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| 1 | Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong显示文摘瞄准:用香港汉语调查流行和胃肠的基质肿瘤(大意) 的临床的模式,并且估计发病率的 CD117 的介绍的影响。方法:从 Yan Chai 医院的病理的部门的数据库, 47 个病人,在这研究与到 2003 年 12 月的从 1995 年 9 月的大意被包括。十大意在 CD117 的介绍前被诊断。临床的特征,肿瘤特征,和治疗被分析。预言肿瘤的因素联系了死亡或复发与比例的危险建模的考克斯一起被学习。结果:病人包括了 26 男性和 21 女性,与 66.6 年的吝啬的年龄(SD 13.1,范围 29-87 年) 。大意的估计的流行每 100,000 个人是 13.4-15.6,与每 100,000 个人的 1.68-1.96 的年度发生。在 CD117 的介绍前后的大意的年度发生每 100,000 个人是 1.1 并且 2.1 每 100,000 个人分别地。胃(34 个病人, 72.3%) 是为肿瘤的最普通的地点,由小肠列在后面(8 个病人, 17.0%) ,食管(2 个病人, 4.3%) ,网膜(2 个病人, 4.3%) 并且冒号(1 个病人, 2.1%) 。31 个病人(66%) 有完全的肿瘤切除术。十一从 16 死亡(23%) 是肿瘤相关的。中部的生存时间是 26 瞬间。五年的幸存率是 61.3% 。与肿瘤相关的死亡或复发联系的重要因素是不完全的切除术,肿瘤尺寸 5 厘米以上,侵略到转移的邻近的机关或存在。结论:在香港的大意的发生在美国比得上那,但是在芬兰比那降低。大意的真发生能在 CD117 的介绍前被低估。不完全的切除术,肿瘤尺寸 5 厘米以上,到转移的邻近的机关或存在的侵略是预言肿瘤相关的死亡或复发的因素。 | Kam Hoi Chan Chun Wing Chan Wai Hung Chow Wai Keung Kwan Chi Kwan Kong Ka Fung Mak Miu Yi Leung Lin Kiu Lau | 2006 | World Journal of Gastroenterology2006，12，14： | 12 |
| 2 | Intravenous fluid selection rationales in acute clinical management显示文摘BACKGROUND: Intravenous fluid(IVF) is commonly used in acute clinical management. This study aimed to review the choice and primary considerations in IVF prescriptions and to evaluate the adequacy of guidelines and trainings on it in the New Territories West Cluster(NTWC) of Hong Kong.METHODS: This is a descriptive study based on data collected from an online survey. Data were processed by SPSS for statistical analysis. This study focused on a general description and doctor-nurse between group comparison. Participants were asked the choice of IVF for nine acute clinical scenarios and provide reason. A 1–10 scale was used to assess the sufficiency of guideline, training and information, and time for revision on IVF prescription.RESULTS: 0.9% sodium chloride was the most familiar IVF(36%), followed by 5% Dextrose solution(26%). In the nine scenarios, the most chosen IVF was 0.9% sodium chloride(37%–61%). There was significant difference in the choice of IVF between doctors and nurses in 7 cases. The second most chosen IVF for doctors was Plasma-Lyte A while that for nurses was Gelofusine. Departmental practice was the most chosen reason to account for the prescription. The adequacy of guideline, information and training, and time for revision was rated 5. Doctors had significantly more time at work than nurses to update knowledge in IVF prescription(5.41 versus 4.57).CONCLUSION: 0.9% sodium chloride was mostly chosen. The choice of IVF was mainly based on departmental practice. Adequacy of guideline, information and training, and time for revision on IVF prescription were average, indicating significant training deficit. | Wing Yan Shirley Cheung Wai Kwan Cheung Chun Ho Lam Yeuk Wai Chan Hau Ching Chow Ka Lok Cheng Yau Hang Wong Chak Wah Kam | 2018 | World Journal of Emergency Medicine2018，9，1： | 3 |
| 3 | Epstein-Barr virus-associated infectious mononucleosis in Chinese children显示文摘 | Chan Chun Wing Chiang | 2003 | Pediatr Infect Dis J2003，22，11： | 1 |
| 4 | Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry显示文摘 | Kong Alice PS Yang Xilin Luk Andrea Ma Ronald CW So Wing Yee Ozaki Risa Ting Rose Cheung Kitty Ho Chung Shun Chan Michael HM Chow Chun Chung Chan Juliana CN | 2014 | Diabetes Care2014，，4： | 1 |
| 5 | Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties显示文摘A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC 16872.Heterologous production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 VrcB.Intriguingly,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic window.Our study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities. | Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 6 | 卡马西平与库欣综合征的假阳性地塞米松抑制试验显示文摘 | Ronald C W Ma Wing Bun Chan Wing Yee So Peter C Y Tong Juliana C N Chan Chun Chung Chow 肖新华(译) 王姮(校) | 2005 | 英国医学杂志中文版2005，8，4： | 0 |
| 7 | A historical re-analysis of the calamitous midget typhoon passing through Hong Kong region on 18 September 1906 and its storm surge impact to Hong Kong region显示文摘A typhoon passed through Hong Kong region suddenly and unexpectedly on 18 September 1906(the“Typhoon 1906”)and had a disastrous impact on Victoria Harbour and its surroundings in just a couple of hours.Since the year 1906 was the“Bingwu”year in the Chinese calendar,the typhoon is also known historically as the“Bingwu Typhoon”.Tremendous loss of lives and property resulted,and the shipping and fishing communities were devastated.Two mysteries arising from this calamitous typhoon have existed to date:1)Why the Hong Kong region Observatory was not able to provide any forewarning?2)whether the storm surge reported in some contemporary records is entirely credible?This paper will focus on both of these.In this paper,we re-analyse historical weather observations recorded in various historical documents and estimate the possible storm size,intensity and track of Typhoon 1906 using tropical cyclone models.Based on the re-analyses,the storm surges,storm tides and wave heights in Hong Kong region are also estimated using storm surge and wave models.The results reveal that Typhoon 1906 was a midget typhoon,with a radius of maximum winds of 11 km or smaller,during its passage through Hong Kong region.This explains why it was technically impossible for a forewarning to be given at that time when real-time weather observations from ships,meteorological satellites and radars were non-existent.We also estimate that the maximum storm surges(storm tides)in Hong Kong region were not higher than 0.82 m(2.43 mCD)and 1.98 m(4.15 mCD)in Victoria Harbour and Tolo Harbour respectively.These figures are found to be limited by the intensity and the storm size of the typhoon.Therefore,we conclude that the previously documented storm surge figures are not supported by the present study. | Hing Yim Mok Chi Ming Shun Stephen Davies Wing Hong Lui Dick Shum Lau Kai Chun Cheung Kwan Yin Kong Sai Tick Chan | 2022 | Tropical Cyclone Research and Review2022，11，3： | 0 |
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