutrophil- lymphocyte ratio as a prognostic factor in colorectal cancer显示文摘 | Walsh S R Cook E J Goulder F | 2005 | J Surg Oncol2005，91，3： | 1 |
| 9 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Scienee1999，41，9： | 1 |
| 10 | Self-processing 2A polyproteins-a system for co-ordinate expression of multiple pro teins in transgenic plants显示文摘 | Halpin C Cooke S E Barakate A | 1999 | J The Plant Joural1999，17，4： | 1 |
| 11 | Testing computer-controlled infusion pumps by simulation显示文摘 | SHAFER S L SIEGEL L C COOKE J E | 1988 | Anesthesiology1988，68，26： | 1 |
| 12 | Evaluation and outcome of emergency room patients with transient loss of consciousness显示文摘 | DAY S COOK E FUNKENSTEIN H | 1982 | Am J Med1982，73，： | 1 |
| 13 | Stability of meropenem in intravenous solutions显示文摘 | Patel P R Cook S E | 1997 | Am J Health Syst Pharm1997，54，4： | 1 |
| 14 | Stability of meropenem in intravenous solutions 显示文摘 | Patel P R Cook S E | 1997 | Am J Health Syst Pharm1997，54，15： | 1 |
| 15 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 16 | Further evidence for a possible role of conformation in the immunogenicity and antigenicity of the oxidative DNA lesion, 8-oxxo-2'-deoxyguanosine显示文摘 | Cooke M S Herbert K E and Butler P C | 1998 | Free Radical Research1998，28，： | 1 |
| 17 | Galactosylated polyethylenimine-graft-poly (vinylpyrrolidone) as a hepatocyte-targetinggene carrier 显示文摘 | COOK S E PARK I K KIM E M | 2005 | J Control Release2005，105，2： | 1 |
| 18 | Evaluation of alkaline phosphatase- and digoxigenin-labeled probes for detection of the thermolabile hemolysin (tlh) gene of Vibrio parahaemolyticus 显示文摘 | McCarthy S A DePaola A Cook D W Kaysner C A and Hill W E | 1999 | Letters in Applied Microbiology1999，28，： | 1 |
| 19 | Selective ring opening of naphthenic molecules显示文摘 | McVicker G B Daage M Touvelle M S Hudson C W Klein D P Baird W C Cook B R Chen J G Hantzer S Vaughan D E W Ellis E S Feeley O C | | 0，，01： | 1 |
| 20 | Cytomegalovirus quantitation by real-time PCR is unaffected by delayed separation of plasma from whole blood 显示文摘 | Nesbitl S E Cook L Jeronle K R | 2004 | J Clin Microbiol2004，42，3： | 1 |
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