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| 1 | 聚乙二醇化干扰素a-2b治疗HBeAg阳性慢性乙型肝炎:HBsAg转阴与HBV基因型相关显示文摘HBsAg转阴是慢性乙型肝炎抗病毒治疗完全应答的纯正标志。方法为在一项多中心随机对照试验中,266例HBeAg阳性慢性乙型肝炎病人接受聚乙二醇化干扰素a-2b(100μg/d)联合拉米夫定(100mg/d)或安慰剂的治疗,疗程52wk;治疗结束后随访26wk。 | Flink HJ van Zonneveld M Hansen BE 陆伟(摘译) 张占卿(审校) | 2006 | 世界感染杂志2006，6，4： | 45 |
| 2 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 3 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 4 | Immunoreactivity of CD45,a protein phosphotyrosine phosphatase,in Alzheimer' s disease 显示文摘 | Masliah E Mallory M Hansen L Alford M Albright T Terry R | 1991 | Acta Neuropathol( Berl )1991，83，1： | 2 |
| 5 | Reflectance measurement of canopy biomass and nitrogen status in wheat crops using normalized difference vegetation indices and partial least squares regression显示文摘 | HANSEN P M SCHJOERRING J K | 2003 | Remote Sensing of Environment2003，86，： | 2 |
| 6 | Model selection and the principle of minimum description length显示文摘 | Hansen M H Yu B | 1998 | Journal of the American Statistical Association1998，96，454： | 2 |
| 7 | Global discrimination of land cover types from metrics derived from AVHRR pathfinder data 显示文摘 | DEFRIES R HANSEN M TOWNSHEND J | 1995 | Remote Sensing Environment1995，54，： | 2 |
| 8 | 西双版纳傣族及上海汉族群体HLA-DR2相关的DR/DQ单倍型分析显示文摘对44名西双版纳傣族和9名上海地区汉族DK2阳性个体进行了与其相关的DR/DQ单倍型组合的分析。傣族群体中DRBI-DR2亚型分布以*1602与*1502为最常见,其等位基因频率分别为43.6%与,40.0%和汉族群体中以*1501为主明显不同。傣族群体中共检出10种与DR2相关联的DR/DQ单倍型;最常见的是DRB1*1602、DRB5*0101、DQA1*0102、DQB1*0502(34.5%)与汉族及其他群体明显不同,本研究表明傣族不仅具有高频率的DR2,而且与DR2相关联的DRB1、DRB5、DQA1、DQB1单倍型组合有其独特性。 | 范丽安 杨珏琴 姚芳娟 董建中 许玲娣 陈仁彪 M Sirkong R Vongrathna P Longta S Lekmak D Chandanayingyong A Smith J Hansen | 1995 | 中华医学遗传学杂志1995，12，3： | 2 |
| 9 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 10 | Pattern selective color image fusion显示文摘 | L Bogoni M Hansen | 2001 | Pattern Recognition2001，34，8： | 1 |
| 11 | Crisis in corporate America:The role of strategy 显示文摘 | HANSEN F D SMITH M C | 2003 | Business Horizons2003，15，1： | 1 |
| 12 | A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion显示文摘 | Hansen C L Skordalakes E Berger J M | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 13 | Epilepsy and pregnancy : lamotrigine as main drug used 显示文摘 | Sabers A Dam M A - Rogvi - Hansen B | 2004 | Acta Neurol Stand2004，109，： | 1 |
| 14 | Thalassiolins A-C: new marine-derived inhibitors of HIV eDNA integrase显示文摘 | Rowley D C Hansen M S T Rhodes D | 2002 | Bioorg Med Chen2002，10，： | 1 |
| 15 | Clinical management of metabolic syndrome: report of the Ameri- can Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management显示文摘 | Grundy S M Hansen B Smith S C Jr | 2004 | Circulation2004，109，4： | 1 |
| 16 | The Problem of Nonresponse in Sample Surveys显示文摘 | Hansen M H Hurwitz W N | 1946 | Journal of the American Statistical Association1946，，41： | 1 |
| 17 | The first X-ray structural evidence demonstrating thiolate coordination in an organocobalt B12 model complex:implications for methionine syntheses显示文摘 | Polson S M Hansen L Marzilli L G | 1997 | Inorg Chem1997，36，2： | 1 |
| 18 | Brain metastases in adenocarcinoma of the lung:frequency,risk groups and prognosis显示文摘 | Sorensen JB Hansen HH Hansen M | 1988 | J Clin oncol1988，6，912： | 1 |
| 19 | Virtual-flux-based direct power control of three-phase PWM rectifier显示文摘 | Aalinowski M Kazmierkowski M P Hansen S | 2001 | IEEE Transaction on Industry Applications2001，37，： | 1 |
| 20 | Movement of foliar boron out of leaves and accumulation in flower buds and flower parts of Italion prune显示文摘 | HANSEN M H CHAPLIN P J | 1985 | HortScience1985，20，： | 1 |
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