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| 1 | Blood-testis barrier and spermatogenesis: lessons From genetically-modified mice显示文摘血睾丸障碍(BTB ) 在它在生精的试管为 meiotic 和 postmeiotic 细菌房间的发展和成熟创造唯一的微型环境的睾丸在邻近的 Sertoli 房间之间被发现。它是复合 proteinous 结构,包括紧密的连接(TJ ) 的房间连接的几种类型镇静,粘附连接和差距连接(GJ ) 。一些 junctional 蛋白质作为 BTB 的结构的蛋白质工作,一些有规章的角色。删除或编码这些蛋白质的基因的功能的 silencing 可以破坏 BTB,它可以引起到 meiotic 和 postmeiotic 房间的免疫学的或另外的损坏并且最终导致 spermatogenic 拘捕和不孕。在这评论,我们将在 BTB 结构上总结调查结果并且从遗传上修改的老鼠模型工作并且讨论未来观点。 | Xiao-Hua Jiang Ihtisham Bukhari Wei Zheng Shi Yin Zheng Wang Howard J Cooke Qing-Hua Shi | 2014 | Asian Journal of Andrology2014，16，4： | 9 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 4 | Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial显示文摘 | A Cuschieri V Joypaul P Fayers P Cook J Fielding J Craven J Bancewicz | 1996 | The Lancet . 1996 (9007)1996，，： | 2 |
| 5 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，： | 2 |
| 6 | 相对于男性,女性进行冠状动脉造影产生的额外的心血管病风险与严重受损的冠状动脉血流储备,而非阻塞性疾病相关显示文摘与男性相比,女性的心血管病死亡率更高,但是阻塞性冠状动脉疾病(coronary artery disease,CAD)在女性中不太普遍。冠状动脉血流储备(coronary flow reserve,CFR)是大、小血管CAD和心肌缺血的综合测量指标,可识别出具有心血管病死亡风险的患者,但其在临床实践中不是常规测量的指标。该研究试图调查性别、CFR和血管造影CAD严重程度对不良心血管事件的影响。 | 刘莉 叶鹏 Taqueti VR Shaw LJ Cook NR Murthy VL Shah NR Foster CR Hainer J Blankstein R Dorbala S Di Carli MF | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 7 | Venous thromboembolic disease: an obeervational study in medical- surgical intensive care unit patients显示文摘 | Cook D Atria J Weaver B | 2000 | J Crit Care2000，15，： | 2 |
| 8 | PGE1 suppresses macrophage infiltration and ameliorates injury in an experimental model of macrophages in anti-glomerulonephritis显示文摘 | Cattell V Suith J Cook H T | 1990 | Clin Exp Immunol1990，79，： | 2 |
| 9 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 10 | Corticosteroid treatment for sepsis:a critical appraisal and meta -analysis of the literature显示文摘 | Cronin L Cook D J Carlet J | 1995 | Crit Care Med1995，23，： | 2 |
| 11 | Rock mechanics ap - plied to the study of mckbursts 显示文摘 | Cook N G W Hook E Pretorious J P G | 1966 | J S Afr Inst Min Metall1966，66，10： | 1 |
| 12 | DEA models for supply chain efficiency evaluation显示文摘 | Liang L Feng Y Cook W D Zhu J | 2006 | Annals of Operations Research2006，145，1： | 1 |
| 13 | The CFRD 1899-1999 显示文摘 | Cooke J B | 1999 | International Journal on Hydropower & Darns1999，6，6： | 1 |
| 14 | Evaluation of a practice guideline for noninvasive positive pressure ventilation for acute respiratory failure显示文摘 | Sinuff T Cook Dj Randall J | 2003 | Chest2003，123，6： | 1 |
| 15 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 16 | Software process validation:quantitatively measuring the correspondence of a process to a model显示文摘 | WOLF A L | 1999 | ACM Transactions on Software Engineering and Methodology1999，8，2： | 1 |
| 17 | Prevention of ventilator associated pneumonia:Current practice in Canadian intensive care units显示文摘 | Heyland D K Cook D J Dodek P M | 2002 | J Crit Care2002，17，3： | 1 |
| 18 | Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis显示文摘 | Haake V Cook D Riechmann J L | 2002 | Plant Physiology2002，130，： | 1 |
| 19 | A case series of the use of the ProSeal laryngeal mask airway in emergency lower abdominal surgery显示文摘 | Fabregat-López J Garcia-Rojo B Cook TM | 2008 | Anaesthesia2008，63，9： | 1 |
| 20 | Ricin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 ℃显示文摘 | Mayerhofer P U Cook J P Wahlman J | 2009 | J Biol Chem2009，284，10： | 1 |
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