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| 1 | Laugier-Hunziker syndrome显示文摘 | Lenane P Sullivan DO Keane CO | 2001 | J Eur Acad Dermatol Venereol2001，15，6： | 1 |
| 2 | Long-term potentiation in direct perforant path projections to the hippocampal CA3 region in vivo显示文摘 | Do VH Martinez CO Martinez JL | 2002 | J Neurophysiol2002，87，2： | 1 |
| 3 | Dendritic Cells Amplify T Cell-Mediated Immune Responses in the Central Nervous System显示文摘 | Karman J Chu HH Co DO | 2006 | Immunol2006，177，11： | 1 |
| 4 | Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by eytokines, catecholamines, and PPARgamma 显示文摘 | do Nascimento CO Hunter L Trayhurn P | 2004 | Biochem Biophys Res Commun2004，313，3： | 1 |
| 5 | T cell contributions to theditlerent phases of granuloma fonnation显示文摘 | Co DO Hogan LH II-Kim S | 2004 | Immunol Lett2004，92，12： | 1 |
| 6 | Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats 显示文摘 | Barros DO Xavier SML Barbosa CO Silva RF Freitas RLM Maia FD | 2007 | Neurosci Lett2007，416，3： | 1 |
| 7 | The problems of indeterminate HIV results in blood transfusion services in Nigeria显示文摘 | Elemuwa CO Olaleye DO | 2005 | Trop Doct2005，35，3： | 1 |
| 8 | Prevention ofventilator-as-sociated, pneumonia: current pracficeinCana dianintensive care units显示文摘 | Heyland DK CO ok DJ DO dek PM | 2002 | J Crit Care2002，17，3： | 1 |
| 9 | Natural killer cells in obesity:impaired function and increased susceptibility to the effects of cigarette smoke显示文摘 | Shea DO Cawood TJ Farrelly CO etal | 2010 | PloS One2010，5，： | 1 |
| 10 | Juvenile dermatomyositis:immunopathogenesis,role of myositis-specific autoantibodies,and review of rituximab use显示文摘 | Chiu YE Co DO | | 0，，04： | 1 |
| 11 | Associative long-term potentiation(LTP) among extrinsic afferents of the hippocampal CA3 region in vivo显示文摘 | Do VH Martinez Jr JL | 2002 | Brain Res2002，940，12： | 1 |
| 12 | High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C显示文摘 | D.C.B.L. Aroucha R.F. do Carmo P. Moura J.L.A. Silva L.R.S. Vasconcelos M.S.M. Cavalcanti M.T.C. Muniz M.L. Aroucha E.R.F. Siqueira G.G.O.M. Cahú L.M.M.B. Pereira M.R.C.D. Coêlho | 2013 | Cytokine2013，，3： | 1 |
| 13 | The Laugier-Hunzik- er syn-drome显示文摘 | Lenane P Sullivan DO Keane CO | 2001 | J Eur Acad Derrnatol Venereol2001，15，6： | 1 |
| 14 | Comparison of99mTc(V)-DMSA,201Tl and99mTc-MIBI imaging in the follow-up of patients with medullary carcinoma of the thyroid显示文摘 | ?mer U?ur Lale Kostako?lu Nilüter Güler Biray Caner U?ur Uysal Nazenin Elahi Mithat Haflo?lu Do?angün Yüksel Tülin Aras Hikmet Bayhan Co?kun Bekdik | 1996 | European Journal of Nuclear Medicine1996，，10： | 1 |
| 15 | Overexpression of Galectin-3 and its clinical significance in ovarian carcinoma显示文摘 | Kim MK Sung CO Do IG | 2011 | Int J ClinOncol2011，16，4： | 1 |
| 16 | Epigenetic mechanisms in gastric cancer显示文摘 | Gigek CO Chen ES Calcagno DO | 2012 | Epigenomics2012，4，3： | 1 |
| 17 | Effects of interface trap generation and annihilation on the data retention characteristics of flash memory cells 显示文摘 | LEE J D CHOI J H PARK D KIM K CO S E DO G | 2004 | IEEE Transactions on Device Material Reliability2004，4，1： | 1 |
| 18 | Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice显示文摘BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity.Since pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the colon.The precise pathophysiology remains poorly understood.AIM To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms involved.METHODS Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane anesthesia.Colorectal sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal distensions.Myeloperoxidase,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using immunohistochemistry.Green fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal cord.The expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western blot.RESULTS Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d postinjection.No increased permeability or inflammation was shown in the bladder or colon 7 d postinjection.Visceral hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after injection(P=0.007 and 0.023 respectively).Colorectal sensitization was prevented by intrathecal or intracerebroventricular injections of minocycline,a microglia inhibitor,by intracerebroventricular injection of CP-99994 dihydrochloride,a NK1 antagonist,and by intracerebroventricular injection of SB203580,a MAPK-p38 inhibitor.CONCLUSION We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice.Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension,mediated by neuroglial interactions,MAPK-p38 phosphorylation and the NK1 receptor. | Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol | 2022 | World Journal of Gastroenterology2022，28，48： | 1 |
| 19 | Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats显示文摘 | Barros DO Xavier SM Barbosa CO | 2007 | Neurosci Lett2007，416，3： | 1 |
| 20 | Laugier-Hunziker syndrome 显示文摘 | Lenane P Sullivan DO Keane CO | 2001 | J Eur Aead Dermatol Venereol2001，15，6： | 1 |
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