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| 1 | Pharmacomicrobiomics: a novel route towards personalized medicine?显示文摘在药反应的内部个人的异质是影响病人幸福并且在社会水平上提出庞大的临床、金融的负担的一个严重问题。Pharmacogenomics 在关于药反应可变性或药毒性的对单个基因背景的影响的研究的最前线,并且最近,内脏 microbiome,也被称为第二个染色体,在这个方面作为一个重要播放器被认出了。而且, microbiome 是为由于机会改进药功效和安全操作它的作文的一个很吸引人的目标。Pharmacomicrobiomics 是调查 microbiome 变化和药反应和布置(吸收,分发,新陈代谢和排泄) 的相互影响的一个新兴的领域。在这评论,我们提供历史的概述并且在在内脏 microbiome,主人和药之间的复杂相互作用上检验当前的最先进的知识。我们主张那联合 pharmacogenomics 和 pharmacomicrobiomics 将为在个性化的药做主要进展提供一个重要基础。 | Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga Jingyuan Fu | 2018 | Protein & Cell2018，9，5： | 7 |
| 2 | Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients显示文摘AIM:To assess the distribution of human leukocyteantigen(HLA)-DQ2 and-DQ8 in Iranian celiac disease(CD)patients and compare them to healthy Iranian controls.METHODS:To predict the HLA-DQA1 and-DQB1genes,we used six previously reported HLA-tagging single nucleotide polymorphism to determine HLA genotypes in 59 Iranian patients with‘biopsy-confirmed’CD and in 151 healthy Iranian individuals.To test the transferability of the method,50 cases and controls were also typed using a commercial kit that identifies individual carriers of DQ2,DQ7 and DQ8 alleles.RESULTS:In this pilot study 97%of CD cases(n=57)and 58%of controls(n=87)were carriers of HLADQ2 and/or HLA-DQ8 heterodimers,either in the homozygous or heterozygous state.The HLA-DQ pattern of these 57 CD patients:heterozygous DQ2.2(n=14)and homozygous DQ2.2(n=1),heterozygous DQ2.5(n=33)and homozygous DQ2.5(n=8),heterozygous DQ8(n=13)and homozygous DQ8(n=2).Two CD patients were negative for both DQ2 and DQ8(3%).CONCLUSION:The prevalence of DQ8 in our CD population was higher than that reported in other populations(25.4%).As reported in other populations,our results underline the primary importance of HLA-DQ alleles in the Iranian population’s susceptibility to CD. | Mohammad Rostami-Nejad Jihane Romanos Kamran Rostami Azita Ganji Mohammad Javad Ehsani-Ardakani Ali-Reza Bakhshipour Homayoun Zojaji Seyed Reza Mohebbi Mohammad-Reza Zali Cisca Wijmenga | 2014 | World Journal of Gastroenterology2014，20，20： | 1 |
| 3 | From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases显示文摘 | Vinod Kumar Cisca Wijmenga Sebo Withoff | 2012 | Seminars in Immunopathology2012，，4： | 1 |
| 4 | Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11显示文摘 | Lucio H Castilla Cisca Wijmenga Qing Wang Terryl Stacy Nancy A Speck Michael Eckhaus Miguel Marín-Padilla Francis S Collins Anthony Wynshaw-Boris Pu P Liu | 1996 | Cell1996，，4： | 1 |
| 5 | Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac Disease显示文摘 | Jihane Romanos Cleo C. van Diemen Ilja M. Nolte Gosia Trynka Alexandra Zhernakova Jingyuan Fu Maria Teresa Bardella Donatella Barisani Ross McManus David A. van Heel Cisca Wijmenga | 2009 | Gastroenterology2009，，3： | 1 |
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