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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 3 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 4 | Compression of power quality event data using 2D representation显示文摘 | Omer N G Do an G E | 2008 | Electric Power Systems Research2008，78，6： | 1 |
| 5 | The value of pos- tural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia显示文摘 | Frankle HL Hancock DO Hyslop G | 1969 | Paraplegia1969，7，3： | 1 |
| 6 | Compression of power quality event data using 2D representation显示文摘 | Omer N G Do an G E | 2008 | Electric Power Systems Research2008，78，6： | 1 |
| 7 | Slump loss control of cement paste by adding polycarboxylic type slump-releasing dispersant 显示文摘 | GYE G SEONG S H DO S K | 1999 | Cem Concr Res1999，29，2： | 1 |
| 8 | Intrathecal epinephrine in combined spinal-epidural analgesia for labor: dose-response relationship for epinephrine added to a local anesthetic-opioid combination显示文摘 | Gurbet A Turker G Kose DO | 2005 | Int J Obstet Anesth2005，14，2： | 1 |
| 9 | A long reset-time power-on re- set circuit with brown-out detection capability 显示文摘 | Le H B Do X D Lee S G | 2011 | Circuits and Systems II: Express Briefs IEEE Transactions on2011，58，： | 1 |
| 10 | The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia显示文摘 | Frankel HL Hancock DO Hyslop G | 1969 | Spinal Cord1969，7，3： | 1 |
| 11 | Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases 显示文摘 | Wang G Do MT | 1997 | J Exp Med1997，186，： | 1 |
| 12 | The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells(hMSCs)and in-duce chondrogenesis显示文摘 | Kim J H Park J S Yang H N Woo D G Jeon S Y Do H J | 2011 | Biomaterials2011，32，： | 1 |
| 13 | Preparation of economical sorbents for SO2 and NOx removal using coal washery reject显示文摘 | Lu G Q Do D D | 1991 | Carbon1991，29，2： | 1 |
| 14 | The value of pos-tural reduction in the initial management of closed injuriesof the spine with paraplegia and tetraplegia 显示文摘 | Frankel HL Hancock DO Hyslop G | 1969 | Paraplegia1969，7，3： | 1 |
| 15 | A novel analysis algorithm for po- tential quantitative assessment of myocardial computed tomo- graphy perfusion显示文摘 | Liew G Ail N Do S | 2013 | Acad Radiol2013，20，10： | 1 |
| 16 | Intrinsically Microporous Soluble Polyimides Incorporating Troger’s Base for Membrane Gas Separation显示文摘 | Zhuang Y Seong J G Do Y S | 2014 | Macromolecules2014，47，10： | 1 |
| 17 | The value of postural reduction in the initial management of closed in-juries of the spine with paraplegia and tetraplegia 显示文摘 | Frankel HL Hancock DO Hyslop G | 1969 | Paraplegia1969，7，3： | 1 |
| 18 | Increased expression of basci fibroblast growth factor (bFGF) following focal cerebral infarction in the rat 显示文摘 | Elizabeth K Cornelio G Tuyen Do | 1996 | Molecular Brain Research1996，39，： | 1 |
| 19 | The association betweenserum uric acid level and coronary artery disease显示文摘 | Sinan DO Kabakci G Okutucu S | 2010 | Int J Clin Pract2010，64，7： | 1 |
| 20 | Application of Design Axioms for Glass Bulb Design and Software Development for Design Automatiom显示文摘 | Do S H Park G J | 2001 | Journal of Mechanical Design2001，123，： | 1 |
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