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| 1 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 4 | Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion 显示文摘 | Lin TN Wang CK Cheung WM | 2000 | Journal of Cerebral Blood Flow & Metabolism2000，20，2： | 1 |
| 5 | Molecular mechanisms ofcytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation 显示文摘 | Cheung PF Wong CK Lam CW | 2008 | J Immtmol2008，180，8： | 1 |
| 6 | Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60cells显示文摘 | Wan CK Wang C Cheung HY | 2006 | Cancer Lett2006，241，1： | 1 |
| 7 | Mouse testin:complementary DNA cloning,genomicorganization,and characterization of its proximal promoterregion显示文摘 | Cheng CK Cheung CH Lee W | 2003 | Biol Reprod2003，68，4： | 1 |
| 8 | Triptolide induces bcl -2 cleavage and mitochondria dependent apoptosis in p53-deft-cient HL-60 celts 显示文摘 | Wan CK Wang C Cheung HY | 2006 | Cancer Lett2006，241，1： | 1 |
| 9 | Interleukin-25 induced chemokines and interleukin-6 release from eosinophils is mediated by p38显示文摘 | Wong CK Cheung PF lp WK | 2000 | Genomics2000，66，2： | 1 |
| 10 | Repeatability and reproduc- ibility of anterior chamber angle measurement with anterior seg- ment optical coherence tomography显示文摘 | Li H Leung CK Cheung CY | 2007 | Br J Ophthalmol2007，91，11： | 1 |
| 11 | An update onthe pathogenesis and treatment of IgA nephropathy 显示文摘 | Boyd JK Cheung CK Molyneux K | 2012 | Kidney Int2012，81，9： | 1 |
| 12 | Neurological recovery after decompressive craniectomy for massive ischemic stroke显示文摘 | Cheung A Telaghani CK Wang J | 2005 | Neurocrit Care2005，3，3： | 1 |
| 13 | Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology ofallergie inflammation 显示文摘 | Wong CK Cheung PF Lam CW | 2007 | Eur J Immunol2007，37，8： | 1 |
| 14 | Childhood nephrotic syndrome in relapse is associated with down-regulation of monocyte CD14 expression and lipopolysaccharide-induced tumour necrosis factor-alpha production 显示文摘 | Chen SP Cheung W Heng CK Jordan SC Yap HK | 2003 | Clin Exp Immunol2003，134，1： | 1 |
| 15 | TSLP induces chemotactic and prosurvival effects in eosinophils: implications in allergic in- flammation显示文摘 | Wong CK Hu S Cheung PF | 2010 | Am J Respir Cell Mol Biol2010，43，3： | 1 |
| 16 | Immunoassay of a tartrate-resistant acid phosphatase in serum显示文摘 | Cheung CK Panesar NS Haines C | 1995 | Clin Chem1995，41，5： | 1 |
| 17 | Urinary excretion of transferring by NIDD:a marker for early complications显示文摘 | Cheung CK Cockram CS Barker CF | 1989 | Clin Chem1989，35，： | 1 |
| 18 | Increased messenger RNA expression of vascular endothelial growth factor and its receptors in the implantation site of the human oviduct with ectopic gestation显示文摘 | Lam PM Briton-Jones C Cheung CK | 2004 | Fertil Steril2004，82，3： | 1 |
| 19 | Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography:a variability and diagnostic performance study显示文摘 | Leung CK Cheung CY Weinreb RN | 2009 | Ophthalmology2009，116，7： | 1 |
| 20 | Interference of creatinine measurement in CAPD fluid is dependent on glucose and creatinine concentrations显示文摘 | Mak TW Cheung CK Cheung CM | 1997 | Nephrol Dial Transplant1997，12，1： | 1 |
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