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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Karaoke Theory in the Rehabilitation of mental patient显示文摘 | CM Leung Lee G Cheung B | 1998 | Singapore Medical Journal1998，4，： | 2 |
| 3 | Epidemiology of renal dysfunction and patient outcome in atherosclerotic renal artery occlusion 显示文摘 | Cheung CM Wright JR Shurrab AE | 2002 | J Am Soc Nephrol2002，13，1： | 1 |
| 4 | Computed tomography-guided core-needle biopsy specimens demonstrate epidermal growth factor receptor mutations in patients with non-small cell lung cancer显示文摘 | Chen CM Chang JW Cheung YC | 2008 | Acta Radiol2008，49，： | 1 |
| 5 | Using the National Institutes of Health Stroke Scale (NIHSS) to predict the mortality and outcome of patients with intracerebral haemorrhage显示文摘 | Cheung CM Tsoi TH Hon SF | 2008 | Hong Kong Med J2008，14，5： | 1 |
| 6 | Increase in plasmaadrenomedullin in patients with heart failure characterised bydiastolic dysfunction显示文摘 | Yu CM Cheung BM Leung R | 2001 | Heart2001，86，2： | 1 |
| 7 | Hospitalization fatali-ty risk of influenza A( H1N1) : a aystematic review and me-ta-analysis显示文摘 | Wong JY Kelly H Cheung CM | 2015 | Am J Epidemiol2015，182，4： | 1 |
| 8 | Transvenous embolisation of dural carotid-cavernous fistulas by multiple venous routes:a series of 27 cases显示文摘 | Chan CM Cheung YL | 2003 | Acta Neurochir (Wien)2003，145，： | 1 |
| 9 | Evaluation of dalba- vancin, tigecycline, minocycline, tetracycline, teicoplanin and vancomycin against community-associated and multidrug-re- sistant hospital-associated meticillin-resistant Staphylococ- cus aureus显示文摘 | Huang V Cheung CM Kaatz GW | 2010 | Int J Antimicrob Agents2010，35，1： | 1 |
| 10 | Effects of the intensity of down-regulation on Outcome of in vitro fertilization and embry transfer显示文摘 | Lam PM cheung LP Ohey CM | 2002 | Gynecol Endocimol2002，16，2： | 1 |
| 11 | Management of acuterenal failure in the elderly patient: a clinician's guide 显示文摘 | Cheung CM Ponnusamy A Anderton JG | 2008 | DrugsAging2008，25，45： | 1 |
| 12 | Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age 显示文摘 | Doesburg SM Chau CM Cheung TP | 2013 | Pain2013，154，10： | 1 |
| 13 | Choroidalneovascularization in pathological myopia显示文摘 | Neelam K Cheung CM Ohno-Matsui K | 2012 | ProgRetin Eye Res2012，31，5： | 1 |
| 14 | Transvenous embolization of dural carotid cavernous fistulas by multiple venous routes:A series of 27 cases显示文摘 | Cheng KM Chan CM Cheung YL | 2003 | Acta Neurochir2003，145，： | 1 |
| 15 | Development and validation of a disease specific quality of life questionnaire for gastro- oesophageal reflux disease: the GERD- QOL questionnaire 显示文摘 | Chan Y Ching JY Cheung CM | 2010 | Aliment Pharmacol Ther2010，31，3： | 1 |
| 16 | Interference of creatinine measurement in CAPD fluid is dependent on glucose and creatinine concentrations显示文摘 | Mak TW Cheung CK Cheung CM | 1997 | Nephrol Dial Transplant1997，12，1： | 1 |
| 17 | More severe type 2 diabetes-associated isehemie stroke injury is alleviated in aldose reductase-deficient mice显示文摘 | Yeung CM Lo AC Cheung AK | 2010 | J Neurosci Res2010，88，9： | 1 |
| 18 | One-year outcomes in survivors of the acute respiratory distress syndrome显示文摘 | Herridge MS Cheung AM Tansey CM | | 0，，08： | 1 |
| 19 | Choroidal neovascu- larization in pathological myopia 显示文摘 | Neelam K Cheung CM Ohno-Matsui K | 2012 | Prog Retin Eye Re s2012，31，5： | 1 |
| 20 | Two-year outcomes,health care use,and costs of survivors of acute respiratory distress syndrome显示文摘 | Cheung AM Tansey CM Tomlinson G | 2006 | Am J Respir Crit Care Med2006，174，5： | 1 |
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