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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Near-total thyroidectomy could be the best treatment for thyroid disease in endemic regions显示文摘 | Acun Z Comert M Cihan A | 2004 | Arch Surg2004，139，4： | 1 |
| 3 | Near-total thyroidectomycould be the best treatment for thyroid disease in endemicregions显示文摘 | Acun Z Comert M Cihan A | 2004 | Arch Surg2004，139，4： | 1 |
| 4 | Has the oxidative stress a role in late phase of experimental acute necrotizing pancreatitis显示文摘 | Yasar M Mas MR Comert B | 2002 | Hepatogastroenterology2002，49，48： | 1 |
| 5 | Queue length estimation from probe vehicle location and the impacts of sample size 显示文摘 | Comert G Cetin M | 2009 | European Journal of Operational Research2009，197，1： | 1 |
| 6 | The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis 显示文摘 | Akyol S Mas M R Comert B | 2003 | Pancreas2003，26，4： | 1 |
| 7 | Postoperative complicationsafter abdominal surgery in patients with chronic obstructive pul-monary disease显示文摘 | Atalay F Uygur F Comert M | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
| 8 | Superiority ofasymmetric modified Limberg flap for surgical treatment ofpilonidal disease显示文摘 | Cihan A Ucan BH Comert M | 2006 | Dis Colon Rectum2006，49，： | 1 |
| 9 | Postoperative complicationsafter abdominal surgery in patients with chronic obstructivepulmonary disease 显示文摘 | Atalay F Uygur F Comert M | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
| 10 | The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis 显示文摘 | Akyol S Mas M R Comert B | 2003 | Pancreas2003，26，4： | 1 |
| 11 | The effect of combination therapy of hyperbaric oxygen,meropenem,and selective mitric oxide synthase inhibitor in experimental acute pancreatitis显示文摘 | Isik A T Mas M R Comert B | 2004 | Pancreas2004，28，： | 1 |
| 12 | Near-total thyroidectomy could be the best treatment for thyroid disease in endemic regions显示文摘 | Acun Z Comert M Cihan A | | 0，，： | 1 |
| 13 | Queue length estimation from probe vehicle location and the impacts of sample size 显示文摘 | COMERT G CETIN M | 2009 | European Journal of Operational Research2009，197，1： | 1 |
| 14 | A comparison of borides formed on AISI 1040 and AISI P20 steels显示文摘 | Uslu I Comert H Ipek M | 2007 | Material & Design2007，28，： | 1 |
| 15 | Analytical evaluation of the error in queue length estimation at traffic signals from probe vehicle data 显示文摘 | COMERT G CETIN M | 2011 | IEEE Transactions on Intelligent Transportation Systems2011，12，2： | 1 |
| 16 | Evaluation of borides formed on AISI P20 steel显示文摘 | Uslu I Comert H Ipek M | | 0，，： | 1 |
| 17 | Intracranial involvement in a patient with Hodgkin's lymphuma 显示文摘 | Comert M Bassullu N Kaya E | 2011 | Singapore Med J2011，52，9： | 1 |
| 18 | Colonic tuberculosis mimicking tumor perforation: a case report and review of the literature 显示文摘 | COMERT F B COMERT M KULAH C | 2006 | Dig Dis Sci2006，51，6： | 1 |
| 19 | Queue length estimation from probe vehicle location and the impacts of sample size显示文摘 | COMERT G CETIN M | 2009 | European Journal of Operational Research2009，197，1： | 1 |
| 20 | Queue length estimation from probe vehicle location and the impacts of sample size 显示文摘 | COMERT G CETIN M | 2009 | European Journal of Operational Research2009，197，： | 1 |
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