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| 1 | 结直肠癌组织中环指蛋白2的表达及其临床意义显示文摘目的检测结直肠癌组织中环指蛋白2(RNF2)的表达,探讨其与临床病理特征的关系。方法收集2017年5月至2019年5月沧州市中心医院行手术切除并经病理证实的84例结直肠癌患者的肿瘤组织和癌旁组织。实时定量PCR检测其中25对肿瘤组织及癌旁组织样本RNF2 mRNA的表达;免疫组化法检测所有样本中RNF2蛋白表达,并分析RNF2表达与临床病理特征的关系。结果免疫组化显示RNF2主要表达于结直肠癌组织细胞核内,其在结直肠癌组织中的阳性表达率显著高于癌旁组织(P<0.05)。RNF2表达与结直肠癌患者肿瘤分期、分化程度、淋巴结转移有关(均P<0.05),而与性别、年龄及肿瘤部位无关(均P>0.05)。实时定量PCR显示结直肠癌组织RNF2 mRNA相对表达量显著高于癌旁组织(P<0.001)。结论RNF2在结直肠癌组织中高表达,可能参与结直肠癌的发生发展。 | 贾楠 宋哲 陈宝胜 程进生 | 2020 | 中华生物医学工程杂志2020，26，1： | 1 |
| 2 | Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system显示文摘High-throughput sequencing has facilitated the identification of many types of non-coding RNAs(ncRNAs)involved in diverse cellular processes.NcRNAs as epigenetic mediators play key roles in neuronal development,maintenance,and dysfunction by controlling gene expression at multiple levels.NcRNAs may not only target specific DNA or RNA for gene silence but may also directly interact with chromatin-modifying proteins like Polycomb group(PcG)proteins to drive orchestrated transcriptional programs.Recent significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional,post-transcriptional,and epigenetic regulation.More importantly,dysregulation of ncRNAs,PcG proteins,and interplay among them is closely associated with the pathogenesis of central nervous system(CNS)disorders.In this review,we focus on the interplay between ncRNAs and PcG proteins in the CNS and highlight the functional roles of the partnership during neural development and diseases. | Ya-Jie Xu Pei-Pei Liu Shyh-Chang Ng Zhao-Qian Teng Chang-Mei Liu | 2020 | Journal of Molecular Cell Biology2020，12，5： | 0 |
| 3 | E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation显示文摘Hedgehog(Hh)signalling plays conserved roles in controlling embryonic development;its dysregulation causes many diseases including cancers.The G protein-coupled receptor Smoothened(Smo)is the key signal transducer of the Hh pathway,whose posttranslational regulation has been shown to be critical for its accumulation and activation.Ubiquitination has been reported an essential posttranslational regulation of Smo.Here,we identify a novel E3 ligase of Smo,Herc4,which binds to Smo,and regulates Hh signalling by controlling Smo ubiquitination and degradation.Interestingly,our data suggest that Herc4-mediated Smo degradation is regulated by Hh in PKA-primed phosphorylation-dependent and independent manners. | Weirong jiang Xia Yao Zhaoliang Shan Wenting Li Yuxue Gao Qing Zhang | 2019 | Journal of Molecular Cell Biology2019，11，9： | 0 |
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