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| 1 | Role of electrodes in ambient electrolytic decomposition of hydroxylammonium nitrate (HAN) solutions显示文摘Decomposition of hydroxylammonium nitrate (HAN) solution with electrolytic decomposition method has attracted much attention in recent years due to its efficiencies and practicability.However,the phenomenon has not been well-studied till now. By utilizing mathematical model currently available,the effect of water content and power used for decomposition was studied. Experiment data shows that sacrificial material such as copper or aluminum outperforms inert electrodes in the decomposition of HAN solution. In the case of using copper wire to electrolyse HAN solutions, approximately 10 seconds is required to reach 100℃ regardless of concentration of HAN. In tem of power consumption,100W-300W was found to be the range in which decomposition could be triggered effectively using copper wire as electrodes. | Kai SengKoh Jitkai Chin Tengku F.Wahida Ku Chik | 2013 | Propulsion and Power Research2013，2，3： | 12 |
| 2 | 细胞因子诱导支气管上皮细胞表达嗜酸粒细胞趋化因子显示文摘Eotaxin和新近发现的Eotaxin-2在支气管上皮细胞中的表达以及Th2型细胞因子的调节作用。以支气管上皮细胞株BEAS-2B细胞为研究对象,通过RT-PCR的方法测定Th2型细胞因子IL-4、IL-13以及促炎症因子TNF-α单独和协同刺激下BEAS-2B细胞Eotaxin和Eotaxin-2的基因表达,通过ELISA方法测定细胞培养上清液中Eotaxin蛋白的表达。EotaxinmRNA在TNF-α刺激12h后表达最高,Th2型细胞因子IL-4和IL-13与TNF-α协同刺激后表达进一步增强,Eotaxin蛋白的表达在协同刺激下也呈剂量和时间依赖性增高(P<0.01)。Eotaxin-2mRNA在TNF-α的刺激下于8h表达最高,IL-4或IL-13与TNF-α的协同刺激也使表达进一步增强,Eotaxin和Eotaxin-2两者基因表达具有相关性(P<0.05)。Th2型细胞因子可与促炎症因子TNF-α协同刺激支气管上皮细胞增强表达嗜酸粒细胞趋化因子Eotaxin和Eotaxin-2,从而吸引嗜酸粒细胞浸润至气道参与哮喘炎症过程。 | 汤葳 Albert Chan Stanley Chik Adrain Wu 邓伟吾 | 2005 | 现代免疫学2005，25，1： | 11 |
| 3 | 儿童NTRK重排间叶源性肿瘤临床病理学观察显示文摘目的:探讨儿童NTRK重排间叶源性肿瘤临床和病理学特征,以提高对该类疾病的认识。方法:收集上海交通大学医学院附属上海儿童医学中心及新加坡KK Women′s and Children′s Hospital从2017年1月至2019年9月5例手术切除标本,采用EnVision法检测免疫组织化学表型,荧光原位杂交(FISH)检测相关基因并对NTRK基因重排进行克隆性分析。结果:该组5例患儿,3例男性,2例女性。年龄从3个月到13岁,部位包括软组织(膝、胸腔、腹壁)和肾,肿瘤大小为4.5~12.5 cm。组织学检查主要呈梭形细胞肿瘤,浸润性生长,可伴有炎性细胞。免疫表型上,肿瘤细胞阳性表达Pan-TRK,分子检测均存在NTRK基因重排,包括DCTN1-NTRK1的发现。除2例目前接受靶向药物治疗,其余均为无疾病进展病例,随访时间9~29个月。结论:NTRK重排间叶源性肿瘤,其肿瘤发生部位广泛,组织学图像多变。免疫组织化学Pan-TRK可以帮助诊断,NTRK基因检测确认其存在重排是诊断的金标准,对不能完整切除或有复发、转移病例建议靶向药物治疗。 | 殷敏智 马靖 何巧 沈萍 陈洁枫 金晓婷 张忠德 Chik Hong Kuick Chen Huiyi Eileen Hui Qi Ng Sze Jet Aw Kenneth Tou En Chang | 2020 | 中华病理学杂志2020，49，7： | 6 |
| 4 | MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease显示文摘AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. | Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 5 | A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant显示文摘Dear Editor,Since the outbreak of Coronavirus Disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,numerous SARS-CoV-2 variants of concern(VOCs),such as Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2),have emerged.Recently,the newly identified SARS-CoV-2 VOC,Omicron(B.1.1.529),has rapidly spread in many countries1 and is expected to replace Delta as the dominant variant circulating in the world.Compared to other VOCs,Omicron contains at least 32 mutations in spike(S)protein,including 15 mutations in the receptor-binding domain(RBD),and these mutations are known to confer resistance to neutralizing antibodies(nAbs)and sera of convalescent patients and people who have received COVID-19 vaccines.2–5 Therefore,vaccines able to induce potent and durable neutralizing antibodies against Omicron and other VOCs are urgently needed. | Zezhong Liu Jasper Fuk-Woo Chan Jie Zhou Meiyu Wang Qian Wang Guangxu Zhang Wei Xu Kenn Ka-Heng Chik Yilong Zhang Youchun Wang Kwok-Yung Yuen Lu Lu Shibo Jiang | 2022 | Cell Research2022，32，5： | 4 |
| 6 | 具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌临床病理学观察显示文摘目的:探讨具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌(ESC RCC)临床病理特征、免疫组织化学及分子遗传学特征和预后。方法:收集2017年至2018年2例ESC RCC临床资料,HE和免疫组织化学染色(EnVision)法进行形态学观察;荧光原位杂交检测TFE3、TFEB断裂重排基因;分子基因检测,PCR扩增,二代测序。结果:2例ESC RCC为男性,年龄分别9岁8个月和13岁,均发生在右肾。肿瘤大小5~7 cm,切面囊实性,灰红、灰白鱼肉样。显微镜下肿瘤具有纤维性包膜,肿瘤细胞突破胞膜。肿瘤细胞弥漫分布,圆形、多边性,胞质丰富,嗜伊红,可见大小不一的空泡,呈透明细胞样;部分区域类似乳头样结构,可见纤维轴心。细胞核圆形、泡状核,易见多核及巨核细胞,核分裂象未见;少量大小不一的囊样结构,囊壁可见单层瘤细胞被覆呈钉突样。间质见厚壁血管,灶状淋巴细胞浸润;较多嗜伊红坏死,可见钙化和胆固醇结晶。免疫组织化学阳性表达:PAX8(弥漫)、细胞角蛋白(CK)20、广谱细胞角蛋白(CKpan,局灶)、CD10(1例局灶/1例弥漫)、INI1、波形蛋白、CD68阳性,Ki-67阳性指数5%~10%。HMB45、S-100蛋白、Melan A、p53、结蛋白、TFE3、CK7、CK19、上皮细胞膜抗原(EMA)、CD56、嗜铬粒素A(CgA)、突触素、CD30、CD117、WT1、平滑肌肌动蛋白(SMA)阴性。分子遗传学检测:TFE3、TFEB断裂重排阴性。二代测序:例1,TSC2 p.Lys574Ter(0.198);例2,TSC2 p.Arg406Ter(0.355)。结论:ESC RCC儿童发病比较罕见,容易误诊,其具有独特的病理形态学特征、免疫表型和分子遗传学改变,预后较好。 | 杨文萍 Kenneth Tou En Chang 徐红艳 Chik Hong Kuick Eileen Hui Qi Ng 黄慧 熊枫 吴艳 曾松涛 樊金星 Xinyi Loh | 2020 | 中华病理学杂志2020，49，7： | 3 |
| 7 | 白细胞介素5受体α链在支气管上皮细胞BEAS-2B的表达显示文摘目的白细胞介素5(n5)作为参与嗜酸粒细胞成熟、分化过程的最主要因子,其作用通过特异性受体IL-5Rα介导。本文以支气管上皮细胞株为研究对象,证实该上皮细胞株在炎症因子的刺激下可以表达IL-5Rα。方法通过促炎症因子TNF-α和TH2型细胞因子IL-4、IL-5、IL-13以及白三烯成分之一的LTC4(白三烯C4)对细胞进行单独或协同刺激,以RT-PCR方法、流式细胞检测技术评价上皮细胞对IL-5Rα的基因和蛋白质的表达,同时评价在IL-5和TNF-α的协同刺激下IL-5Rα、ICAM-1和VCAM-1的协同表达。结果正常支气管上皮细胞在TH2型细胞因子、LTC4和TNF-α的刺激下可以表达IL-5Rα基因,在TNF-α单独或与其他因子的协同刺激下表达显著增强,更可以表达IL-5Rα蛋白。流式细胞检测分析显示TNF-α单独或协同刺激后16h IL-5Rα蛋白表达最高,并随时间的延长表达下降。当TNF-α与IL-5协同刺激后上皮细胞可以同时表达VCAM-1和IL-5Rα,而ICAM-1呈持续表达。结论通过对支气管上皮细胞的研究证实了支气管上皮细胞可以在炎症因子仆Bα和TH2型细胞因子的协同刺激下进一步表达IL-5特异性受体IL-5Rα,并在IL-5和TNF-α的刺激下进一步表达黏附分子VCAM-1,吸引嗜酸粒细胞及其前体细胞浸润至气道参与炎症。说明支气管上皮细胞不仅在哮喘炎症反应中是最主要的受累器官,也是导致炎症的参与者之一。 | 汤葳 Albert Chan Stanley Chik Adrain Wu 邓伟吾 | 2007 | 中华微生物学和免疫学杂志2007，27，1： | 2 |
| 8 | Noise Reduction Technique Applied to the Multichannel Analysis of Surface Waves显示文摘This paper shows the presence of noises and technique to reduce these noises during the surface wave analysis. The frequency-dependent properties of Rayleigh-type surface waves can be used for imaging and characterizing the shallow subsurface. Interference by coherent source-generated noise inhibits the reliability of shear-wave velocities determined through inversion of the phase velocities of Rayleigh waves. Among these interferences by non-planar, non-fundamental mode Rayleigh waves (noise) are body waves, scattered and non-source-generated surface waves, and highermode surface waves. For the reduction of noise, the filtering technique is implemented in this paper for the multichannel analysis of surface wave method (MASW). With the denoising technique during the MASW method, more robust and reliable outcome is achieved. The significance of this paper is to obtain pre-awareness about noises during surface wave analysis and take better outcomes with denoising performance in near surface soil investigations. | Taohidul ISLAM Zamri CHIK Mohd Marzuki MUSTAFA | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 2 |
| 9 | Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant显示文摘Dear Editor,Most recently,a new SARS-CoV-2 variant of concern(VOC)Z Omicron(B.1.1.529),was first reported to the World Health Organization(WHO)from South Africa and then quickly spread to many countries,1,2 posing a serious threat to current vaccine prevention and antibody therapeutic strategies.Several studies have reported that the Omicron variant successfully escapes from neutralizing antibodies elicited by COVID-19 vaccines or from COVID-19 convalescent patients. | Shuai Xia Jasper Fuk-Woo Chan Lijue Wang Fanke Jiao Kenn Ka-Heng Chik Hin Chu Qiaoshuai Lan Wei Xu Qian Wang Chao Wang Kwok-Yu ng Yuen Lu Lu Shibo Jiang | 2022 | Cell Research2022，32，4： | 2 |
| 10 | 显示文摘 | Chik H Xu J M | 2004 | Mater Sei Eng Rev R2004，43，4： | 1 |
| 11 | Comparative study of cytokine content in the plasma and wound exudate from children with severe burns显示文摘 | Mikhal' chik EV Piterskaya J A Budkevich LY eta| | 2009 | Bull Exp Biol Med2009，148，5： | 1 |
| 12 | Anti-inflammatory effects of high-dose montelukast in an animal model of acute asthma显示文摘 | Wu AY Chik SC Chan AW | 2003 | Clin Exp Allergy2003，33，3： | 1 |
| 13 | The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines显示文摘 | KO J K S CHIK C W S | 2009 | Cytokine2009，47，2： | 1 |
| 14 | The singapore personal data protection act and an assessment of future trends in data privacy reform 显示文摘 | CHIK W B | 2013 | Com- puter Law & Security Review2013，29，5： | 1 |
| 15 | Influence of axial load on the lateral pile groups response in cohesionless and cohesive soil显示文摘The lateral response of single and group of piles under simultaneous vertical and lateral loads has been analyzed using a 3D finite element approach. The response in this assessment considered lateral pile displacement and lateral soil resistance and corresponding p-y curve. As a result, modified p-y curves for lateral single pile response were improved with respect to the influence of increasing axial load intensities. The improved plots can be used for lateral loaded pile design and to produce the group action design p-multiplier curves and equations. The effect of load combination on the lateral pile group response was performed on three pile group configurations (i.e., 2 × 1, 2 × 2 and 3 × 2) with four pile spacings (i.e., s = 2D, 4D, 6D and 8D). As a result, design curves were developed and applied on the actual case studies and similar expected cases for assessment of pile group behavior using improved p-multiplier. A design equation was derived from predicted design curves to be used in the evaluation of the lateral pile group action taking into account the effect of axial load intensities. It was found that the group interaction effect led to reduced lateral resistance for the pile in the group relative to that for the single pile in case of pure lateral load. While, in case of simultaneous combined loads, large axial load intensities (i.e., more than 6H, where H is lateral load values) will have an increase inp-multiplier by approximately 100% and will consequently contribute to greater group piles capacities. | Jasim M. ABBASA Zamri CHIK Mohd Raihan TAHA | 2015 | Frontiers of Structural and Civil Engineering2015，9，2： | 1 |
| 16 | Correctly identifying the microsomic fetus improving ultrasonography - based prediction显示文摘 | Soko(R) Chik L Dombrowski MP | 2000 | Am J Obstet Gynecol2000，186，： | 1 |
| 17 | Application of Electroless Plating in the Semiconductor Microcircuit Industry 显示文摘 | Wong K Chik Rongappan | 1988 | Plating and Surface Finishing1988，75，7： | 1 |
| 18 | Anti-inflammatory effects of high-dose montelukast in an animal model of acute asthma显示文摘 | Wu AY Chik SC Chan AW | 2003 | Clin Exp Allergy2003，33，3： | 1 |
| 19 | Anti-inflammatory effects of highdose montelukast in an animal model of acute asthma显示文摘 | Wu AY Chik SC Chan AW | 2003 | Clin Exp Allergy2003，33，： | 1 |
| 20 | The effects of erodent composition and shape on the erosion of steel显示文摘 | Levy A Chik P | 1983 | Wear1983，89，： | 1 |
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