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| 1 | 2D materials via liquid exfoliation:a review on fabrication and applications显示文摘Since graphene was discovered, the study of two-dimensional(2D) materials with atomic thickness has become a hot spot. To prepare different 2D materials,different methods have been groped, such as mechanical exfoliation, chemical vapor deposition(CVD), liquid-phase exfoliation. This review mainly introduced the sonication liquid-phase exfoliation, an effective method to prepare 2D materials. Compared with mechanical exfoliation and CVD methods, liquid-phase exfoliation is convenient and costeffective and provides high yield. We focused on both theoretical and experimental details of this method. This method was reviewed according to the development of 2D materials from graphene, h-BN to transition metal chalcogenides(TMDs) and black phosphorus nanosheets.We discussed the applications of liquid-exfoliated 2D materials including micro- and nanoelectrical devices,photoelectric devices, and energy storage devices. | Chengxue Huo Zhong Yan Xiufeng Song Haibo Zeng | 2015 | Science Bulletin2015，60，23： | 20 |
| 2 | A retrospective comparison of the modified tension band technique and the parallel titanium cannulated lag screw technique in transverse patella fracture显示文摘 | Wang Chengxue Tan Lei Qi Baochang Hou Xiangfeng Huang Yulong Zhang Haipeng Yu Tiecheng | 2014 | Chinese Journal of Traumatology2014，17，4： | 14 |
| 3 | MiRNA-429 suppresses the growth of gastric cancer cells in vitro显示文摘Micro-RNAs(miRNAs) have been found to be implicated in a very wide range of physiological processes.This study was aimed to investigate the regulation of miRNA-429(miR-429) in gastric cancer cells on cell proliferation and apoptosis.Quantitative PCR was employed to detect the expressions of miR-429 after eukaryotic expression plasmid of miR-429 and its inhibitor were transiently transfected into poorly differentiated human gastric can-cer cell line BGC823.The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) reduction as-says were used to examine proliferation ability.Apoptosis was analyzed by flow cytometry after transfection.The results showed that 48 h after transfection,overexpression of miR-429 reached maximum efficiency.Compared with mock transfection,miR-429 inhibited tumor cell proliferation significantly(P < 0.05) at 48 h and 72 h.of Overexpression of miR-429 promoted tumor cell apoptosis when compared with mock transfected cells(P < 0.05).On the contrary,miR-429 inhibitor promoted tumor cell proliferation and inhibited apoptosis when compared with controls(P < 0.05).Our results suggested that miRNA-429 may serve as a tumor suppressor during tumorigenesis of gastric cancer and may be a potential gastric cancer therapeutic target. | Di Liu Peng Xia Dongmei Diao Yao Cheng Hao Zhang Dawei Yuan Chen Huang Chengxue Dang | 2012 | The Journal of Biomedical Research2012，26，5： | 12 |
| 4 | UNCONFINED SEEPAGE ANALYSIS OF DISCONTINUOUS ROCK SLOPE显示文摘The unconfined seepage field of arch dam abutment s lope was studied. This paper is composed of two parts. The first part concerns with the numerical methods used in the analysis, which i ncludes the identification of rock blocky system and the algorithm of the unconf ined seepage flow in the discontinuity network with the consideration of the gro uting curtain and drainage curtain. In the second part a complicated arch dam ab utment slope was studied, for which the seepage flow field characteristics was a nalyzed and the seepage control system was evaluated. | Chen, Shenghong Wang, Weiming She, Chengxue Xu, Mingxi | 2000 | Journal of Hydrodynamics2000，12，3： | 11 |
| 5 | Optimized design and performance evaluation of an electric cup-chain potato metering device显示文摘The cup-chain metering device is commonly used in potato planters despite its problems of missing-seeding,double-seeding and ground wheel sliding.A mechanical-electrical design was developed for planters to resolve these problems.A regression experiment was conducted with three factors(chain speed,chain tightening distance and cup tilting)and two indicators(missing-seeding rate and double-seeding rate).Based on the results of regression experiment,a numerical regression model was built and a multi-objective optimization method was used to get an optimal solution.Subsequently,the optimized device was tested in the field.The device design presents a tilting seed cup with a guard plate and an electric control system.The laboratory test showed that the missing-seeding rate increased with the chain speed.It initially decreases and then increases with the chain tightening distance and cup tilting angle.The double-seeding rate declines with chain speed.It increases initially and declines afterward with the chain tightening distance.The optimization resulted in a missing-seeding rate of 4.39%and a double-seeding rate of 8.78%under the parameters of 0.32 m/s seeding speed,0.94×10-3 m tightening distance,and 12.5°cup tilting angle.The field test demonstrated that electric control instead of ground wheel-driven chain enables fast seeding and precise intra-row seeding distance. | Niu Kang Fang Xianfa Liu Yangchun Lü Chengxu Yuan Yanwei | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 5 |
| 6 | Therapeutic potential of colchicine in cardiovascular medicine:a pharmacological review显示文摘Colchicine is an ancient herbal drug derived from Colchicum autumnale.It was first used to treat familial Mediterranean fever and gout.Based on its unique efficacy as an anti-inflammatory agent,colchicine has been used in the therapy of cardiovascular diseases including coronary artery disease,atherosclerosis,recurrent pericarditis,vascular restenosis,heart failure,and myocardial infarction.More recently,colchicine has also shown therapeutic efficacy in alleviating cardiovascular complications of COVID-19.COLCOT and LoDoCo2 are two milestone clinical trials that confirm the curative effect of long-term administration of colchicine in reducing the incidence of cardiovascular events in patients with coronary artery disease.There is growing interest in studying the anti-inflammatory mechanisms of colchicine.The anti-inflammatory action of colchicine is mediated mainly through inhibiting the assembly of microtubules.At the cellular level,colchicine inhibits the following:(1)endothelial cell dysfunction and inflammation;(2)smooth muscle cell proliferation and migration;(3)macrophage chemotaxis,migration,and adhesion;(4)platelet activation.At the molecular level,colchicine reduces proinflammatory cytokine release and inhibits NF-κB signaling and NLRP3 inflammasome activation.In this review,we summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.We also systematically discuss the mechanisms of colchicine action in cardiovascular therapeutics.Altogether,colchicine,a bioactive constituent from an ancient medicinal herb,exerts unique anti-inflammatory effects and prominent cardiovascular actions,and will charter a new page in cardiovascular medicine. | Fan-shun Zhang Qing-ze He Chengxue Helena Qin Peter JLittle Jian-ping Weng Suo-wen Xu | 2022 | Acta Pharmacologica Sinica2022，43，9： | 5 |
| 7 | Dicarboxylate CaC8H4O4 as a high-performance anode for Li-ion batteries显示文摘当前,许多器官的材料正在被看作电极材料并且显示好电气化学的行为。然而,与器官的电极的宽使用有关的最关键的问题由于他们在电解质的高溶解度是他们的低热稳定性和差的骑车性能。集中于最常规的羧化物之一器官的材料,也就是锂 terephthalate 李<潜水艇class=“ a-plus-plus ”> 2 C <潜水艇class=“ a-plus-plus ”> 8 H <潜水艇class=“ a-plus-plus ”> 4 O <潜水艇class=“ a-plus-plus ”> 4 ,我们经由修改它的分子的结构处理这些典型劣势由阳离子替换。 CaC <潜水艇class=“ a-plus-plus ”> 8 H <潜水艇class=“ a-plus-plus ”> 4 O <潜水艇class=“ a-plus-plus ”> 4 和艾尔<潜水艇class=“ a-plus-plus ”> 2 (C 8 H <潜水艇class=“ a-plus-plus “> 4 O <潜水艇class=” a-plus-plus “> 4 ) 3 经由灵巧的阳离子交换反应被准备。这些, CaC < 潜水艇 class= “ a-plus-plus ” > 8 H < 潜水艇 class= “ a-plus-plus ” > 4 O < 潜水艇 class= “ a-plus-plus ” > 4 与热稳定性介绍最好骑车的表演直到 | Liping Wang Haiquan Zhang Chengxu Mou Qianling Cui Qijiu Deng Jing Xue Xinyi Dai Jingze Li | 2015 | Nano Research2015，8，2： | 3 |
| 8 | Trp_(548)Met mutation of acetolactate synthase in rice confers resistance to a broad spectrum of ALS-inhibiting herbicides显示文摘Herbicide resistance in crop plants is valuable for integrated weed management in agriculture. Herbicide resistant rice, in particular, is important to management of weedy rice, a close relative of cultivated rice and a noxious weed prevalent in rice fields that remains challenging to farmers worldwide. Herbicide resistant plants can be obtained through transgenic approach or by mutagenesis of regular plant and screening of mutants with elevated resistance to herbicide. In this study, we conducted ethyl methyl sulfonate mutagenesis(EMS) to elite indica cultivar Huanghuazhan(HHZ) and screened for mutants resistant to imazapic, a herbicide that can inhibit the acetolactate synthase(ALS) in plants. We obtained three mutants of Os ALS gene that have not been reported previously in rice. One of the mutants, with Trp_(548) changed to Met(W_(548)M), was analyzed in more details in this study. This mutation had no negative effect on the plant physiology and morphology as well as rice yield. Compared with the imidazolinone-resistant mutant S_(627)N(Ser_(627) changed to Asn) that has been deployed for Clearfield rice development, W_(548)M mutant showed high levels of resistance to a broad spectrum of five families of ALSinhibiting herbicides, in addition to a higher level of resistance to herbicides of the imidazolinone family.The herbicide-resistance was stably inherited by crossing into other rice lines. Thus, the W_(548)M mutation provides a valuable resource for breeding of herbicide resistant rice and weed management. | Lei Chen Gang Gu Chengxu Wang Zhufeng Chen Wei Yan Man Jin Gang Xie Junli Zhou Xing Wang Deng Xiaoyan Tang | 2021 | The Crop Journal2021，9，4： | 3 |
| 9 | Recent progress in synthesis of lanthanide-based persistent luminescence nanoparticles显示文摘Persistent luminescence nanoparticles(PLNPs)are a kind of phosphors that can remain luminescent for seconds to several days after the stoppage of excitation.Lanthanides show the special capability to largely broaden the emission range and enhance the luminescence intensity of PLNPs due to their dense energy structure and unique electronic configurations.In the past decades,various methods have been developed for the synthesis of lanthanide-based PLNPs with excellent pe rsistent luminescence propertie s,and the lanthanide-based PLNPs are widely studied in areas including biome dicine,energy,and information storage.In this review,we summarized the research progress in the synthe sis of lanthanidebased PLNPs and outline d several typical synthesis methods.We discussed the fundamental concepts of preparation methods as well as the advantages and drawbacks of the typical synthetic approache s.Moreove r,the current challenges and the potential solutions for the development of lanthanide-based PLNP s are also discussed in an attempt to provide strate gies to further improve the optical properties of lanthanide-based PLNPs.We hope this review can contribute to the design of lanthanide-based PLNPs with desired properties and further promote their applications in biomedicine,energy,and information science. | Yurong Wei Chengxu Gong Min Zhao Lei Zhang Shaodan Yang Peixu Li Zhao Ding Quan Yuan Yanbing Yang | 2022 | Journal of Rare Earths2022，40，9： | 2 |
| 10 | Detection of hypermethylated fibrillin-1 in the stool samples of colorectal cancer patients显示文摘 | Qi Guo Yongchun Song Hao Zhang Xuandi Wu Peng Xia Chengxue Dang | 2013 | Medical Oncology2013，，4： | 2 |
| 11 | Deficiency of two-pore segment channel 2 contributes to systemic lupus erythematosus via regulation of apoptosis and cell cycle显示文摘Background:Systemic lupus erythematosus(SLE)is a complex autoimmune disease,and the mechanism of SLE is yet to be fully elucidated.The aim of this study was to explore the role of two-pore segment channel 2(TPCN2)in SLE pathogenesis.Methods:Quantitative reverse transcription polymerase chain reaction(qRT-PCR)was used to detect the expression ofTPCN2 in SLE.We performed a loss-of-function assay by lentiviral construct in Jurkat and THP-1 cell.Knockdown ofTPCN2 were confirmed at the RNA level by qRT-PCR and protein level by Western blotting.Cell Count Kit-8 and flow cytometry were used to analyze the cell proliferation,apoptosis,and cell cycle ofTPCN2-deficient cells.In addition,gene expression profile ofTPCN2-deficient cells was analyzed by RNA sequencing(RNA-seq).Results:TPCN2 knockdown with short hairpin RNA(shRNA)-mediated lentiviruses inhibited cell proliferation,and induced apoptosis and cell-cycle arrest of G2/M phase in both Jurkat and THP-1 cells.We analyzed the transcriptome of knockdown-TPCN2-Jurkat cells,and screened the differential genes,which were enriched for the G2/M checkpoint,complement,and interleukin-6-Janus kinase-signal transducer and activator of transcription pathways,as well as changes in levels of forkhead box O,phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin,and T cell receptor pathways;moreover,TPCN2 significantly influenced cellular processes and biological regulation.Conclusion:TPCN2 might be a potential protective factor against SLE. | Keke Li Jingkai Xu Ke Xue Ruixing Yu Chengxu Li Wenmin Fei Xiaoli Ning Yang Han Ziyi Wang Jun Shu Yong Cui | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 12 | Prognostic value of the D‐dimer test in oesophageal cancer during the perioperative period显示文摘 | Dongmei Diao Kun Zhu Zhe Wang Yao Cheng Kang Li Leilei Pei Chengxue Dang | 2013 | J. Surg. Oncol2013，，1： | 2 |
| 13 | O-linked N-acetylglucosamine transferase(OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma显示文摘The aim of this present study was to explore the expression and clinical significance of O-linked N-acetylglucosamine(O-GlcNAc) transferase(OGT) and enzymatic O-linked glycosylation(O-GlcNAcation) through the addition of O-linked-β-N-acetylglucosamine in esophageal squamous cell carcinoma.OGT expression and O-GlcNAcation in 40 samples from patients with esophageal squamous cell carcinoma was detected by immunohistochemical staining with anti-OGT antib ody and O-GlcNAc-specific antibody RL 2,respectively.The relationship between pathological and clinical factors of patients was analyzed.We found that the expression of OGT was higher in esophageal squamous cell carcinoma samples compared to the normal tissues.RL 2 antibody level was positively correlated with OGT expression,and the metastasis of lymph node,which means the level of O-GlcNAcation was high and related to the metastasis of lymph node in esophageal squamous cell carcinoma.In conclusion,OGT activation is the main reason for promoting the level of O-GlcNAcation in esophageal squamous cell carcinoma.O-GlcNAcylation may play an important role in esophageal squamous cell carcinoma. | Zhe Qiao Chengxue Dang Bin Zhou Shaomin Li Wei Zhang Jiantao Jiang Jin Zhang Ranran Kong Yuefeng Ma | 2012 | The Journal of Biomedical Research2012，26，4： | 2 |
| 14 | Effect of TiN diffusion barrier on elements interdiffusion behavior of Ni/GH3535 system in LiF-NaF-KF molten salt at 700℃显示文摘A TiN interlayer with high electrical conductivity was prepared between the GH3535 alloy and the Ni coating as a diffusion barrier to elements interdiffusion with the goal of increasing the corrosion resistance of GH3535 alloy in molten FLiNaK salt at 700℃.Results indicated that Ni coating could be directly electroplated on the TiN coated GH3535 alloy without extra conductive transition layer.TiN layer showed excellent thermal and chemical stabilities at elevated temperature in this molten salt system,without phase decomposition.The Ni/TiN composite coating was stable enough to resist corrosion in LiF-NaF-KF molten salt at 700℃.Elements interdiffusion between the substrate and Ni coating could be effectively inhibited and the corrosion resistance of the alloy was greatly enhanced.Besides,the TiN interlayer remained continuous and well adhered to the Ni coating as well as the substrate after corrosion test. | Chengxu Wang Wei Chen Minghui Chen Demin Chen Ke Yang Fuhui Wang | 2020 | Journal of Materials Science & Technology2020，42，10： | 2 |
| 15 | Acceleration Process of the Interception Projectile in Active Electromagnetic Armor 显示文摘 | Cao Yanjie Wang Huijin Wang Chengxue | 2009 | IEEE Transactions on Magnetics2009，45，1： | 1 |
| 16 | Direct gas-phase epoxidation of hexafluoropropylene with molecular oxygen using Ag catalyst显示文摘 | Zhongxi Huang Yongming Zhang Chengxue Zhao | 2006 | Applied catalysis A:General2006，303，1： | 1 |
| 17 | Plasma graft- polymerization for synthesis of high ly stable hydroxide exchange membrane显示文摘 | Hu Jue Zhang Chengxu Jiang Lin | 2014 | Journal of Power Sources2014，248，： | 1 |
| 18 | Simulation of electromagnetic launcher of active electromagnetic armor显示文摘 | Cao Yanjie Wang Chengxue Wang Huijin | 2008 | IEEE Trans on Magnetics2008，43，1： | 1 |
| 19 | Pro-motional effect of La2O3 and CeO2 on Ni/γ-Al2O3 cata-lysts for CO2 reforming of CH4显示文摘 | YANG Ruiqin XING Chuang LV Chengxue | 2010 | Applied Catalysis A:General2010，385，2： | 1 |
| 20 | Recrystallization nucleation under close-setδphase in a nickel-based superalloy during annealing显示文摘Annealing is one of the most efficient heat treatment to refine the grain microstructure in metal alloys.Prior to the annealing,an aging treatment can be implemented to precipitate the second phases for more nucleation sites in deformed mixed grains during subsequent recrystallization.However,the underlying mechanism behind the second phases and recrystallization has not yet been fully understood.Taking a typical deformed nickel(Ni)-based(GH4169)superalloy as an exapmle,this research aims to clairfy the connections between the recrystallization and delta(δ)phase(Ni_(3)Nb) during annealing.All deformed samples were also treated by aging and then annealing.The results show that the microstructure and component ofδphase dominated the recrystallization nucleation in the Ni-based alloy.Moreover,there was the presence of theδphase interval limiting nucleation(PILN)andδphase protecting nucleation(PPN),when a high content of close-set phase was precipitated from the matrix.The PILN determined the primary condition for the recrystallization nucleation that happended at the interval ofδphase larger than the critical nucleation size.The peak nucleation occurred in the PPN,where the recrystallization nucleus were free of the penetration by the adjacent grains,before the nucleation incubation time was reached.Thus,a new feasible JNtheory was proposed to determine the maximum domain of recrystallization nucleation under close-set precipitated phases.All the possible nucleation sites were assumed under PPN in the JNtheory.As such,the original microstructure can be expected to design for the annealing via the aging process.A quantitative evaluation of recrystallization nucleation can also achieved in the Ni-based alloys during aging. | Guanqiang Wang Mingsong Chen Yongcheng Lin Hongbin Li Yuqiang Jiang Yanyong Ma Chengxu Peng Jinliang Cai Quan Chen | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
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