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| 1 | MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease显示文摘AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. | Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources显示文摘 | Constance L Senior Joseph J Helble Adel F Sarofim | 2000 | Fuel Processing Technology2000，，： | 2 |
| 3 | Gas-phase transformations of mercury in coal-fired power plants显示文摘 | Constance L Senior Adel F Sarofim Taofang Zeng Joseph J Helble Ruben Mamani-Paco | 2000 | Fuel Processing Technology2000，，2： | 2 |
| 4 | Effect of nonylphenol on serum testosterone levels and testicular steroidogenie enzyme activity in neonatal,pubertal, and adult rats显示文摘 | ELIZABETH M L GANESH B CONSTANCE W | 2002 | Chemico-Biological Interactions2002，139，1： | 1 |
| 5 | Pilot scale study of trace element vaporization and condensation during combustion of a pulverized subbituminous coal显示文摘 | Constance L Lawrence E | 2000 | Fuel Processing Technology2000，，63： | 1 |
| 6 | Mercury in coal and the impact of coal quality on mercury emissions from combustion system 显示文摘 | Kolker A Constance L S Jeffrey C Q | 2006 | Applied Geochemistry2006，21，11： | 1 |
| 7 | Prospective evaluation of flex-rigid pleuroscopy for indeterminate pleural effusion:Accuracy, safety and outcome 显示文摘 | Pyng L E E Anne H S U Constance L O | 2007 | Respirology2007，，12： | 1 |
| 8 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 9 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources 显示文摘 | SENIOR CONSTANCE L HELBLE JOSEPH J SAROFIM ADEL F | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 10 | Antimi- crobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia 显示文摘 | Lai Wah Chan Emily L C Cheah Constance L L Saw | 2008 | Chin Med J2008，，3： | 1 |
| 11 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources显示文摘 | SENIOR CONSTANCE L HELBLE JOSEPH J SAROFIM ADEL F | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 12 | Diagnosis and management of hyperprolactinemia显示文摘 | Omar Serri Constance L Chik | 2003 | CMAJ2003，169，： | 1 |
| 13 | Emissions of mercury,trace elements,and fine particles from stationay combustion sources显示文摘 | Constance L Senior Joseph J Heible Adel F Sarofim | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 14 | Return Migration to Malta: Neither Failed Immigrants nor Successful Guest Workers 显示文摘 | Constance L | 1989 | Journal of Sociology1989，25，： | 1 |
| 15 | Gas - phase transformation of mercury in coal - fired power plants显示文摘 | Constance L Adel F S Zeng T F | 2000 | Flue Processing Technology2000，，63： | 1 |
| 16 | Gas - phase transformations of mercury in coal - fired power plants 显示文摘 | Constance L S Sarofim A F Zeng T F | 2000 | Fuel Processing Technology2000，63，23： | 1 |
| 17 | Pilot scale study of trace element vaporization and condensation during combustion of a pulverized sub-bituminous coal 显示文摘 | Constance L Senior Lawrence E Bool Ⅲ Srivats Srinivasachar | 2000 | Fuel Processing Technology2000，63，： | 1 |
| 18 | , Gas-phase transformations of mercury in coal-fired power plants显示文摘 | Constance L S Adel F S Taofang Z | 2000 | Fuel Processing Technology2000，，63： | 1 |
| 19 | Crx , a Novel otx -like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation显示文摘 | Takahisa Furukawa Eric M Morrow Constance L Cepko | 1997 | Cell1997，，4： | 1 |
| 20 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources 显示文摘 | Constance L Senior J Helble A | 2000 | Fuel ProcessingTecbnology2000，6566，1： | 1 |
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