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| 1 | Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children显示文摘To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported cases.Nine(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1%)were symptomatic and 21(42.9%)were asymptomatic.Neither asymptomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control. | Jiehao Cai Xiangshi Wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali Wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning Wang Jianshe Wang Qirong Zhu Xiaowen Zhai Mei Zeng | 2020 | Virologica Sinica2020，35，6： | 4 |
| 2 | Idempotence-Preservers Linear Operators on 2:2 Upper Triangular Matrix Spaces over any Field显示文摘 | Ge Yanling Cao Chongguang | 2012 | Proceeding of The Seventh Workshop on Matrix and Operators2012，3234，： | 1 |
| 3 | Cadmium toxicity and translocation in rice seedlings are reduc by hydrogen peroxide pretreatment 显示文摘 | Hu Yanling Ge Ying Zhang Chunhua | 2009 | Plant Growth ReguL2009，59，1： | 1 |
| 4 | Mild Cytokine Elevation, Moderate CD4^+ T Cell Response and Abundant Antibody Production in Children with COVID-19显示文摘Children with Coronavirus Disease 2019(COVID-19) were reported to show milder symptoms and better prognosis than their adult counterparts, but the difference of immune response against SARS-CoV-2 between children and adults hasn’t been reported. Therefore we initiated this study to figure out the features of immune response in children with COVID-19.Sera and whole blood cells from 19 children with COVID-19 during different phases after disease onset were collected.The cytokine concentrations, SARS-CoV-2 S-RBD or N-specific antibodies and T cell immune responses were detected respectively. In children with COVID-19, only 3 of 12 cytokines were increased in acute sera, including interferon(IFN)-cinduced protein 10(IP10), interleukin(IL)-10 and IL-16. We observed an increase in T helper(Th)-2 cells and a suppression in regulatory T cells(Treg) in patients during acute phase, but no significant response was found in the IFN-cproducing or tumor necrosis factor(TNF)-a-producing CD8?T cells in patients. S-RBD and N IgM showed an early induction, while S-RBD and N IgG were prominently induced later in convalescent phase. Potent S-RBD IgA response was observed but N IgA seemed to be inconspicuous. Children with COVID-19 displayed an immunophenotype that is less inflammatory than adults, including unremarkable cytokine elevation, moderate CD4?T cell response and inactive CD8?T cell response, but their humoral immunity against SARS-CoV-2 were as strong as adults. Our finding presented immunological characteristics of children with COVID-19 and might give some clues as to why children develop less severe disease than adults. | Ran Jia Xiangshi Wang Pengcheng Liu Xiaozhen Liang Yanling Ge He Tian Hailing Chang Hao Zhou Mei Zeng Jin Xu | 2020 | Virologica Sinica2020，35，6： | 1 |
| 5 | A Feedback Scheme for Fountain Codes Based Transport Protocol in Space Communications显示文摘This paper proposed a practicalfeedback scheme for fountain codes based transportprotocol in space communications. In the proposed scheme,the sender is signaled by two types of acknowledgment(ACK) packets.Before decoding, packet loss probability isestimated on the receiver side and encapsulated intoa soft ACKand sent to the sender.After decoding,decoding results are encapsulated into hard ACKsandsent to the sender.There are two contributions in the proposed scheme: 1. Employing physical layer calculation instead of application layer statistics to estimate the packet loss probability of space channel, which can improvethe accuracy and practicality. 2. A cascade overhead-failure probabilityrelationship between the sender and the receiver has been analyzed to help determine the exact numberof packetsneeded byfountain decoding.Simulations show that for space communications,compared with the existing space transport protocols, fountain codes based transport protocolwith the proposed schemecan not only ensure transmission reliability, but also greatly improvelink utilization. | XING Yanling GE Ning | 2015 | China Communications2015，12，8： | 1 |
| 6 | Iodine status and thyroid function of pregnant lactating women and infants (0-1yr) residing in areas with an effective Universal Salt Iodization program 显示文摘 | WANG Yanling ZHANG Zhongliang GE Pengfei | 2009 | Asia Pae ] Clin Nutr2009，18，1： | 1 |
| 7 | Design and Synthesis of a Series of Novel Macrocycle Janus Kinase 2 Inhibitors显示文摘Summary of main observation and conclusion Macrocycle has attracted the attention of many researchers in the field of medicinal chemistry due to its unique advantages and good prospects,but the difficulties in drug design and synthesis of macrocycle limit its applications.In this study,a series of macrocyclic derivatives designed from anaplastic lymphoma kinase(ALK)inhibitor lorlatinib were synthesized as Janus kinase 2(JAK2)selective inhibitors.Among them,17f had the best inhibitory activity(IC50=0.177μmol·L^-1)and selectivity for JAK2 over JAK1 and JAK3,which indicated that design of the macrocyclic derivatives might be a feasible strategy for the discovery of novel selective JAK2 inhihitors. | Yanling Wang Huan Ge Disha Wang Huan He Lu Li Yanyan Diao Zihao Shen Lili Zhu Shiliang Li Zhenjiang Zhao Honglin Li | 2019 | Chinese Journal of Chemistry2019，37，12： | 1 |
| 8 | Resource-constrained maximum network throughput on space networks显示文摘This paper investigates the maximum network throughput for resource-constrained space networks based on the delay and disruption-tolerant networking(DTN) architecture. Specifically,this paper proposes a methodology for calculating the maximum network throughput of multiple transmission tasks under storage and delay constraints over a space network. A mixed-integer linear programming(MILP) is formulated to solve this problem. Simulations results show that the proposed methodology can successfully calculate the optimal throughput of a space network under storage and delay constraints, as well as a clear, monotonic relationship between end-to-end delay and the maximum network throughput under storage constraints. At the same time, the optimization results shine light on the routing and transport protocol design in space communication, which can be used to obtain the optimal network throughput. | Yanling Xing Ning Ge Youzheng Wang | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 1 |
| 9 | Information technology and artificial intelligence support in management experiences of the pediatric designated hospital during the COVID-19 epidemic in 2022 in Shanghai显示文摘Objective:To describe the information technology and artificial intelligence support in management experiences of the pediatric designated hospital in the wave of COVID-19 in Shanghai.Methods:We retrospectively concluded the management experiences at the largest pediatric designated hospital from March 1st to May 11th in 2022 in Shanghai.We summarized the application of Internet hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward and the structed electronic medical record in the inpatient system.We illustrated the role of the information system through the number and prognosis of patients treated.Results:The COVID-19 designated hospitals were built particularly for critical patients requiring high-level medical care,responded quickly and scientifically to prevent and control the epidemic situation.From March 1st to May 11th,2022,we received and treated 768 children confirmed by positive RT-PCR and treated at our center.In our management,we use Internet Information on the Internet Hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward,structed electronic medical record in the inpatient system.No deaths or nosocomial infections occurred.The number of offline outpatient visits dropped,from March to May 2022,146,106,48,379,57,686 respectively.But the outpatient volume on the internet hospital increased significantly(3,347 in March 2022 vs.372 in March 2021;4,465 in April 2022 vs.409 in April 2021;4,677 in May 2022 vs.538 in May 2021).Conclusions:Information technology and artificial intelligence has provided significant supports in the management.The system might optimize the admission screening process,increases the communication inside and outside the ward,achieves early detection and diagnosis,timely isolates patients,and timely treatment of various types of children. | Yu Shi Jin Fu Mei Zeng Yanling Ge Xiangshi Wang Aimei Xia Weijie Shen Jiali Wang Weiming Chen Siyuan Jiang Xiaowen Zhai | 2023 | Intelligent Medicine2023，3，1： | 0 |
| 10 | Functional evaluation of the insulin/insulin-like growth factor signaling pathway in determination of wing polyphenism in pea aphid显示文摘Wing polyphenism is a common phenomenon that plays key roles in environmental adaptation of insects.Insulin/insulin-like growth factor signaling(IIS)pathway is a highly conserved pathway in regulation of metabolism,development,and growth in metazoans.It has been reported that IS is required for switching of wing morph in brown planthopper via regulating the development of the wing pad.However,it remains elusive whether and how IIS pathway regulates transgenerational wing dimorphism in aphid.In this study,we found that pairing and solitary treatments can induce pea aphids to produce high and low percentage winged offspring,respectively.The expression level of ILP5(insulin-like peptide 5)in maternal head was significantly higher upon solitary treatment in comparison with pairing,while silencing of ILP5 caused no obvious change in the winged offspring ratio.RNA interference-mediated knockdown of FoxO(Forkhead transcription factor subgroup O)in stage 20 embryos significantly increased the winged offspring ratio.The results of pharmacological and quantitative polymerase chain reaction experiments showed that the embryonic insulin receptors may not be involved in wing polyphenism.Additionally,ILP4 and ILP11 exhibited higher expression levels in 1st wingless offspring than in winged offspring.We demonstrate that FoxO negatively regulates the wing morph development in embryos.ILPs may regulate aphid wing polyphenism in a developmental stage-specific manner.However,the regulation may be not mediated by the canonical IIS pathway.The findings advance our understanding of IIS pathway in insect transgenerational wing polyphenism. | Yiyang Yuan Yanyan Wang Wanwan Ye Erliang Yuan Jian Di Xin Chen Yanling Xings Yucheng Sun Feng Ge | 2023 | Insect Science2023，30，3： | 0 |
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