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| 1 | Exosomal lncRNAs: the newest promising liquid biopsy显示文摘LncRNAs are defined as RNA transcripts greater than 200 nucleotides in length that have no or limited protein-coding potential.Basal expression of lncRNAs appeared important for various homeostatic processes,like gene imprinting cell differentiation and organogenesis.Moreover,it has been demonstrated that lncRNAs play an important role in tumorigenesis and metastasis.Some lncRNAs were stably detected in exosomes,which are widely found in body fluids.Several studies validated the use of exosomal lncRNAs as minimally invasive diagnostic and prognostic markers in several types of cancers.In addition,exosomal lncRNAs have been associated with drug resistance of tumor cells,suggesting a clinical application in cancer-targeted therapy.Despite the recent increase of studies on exosomal lncRNAs,their clinical significance in cancer diagnosis,prognosis and treatment needs to be fully explored.The methodologies for their detection with high purity and accuracy must be also improved in order to implement their use in clinical routine.This review aims to summarize the main recent technologies available for the isolation of exosomal lncRNAs,their status as a liquid biopsy as well as their future perspectives. | Marta Tellez-Gabriel Dominique Heymann | 2019 | Cancer Drug Resistance2019，2，4： | 2 |
| 2 | Role of IL-17 and Th17 Cells in Liver Diseases显示文摘 | Linda Hammerich Felix Heymann Frank Tacke T. Nakayama | 2010 | Clinical and Developmental Immunology2010，，： | 2 |
| 3 | Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study显示文摘AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. METHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. RESULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPE ; CREB3L1 ; NEDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NEDD4L ; SLC6A8), transcription (AKAP7 ; CREB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDEC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may help better understand tumor radioresistance. | Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann Marc-Andre Mahé Emmanuel Rio Michel Chérel | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 4 | Production of nephrotic syndrome in rats by freund's adjuvant and rat kidney suspension显示文摘 | Heymann W | 1959 | Proc Soc Exp Biol Med1959，100，： | 2 |
| 5 | Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities显示文摘 | Y Wittrant S Theoleyre S Couillaud C Dunstan D Heymann F Rédini | 2003 | Experimental Cell Research2003，，2： | 2 |
| 6 | E- and N-cad- herin distribution in developing and functional human teeth under normal and pathological conditions显示文摘 | Heymann R About I Lendahl U | 2002 | Am J Pathol2002，160，6： | 1 |
| 7 | Global search for critical failure surface in slope stability analysis显示文摘 | Bolton H P J Heymann G Groenwold A A | 2003 | Engineering Optimization2003，35，： | 1 |
| 8 | Structural determinants of water permeation through aquaporin-1 显示文摘 | MIYAMOTO K MITSUOKA K HIRAI T WALZ T AGRE P HEYMANN J B ENGEL A FUJIYOSHI Y | 2000 | Nature2000，407，： | 1 |
| 9 | Fighting spam on social Web sites: A survey of approaches and future challenges显示文摘 | Heymann P Koutrika G Garcia-Molina H | 2007 | IEEEInternetComputing2007，11，6： | 1 |
| 10 | Influence of metal ion solutions on rabbit osteoclast activities in vitro 显示文摘 | Rousselle AV Heymann D Demais V | 2002 | Histol Histopat- ho12002，17，4： | 1 |
| 11 | Osteoclastic acidification pathways during bone resorption显示文摘 | Rousselle A V Heymann D | 2002 | Bone2002，30，4： | 1 |
| 12 | Enhanced tumor regression and tissure repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma显示文摘 | Heymann D Ory B Blanchard F | 2005 | Bone2005，37，1： | 1 |
| 13 | Autophagy: A protective mechanism in re- sponse to stress and inflammation显示文摘 | Heymann D | 2006 | Curr Opin Investig Drugs2006，7，5： | 1 |
| 14 | The apparent contact dimension and covariates among orthodontically treated and nontreated subjects显示文摘 | Raj V Heymann HO Hershey HG | 2009 | J Esthet Restor Dent2009，21，2： | 1 |
| 15 | Osteoclastic acidification pathways during bone resorption显示文摘 | Rousselle AV Heymann D | 2002 | Bone2002，30，4： | 1 |
| 16 | Working parents:What factors are involved in their ability to take time off from work when their children are sick?显示文摘 | Heymann SJ Toomey S Furstenberg F | 1999 | Arch Pediatr Adolesc Med1999，153，8： | 1 |
| 17 | Mechanical properties of a new mica- based machinable glass ceramics for CAD/CAM restorations显示文摘 | Thompson JY Bayne SC Heymann HO | 1996 | J Prosthet Dent1996，76，6： | 1 |
| 18 | Stiffness ofgeomaterials at very small strains显示文摘 | CLAYTON C R I HEYMANN G | 2001 | Geotechnique2001，51，3： | 1 |
| 19 | The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowel syndrome 显示文摘 | Heymann -- Monnikes I Arnold R Florin I | 2000 | Am J Gastroenterol2000，，： | 1 |
| 20 | Potassiumiodi deindermatology : a 19 thcentury drug for the 21 stcentury - uses, pharama cology, adverseeffects, and contraindications显示文摘 | Sterling JB Heymann WR | 2000 | J Am Acad Dermatol2000，43，： | 1 |
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