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| 1 | Generation of super-resolved optical needle and multifocal array using graphene oxide metalenses显示文摘Ultrathin flat metalenses have emerged as promising alternatives to conventional diffractive lenses,offering new possibilities for myriads of miniaturization and interfacial applications.Graphene-based materials can achieve both phase and amplitude modulations simultaneously at a single position due to the modification of the complex refractive index and thickness by laser conversion from graphene oxide into graphene like materials.In this work,we develop graphene oxide metalenses to precisely control phase and amplitude modulations and to achieve a holistic and systematic lens design based on a graphene-based material system.We experimentally validate our strategies via demonstrations of two graphene oxide metalenses:one with an ultra-long(~16λ)optical needle,and the other with axial multifocal spots,at the wavelength of 632.8 nm with a 200 nm thin film.Our proposed graphene oxide metalenses unfold unprecedented opportunities for accurately designing graphene-based ultrathin integratable devices for broad applications. | Hongtao Wang Chenglong Hao Han Lin Yongtian Wang Tian Lan Chengwei Qiu Baohua Jia | 2021 | Opto-Electronic Advances2021，4，2： | 10 |
| 2 | Domain structure and defects of highly ordered Bi_4Si_3O_(12) micro-crystals显示文摘Highly ordered Bi4Si3O12 micro-crystals were prepared at normal atmosphere. Phase identification of the prepared crystals was accomplished by X-ray diffractometer (XRD). Domain structure and defects were characterized by environmental scanning electron microscopy (ESEM). XRD shows that the obtained micro-crystals are of eulytite structure with chemical formulation of Bi4Si3O12. A highly ordered growth pattern is confirmed due to the faster growth of the {124} faces than that of the {204} faces by ESEM. The growing process of the domain structure is of pollen parent and filial generation pattern. The filial generations of Bi4Si3O12 crystals are generated from the pollen parent. Cracks generate from the defect areas and propagate along the {124} faces due to their lower binding energy under a proper temperature gradient, contributing to the total transcrystalline fracture. It is confirmed that the generation and development of the voids in the crystal grains can be developed when unmatched dimensions of the two opposite faces are formed. And the development of the voids is dependent on the dimensions and orientations of the two opposite faces. | TIAN QingQuan, WANG XiuFeng, YU ChengLong, JIANG HongTao, ZHANG ZhengGuang, WANG Yan & LIN SheBao School of Materials Science and Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China | 2009 | Science China(Technological Sciences)2009，52，8： | 8 |
| 3 | Rapid drift of the Tethyan Himalaya terrane before two-stage India-Asia collision显示文摘The India-Asia collision is an outstanding smoking gun in the study of continental collision dynamics.How and when the continental collision occurred remains a long-standing controversy.Here we present two new paleomagnetic data sets from rocks deposited on the distal part of the Indian passive margin,which indicate that the Tethyan Himalaya terrane was situated at a paleolatitude of∼19.4°S at∼75 Ma and moved rapidly northward to reach a paleolatitude of∼13.7°N at∼61 Ma.This implies that the Tethyan Himalaya terrane rifted from India after∼75 Ma,generating the North India Sea.We document a new two-stage continental collision,first at∼61 Ma between the Lhasa and Tethyan Himalaya terranes,and subsequently at∼53−48 Ma between the Tethyan Himalaya terrane and India,diachronously closing the North India Sea from west to east.Our scenario matches the history of India-Asia convergence rates and reconciles multiple lines of geologic evidence for the collision. | Jie Yuan Zhenyu Yang Chenglong Deng Wout Krijgsman Xiumian Hu Shihu Li Zhongshan Shen Huafeng Qin Wei An Huaiyu He Lin Ding Zhengtang Guo Rixiang Zhu | 2021 | National Science Review2021，8，7： | 7 |
| 4 | Human ACE2-Functionalized Gold“Virus-Trap”Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection显示文摘The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus.Here,we present a Human Angiotensin-converting-enzyme 2(ACE2)-functionalized gold“virus traps”nanostructure as an extremely sensitive SERS biosensor,to selectively capture and rapidly detect S-protein expressed coronavirus,such as the current SARS-CoV-2 in the contaminated water,down to the single-virus level.Such a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as“virus-traps”composed of oblique gold nanoneedles,and 109-fold enhancement of Raman signals originating from multi-component SERS effects.Furthermore,the identification standard of virus signals is established by machine-learning and identification techniques,resulting in an especially low detection limit of 80 copies mL^(−1) for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min,which is of great significance for achieving real-time monitoring and early warning of coronavirus.Moreover,here-developed method can be used to establish the identification standard for future unknown coronavirus,and immediately enable extremely sensitive and rapid detection of novel virus. | Yong Yang Yusi Peng Chenglong Lin Li Long Jingying Hu Jun He Hui Zeng Zhengren Huang Zhi-Yuan Li Masaki Tanemura Jianlin Shi John R.Lombardi Xiaoying Luo | 2021 | Nano-Micro Letters2021，13，7： | 6 |
| 5 | Expressions of apoptosis-related proteins in rats with focal cerebral ischemia after Angong Niuhuang sticker point application显示文摘In this study, we extracted and purified components in the Angong Niuhuang pill. Then we applied transdermal enhancers to Angong Niuhuang stickers by modern technology. The Angong Niuhuang sticker includes extracts from curcuma, berberine hydrochloride, baicalin, geniposide, borneol, and musk. Angong Niuhuang stickers at different point application doses (1.35, 2.7, and 5.4 g/kg) were administered to Dazhui (DU14), Qihai (RN6) and Mingmen (DU4). Rats in the different dose point application and acupuncture groups were continuously administered for 7 days. Then a middle cerebral artery occlusion model was prepared for simulating human cerebral ischemia. Twelve hours later, expressions of Bcl-2, Bax and p53 protein in hippocampal CA1 were detected with immunohistochemistry. The expression level of Bcl-2, an anti-apoptotic protein, significantly increased in the high-, medium- and low-dose point application groups and the acupuncture group, while the expression of the pro-apoptotic proteins, Bax and p53, significantly decreased compared with the middle cerebral artery occlusion rats; and the Bcl-2/Bax ratio was significantly increased. The difference was noticeable for the high-dose point application group, which showed statistical difference compared with the low-dose point application group and the acupuncture group. Our experimental findings indicate that point application with Angong Niuhuang stickers promotes the expression of Bcl-2, and inhibits the expressions of Bax and p53 in the hippocampal CA1 area of rats after focal cerebral ischemia. Thus, point application of Angong Niuhang stickers protects brain tissues from cerebral ischemia. | Dongshu Zhang Maodong Fu Chenglong Song Caiyun Wang Xiaochun Lin Yuanliang Liu | 2012 | Neural Regeneration Research2012，7，30： | 6 |
| 6 | Challenges and strategies for in situ endothelialization and long-term lumen patency of vascular grafts显示文摘Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,which even result in dysfunction and death.Vascular regeneration or artificial vascular graft,as the conventional treatment modality,has received keen attentions.However,small-diameter(diameter<4 mm)vascular grafts have a high risk of thrombosis and intimal hyperplasia(IH),which makes long-term lumen patency challengeable.Endothelial cells(ECs)form the inner endothelium layer,and are crucial for anti-coagulation and thrombogenesis.Thus,promoting in situ endothelialization in vascular graft remodeling takes top priority,which requires recruitment of endothelia progenitor cells(EPCs),migration,adhesion,proliferation and activation of EPCs and ECs.Chemotaxis aimed at ligands on EPC surface can be utilized for EPC homing,while nanofibrous structure,biocompatible surface and cell-capturing molecules on graft surface can be applied for cell adhesion.Moreover,cell orientation can be regulated by topography of scaffold,and cell bioactivity can be modulated by growth factors and therapeutic genes.Additionally,surface modification can also reduce thrombogenesis,and some drug release can inhibit IH.Considering the influence of macrophages on ECs and smooth muscle cells(SMCs),scaffolds loaded with drugs that can promote M2 polarization are alternative strategies.In conclusion,the advanced strategies for enhanced long-term lumen patency of vascular grafts are summarized in this review.Strategies for recruitment of EPCs,adhesion,proliferation and activation of EPCs and ECs,anti-thrombogenesis,anti-IH,and immunomodulation are discussed.Ideal vascular grafts with appropriate surface modification,loading and fabrication strategies are required in further studies. | Yu Zhuang Chenglong Zhang Mengjia Cheng Jinyang Huang Qingcheng Liu Guangyin Yuan Kaili Lin Hongbo Yu | 2021 | Bioactive Materials2021，6，6： | 5 |
| 7 | Charge‑Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS‑CoV‑2 S Protein Detection显示文摘The outbreak of coronavirus disease 2019 has seriously threatened human health.Rapidly and sensitively detecting SARSCoV-2 viruses can help control the spread of viruses.However,it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity.Therefore,it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity.Herein we report,for the first time,Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement,which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement.Their SERS sensitivity is optimized to 3.0×10^6 and 1.4×10^6 under the optimal resonance excitation wavelength of 532 nm.Additionally,remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein.Moreover,its detection limit is as low as 5×10^−9 M,which is beneficial to achieve real-time monitoring and early warning of novel coronavirus.This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology. | Yusi Peng Chenglong Lin Li Long Tanemura Masaki Mao Tang Lili Yang Jianjun Liu Zhengren Huang Zhiyuan Li Xiaoying Luo John RLombardi Yong Yang | 2021 | Nano-Micro Letters2021，13，3： | 3 |
| 8 | Low-depth whole genome sequencing reveals copy number variations associated with higher pathologic grading and more aggressive subtypes of lung non-mucinous adenocarcinoma显示文摘Objective:Histology grade,subtypes and TNM stage of lung adenocarcinomas are useful predictors of prognosis and survival.The aim of the study was to investigate the relationship between chromosomal instability,morphological subtypes and the grading system used in lung non-mucinous adenocarcinoma(LNMA).Methods:We developed a whole genome copy number variation(WGCNV)scoring system and applied next generation sequencing to evaluate CNVs present in 91 LNMA tumor samples.Results:Higher histological grades,aggressive subtypes and more advanced TNM staging were associated with an increased WGCNV score,particularly in CNV regions enriched for tumor suppressor genes and oncogenes.In addition,we demonstrate that 24-chromosome CNV profiling can be performed reliably from specific cell types(<100 cells)isolated by sample laser capture microdissection.Conclusions:Our findings suggest that the WGCNV scoring system we developed may have potential value as an adjunct test for predicting the prognosis of patients diagnosed with LNMA. | Zheng Wang Lin Zhang Lei He Di Cui Chenglong Liu Liangyu Yin Min Zhang Lei Jiang Yuyan Gong Wang Wu Bi Liu Xiaoyu Li David S Cram Dongge Liu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 1 |
| 9 | Effect of Heat Treatment on the Structure and Surface Roughness of TiO2 Nanotube显示文摘 | Yueji Wang Chenglong Liu Lin Xie er al | 2011 | Scientific Research2011，，3： | 1 |
| 10 | Near-infrared chemiluminescent carbon nanogels for oncology imaging and therapy显示文摘Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents. | Chenglong Shen Tianci Jiang Qing Lou Wenbo Zhao Chaofan Lv Guangsong Zheng Hangrui Liu Pengfei Li Lingling Dai Kaikai Liu Jinhao Zang Feng Wang Lin Dong Songnan Qu Zhe Cheng Chongxin Shan | 2022 | SmartMat2022，3，2： | 1 |
| 11 | Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials显示文摘 | Yan Wang Chenglong Xie Lin Lu | 2012 | Evidence-based complementary and alternative medecine2012，53，486： | 1 |
| 12 | Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice显示文摘 | Grace-Ifeyinwa Onimoe Aiguo Liu Li Lin Chang-Ching Wei Eric Schwartz Deepak Bhasin Chenglong Li James Fuchs Pui-kai Li Peter Houghton Amanda Termuhlen Thomas Gross Jiayuh Lin | 2012 | Investigational New Drugs2012，，3： | 1 |
| 13 | Boosting reversible anionic redox reaction with Li/Cu dual honeycomb centers显示文摘The anionic redox reaction(ARR)is a promising charge contributor to improve the reversible capacity of layeredoxide cathodes for Na-ion batteries;however,some practical bottlenecks still need to be eliminated,including a low capacity retention,large voltage hysteresis,and low rate capability.Herein,we proposed a high-Na content honeycomb-ordered cathode,P2–Na_(5/6)[Li_(1/6)Cu_(1/6)Mn_(2/3)]O_(2)(P2-NLCMO),with combined cationic/anionic redox.Neutron powder diffraction and X-ray diffraction of P2-NLCMO suggested P2-type stacking with rarely found P6322 symmetry.In addition,advanced spectroscopy techniques and density functional theory calculations confirmed the synergistic stabilizing relationship between the Li/Cu dual honeycomb centers,achieving fully active Cu^(3+)/Cu^(2+) redox and stabilized ARR with interactively suppressed local distortion.With a meticulously regulated charge/discharge protocol,both the cycling and rate capability of P2-NLCMO were significantly. | Xiaohui Rong Dongdong Xiao Qinghao Li Yaoshen Niu Feixiang Ding Xueyan Hou Qiyu Wang Juping Xu Chenglong Zhao Dong Zhou Ruijuan Xiao Xiqian Yu Wen Yin Lin Gu Hong Li Xuejie Huang Liquan Chen Yong-Sheng Hu | 2023 | eScience2023，3，5： | 0 |
| 14 | Visualized SERS Imaging of Single Molecule by Ag/ Black Phosphorus Nanosheets显示文摘Single-molecule detection and imaging are of great value in chemical analysis,biomarker identification and other trace detection fields.However,the localization and visualization of single molecule are still quite a challenge.Here,we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets(Ag/BP-NS)synthesized by a unique photoreduction method as a surfaceenhanced Raman scattering(SERS)sensor.Such a SERS substrate features the lowest detection limit of 10^(–20) mol L^(−1) for R6G,which is due to the three synergistic resonance enhancement of molecular resonance,photoinduced charge transfer resonance and electromagnetic resonance.We propose a polarization-mapping strategy to realize the detection and visualization of single molecule.In addition,combined with machine learning,Ag/BP-NS substrates are capable of recognition of different tumor exosomes,which is meaningful for monitoring and early warning of the cancer.This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. | Chenglong Lin Shunshun Liang Yusi Peng Li Long Yanyan Li Zhengren Huang Nguyen Viet Long Xiaoying Luo Jianjun Liu Zhiyuan Li Yong Yang | 2022 | Nano-Micro Letters2022，14，5： | 0 |
| 15 | Effects of secukinumab and adalimumab on serum uric acid level in patients with plaque psoriasis显示文摘Background:Psoriasis is a chronic systemic inflammatory disease,and hyperuricemia is a common comorbidity in patients with psoriasis.However,there are limited reports on the relationship between serum uric acid levels and biological treatment efficacy.The purposes of this study were to compare the differences in serum uric acid levels between patients with psoriasis and healthy controls and analyze the risk of hyperuricemia.Methods:A total of 196 patients with psoriasis and 191 age-and sex-matched healthy controls were enrolled in this retrospective cohort study.One hundred and twenty-seven patients with severe psoriasis were treated with biologics.Sixty-eight patients received adalimumab,and 59 patients received secukinumab.Serum uric acid levels were measured at baseline,week 24,and week 48 of treatment.Results:Patients with psoriasis had higher serum uric acid levels than healthy controls(6.4±1.7 mg/dL vs.5.7±1.5 mg/dL,P<0.001).Hyperuricemia was found in 33.7%(66/196)of patients with psoriasis,which was significantly higher than that in healthy controls(13.1%[25/191],P<0.001).Serum uric acid levels and hyperuricemia were not related to the severity of psoriasis(P>0.05).No significant changes in serum uric acid levels and hyperuricemia were observed following adalimumab treatment(P>0.05).The serum uric acid level in patients treated with secukinumab was 6.7±1.6 mg/dL at week 24,which was not statistically different from that at baseline(6.6±1.4 mg/dL,P=0.885).Serum uric acid levels were significantly decreased at week 48(6.3±1.5 mg/dL vs.6.6±1.4 mg/dL,P=0.007)in patients treated with secukinumab.Secukinumab had no significant effect on hyperuricemia either(P>0.05).Conclusions:The serum uric acid levels and prevalence of hyperuricemia in patients with psoriasis were significantly higher than those in healthy controls.Secukinumab treatment for 48 weeks successfully decreased serum uric acid levels in patients with psoriasis,whereas adalimumab had no significant effect on serum uric acid levels. | Zheng Zhao Lin Cai Si Zhang Heng Zhang Xiaoyang Liu Chenglong Li Yan Zhao Jianzhong Zhang | 2022 | Chinese Medical Journal2022，，12： | 0 |
| 16 | Research on Radiation Aging Properties of Boron Polyethylene显示文摘Boron polyethylene is a shielding wall material for the reactor pit cell,which is irradiated by a large dose of radiation for a long time.In order to meet the needs of shielding wall’s subsequent use,maintenance and replacement,we must carry out research on the physical properties of the material after irradiation,so as to provide data support for it. | YU Bintao WANG Chenglong LIN Yun TONG Zhenfeng | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 17 | Hot-melt sub-and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets显示文摘Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub-and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how they work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was combined with glycerin monostearate(GMS) as an outercoat. Hygroscopicity testing indicated that the moisture penetrating into the tablet may result in a significant change in the physical properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between the drug and film excipients shows that the talc and methacrylic acid had a significant catalytic effect on ASA. A hypothesis was proposed that the hydrolysis of ASA enteric coated tablets(ASA-ECT) was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclusion, hot-melt coating technology is an alternative to subcoating or outercoating. Also, GMS sub-coating was a better choice for forming a stable barrier between the tablet core and the polymer coating layer, and increases the structure and chemical stability. | Xiuzhi Wang Puxiu Wang Chenglong Huang Xiaoyang Lin Haoyu Gong Haibing He Cuifang Cai | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，3： | 0 |
| 18 | Improving arsenic mobility concentration from As-polluted soils by the functional strains显示文摘Arsenic(As)contamination has become the environment issue of global concern.In China,large area of farmland and the site soil were contaminated by As,which means that suitable remedying methods were urgently needed.Phytoremediation,as one of environment-friendly soil remediation techniques developed in recent years,shows a bright future for the remediation of As contaminated soils.However,phytoremediation efficiency needs to be enhanced further because of low concentration of bioavailable As in the soils.A triangle flask culture experiment was carried out to study the effects of functional species,isolated from As-polluted soils,that could improve As mobility from the soil.These species included two bacilli,B1 and B2(Brevibacillus)and two fungi,F1(Trichoderma),F2(Fusarium).They could transform the concentration of As fractionation in the soil sterilized by the method of60Co-γray.Through the experiment,the concentrations of non-specifically-sorbed and specifically-sorbed As fractionation,and p H value of culture solution with inoculated treatment were higher than that with the control.Especially,the concentration of non-specifically-sorbed As fractionation in the treatment-inoculated species was 2 to 6 times higher than that of non-inoculation treatment.Moreover,two bacilli and two fungi could produce IAA,which was conducive to the plant survival when they were jointly used in remedying the As-contaminated soil. | BAI JianFeng LIN XianGui DAI Jue HUA JianFeng QIN Hua HU JunLi WANG YiMing ZHANG ChengLong WANG JingWei YUAN WenYi | 2015 | Science China Earth Sciences2015，58，8： | 0 |
| 19 | Formation Process and Mechanical Deformation Behavior of a Novel Laser-Printed Compression-Induced Twisting-Compliant Mechanism显示文摘A novel compression-induced twisting(CIT)-compliant mechanism was designed based on the freedom and constraint topology(FACT)method and manufactured by means of laser powder bed fusion(LPBF).The effects of LPBF printing parameters on the formability and compressive properties of the laserprinted CIT-compliant mechanism were studied.Within the range of optimized laser powers from 375 to 450 W and with the densification level of the samples maintained at above 98%,changes in the obtained relative densities of the LPBF-fabricated CIT-compliant mechanism with the applied laser powers were not apparent.Increased laser power led to the elimination of residual metallurgical pores within the inclined struts of the CIT mechanism.The highest dimensional accuracy of 0.2% and the lowest surface roughness of 20μm were achieved at a laser power of 450 W.The deformation behavior of the CIT-compliant mechanism fabricated by means of LPBF exhibited four typical stages:an elastic stage,a heterogeneous plastic deformation stage,a strength-destroying stage,and a deformation-destroying stage(or instable deformation stage).The accumulated compressive strain of the optimally printed CIT mechanism using a laser power of 450 W went up to 20% before fracturing,demonstrating a large deformation capacity.The twisting behavior and mechanical properties were investigated via a combination of finite-element simulation and experimental verification.An approximately linear relationship between the axial compressive strain and rotation angle was achieved before the strain reached 15% for the LPBF-processed CIT-compliant mechanism. | Jie Gao Dongdong Gu Chenglong Ma Donghua Dai Lixia Xi Kaijie Lin Tong Gao Jihong Zhu Yuexin Du | 2022 | Engineering2022，8，8： | 0 |
| 20 | Preparation of TiN Films on AZ91C by Cathode Multi Arc Ion and Its Performance显示文摘Introduction Magnesium,abundant in natural resource,has many advantages.This make the magnesium alloys attractive as a substitute material of ferrous metals and aluminum alloys.However,there are some unsatisfactory characteristics,which | Fan Duowang Wang Chenglong Ling Xiaoming Zhao Lin Liu Hongzhong | 2007 | 兰州交通大学学报2007，26，6： | 0 |
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