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| 1 | Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study显示文摘AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, respectively.CONCLUSION Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies. | Zeynep Gural Sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder Ahmet Kizir Ethem N Oral | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 3 |
| 2 | Importance of identifying the course of the recurrent laryngeal nerve in total and near-total thy- roid lobectomies 显示文摘 | Acun Z Cinar F Cihan A | 2005 | Am Surg2005，71，3： | 1 |
| 3 | Importance of identifying the course of the recurrent laryngeal nerve in total and near-total thyroid lobectomies显示文摘 | Acun Z Cinar F Cihan A | 2005 | Am Surg2005，71，3： | 1 |
| 4 | Killer toxin of Pichia anomala NCYC 432; purification, characterization and its exo-1,3-glucanase activity显示文摘 | izgu F Ahl nbay D Acun T | 2006 | Enzyme Microbial Technol2006，39，： | 1 |
| 5 | Near-total thyroidectomy could be the best treatment for thyroid disease in endemic regions显示文摘 | Acun Z Comert M Cihan A | 2004 | Arch Surg2004，139，4： | 1 |
| 6 | Pneumothorax in the newborn:clinical presentation,risk factors and outcomes显示文摘 | AIy H Massaro A Acun C | 2014 | J Matern Fetal Neonatal Med2014，27，4： | 1 |
| 7 | Effects of inhaled corticosteroids on growth in asthmatic children 显示文摘 | Acun C Tomac N Ermis B | 2005 | Allergy Asthma Proc2005，26，： | 1 |
| 8 | Fat-plug and paper-patch Myringoplasty in rats显示文摘 | lmamoglu M lsik AU Acuner O | 1998 | J Otolaryngol1998，27，6： | 1 |
| 9 | SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation显示文摘 | Acun T Oztas E Yagci T | 2011 | BMC Cancer2011，11，： | 1 |
| 10 | Near-total thyroidectomycould be the best treatment for thyroid disease in endemicregions显示文摘 | Acun Z Comert M Cihan A | 2004 | Arch Surg2004，139，4： | 1 |
| 11 | Cefifiaxone - induced biliary pseudolithiasis and urinary bladder sludge显示文摘 | Acun C Erdem LO Sogut A | 2004 | Pediatr Iut2004，46，： | 1 |
| 12 | Treatment of toctilon yellow 2G by Chlorella vulgw4a 显示文摘 | Acuner E Dilek F B | 2004 | Process Biochemistry2004，39，5： | 1 |
| 13 | Antioxidant activity, total phenolics and some chemical properties of 0kizgzt3 and Narince grape pomace and grape seed flours显示文摘 | Hu LYA GO L SULTAN ACUN HICRAN EN | 2013 | Journal of Food Agriculture and Envirot2013，11，2： | 1 |
| 14 | Treatment of tectilon yellow 2G by chlorella vulgaris显示文摘 | ACUNER E DILEK F B | 2004 | Process Biochemistry2004，39，5： | 1 |
| 15 | Ceftriaxone - induced biliary pseudolithiasis and urinary bladder sludge 显示文摘 | Acun C Erdem LO Sogut A | 2004 | Pediatrics intemation- al : official journal of the Japan Pediatric Society2004，46，3： | 1 |
| 16 | Importance of identify- ing the course of the recurrent laryngeal nerve in total and near-total thyroid lobectomies 显示文摘 | Acun Z Cinar F Cihan A | 2005 | Am Surg2005，71，3： | 1 |
| 17 | HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis 显示文摘 | Vidyasagar A Reese S Acun Z | 2008 | Am J Physiol Renal Physiol2008，295，3： | 1 |
| 18 | Synthesis of Ni-Mo-W sulphide catalysts by ex situ decomposition of trimetallic precursors显示文摘 | Acun R H Albiter M A Espino J | 2006 | App Catal A: Gen2006，304，10： | 1 |
| 19 | FRP systems in shear strengthening of reinforced concrete structures 显示文摘 | Belarbi A Acun B | 2013 | Procedia Engineering2013，57，： | 1 |
| 20 | Effects of inhaled corticosteroids on growth in asthmatic children 显示文摘 | Acun C Tomac N Ermis B | 2005 | Allergy and Asthma Proceedings: the Official Journal of Regional and State Allergy Societies2005，26，： | 1 |
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