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| 1 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 2 | 肝细胞生长因子基因治疗减轻胆管结扎肝纤维化的实验研究显示文摘目的:验证肝细胞生长因子(HGF)基因治疗在胆管结扎肝纤维化中的保护作用。方法:用雄性CD-1小鼠,随机分为3组。正常对照组仅解剖肝门分离胆总管,不作胆管结扎;胆管结扎的2组,分别给予HGF质粒(pCMV-HGF,1μg/g)和空质粒(pcDNA3),每2周1次。3个月后将小鼠处死,评价肝纤维化程度。结果:肝细胞生长因子基因治疗能显著减少胆管周围胶原的沉积,表现在:肝胶原染色(Masson-Trichrome染色)减少;胆管周围Ⅰ型和Ⅲ型胶原的免疫荧光染色减少。和空质粒组相比,HGF治疗组肝组织羟脯氨酸的含量显著降低(两组分别为0.48±0.04μg/mgvs1.37±0.06μg/mg,P<0.05);肝纤维母细胞的激活减少——表现为肝组织中α-SMA的表达减少(两组分别为0.32±0.05vs.0.84±0.14,P<0.05);TGF-β1的表达减少(两组分别为0.69±0.11vs.1.31±0.23,P(0.01)。结论:在胆管结扎肝纤维化中,肝细胞生长因子基因治疗能减轻肝纤维化的程度,肝细胞生长因子可用于肝纤维化的治疗。 | 夏景林 DAI Chunsun Liu Youhua | 2005 | 中国临床医学2005，12，4： | 2 |
| 3 | Human Bop is a novel BH3-only member of the Bcl-2 protein family显示文摘One group of Bcl-2 protein family,which shares only the BH3 domain(BH3-only),is critically involved in the regulation of programmed cell death.Herein we demonstrated a novel human BH3-only protein(designated as Bop)which could induce apoptosis in a BH3 domain-dependent manner.Further analysis indicated that Bop mainly localized to mitochondria and used its BH3 domain to contact the loop regions of voltage dependent anion channel 1(VDAC1)in the outer mitochondrial membrane.In addition,purified Bop protein induced the loss of mitochondrial transmembrane potential(ΔΨm)and the release of cytochrome c.Furthermore,Bop used its BH3 domain to contact pro-survival Bcl-2 family members(Bcl-2,Bcl-XL,Mcl-1,A1 and Bcl-w),which could inhibit Bop-induced apoptosis.Bop would be constrained by pro-survival Bcl-2 proteins in resting cells,because Bop became released from phosphorylated Bcl-2 induced by microtubule-interfering agent like vincristine(VCR).Indeed,knockdown experiments indicated that Bop was partially required for VCR induced cell death.Finally,Bop might need to function through Bak and Bax,likely by releasing Bak from Bcl-XL sequestration.In conclusion,Bop may be a novel BH3-only factor that can engage with the regulatory network of Bcl-2 family members to process intrinsic apoptotic signaling. | Xiaoping Zhang Changjiang Weng Yuan Li Xiaoyan Wang Chunsun Jiang Xuemei Li Youli Xu Quan Chen Lei Pan Hong Tang | 2012 | Protein & Cell2012，3，10： | 2 |
| 4 | Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction显示文摘 | Junwei Yang Chunsun Dai Youhua Liu | 2003 | Am J Pathol2003，163，2： | 1 |
| 5 | Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation显示文摘 | Xia Jinglin Dai Chunsun Michalopoulos G K | 2006 | Am J Pathol2006，168，5： | 1 |
| 6 | Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends 显示文摘 | Zhang Chunsun Xing Da Li Yuyuan | 2007 | Biotechnology Advances2007，，25： | 1 |
| 7 | Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice显示文摘 | Chunsun Dai Junwei Yang Youhua Liu | 2002 | J Am Soc Nephrol2002，13，2： | 1 |
| 8 | Epithelial - to - Mesenchymal Transition Is a Potential Pathway Leading to Podo- cyte Dysfunction and Proteinufia 显示文摘 | Yingjian L Young Sun K Chunsun D | 2008 | American Joumal of Pa- thology2008，172，： | 1 |
| 9 | PCR microfluidic devices for DNA amplification 显示文摘 | Chunsun Zhang Jinliang Xu Wenli Ma | 2006 | Biotechnology Advances2006，24，3： | 1 |
| 10 | Microfluidic gradient PCR(MG- PCR):a new method for naicroflcuidic DNA amplification显示文摘 | Zhang Chunsun Xing Da | 2010 | Biomedical Microdevices2010，12，12： | 1 |
| 11 | Identification and expression of an APETALA2-Like gene from Nelumbo nucifera显示文摘 | Liu Zhaolei Gu Chunsun Chen Fadi | 2012 | Applied Biochemistry and Biotechnology2012，168，2： | 1 |
| 12 | β-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance显示文摘 | Chunsun Dai Chang-Goo Huh Snorri S. Thorgeirsson Youhua Liu | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 13 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 14 | Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends显示文摘 | Chunsun Zhang Da Xing Yuyuan Li | 2007 | Biotechnology Advances2007，，5： | 1 |
| 15 | Hepatocyte Growth Factor Attenuates Liver Fibrosis Induced by Bile Duct Ligation显示文摘 | Jing-Lin Xia Chunsun Dai George K. Michalopoulos Youhua Liu | 2006 | The American Journal of Pathology2006，，5： | 1 |
| 16 | MIR205HG facilitates carcinogenesis of lung squamous cell carcinoma in vitro revealed by long noncoding RNA profiling显示文摘As a subtype of non-small-cell lung cancer,lung squamous cell carcinoma(LUSC)accounts for one-fifth of all lung cancers.Unfortunately,no specific targetable aberration has yet been identified.Hence,it is of huge urgency and potential to identify aberrantly regulated genes in LUSC.Here,five pairs of LUSC samples and their corresponding adjacent tissues were subject to whole transcriptome sequencing.Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG,LNC_000378,RP11-116G8.5,RP3-523K23.2,and RP5_968D22.1 were significantly upregulated in all five LUSC samples.Importantly,MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines.Interestingly,our results demonstrated that the expression level of MIR205HG is positively correlated with the malignancy.In addition,MIR205HG is required for LUSC cell growth and cell migration.Most importantly,our results showed that MIR205HG prohibits LUSC apoptosis via regulating Bcl-2 and Bax.Taken together,our data shed lights on the IncRNA regulatory nexus that controls the carcinogenesis of LUSC and provided potential novel diagnostic markers and therapeutic targets for LUSC. | Yan Chang Xinying Xue Chunsun Li Wei Zhao Yongfu Ma Fei Xu Zhen Wu Yu Dai Yunjing Li Yang Liu Liang’an Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 1 |
| 17 | Single injection of naked plasmid encoding hepatocyte growth factor prevents cell deathand ameliorates acute renal failure in mice 显示文摘 | Dai Chunsun Yang Junwei Liu Youhua | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 18 | EpitheIial- to-Mesenehymal Transition Is a Potential Pathway Leading to Podoeyte Dysfunction and Proteinuria显示文摘 | Yingjian L Young Sun K Chunsun D | 2008 | American Jour- nal of Pathology2008，172，： | 1 |
| 19 | Micropumps, microvalves and micromixers within PCR microfluidic chips: Advances and trends显示文摘 | Chunsun Zhang Da Xing Yuyuan Li | 2007 | Biotechnology Advances2007，25，5： | 1 |
| 20 | A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition显示文摘 | Junwei Yang Chunsun Dai Youhua Liu | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
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