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| 1 | HER2 in gastric cancer: Comparative analysis of three different antibodies using whole-tissue sections and tissue microarrays显示文摘AIM:To compare the performance of three commercially available anti-human epidermalgrowth factor receptor 2(HER2)antibodies in whole-tissue sections and tissue microarrays(TMAs)of a series of gastric tumors.METHODS:We present a comparative analysis of three anti-HER2 antibodies(HercepTest,4B5 and SP3)using TMA and whole-tissue sections prepared from the same paraffin blocks of 199 gastric adenocarcinomas operated upon between January 2004 and December2008 at a Brazilian cancer hospital.The data on the patients’age,sex,the anatomical location of the tumor and the Lauren’s histological classification were collected from clinical and pathological records.The immunohistochemical(IHC)results were examined by two pathologists and the cases were classified as positive(3+),equivocal(2+)and negative(0 or 1+),according to the criteria of the IHC scoring system of gastric cancer.TMAs and whole-tissue sections were evaluated separately and independently.All cases yielding discordant IHC results and/or scored as 2+were subjected to dual-color in situ hybridization in order to determine the final HER2 status.Besides determining the sensitivity and predictive value for HER2-positive status,we measured the accuracy of each antibody by calculating the area under the receiver operating characteristic(ROC)curve.The agreement between the results obtained using the TMAs and those obtained using the whole-tissue sections was assessed by means of Kappa coefficient.RESULTS:Intratumoral heterogeneity of HER2 expression was observed with all antibodies.HER2-positive expression(3+)in the whole-tissue sections was observed in 23 cases(11.6%)using the 4B5 antibody,in 18 cases(9.1%)using the SP3 antibody and in 10 cases(5.1%)using the HercepTest antibody.In the TMAs,11 positive cases(5.6%)were identified using SP3 antibody,9(4.6%)using the 4B5 antibody and 6(3%)using the HercepTest antibody.The sensitivity using whole-tissue sections and TMA,respectively,was 95.2%and 42.9%with 4B5,90.5%and 66.7%with SP3 and 47.6%and42.9%with HercepTest.The accuracy,calculated from the area under the ROC curve,using whole-tissue sections and TMA,respectively,was 0.91 and 0.79 by 4B5,0.86 and 0.80 by SP3 and 0.73 and 0.71 by HercepTest.The concordance of the results obtained using wholetissue sections and TMA was 97.4%(Kappa 0.75)using HercepTest,85.6%(Kappa 0.56)using SP3 and 84.1%(Kappa 0.38)using 4B5.CONCLUSION:The use of the 4B5 antibody on wholetissue sections was the most accurate IHC method for evaluating HER2 expression in gastric adenocarcinoma. | Lucas Faria Abraho-Machado Alexandre Andrade dos Anjos Jácome Durval Renato Wohnrath José Sebastio dos Santos Estela Cristina Carneseca José Humberto Tavares Guerreiro Fregnani Cristovam Scapulatempo-Neto | 2013 | World Journal of Gastroenterology2013，19，38： | 12 |
| 2 | Cortical laminar necrosis related to migrainous cerebral infarction显示文摘We present a 29-year-old woman with a long history of attacks of migraine with and without visual aura.She was a heavy smoker(20 cigarettes/d) and was currently taking oral contraceptives. During a typical migraine attack with aura, she developed dysarthria,left brachial hemiparesis and hemihypoesthesia and brief and autolimited left clonic facial movements. Four hours after onset, vascular headache and focal sensorimotor neurological deficit were the only persisting symptoms and, on seventh day, she was completely recovered. Brain magnetic resonance imaging on day 20 after onset showed a subacute ischemic lesion in the right temporo-parietal cortex compatible with cortical laminar necrosis(CLN). Extensive neurological work-up done to rule out other known causes of cerebral infarct with CLN was unrevealing. Only ten of 3.808 consecutive stroke patients included in our stroke registry over a 19-year period fulfilled the strictly defined International Headache Society criteria for migrainous stroke. The present case is the unique one in our stroke registry that presents CLN related to migrainous cerebral infarction. Migrainous infarction can result in CLN. | Adrià Arboix Sebastià González-Peris Elisenda Grivé María-José Sánchez Emili Comes | 2013 | World Journal of Clinical Cases2013，1，8： | 4 |
| 3 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis显示文摘 | Jing Yang Sendurai A Mani Joana Liu Donaher Sridhar Ramaswamy Raphael A Itzykson Christophe Come Pierre Savagner Inna Gitelman Andrea Richardson Robert A Weinberg | 2004 | Cell2004，，7： | 3 |
| 4 | 一代与二代抗精神病药物治疗精神分裂症:一项荟萃分析显示文摘背景:由于二代抗精神病药物是否优于一代抗精神病药物尚存争议,因此作者利用来自随机对照试验的数据进行一项荟萃分析,对比这两类药物在精神分裂症患者中的作用。方法:将9种二代抗精神病药物与一代药物进行对比,对其总体效果(主要结果)、阳性症状、阴性症状、抑郁症状、复发情况、生活质量、锥体外系副作用、体重增加以及镇静作用进行评价。结果:纳入了150项双肓研究(多数为短期), | Stefan Leucht Caroline Comes Dieter Arbter | 2009 | 世界临床医学2009，，7： | 2 |
| 5 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 6 | Prognostic value of epidermal growth factor receptors in gastric cancer: a survival analysis by Weibull model incorporating long-term survivors显示文摘 | Alexandre Andrade Anjos Jácome Durval R. Wohnrath Cristovam Scapulatempo Neto Estela C. Carneseca Sérgio V. Serrano Luciano Souza Viana Jo?o S. Nunes Edson Z. Martinez José Sebasti?o Santos | 2014 | Gastric Cancer2014，，1： | 2 |
| 7 | Outrenal artery stenosis managed without revascularization 显示文摘 | Chabova V Schirger A comes of atherosclerotic Stanson AW | 2000 | Mayo Clin Proc2000，75，5： | 1 |
| 8 | Primary malignant lymphoid tum-ours of the intestinal tract,Report of 37 cases with a study of factors infl-uencing prognosis显示文摘 | Dawson I M Comes J S Morson B C | 1961 | Br J Surg1961，49，8： | 1 |
| 9 | Prognostic value of very early seizures for in-hospital mortality in atherothrombotic infarction 显示文摘 | Arboix A Comes E Garcia-Eroles L | 2003 | Eur Neurol2003，50，2： | 1 |
| 10 | Tribological behaviour of Si3N4-BN ceramic materials for dry sliding applications显示文摘 | Carrapichano J M Comes J R Silva R F | 2002 | Wear2002，253，： | 1 |
| 11 | cell-free formation of protease-resistant prion protein显示文摘 | Kocisko D A Come J H Priola S A | 1994 | Nature1994，370，： | 1 |
| 12 | A controlled study of Tourette syndrome,Ⅰ-Ⅶ显示文摘 | COMINGS DE COMINGS BG | 1987 | Am J Hum Genet1987，41，： | 1 |
| 13 | Study of the synthesis of poly(4,4'- diphenylether-1,3,4-oxadiazole) in solutions of poly (phosphoric acid)显示文摘 | Comes D Borges C P Pinto J C | 2001 | Polymer2001，42，3： | 1 |
| 14 | Community acquired pneumonia among pediatric outpatient in Salvador, Northeast Brazil, with emphasis on the role of pnemococcus显示文摘 | Nascimento-Carvalho CM Lopes AA Comes MD | 2001 | Braz J Infect Dis2001，5，1： | 1 |
| 15 | Aberrant inter-hemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks 显示文摘 | Morrison-Stewart SL Velikonja D Coming WC | 1996 | Psychological Medicine1996，26，3： | 1 |
| 16 | Decreasing the 'Bad' for Mixed Public Goods and Bads Sculpture 显示文摘 | Joseph J CoMes Robert S Goldfarh | 2007 | Eastern Economic Journal2007，33，： | 1 |
| 17 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis显示文摘 | Jing Yang Sendurai A Mani Joana Liu Donaher Sridhar Ramaswamy Raphael A Itzykson Christophe Come Pierre Savagner Inna Gitelman Andrea Richardson Robert A Weinberg | 2004 | Cell2004，，7： | 1 |
| 18 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel显示文摘 | Juurlink DN Comes T Ko DT et a1 | | 0，，： | 1 |
| 19 | Mechanisms of virus induced exacerbations of asthma显示文摘 | Come JM Holgate ST | 1997 | Thorax1997，52，4： | 1 |
| 20 | Mutation rates at 14 STR loci in the population from Pernambuco, Northeast Brazil显示文摘 | Andrade ES Comes EV Raposo G | 2009 | Forensic Sci Int Genet2009，3，4： | 1 |
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