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| 1 | METAMORPHIC MECHANISMSAND THEIR CONFIGURATION MODELS显示文摘The concept of metamorphic mechanisms is presented, configuration models and configuration transformations relating to a set of new matrix operations are discussed and proposed. The configuration of a metamorphic mechanism reflects the connectivity change in the mechanism during motions which results in mobility change and presents the characteristics of the mechanism which is discussed in various applications particularly in decorative artifacts. The characteristics is further investigated with mobility analysis. | Dai Jiansheng (Department of Mechanical Engineering, School of Physical Sciences and Engineering, King’s College, University of London,Strand,London WC2R 2LS, United kingdom) Zhang Qixian (Robotics Research Institute,Beijing University of Aeronautics and | 2000 | Chinese Journal of Mechanical Engineering2000，13，3： | 61 |
| 2 | Magnetostratigraphy of the late Cenozoic Laojunmiao anticline in the northern Qilian Mountains and its implications for the northern Tibetan Plateau uplift显示文摘Cenozoic sediments in the foreland basin--Jiuquan Basin in west Hexi Corridor recorded tectonic uplift information of the Qilian Mountains. High resolution paleomagnetic dating of the Laojunmiao (LJM) section across the central LJM anticline in the southern Jiuquan Basin reveals ages of the Getanggou Member, Niugetao Member in the Shulehe Formation, the Yumen Conglomerate, Jiuquan Conglomerate and Gobi Formation at >13-8.3 Ma, 8.3-4.9 Ma, 3.66-0.93 Ma, 0.84-0.14 Ma and 0.14-0 Ma, respectively. Sedimentary evolution study suggests that the Qilian Mountains should begin to rise gradually since ~8-6.6 Ma, accompanied by sedimentary environments changing from lacustrine mudstones-sandstones to alluvial conglomerates. Rapid uplift of the Qilian Mountains began at ~3.66 Ma, followed by a series of stepwise or intermittent intensive uplifts at about <1.8-1.23 Ma, 0.93-0.84 Ma and 0.14 Ma, which finally resulted in the present high Qilian Mountains. | FANG Xiaomin1,2, ZHAO Zhijun3,2, LI Jijun2, YAN Maodu2, PAN Baotian2, SONG Chunhui2 & DAI Shuang2 1. Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100085, China 2. Key Laboratory of Western China’s Environmental Systems, Ministry of Education & College of Resources and Environment, Lanzhou University, Lanzhou 730000, China 3. College of Geography, Nanjing Normal University, Nanjing 210097, China | 2005 | Science China Earth Sciences2005，48，7： | 61 |
| 3 | 上海市15年妊娠合并心脏病的临床资料分析显示文摘目的:探讨妊娠合并心脏病的变化趋势。方法:对上海市10所教学医院1981~1995年住院分娩的妊娠合并心脏病患者的临床资料进行回顾性分析。结果:379065例分娩中,合并心脏病2680例,发病率为0.71%;死亡15例,病死率为0.56%,死亡专率为3.96/10万,占孕产妇总死亡数的12.40%。将15年分为1981~1985年、1986~1990年、1991~1995年3个时期观察,心脏病孕妇的死亡率分别占总死亡数的4.48%、22.86%及21.05%。先天性心脏病孕妇1333例,占49.74%;风湿性心脏病孕妇759例,占28.32%,前者与后者之比为1.761,从3个时期的资料来看,二者的比例分别为1.271,2.371及2.811。心功能Ⅰ级与Ⅱ级者共占妊娠合并心脏病患者总数的85.45%,发生心力衰竭者为7.60%。妊娠合并心脏病的围产儿死亡率为7.76‰。分娩方式常采用剖宫产。结论:妊娠合并心脏病至今仍是孕产妇死亡的主要原因之一。应建立孕前咨询中心,根据其心脏病种类及分型、心功能状况进行评分,以判定该患者能否妊娠。 | Luo Laimin, Dai Zhongying. Shanghai Sixth People’s Hospital, Shanghai 200233 | 1997 | 中华妇产科杂志1997，32，6： | 35 |
| 4 | Changed clinical aspects of primary liver cancer in China during the past 30 years显示文摘BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, which ensures a prognosis. | Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 20 |
| 5 | Influence of whole peptidoglycan of bifidobacterium on cytotoxic effectors produced by mouse peritoneal macrophages显示文摘INTRODUCTIONBifidobacteria are physiologically beneficial bacteria which are perdominant in human intestine ,and possess the most important functions .They play an important role in maintaining microbial balance of the intestine .Furthermore , their presence is thought to be an important indication of health of the body [1-4].Whole peptidoglycan ( WPG) is the major component in the cell wall of bifidobacterium ,which is also a biological responsemodifier with nontoxic side dffcets. | Li Sheng Wang~1 Hui Ming Zhu~1 Dian Yuan Zhou~2 Yu Lin Wang~1 Wan Dai Zhang~2 ~1Departrnent of Gastroenterology,Shenzhen Municipal People’s Hospital,Jinan University of Medical Sciences,Shenzhen 518020,Guangdong Province,China ~2Chinese PLA Institute of Digestion,the First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaLi Sheng Wang graduated and obtained Ph.D,from the First Military Medical University in 1998,now working at Department of Gastroenterology,Shenzhen Municipal People’s Hospital.Jinan University of Medical Sciences.having 35 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 15 |
| 6 | Genetics of coronary artery disease and myocardial infarction显示文摘Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI. | Xuming Dai Szymon Wiernek James P Evans Marschall S Runge | 2016 | World Journal of Cardiology2016，8，1： | 15 |
| 7 | Crank conditions and rotatability of 3-RRR planar parallel mechanisms显示文摘This paper investigates the rotatability of planar parallel mechanisms by revealing the crank conditions that relate to link parameters.The paper extends the theorem of assemblability and the rotatability criterion and applies these criteria to parallel mechanisms in investigating the crank conditions of a parallel mechanism,leading to classification of three types of crank existing conditions including three-crank’s,six-crank’s and nine-crank’s of 3-RRR planar parallel mechanisms.The results are summarized as constraint conditions in relation with link parameters with a concluding table and case studies. | LI RuiQin 1 &DAI Jian S 2 1 College of Mechanical Engineering and Automation,North University of China,Taiyuan 030051,China 2 Department of Mechanical Engineering,King’s College London,University of London,WC2R 2LS,UK | 2009 | Science China(Technological Sciences)2009，52，12： | 12 |
| 8 | GJB2 mutation spectrum in deaf population in a typical southeastern area of China显示文摘Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In China, 30,000 infants are born with congenital hearing impairment annually. In order to provide appropriate genetic testing and counseling to the families, we investigated the molecular etiology of nonsyndromic deafness in 103 unrelated school children attending Nantong School for the Deaf and Mute in Jiangsu Province, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. Sixty two GJB2 mutant alleles were identified in 35.9% (37/103) of the patients. Twenty five patients carried two pathogenic mutations and 12 patients carried one mutant allele. The 235delC was the most common mutation accounting for 69.4% (43/62) of GJB2 mutant alleles. The GJB2 mutant alleles accounted for 30.1% (62/206) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 3 most prevalent deleterious frame shift mutations in this cohort detected 100% of all GJB2 mutant alleles. These results demonstrate that an effective genetic testing of GJB2 gene for patients and families with nonsyndromic hearing impairment is possible. | DAI Pu1*, YOU Yi-wen2*, CUI Jing-hong2*, YU Fei1, HAN Bing 1, KANG Dong-yang1, YUAN Hui-jun1, HAN Dong-yi1, 1. Department of Otolaryngology, PLA General Hospital, Beijing, People’s Republic China, 100853 2. Department of Otolaryngology, Nantong University Affiliated Hospital, Nantong, Jiangsu Province, People’s Republic China, 226001 *Pu Dai, Yiwen You, Jinghong Cui contribute equally to this paper | 2006 | Journal of Otology2006，1，2： | 10 |
| 9 | Climate Changes in the 21st Century over the Asia-Pacific Region Simulated by the NCAR CSM and PCM显示文摘The Climate System Model (CSM) and the Parallel Climate Model (PCM), two coupled global climate models without flux adjustments recently developed at NCAR, were used to simulate the 20th century climate using historical greenhouse gas and sulfate aerosol forcing. These simulations were extended through the 21st century under two newly developed scenarios, a business-as-usual case (BAU, CO2≈710 ppmv in 2100) and a CO2 stabilization case (STA550, CO2≈540 ppmv in 2100). The simulated changes in temperature, precipitation, and soil moisture over the Asia-Pacific region (10°-60°N, 55°-155°) are analyzed, with a focus on the East Asian summer monsoon rainfall and climate changes over the upper reaches of the Yangtze River. Under the BAU scenario, both the models produce surface warming of about 3-5℃ in winter and 2-3℃ in summer over most Asia. Under the STA550 scenario, the warming is reduced by 0.5-1.0℃ in winter and by 0.5℃ in summer. The warming is fairly uniform at the low latitudes and does not induce significant changes in the zonal mean Hadley circulation over the Asia-Pacific do- main While the regional precipitation changes from single CSM integrations are noisy, the PCM ensemble mean precipitation shows 10%-30% increases north of ~ 30°N and~10% decreases south of ~ 30°N over the Asia-Pacific region in winter and 10%-20% increases in summer precipitation over most of the region. Soil moisture changes are small over most Asia The CSM single simulation suggests a 30% increase in river runoff into the Three Gorges Dam, but the PCM ensemble simulations show small changes in the | Aiguo Dai, G.A. Meehl, W.M. Washington, and T.M.L. Wigley National Center for Atmospheric Research P.O. Box 3000, Boulder, CO 80307 ) Email: adai@ ucar. edu The National Center for Atmospheric Research is sponsored by the U S National Science Foundation. | 2001 | Advances in Atmospheric Sciences2001，18，5： | 9 |
| 10 | 超环面行星蜗杆传动的运动学和动力学仿真显示文摘建立了超环面行星蜗杆传动的啮合坐标系统以及中心蜗杆和内超环面齿轮齿面的数学模型,完成了超环面行星蜗杆传动减速器各零件的三维实体建模和减速器整机虚拟装配,在此基础上,完成了基于超环面行星蜗杆传动减速器的运动学和动力学仿真。 | 魏国武 姚立纲 朱晓林 Jian S Dai | 2005 | 机械设计与研究2005，21，5： | 9 |
| 11 | Mitochondrial DNA A1555G mutation screening using a testing kit method and its significance in preventing aminoglycoside-related hearing loss显示文摘To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics. | LIU Xin,1 DAI Pu,1* HUANG Deliang,1 YUAN Huijun,1 LI Weiming,1 YU Fei,1 ZHANG Xin,1 KANG Dongyang,1 CAO Juyang,1 YANG Weiyan,1 HAN Dongyi,1 JIN Zhengce2, GUAN Minxin3 1. Department of Otolaryngology, Chinese PLA General Hospital, Beijing, China2. Weihai Aomaier Gene Technological CO.,LTD.,Weihai,Shandong 264200, China.3. Division and Program in Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA | 2006 | Journal of Otology2006，1，1： | 7 |
| 12 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 13 | Biological responses of small yellow croaker(Larimichthys polyactis) to multiple stressors: a case study in the Yellow Sea, China显示文摘Temporal changes in biological characteristics of small yellow croaker Larimichthys polyactis in the Yellow Sea were examined for the period of 1960–2008. The body size and age of small yellow croaker decreased substantially, in particular, average length of fish in 2008 was reduced by ~85% than those occurring in 1985, and at that time ~93% of the total catch was dominated by one-year-old individuals. Correspondingly, growth parameters also varied significantly over the years, i.e., k(growth coefficient) and t_0(zero-length age) gradually increased from 0.26 and –0.58 year in 1960 to 0.56 and –0.25 year in 2008, respectively. Although, L∞(body length)sharply decreased from 34.21 cm in 1960 to 24.06 cm in 2008, and t_r(inflexion age) decreased from 3.78 year in1960 to 1.61 year in 2008. There was a great increase both in natural mortality coefficient and fishing mortality coefficient. However, according to the gray correlation analysis, changes in the biological characteristics of small yellow croaker were induced by different stressors ranked as: fishing vessel power>feeding grade>sea surface temperature. This study suggests that the active fishery management measures for biological characters of fish populations should be considered. | SHAN Xiujuan LI Xiansen YANG Tao SHARIFUZZAMAN S M ZHANG Guozheng JIN Xianshi DAI Fangqun | 2017 | Acta Oceanologica Sinica2017，36，10： | 5 |
| 14 | Water limitation and rootstock genotype interact to alter grape berry metabolism through transcriptome reprogramming显示文摘Grapevine is a perennial crop often cultivated by grafting a scion cultivar on a suitable rootstock.Rootstocks influence scions,particularly with regard to water uptake and vigor.Therefore,one of the possibilities to adapt viticulture to the extended drought stress periods is to select rootstocks conferring increased tolerance to drought.However,the molecular mechanisms associated with the ability of rootstock/scion combination to influence grape berry metabolism under drought stress are still poorly understood.The transcriptomic changes induced by drought stress in grape berries(cv.Pinot noir)from vines grafted on either 110R(drought-tolerant)or 125AA(drought-sensitive)rootstock were compared.The experiments were conducted in the vineyard for two years and two grape berry developmental stages(50%and 100%veraison).The genome-wide microarray approach showed that water stress strongly impacts gene expression in the berries,through ontology categories that cover cell wall metabolism,primary and secondary metabolism,signaling,stress,and hormones,and that some of these effects strongly depend on the rootstock genotype.Indeed,under drought stress,berries from vines grafted on 110R displayed a different transcriptional response compared to 125AA-concerning genes related to jasmonate(JA),phenylpropanoid metabolism,and pathogenesis-related proteins.The data also suggest a link between JA and secondary metabolism in water-stressed berries.Overall,genes related to secondary metabolism and JA are more induced and/or less repressed by drought stress in the berries grafted on the drought-sensitive rootstock 125AA.These rootstock-dependent gene expression changes are relevant for berry composition and sensory properties. | Mariam Berdeja Philippe Nicolas Christian Kappel Zhan Wu Dai Ghislaine Hilbert Anthony Peccoux Magali Lafontaine Nathalie Ollat Eric Gomès Serge Delrot | 2015 | Horticulture Research2015，2，1： | 5 |
| 15 | Contemporary review of minimally invasive pancreaticoduodenectomy显示文摘AIM To assess the current literature describing various minimally invasive techniques for and to review short-term outcomes after minimally invasive pancreaticoduodenectomy(PD). METHODS PD remains the only potentially curative treatment for periampullary malignancies, including, most commonly, pancreatic adenocarcinoma. Minimally invasive approaches to this complex operation have begun to be increasingly reported in the literature and are purported by some to reduce the historically high morbidity of PD associated with the open technique. In this systematic review, we have searched the literature for high-quality publications describing minimally invasive techniques for PD-including laparoscopic, robotic, and laparoscopicassisted robotic approaches(hybrid approach). We have identified publications with the largest operative experiences from well-known centers of excellence for this complex procedure. We report primarily short term operative and perioperative results and some short term oncologic endpoints. RESULTS Minimal y invasive techniques include laparoscopic, robotic and hybrid approaches and each of these techniques has strong advocates. Consistently, across all minimally invasive modalities, these techniques are associated less intraoperative blood loss than traditional open PD(OPD), but in exchange for longer operating times. These techniques are relatively equivalent in terms of perioperative morbidity and short term oncologic outcomes. Importantly, pancreatic fistula rate appears to be comparable in most minimally invasive series compared to open technique. Impact of minimally invasive technique on length of stay is mixed compared to some traditional open series. A few series have suggestedthat initiation of and time to adjuvant therapy may be improved with minimally invasive techniques, however this assertion remains controversial. In terms of shortterms costs, minimally invasive PD is significantly higher than that of OPD. CONCLUSION Minimally invasive approaches to PD show great promise as a strategy to improve short-term outcomes in patients undergoing PD, but the best results remain isolated to high-volume centers of excellence. | Rui Dai Ryan S Turley Dan G Blazer | 2016 | World Journal of Gastrointestinal Surgery2016，8，12： | 5 |
| 16 | Orientation angle workspaces of planar serial three-link manipulators显示文摘This paper presents a classification on the workspaces of planar serial three-link manipulators, that is, position workspace and orientation angle workspace. Position workspace indicates the region reached by the reference point on the end-effector. Orientation angle workspace indicates a set of angle ranges by which the end-effector can reach with certain orientation for every point in the reachable position workspace. By introducing a virtual equivalent mechanism, reachable position workspace can be di- vided into several Grashof intervals and non-Grashof intervals. The calculation equations of orientation angle workspace are deduced in three situations according to the relationships among four link lengths in the virtual four-bar chain. Three examples are given for three kinds of relationship of link lengths. The orientation angle workspace of extended groups, that is, two of the three link lengths equal, and the orientation angle workspace when the reference point on the end-effector moves along a non-radial direction are also discussed. A program is developed to calculate orientation angle workspaces and output variation curves of orientation angle workspace and key data within the position workspace. The approach and program in this paper can be used for fast calculation and identification of the variation rule of the orientation angle workspace of any given planar serial three-link manipulator on the basis of its link parameters, and for the design of a highly dexterous serial manipulator with proposed link rela- tions. | DAI Jian S | 2009 | Science China(Technological Sciences)2009，52，4： | 4 |
| 17 | Prevalence of the GJB2 Mutations in Deafness Patients of Different Ethnic Origins in Xinjiang显示文摘Objective To investigate GJB2 mutation prevalences in the Uigur and Han ethnic groups in Xinjiang, China, and determine the relationship between ethnicity and GJB2 gene mutations. Methods Information regarding ethnicity of patients' families was obtained through medical records review and/or patient interview. Blood samples were collected from 61 Uigurs and 66 Hans for direct sequencing of the coding region and intron/exon boundaries of the GBJ2 gene. Results Carrier frequency of GJB2 mutations was similar between the Uigur and Han subjects. The GJB2 35delG mutation was seen only in Uigur patients with hearing loss, whereas the 235delC mutation was identified in both Uigur and Han patients. The allelic Frequency of 35delG mutation was 7.4% (9/122) in Uigur deaf students, but none in Han deaf students (0/128) and Uigur controls (0/196). The allelic frequency of GJB2 235delC mutation in Uigur and Han deaf students was 5.7% and 9.8%, and that of 299-300delAT mutation was 0.8% and 5.5%, respectively. V27I and E114G were the most frequent types of polymorphism. Conclusion We found an Asian-specific GJB2 diversity among Uigurs, and comparable GJB2 contribution to deafness in Uigur and Han patients. The high carrier frequency of 35delG in Uigurs (11.5%) is probably defined by gene drift/founder effect in a particular group. Even though GJB2 mutations have been widely reported in the literature, this discussion represents the first report of GJB2 mutations in Chinese multi-ethnic populations. | LI Qi1, DAI Pu1, HUANG De-liang1, ZHANG Jin2, WANG Guo-jian1, ZHU Qing-wen1, Liu Xin3, HAN Dong-yi1 1 Department of otolaryngology Head & Neck Surgery/Institute of Otorhinolaryngology, Genetic Testing Genter for Deafness, PLA General Hospital, Beijing 100853 2 Department of otolaryngology Head & Neck Surgery, Xinjiang Uigur Municipality People’s Hospital 3 Department of otolaryngology Head & Neck Surgery, PLA sixteenth Hospital | 2007 | Journal of Otology2007，2，1： | 3 |
| 18 | Dynamic Behaviour of a Caisson Quaywall Under Strong Earthquake显示文摘—Effective stress analysis is performed to evaluate the residual displacement of a caissonquaywall during 1994 Hokkaido-Toho-Oki Earthquake and 1993 Kushiro-Oki Earthquake.Theconstitutive model used in this study is a multiple shear mechanism type defined in strain space and cantake into account the effect of rotation of principal stress axis.The earthquake accelerations recorded atthe outcropping rock during the earthquake are used as input bedrock motion.The results of finite ele-ment analysis are in good agreement with the observed behaviour of the quaywall.The analysis also indi-cates that liquefaction and high excess pore water pressure have a significant effect on the deformation ofthe caisson.Soil improvement is speculated as the most reliable measures against liquefaction.The influ-ence of soil improvement and the reasonable improved area are discussed in the paper. | Liu, HL Dai, HC Iai, S | 1999 | China Ocean Engineering1999，14，1： | 3 |
| 19 | Expressions of p53 and inducible nitric oxid synthase in congenital choledochal cysts显示文摘BACKGROUND: Choledochal cyst, an isolated defect un- restricted to the bile duct, is more appropriately regarded as the sentinel feature of a constellation of anomalies affect- ing the pancreatobiliary system. This study was to assess the relationship between the expression of inducible nitric oxide synthase (iNOS) and the p53 gene as well as the pathoge- nesis of choledochal cysts. METHODS: iNOS and p53 were detected by immunohisto- chemistry staining in 26 patients with congenital choledo- chal cysts. Histopathologically, hyperplasia of the mucosa of the cysts and the amylase level in the bile were also inve- stigated. RESULTS: Patients with a high level of amylase in the bile had higher expression of iNOS than those with a low level of amylase. p53 protein was expressed neither in fusiform type nor in cystic type. The incidence of mucosal hyperpla- sia was significantly higher in the fusiform type than that in the cystic type. CONCLUSIONS: Higher expression of iNOS may partici- pate in hyperplasia and carcinogenesis of the mucosa of choledochal cysts. The regurgitation of pancreatic juice in- to the biliary system might induce mucosal hyperplasia of the biliary tract and inflammatory reaction. In preventing regurgitation-caused hyperplasia and malignancy of the bi- liary tract, early surgery is important for children with con- genital choledochal cysts. | Jiang-Hua Zhan, Xiao-Li Hu, Chun-Juan Dai, Jun Niu and Ji-Qing Gu Tianjin, China Department of Pediatric Surgery, Tianjin Children’s Hospital, Tianjin 300000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 2 |
| 20 | Orientation angle rotatability of planar serial n-link manipulators显示文摘This paper presents a new method of analyzing the orientation angle rotatability of a planar serial n-link manipulator by examining the rotatability of its virtual equivalent mechanism.Workspace orientation boundary region decomposition is proposed based on the polynomial discriminant derived from a serial three-link manipulator.Orientation angle workspace indicates a set of angle ranges by which the end-effector can reach with certain orientation for every point in the reachable position workspace.By introducing a virtual equivalent mechanism,the open-chain kinematic problem is converted into a close-chain mechanism,and the Grashof-type condition is used to examine the rotatability of the end-effector link.The reachable position workspace can be divided into several Grashof intervals and non-Grashof intervals based on the extreme positions and singular configurations of a manipulator.The derived equations in this paper can be used to calculate the variation rule of the orientation angle workspace of any given planar serial n-link manipulator on the basis of its link parameters.The orientation angle rotatability of a seven-link serial manipulator is solved by the proposed method and graphical representations of the orientation angle workspaces are mapped onto a three-dimensional coordinate system.The theoretical approach has practical significance for the design of a highly dexterous serial n-link manipulator with proposed link relations. | LI RuiQin1,XIAO DengHong1 & DAI Jian S2 1 College of Mechanical Engineering and Automation,North University of China,Taiyuan 030051,China 2 Department of Mechanical Engineering,King’s College London,University of London,London WC2R 2LS,UK | 2010 | Science China(Technological Sciences)2010，53，6： | 2 |
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