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| 1 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 2 | Human Bop is a novel BH3-only member of the Bcl-2 protein family显示文摘One group of Bcl-2 protein family,which shares only the BH3 domain(BH3-only),is critically involved in the regulation of programmed cell death.Herein we demonstrated a novel human BH3-only protein(designated as Bop)which could induce apoptosis in a BH3 domain-dependent manner.Further analysis indicated that Bop mainly localized to mitochondria and used its BH3 domain to contact the loop regions of voltage dependent anion channel 1(VDAC1)in the outer mitochondrial membrane.In addition,purified Bop protein induced the loss of mitochondrial transmembrane potential(ΔΨm)and the release of cytochrome c.Furthermore,Bop used its BH3 domain to contact pro-survival Bcl-2 family members(Bcl-2,Bcl-XL,Mcl-1,A1 and Bcl-w),which could inhibit Bop-induced apoptosis.Bop would be constrained by pro-survival Bcl-2 proteins in resting cells,because Bop became released from phosphorylated Bcl-2 induced by microtubule-interfering agent like vincristine(VCR).Indeed,knockdown experiments indicated that Bop was partially required for VCR induced cell death.Finally,Bop might need to function through Bak and Bax,likely by releasing Bak from Bcl-XL sequestration.In conclusion,Bop may be a novel BH3-only factor that can engage with the regulatory network of Bcl-2 family members to process intrinsic apoptotic signaling. | Xiaoping Zhang Changjiang Weng Yuan Li Xiaoyan Wang Chunsun Jiang Xuemei Li Youli Xu Quan Chen Lei Pan Hong Tang | 2012 | Protein & Cell2012，3，10： | 2 |
| 3 | Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends 显示文摘 | Zhang Chunsun Xing Da Li Yuyuan | 2007 | Biotechnology Advances2007，，25： | 1 |
| 4 | PCR microfluidic devices for DNA amplification 显示文摘 | Chunsun Zhang Jinliang Xu Wenli Ma | 2006 | Biotechnology Advances2006，24，3： | 1 |
| 5 | Microfluidic gradient PCR(MG- PCR):a new method for naicroflcuidic DNA amplification显示文摘 | Zhang Chunsun Xing Da | 2010 | Biomedical Microdevices2010，12，12： | 1 |
| 6 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 7 | Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends显示文摘 | Chunsun Zhang Da Xing Yuyuan Li | 2007 | Biotechnology Advances2007，，5： | 1 |
| 8 | Micropumps, microvalves and micromixers within PCR microfluidic chips: Advances and trends显示文摘 | Chunsun Zhang Da Xing Yuyuan Li | 2007 | Biotechnology Advances2007，25，5： | 1 |
| 9 | Effect of additives on formation of natural gas hydrate 显示文摘 | ZHANG Chunsun FAN Shuanshi LIANG Deqing | 2004 | Fuel2004，83，16： | 1 |
| 10 | Muhichannel oscillatory-flow multiplex PCR microfluidics for high-through- put and fast detection of foodbome bacterial pathogens显示文摘 | Zhang Chunsun Wang Haiying Xing Da | 2011 | Biomed Microdevices2011，13，5： | 1 |
| 11 | Micropumps, microvalves and micromixers within PCR microfluidic chips: Advances and trends显示文摘 | Zhang Chunsun Xing Da Li Yuyuan | 2007 | Biotechnology Advances2007，，25： | 1 |
| 12 | PCR microfluidic devices for DNA amplification 显示文摘 | Zhang Chunsun Su Jinliang Ma Wenlr | 2006 | Biotechnology Advances2006，24，3： | 1 |
| 13 | Micropumps,microvalves,and micromixers within PCR microfluidic chips:advances and trends显示文摘 | Zhang Chunsun Xing Da Li Yuyuan | 2007 | Biotechnology Advances2007，31，2： | 1 |
| 14 | Effect of Additives on Formation of Natural Gas Hydrate 显示文摘 | ZHANG Chunsun FAN Shuanshi LIANG Deqing | 2004 | Fuel2004，83，16： | 1 |
| 15 | Bid BH3 peptide,but not its mutant form G^(94)E, induces permeability transition pore opening and cytochrome c release in vitro显示文摘It has been shown that Bid and its truncated form tBid could induce cytochrome c (cyt c) release without impacting on PTP. We first show that Bid BH3 peptide, but not its mutant form of Bid BH3 peptide G94E, which is unable to bind to Bcl-xL, induces permeability transition pore (PTP) opening in a dose dependent manner. Bid BH3 peptide also induces the reduction of mitochondria membrane potential (Ψm) and cyt c release from mitochondrial in vitro. PTP opening and the loss of Ψm, were inhibited by Bcl-xL, cyclosporin A and ruthenium red, and the latter was an inhibitor of Ca2+ uniporter in the mitochondrial membrane. These results indicate that Bid BH3 peptide could antagonize Bcl-xL to induced PTP opening and mitochondrial dysfunction. | XIATian, JIANG Chunsun, LI Linjiang, ZHANG Yong, JIN Haijing, LIU Shusen, WU Caihong & CHEN QuanThe National Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China The National Ke | 2002 | Chinese Science Bulletin2002，47，7： | 1 |
| 16 | Knowledge-Based Image Analysis for 3D Road Construction显示文摘 | Zhang Chunsun Baltsavias E Gruen A | 2001 | Asian Journal of Geoinfomatics2001，1，4： | 1 |
| 17 | Rare earth permanent magnet boosts the development of wind power generation in China显示文摘1.Wind energy Wind is a kind of clean,pollution-free and renewable energy with great potential.Wind power generation refers to the use of wind turbines to convert wind energy into electricity directly.Among the various forms of wind energy utilization,wind power generation is the main form of wind energy utilization,and it is also one of the most mature technologies,the most profitable prospects of renewable energy. | Zhang Anwen Wang Chunsun | 2021 | China Rare Earth Information2021，27，1： | 0 |
| 18 | A flow chemiluminescence paper-based microfuidic device for detection of chromium(Ⅲ)in water显示文摘In this work,a solely gravity and capillary force-driven flow chemiluminescence(GCF-CL)paper-based microfuidic device has been proved for the first time as a new platforn for inex-pensive,usable,mini mally instrumented dynamic chemiluninescence(CL)detection of chromium(Ⅲ)[Cr(Ⅲ)],where an appropriate angle of inclination between the loading and detection zones on the paper produces a rapid flow of CL prompt solution through the paper charnel.For this study,we use a cost-effective paper device that is manufactured by a simple wax screen-printing method,while the signal generated from the Cr(Ⅲ)-catalyzed oxidation of luminol by H_(2)O_(2) is recorded by a low-cost and luggable CCD camera.A series of GCF-CL affecting factors have been evaluated carefully.At optimal conditions,two linear relationships between GCF-CL intensities and the logarithms of Cr(Ⅲ)concentrations are obtained in the concentration mnges of 0.025-35 mg/L and 50-500 mg/L separately,with the detection limit of 0.0245mg/L for a les than 30s assay,and relative standard deviations(RSDs)of 38%,4.5%and 2.3%for 0.75,5 and 50 mg/L of Cr(Ⅲ)(n=8).The above results indicate that the GCF-CL paper-based microfluidic device possesses a receivable sensitivity,dynamic range,storage stability and reproducibility.Finally,the developed GCF-CL is utilized for Cr(Ⅲ)detection in real water samples. | Qiuping Shang Peng Zhang Huijie Li Rui Liu Chunsun Zhang | 2019 | Journal of Innovative Optical Health Sciences2019，，6： | 0 |
| 19 | A smartphone-based automated fluorescence analysis system for point-of-care testing of Hg(Ⅱ)显示文摘This work demonstrates a smartphone-based automated fluorescence analysis system(SAFAS)for point-of-care testing(POCT)of Hg(Ⅱ).This system consists of three modules.The smartphone module is used to provide an excitation light source,and to collect and analyze fluorescent images.The dark box module is applied to integrate the desired optical elements and offers a dark environment.The cost of the integrated dark box mainly includes the upper cover,box body,lower bottom,¯xture and some optical elements which is about$109.The chip module is used for fluorescence sensing,which is composed of an upper plate,bottom plate and cloth-based chip.Due to the integration of multiple smartphone functions,the SAFAS eliminates the need for additional power sources,light sources and analysis systems.The dark box and upper and bottom plates are made by 3D printer.The cloth-based chip(about$0.005 for each chip)is fabricated using the wax screenprinting technique,with no need for expensive and complex fabrication equipments.To our knowledge,the cloth-based microfluidic fluorescence detection method combined with smartphone functions is first reported.By using optimal conditions,the designed system can realize the quantitative detection of Hg(Ⅱ),which has a linear range of 0.001–100μgmL^(-1)and a detection limit of 0.5 ngmL^(-1).Additionally,the SAFAS has been successfully applied for detecting Hg(Ⅱ)in actual water samples,with recoveries of 100.1%–111%,RSDs of 3.88%–9.74%,and fast detection time of about 1 min.Obviously,the proposed SAFAS has the advantages of high sensitivity,wide dynamic range,acceptable reproducibility,good stability and low cost.Therefore,it is believed that the presented SAFAS has great potential to perform the POCT of Hg(II)in different water samples. | Yafei Chen Ke Zhang Yuan Liu Chunsun Zhang | 2022 | Journal of Innovative Optical Health Sciences2022，15，5： | 0 |
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