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| 1 | Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis显示文摘BACKGROUND Liver cirrhosis is a significant source of morbidity and mortality worldwide.The disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur.A major challenge is to diagnose advanced fibrosis as early as possible,using simple and non-invasive diagnostics tools.Thrombocytopenia represents advanced fibrosis and portal hypertension(HTN)and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk factor.However,little is known about the association between longitudinal changes in platelet counts(PTC),when still within the normal range,and the risk of cirrhosis.AIM To explore whether platelet counts trajectories over time,can predict advanced liver fibrosis across the different etiologies of liver diseases.METHODS A nested case-control study utilizing a large computerized database.Cirrhosis cases(n=5258)were compared to controls(n=15744)matched for age and sex at a ratio of 1:3.All participants had multiple laboratory measurements prior to enrollment.We calculated the trends of PTC,liver enzymes,bilirubin,international normalized ratio,albumin and fibrosis scores(fibrosis-4 and aspartate transaminase-to-platelet ratio index)throughout the preceding 20 years prior to cirrhosis diagnosis compared to healthy controls.The association between PTC,cirrhosis complications and fibrosis scores prior to cirrhosis diagnosis was investigated.RESULTS The mean age in both groups was 56(SD 15.8).Cirrhotic patients were more likely to be smokers,diabetic with chronic kidney disease and had a higher prevalence of HTN.The leading cirrhosis etiologies were viral,alcoholic and fatty liver disease.The mean PTC decreased from 240000/μL to 190000/μL up to 15 years prior to cirrhosis diagnosis compared to controls who’s PTC remained stable around the values of 240000/μL.This trend was consistent regardless of sex,cirrhosis etiology and was more pronounced in patients who developed varices and ascites.Compared to controls whose values remained in the normal range,in the cirrhosis group aspartate aminotransferase and alanine aminotransferase,increased from 40 U/L to 75 U/L and FIB-4 increased gradually from 1.3 to 3 prior to cirrhosis diagnosis.In multivariable regression analysis,a decrease of 50 units in PTC was associated with 1.3 times odds of cirrhosis(95%CI 1.25-1.35).CONCLUSION In the preceding years before the diagnosis of cirrhosis,there is a progressive decline in PTC,within the normal range,matched to a gradual increase in fibrosis scores. | Neta Gotlieb Naama Schwartz Shira Zelber-Sagi Gabriel Chodick Varda Shalev Oren Shibolet | 2020 | World Journal of Gastroenterology2020，26，38： | 3 |
| 2 | In vitro release of interferon-gamma from peripheral blood lymphocytes in cutaneous adverse drug reactions显示文摘 | Goldberg I Hanson M Chodick G | 2012 | Clin Dev Immunol2012，2012，68： | 1 |
| 3 | The risk of overt diabetes meUitus among women with gestational diabetes: a population- based study 显示文摘 | Chodick G Elchalal U Sella T | 2010 | Diabet Med2010，27，7： | 1 |
| 4 | Continuation of statin treatment and all-canse mortality: a population-based cohort study 显示文摘 | Shalev V Chodick G Silber H et ed | 2009 | Arch Intern Med2009，169，3： | 1 |
| 5 | Continuation of statin treatment and all cause mortality:a population based cohort study显示文摘 | Shalev V Chodick G Silber H | 2009 | Arch Intern Med2009，169，3： | 1 |
| 6 | In Vitro Fertilization and Risk of Breast and Gynecologic Cancers: A Retrospective Cohort Study within the Israeli Maccabi Healthcare Services显示文摘 | Louise A. Brinton Britton Trabert Varda Shalev Eitan Lunenfeld Tal Sella Gabriel Chodick | 2012 | Fertility and Sterility2012，，： | 1 |
| 7 | The risk of overt diabetes mellitus among women with gestati0nal diabetes: a population- based study显示文摘 | Chodick G Elchalal U Sella T | 2010 | Diabet Med2010，27，7： | 1 |
| 8 | Uptake of Pap smears among women in a large Israeli HMO between 2006 and 2008显示文摘 | R. Raz O. Shavit M. Stein R. Cohen E. Schejter G. Chodick V. Shalev | 2012 | Public Health2012，，7： | 1 |
| 9 | The achievement of target cholesterol level differs between coronary heart disease and diabetic pa- tients 显示文摘 | Elis A Chodick G Heymann AD | 2011 | European Journal of Internal Medicine2011，22，3： | 1 |
| 10 | Continuation of statin treatment and all-cause mortality: a population- based cohort study显示文摘 | Shahv V Chodick G Silber H | 2009 | Arch Intern Med2009，169，： | 1 |
| 11 | Risk of cataract after exposure to low doses of ionizing radiation:a 20-year prospective cohort study among US radiologic technologists显示文摘 | CHODICK G BEKIROGLU N HAUPTMANN M | 2008 | Am J Epidemiol2008，168，6： | 1 |
| 12 | Persistence with Statins and Incident Cataract: A Population-Based Historical Cohort Study显示文摘 | Gabriel Chodick Anthony D. Heymann Shira Flash Ehud Kokia Varda Shalev | 2010 | Annals of Epidemiology2010，，2： | 1 |
| 13 | Risk of cataract after exposure to low doses of ionizing radiation : a 20-year pro- spective cohort study among US radiologic technologists 显示文摘 | CHODICK G BEKIROGLU N HAUPTMANN M | 2008 | Am J Epidemiol2008，168，6： | 1 |
| 14 | Excess lifetime cancer mortality risk attributable to radiation exposure from computed tomography examinations in children显示文摘 | Chodick G Ronckers CM Shalev V | 2007 | Isr MedAssoc J2007，9，8： | 1 |
| 15 | Excess lifetime cancer mortality risk attributable to radiation exposure from computed tomography examinations in children显示文摘 | Chodick G Ronckers CM Shalev V | 2007 | Isr Med Assoc J2007，9，8： | 1 |
| 16 | Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer:evidence from 261 cases in Israel,1976-1999显示文摘 | Chodick G Struewing JP Ron E | 2008 | Eur J Med Genet2008，51，2： | 1 |
| 17 | Diabetes and risk of incident cancer: a large population-based cohort study in Israel显示文摘 | Gabriel Chodick Anthony D. Heymann Lena Rosenmann Manfred S. Green Shira Flash Avi Porath Ehud Kokia Varda Shalev | 2010 | Cancer Causes & Control2010，，6： | 1 |
| 18 | The long term risk of myelo- dysplastic syndromes among anemia patients: a population-based study显示文摘 | Meytes D Chodick G Shalev V | 2012 | Leuk Res2012，36，3： | 1 |
| 19 | Chronic urticaria and autoimmunity: associations found in a large population study 显示文摘 | Cohen R Chodick G Shalev V | 2012 | J Allergy Clin Immunol2012，129，5： | 1 |
| 20 | Continuation of statin treatment and all-cause mortality: a population based cohort study显示文摘 | Shalev V Chodick G Silber H | 2009 | Arch Intern Med2009，169，： | 1 |
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