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| 1 | Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis显示文摘AIM To evaluate the prognostic value of site-specific metastases among patients with metastatic pancreaticc arcinoma registered within the Surveillance, Epidemiology and End Results(SEER) database.METHODS SEER database(2010-2013) has been queried through SEER*Stat program to determine the presentation, treatment outcomes and prognostic outcomes of metastatic pancreatic adenocarcinoma according to the site of metastasis. In this study, metastatic pancreatic adenocarcinoma patients were classified according to the site of metastases(liver, lung, bone, brain and distant lymph nodes). We utilized chi-square test to compare the clinicopathological characteristics among different sites of metastases. We used Kaplan-Meier analysis and log-rank testing for survival comparisons. We employed Cox proportional model to perform multivariate analyses of the patient population; and accordingly hazard ratios with corresponding 95%CI were generated. Statistical significance was considered if a two-tailed P value < 0.05 was achieved. RESULTS A total of 13233 patients with stage Ⅳ pancreatic cancer and known sites of distant metastases were identified in the period from 2010-2013 and they were included into the current analysis. Patients with isolated distant nodal involvement or lung metastases have better overall and pancreatic cancer-specific survival compared to patients with isolated liver metastases(for overall survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001)(for pancreatic cancer-specific survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001). Multivariate analysis revealed that age < 65 years, white race, being married, female gender; surgery to the primary tumor and surgery to the metastatic disease were associated with better overall survival and pancreatic cancer-specific survival.CONCLUSION Pancreatic adenocarcinoma patients with isolated liver metastases have worse outcomes compared to patients with isolated lung or distant nodal metastases. Further research is needed to identify the highly selected subset of patients who may benefit from local treatment of the primary tumor and/or metastatic disease. | Hani Oweira Ulf Petrausch Daniel Helbling Jan Schmidt Meinrad Mannhart Arianeb Mehrabi Othmar Schob Anwar Giryes Michael Decker Omar Abdel-Rahman | 2017 | World Journal of Gastroenterology2017，23，10： | 13 |
| 2 | Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high‐level CpG Island methylator phenotype and mismatch repair‐deficiency显示文摘 | Heather Dawson José A. Galván Melina Helbling Dominique‐Elisabeth Muller Eva Karamitopoulou Viktor H. Koelzer Mary Economou Caroline Hammer Alessandro Lugli Inti Zlobec | 2014 | Int. J. Cancer2014，，10： | 2 |
| 3 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources显示文摘 | Constance L Senior Joseph J Helble Adel F Sarofim | 2000 | Fuel Processing Technology2000，，： | 2 |
| 4 | Gas-phase transformations of mercury in coal-fired power plants显示文摘 | Constance L Senior Adel F Sarofim Taofang Zeng Joseph J Helble Ruben Mamani-Paco | 2000 | Fuel Processing Technology2000，，2： | 2 |
| 5 | Generation of con- ditional mutants in higher eukaryotes by switching between the expression of two genes 显示文摘 | Baron U Schnappinger D Helbl V | 1999 | Proc Natl Acad Sci USA1999，96，3： | 1 |
| 6 | Spinal segmental stabilisation exercises for chronic low back pain programme adher- ence and its in fcuence on clinical outcome显示文摘 | Mannion AF Helbling D Pulkovski N | 2009 | Eur Spine J2009，18，12： | 1 |
| 7 | Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity显示文摘 | Thibodeau MS Giardina C Knecht DA Helble J Hubbard AK | 2004 | Toxicol Sci2004，80，1： | 1 |
| 8 | When bubbles burst 显示文摘 | HELBLING T TERRONES M | 2003 | World Economic Outlook2003，，2： | 1 |
| 9 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources显示文摘 | SENIOR C L HELBLE J J SAROFIM A F | 2000 | Fuel Process Technol2000，6566，： | 1 |
| 10 | Fabrication of single-walled carbon-nanotube-based pressure sensors 显示文摘 | STAMPFE C HELBLING T OBERGFELLD | 2006 | Nano Letters2006，，6： | 1 |
| 11 | Advanced effluent treatment in the pulp and paper industry with a combined process of ozonation and fixed bed biofilm reactors显示文摘 | Alfred Helble Wolfgang Schlayer Pierre-Andre Liechti | 1999 | Water Sci Technol1999，40，： | 1 |
| 12 | Continuous adrninistra?tion of sorafenib in combination with transarterial che?moembolization in patients with hepatocellular carcino?ma s results of a phase I study显示文摘 | DufourJ Fv Hoppe H Heim M H Helbling B Mau?rho fer 0 Szucs- Farkas Z | 2010 | Oncoiogist2010，15，11： | 1 |
| 13 | Laparoseopic appendectomy using endoloops a prospective, randomized clinical trial显示文摘 | Beldi G Muggli K Helbling C | 2004 | Surg Endosc2004，18，5： | 1 |
| 14 | Timeresolved evolution of fly ash during pulverized coal combustion显示文摘 | KANG S G HELBLE J J SAROFIM A F | 1988 | Symposium(International)on Combustion1988，22，1： | 1 |
| 15 | MSG1,a surface-localised protein of Mycoplasma suis is involved in the adhesion to erythrocytes显示文摘 | Hoelzle L E Hoelzle K Helbling M | 2007 | Microbes Infect2007，9，4： | 1 |
| 16 | Effects of solar UV radiation on germination of conchospores and morphogenesis of sporelings in Porphyra haitanensis ( Rhodophyta ) 显示文摘 | Jiang H X Gao K S Helbling W E | 2007 | Mar Biol2007，151，5： | 1 |
| 17 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources 显示文摘 | SENIOR CONSTANCE L HELBLE JOSEPH J SAROFIM ADEL F | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 18 | Influence of char fragmentation on ash particle size distributions显示文摘 | HELBLE J J SAROFIM A F | 1989 | Combustion and Flame1989，76，2： | 1 |
| 19 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources显示文摘 | SENIOR CONSTANCE L HELBLE JOSEPH J SAROFIM ADEL F | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 20 | A laboratory study of the partitioning of trace -elements during pulverized coal combustion 显示文摘 | Bool L E Helble J J | 1995 | Energy Fuels1995，，5： | 1 |
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