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| 1 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 2 | Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer显示文摘Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 and transforming growth factor-beta/transforming growth factor-beta receptor(TGF-P/TGF-βR).Consequently,it is necessary to identify predictive factors of lung cancer patients who are not only resistant to PD-1/PD-LI inhibitors but also sensitive to bifunctional drugs.The purpose of this study was to search for such predictors.Methods:Multivariable Cox regression was used to study the association between the clinical outcome of treatment with PD-1/PD-L1 inhibitors and lym-phocyte recovery after lymphopenia in lung cancer patients.Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice.Bioluminescence imag-ing,flow cytometry,and immunohistochemistry were employed to detrmine response to immunotherapy and function of tumor-infiltrating immune cells.Results:For lung cancer patients treated with anti-PD-1/PD-LI antibodies,poor lymphocyte recovery was associated with a shorter progression-free survival(PFS;P<0.001),an accumulation of regulatory T cells(Tregs),and an elimi-nation of CD8+T cells in the peripheral blood.Levels of CD8+T cells and Treg cells were also imbalanced in the tumors and peripheral immune organs of mice with poor lymphocyte recovery after chemotherapy.Moreover,these mice failed to respond to anti-PD-1 antibodies but remained sensitive to the anti-PD-LI/TGF-βR fusion protein(SHR-1701).Consistently,SHR-1701 but not anti-PD-1 antibod-ies,markedly enhanced IFN-γproduction and Ki-67 expression in peripheral CD8+T cells from patients with impaired lymphocyte recovery.Conclusions:Lung cancer patients with poor lymphocyte recovery and suffer-ing from persistent lymphopenia after previous chemotherapy are resistant to anti-PD-1/PD-L1 antibodies but might be sensitive to second-generation agents such as SHR-1701. | Bo Cheng Kaikai Ding Pengxiang Chen Jianxiong Ji Tao Luo Xiaofan Guo Wei Qiu Chunhong Ma Xue Meng Jian Wang Jinming Yu Yuan Liu | 2022 | Cancer Communications2022，42，1： | 5 |
| 3 | An equilibrium analysis of the land use structure in the Yunnan Province, China显示文摘全球陆地使用结构由于不停的人口生长很快正在变化并且加速都市化,它导致在对的僵硬要求之间的凶猛的竞争布满建筑物区域和栽培土地,森林,和草地的保护。认识到陆地资源的持续发展是大挑战。与社会财务矩阵数据集基于陆地使用变化的一个可计算出来的一般平衡模型,这研究在三种情形下面在 20082020 的时期期间在云南省实现了陆地使用结构的平衡分析,基线情形,低 TFP (全部的因素生产率)情形,并且高 TFP 情形。结果显示在所有三种情形下面,栽培土地的区域与显著扩大一起显著地衰退了布满建筑物区域当森林,草地,和闲置的土地的区域稍微增加了时。TFP 的生长率在扩大上有第一否定然后积极的效果布满建筑物它增加了的栽培土地的区域和衰落。而且,栽培的两个的模仿的变化登陆并且布满建筑物区域在低 TFP 情形下面是最大的,并且远在 2020 在云南省为陆地利用在全面计划超过了限制。基于情形的模拟结果具有为在让土地使用决定的决策者的重要引用价值,平衡在栽培土地和增加的需求为的保护之间的凶猛的比赛布满建筑物区域,和保证食物安全,生态的安全,和陆地资源的持续开发。 | Jiao LUO Jinyan ZHAN Yingzhi LIN Chunhong ZHAO | 2014 | Frontiers of Earth Science2014，8，3： | 5 |
| 4 | Information extraction and CT reconstruction of liver images based on diffraction enhanced imaging显示文摘X-ray phase-contrast imaging (PCI) is a new emerging imaging technique that generates a high spatial resolution and high contrast of biological soft tissues compared to conventional radiography. Herein a biomedical application of diffraction enhanced imaging (DEI) is presented. As one of the PCI methods, DEI derives contrast from many different kinds of sample information, such as the sample’s X-ray absorption, refraction gradient and ultra-small-angle X-ray scattering (USAXS) properties, and the sample information is expressed by three parametric images. Combinedwith computed tomography (CT), DEI-CT can produce 3D volumetric images of the sample and can be used for investigating micro-structures of biomedical samples. Our DEI experiments for liver samples were implemented at the topography station of Beijing Synchrotron Radiation Facility (BSRF). The results show that by using our provided information extraction method and DEI-CT reconstruction approach, the obtained parametric images clearly display the inner structures of liver tissues and the morphology of blood vessels. Furthermore, the reconstructed 3D view of the liver blood vessels exhibits the micro blood vessels whose minimum diameter is on the order of about tens of microns, much better than its conventional CT reconstruction at a millimeter resolution. In conclusion, both the information extraction method and DEI-CT have the potential for use in biomedical micro-structures analysis. | Chunhong Hu Tao Zhao Lu Zhang Hui Li Xinyan Zhao Shuqian Luo | 2009 | Progress in Natural Science:Materials International2009，19，8： | 5 |
| 5 | Neural cell injury microenvironment induces neural differentiation of human umbilical cord mesenchymal stem cells显示文摘 | Jin Zhou Guoping Tia Jinge Wang Xiaoguang Luo Siyang Zhang Jianping Li Li Li Bing Xu FengZhu Xia Wang Chunhong Jia Weijin Zhao Danyang Zhao Aihua Xu | 2012 | Neural Regeneration Research2012，7，34： | 3 |
| 6 | Preparation, characterization, and property of polyaniline/Prussian blue micro-composites in a low-temperature hydrothermal process显示文摘 | Xiaoli Zhang Chunhong Sui Jian Gong Rui Yang Yunqing Luo Lunyu Qu | 2007 | Applied Surface Science2007，，22： | 1 |
| 7 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 8 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 9 | Fabrication and properties of poly(L-lactide)/hydroxyapatite/chitosan fiber ternary composite scaffolds for bone tissue engineering显示文摘 | Jianhao Zhao Chunhong Luo Wanqing Han Mei Tu Rong Zeng Zhengang Cha Changren Zhou | 2012 | Journal of Polymer Engineering2012，32，45： | 1 |
| 10 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 11 | Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP显示文摘Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRNAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little effect.Together, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner. | Weicheng Luo Yi Li Yi Zeng Yining Li Minzhang Cheng Cheng Zhang Fei Li Yiqing Wu Chunhong Huang Xiaolong Yang Joachim Kremerskothen Jianmin Zhang Chunbo Zhang Shuo Tu Zhihua Li Zhijun Luo Zhenghong Lin Xiaohua Yan | 2023 | Journal of Molecular Cell Biology2023，15，2： | 0 |
| 12 | Study on drilling mechanism and optimization of percussion-extruding DTH hammer bit显示文摘The authors tested the percussion-extruding Down-the-hole(DTH)hammer bit with five different structures and mainly analyzed the drilling mechanism between conical bit and stepped bit.In addition,aiming at 'the pile effect' in combination with the advantage of stepped bit,we design a new cam spinning bit and test it outdoors.The result shows that using cam spinning bit can solve the problem of 'the pile effect',which can also obtain higher drilling efficiency than using conical bit in high confining pressure strata.It is characterized by novel structure and high drilling speed as well as good guiding,and it is significant for improving efficiency in percussion-extruding drilling technique. | LUO Chunhong ZHENG Zhichuan CAO Pinlu | 2009 | Global Geology2009，12，1： | 0 |
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