|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Progress in non-invasive detection of liver fibrosis显示文摘Liver fibrosis is an important pathological precondition for hepatocellular carcinoma.The degree of hepatic fibrosis is positively correlated with liver cancer.Liver fibrosis is a series of pathological and physiological process related to liver cell necrosis and degeneration after chronic liver injury,which finally leads to extracellular matrix and collagen deposition.The early detection and precise staging of fibrosis and cirrhosis are very important for early diagnosis and timely initiation of appropriate therapeutic regimens.The risk of severe liver fibrosis finally progressing to liver carcinoma is>50%.It is known that biopsy is the gold standard for the diagnosis and staging of liver fibrosis.However,this method has some limitations,such as the potential for pain,sampling variability,and low patient acceptance.Furthermore,the necessity of obtaining a tissue diagnosis of liver fibrosis still remains controversial.An increasing number of reliable non-invasive approaches are now available that are widely applied in clinical practice,mostly in cases of viral hepatitis,resulting in a significantly decreased need for liver biopsy.In fact,the noninvasive detection and evaluation of liver cirrhosis now has good accuracy due to current serum markers,ultrasound imaging,and magnetic resonance imaging quantification techniques.A prominent advantage of the non-invasive detection and assessment of liver fibrosis is that liver fibrosis can be monitored repeatedly and easily in the same patient.Serum biomarkers have the advantages of high applicability(>95%)and good reproducibility.However,their results can be influenced by different patient conditions because none of these markers are liver-specific.The most promising techniques appear to be transient elastography and magnetic resonance elastography because they provide reliable results for the detection of fibrosis in the advanced stages,and future developments promise to increase the reliability and accuracy of the staging of hepatic fibrosis.This article aims to describe the recent progress in the development of non-invasive assessment methods for the staging of liver fibrosis,with a special emphasize on computer-aided quantitative and deep learning methods. | Chengxi Li Rentao Li Wei Zhang | 2018 | Cancer Biology & Medicine2018，15，2： | 39 |
| 2 | Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance显示文摘Objective: Vascular-targeted therapy is gradually becoming more appealing for patients with lung cancer. It is unclear whether vascular endothelial growth factor receptor 2(VEGFR2) and neuropilin-1(NRP-1) can be biomarkers for clinical treatment. We aimed to investigate the expression levels of VEGFR2 and NRP-1 in human non-small cell lung cancer(NSCLC) and their clinical significance by observing patient prognosis. Methods: VEGFR2 and NRP-1 were assessed by immunohistochemistry(IHC) in 40 patients with NSCLC and in 10 patients with benign lesions of lung; kinase insert domain receptor(KDR) and NRP-1 copy number gain(CNG) was assessed by fluorescence in situ hybridization(FISH). The distributions of overall survival(OS) and progression-free survival(PFS) were estimated using the Kaplan-Meier method and compared between groups by log-rank test.Results: Rates of positive immunostaining for VEGFR2 and NRP-1 were 58% and 55%, respectively. KDR and NRP-1 CNG(+) were detected in 32.5% and 30% of tumors, respectively. Levels of both VEGFR2 and NRP-1 in lung tumors were significantly different than in the control tissue(χ2=11.22, P=0.001; χ2=9.82, P=0.001, respectively); similar results were obtained using CNGs(χ2=4.39, P=0.036; χ2=3.95, P=0.046, respectively). Statistically significant correlations were observed with histological grade, clinical TNM stage and the lymph node status(P<0.05), but not age, gender or pathology type(P>0.05). VEGFR2 showed a strong correlation with NRP-1(Rs=0.68, P=0.00); similar results were observed with KDR and NRP-1 CNG(Rs=0.32, P=0.04). Significant differences in OS and PFS were observed between the groups with higher VEGFR2 and NRP-1 and those with lower expression(P<0.05). Conclusions: According to these data, VEGFR2 and NRP-1 are highly expressed in NSCLC. We can conclude that they play a key role in NSCLC occurrence, development and metastasis and are associated with patient prognosis(P<0.05 for OS and PFS). This information will be beneficial for clinical antiangiogenic treatment in NSCLC. | Manhua Ding Liang Liu Chengxi Hu Yi Liu Yun Qiao Xiaodong Jiang | 2014 | Chinese Journal of Cancer Research2014，26，6： | 11 |
| 3 | Genetic contribution of foreign germplasm to elite Chinese soybean (Glycine max) cultivars revealed by SSR markers显示文摘Simple sequence repeats (SSR) marker analysis, combined with pedigree analysis, was car- ried out to trace the genetic constitutes of Suinong 14 and Hefeng 25 in assessing the contribution of for- eign germplasm to those elite cultivars. The overall goal is to accumulate information for further effective utilization of foreign germplasm in Chinese soybean breeding programs. SSR clustering results indicated that the genetic base of elite Chinese soybean culti- vars, including Suinong 14 and Hefeng 25, were broadened and enhanced via introduction of Amsoy from the U.S. and Shishengchangye from Japan. The pedigree analysis showed a very high coefficient of parentage between Shishengchangye and Hefeng 25, between Shishengchangye and Suinong 14, and between Amsoy and Suinong 14. The genetic simi- larity between Suinong 14 and Hefeng 25 was 60.58%. Among 20 linkage groups, more genomic regions were transferred from Hefeng 25 to Suinong 14 in linkage group (LG) I, L and C2 than other LGs. Among the unique alleles of foreign parents, five specific loci in Amsoy were transferred to Suinong 14, and three loci from Shishengchangye to Suinong 14. Some SSR loci were proved to be correlated with phenotypes: two loci for seed size introgressed from Shishengchangye to Suinong 14, and one locus forprotein content from Amsoy to Suinong 14. These results indicate that the two foreign parents might have important contributions in the development of Suinong 14 and Hefeng 25. | QIN Jun CHEN Weiyuan GUAN Rongxia JIANG Chengxi LI Yinghui FU Yashu LIU Zhangxiong ZHANG Mengchen CHANG Ruzhen QIU Lijuan | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 4 | Synthesis and characteristics of a novel artificial hapten using the copper mercaptide of penicillenic acid from penicillin G for immunoassay of heavy metal ions显示文摘In this paper, we describe the synthesis of a novel copper ion hapten using the copper mercaptide of penicillenic acid (CMPA) derived from penicillin. Results from tests with immune rabbits indicate that: (i) A new antigen synthesized with CMPA has good stability and is safe for immunizing animals with no toxic phenomena being found in animal experiments; (ii) the immunogenic antigen (CMPA-BSA) can stimulate the immune system to produce specific antibodies with high titrations, up to 150000; and (iii) antibodies in antisera showed higher affinity to OVA-GSH-CuCl than OVA-GSH, which indicates that the antibodies have specific affinity towards copper ions. These results confirm that the novel hapten and relevant antigen for copper ion have been successfully synthesized, giving progress towards an immunoassay for copper ions in environmental and food samples. | XU Wu XIE Peng FAN LiuYin CAO ChengXi XI Tao ZHOU Pei | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 5 | Investigation of Transformation for Ultrahigh Strength Steel Aermet 100显示文摘The heat-stagnation curves of two quenched and cryogenically treated ultrahigh strength AF1410 and Aermet 100 steels during heating and cooling in furnace have been measured. The results showed that the curve displayed an abnormal terrace in the course of heating, and within the temperature range corresponding to the terrace, the formation and growth of both cementite Fe3C and secondary hardening phase M2C in the steel make the carbon content in matrix ob- viously vary. It is in the region of terrace that the optimum combination of tensile strength and fracture toughness is obtained because of secondary hardening. Based on the measured heat-stagnation curve, several transformation points have been determined and the correctness was also verified by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Furthermore, the influence of heating rate and tempering temperature on the crystal structure and stability of austenite has been studied. | Liuding WANG+, Lin LIU, Chengxi AO, Xiaojun LIU, Changle CHEN and Mokuang KANG (Northwestern Polytechnical University, Xi’an 710072, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 4 |
| 6 | MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals显示文摘Proteasome 禁止者涉及细胞周期控制,生长并且煽动性的发信号,和有丝分裂的细胞的 transcriptional 规定。最近的研究建议了特定的 proteasome 禁止者 MG132 可以在 vitro 压制 cardiomyocyte 肥大。然而,内在的分子的机制不是清楚的。在这研究,我们在 vivo 在心脏的肥大和相关分子的机制上调查了长期的 MG132 处理的效果。MG132 (0.1 mg/kg/day ) intraperitoneally 与腹的大动脉的 banding (AAB ) 被注射到老鼠 8 个星期。结果证明有显著地稀释的 MG132 的处理留给室(LV ) myocyte 区域, LV 重量 / 身体重量,和肺重量 / 身体重量比率,减少的 LV 心脏舒张的直径和墙厚度,并且在 AAB 老鼠的增加的部分弄短。AAB 在心脏的 myocytes 导致了 ERK1/2, JNK1,和 p38 的 phosphorylation。在 AAB 老鼠的 ERK1/2 和 JNK1 的提高的 phosphorylation 层次被 MG132 处理显著地颠倒。在结论,我们的结果建议有 MG132 的长期的处理稀释 pressure-overload-induced 心脏的肥大并且通过表明小径的 ERK1/2 和 JNK1 的规定在 AAB 老鼠改进心脏的功能。 | Baolin Chen Yuedong Ma Rongsen Meng Zhaojun Xiong Chengxi Zhang Guangqin Chen Aixia Zhang Yugang Dong | 2010 | Acta Biochimica et Biophysica Sinica2010，42，4： | 3 |
| 7 | Estimating impervious surface base on comparison of spectral mixture analysis and support vector machine methods显示文摘对比了线性混合光谱分解模型(SMA)与支持向量机(SVM)在TM影像上估算不透水面覆盖率(ISP)的精度,通过SVM模型拟合TM像元光谱特征与样本ISP间的关联而获得对未知像元ISP的估算能力。对于天津市主城区的TM影像,选择学校区、工矿区和住宅区的高分辨率影像分类结果作为训练样本(7020个)和验证样本(1500个),SVM模型的ISP估算均方差(15.4%)优于SMA估算结果(19.4%);在增加缨帽变化'绿度分量'及混合光谱分解'高反射率分量'作为SVM特征变量后,ISP估算精度提高为12%。研究结果表明:SVM模型能够拟合各像元光谱组分间非线性关系且具有较好小样本泛化的性能,适用于地面样本较少的大区域ISP制图;增加与ISP相关性大的光谱特征向量作为SVM输入能提供更多的区域地物空间分布信息,能够调整无样本的地表类型的ISP估算值,提高区域ISP估算的整体精度。 | CHENGXi SHENZhanfeng LUOJianceng ZHUChangming ZHoUYanan HUXiaodong | 2011 | 遥感学报2011，15，6： | 2 |
| 8 | Predictions ofthe mechanical properties and microstructure evolution of highstrength steel in hot stamping显示文摘 | Cui Junjia Lei Chengxi Xing Zhongwen | 2012 | Journal of Materials Engi-neering and Performance2012，22，11： | 1 |
| 9 | Composite silicone rubber of high piezoresistance repeatability filled with nanoparticles显示文摘The ruthenium oxide nanoparticles with size less than 20 nm were fabricated by annealing the metallic ruthenium nanoparticles in air,which were synthesized by using the thermal reduction in the polyol solution.The rutile structure of the ruthenium oxide was proved by using transmission electron microscopy(TEM)and X-ray photoelectron spectroscopy(XPS).The oxide has good electron conductivity. The surface of the ruthenium oxide was modified by a vinyl silane coupling agent.The assembling of the silane to the oxide surface was proved by Infrared(IR)absorption spectroscopy.By mixing the nanoparticles with poly(methylvinylsiloxane)(PMVS)silicone rubber,a composite filled with dispersive conducting phase was fabricated.The temperature dependent conductivity shows that the electron transportation through composite is mainly dominated by tunneling.The measurement of piezoresistance shows that the composite at low strain has high piezoresistance repeatability.The 3D reconstruction images of the composite filled with carbon black or ruthenium oxide show that the aggregation of the nanoparticles differs much for two composites.The narrow distribution range of the particle size was thought to be the main factor for the high piezoresistance recurrence. | WU JuYing ZHOU ChengXi ZHU QingWen LI EnRong DAI Ge BA Long HUANG YuHong Mei Jun | 2009 | Science China(Technological Sciences)2009，52，12： | 1 |
| 10 | A novel polybenzoxazine containing styrylpyridine structure via the Knoevenagel reaction显示文摘 | Huachuan Zhang Min Li Yuyuan Deng Chengxi Zhang Qichao Ran Yi Gu | 2014 | J. Appl. Polym. Sci2014，，19： | 1 |
| 11 | Perspectiveofmolecularbiologicaltechniquesap-pliedininsectsystematics显示文摘 | ChengXY(成新跃) ZhouHZ(周红章) ZhangGX(张广学) | | 动物分类学报0，，： | 1 |
| 12 | Combined Effect of Aluminum Content and Layer Structure on the Oxidation Performance of Ti_(1-x)Al_xN Based Coatings显示文摘TiN,Ti_(1-x)AI_xN single layer coatings and TiN/Ti_(1-x)AI_xN multilayer coatings were deposited on SKH51 tool steel substrate by arc ion plating.The coatings were annealed in air to study the effect of aluminum and film structure on the oxidation performance.The surface morphology and structure were characterized by scanning electron microscopy and X-ray diffraction.The element distribution on the cross section was analyzed by electron probe microscopy.It is found that the oxidation resistance of these Ti_(1-x)Al_xN based coatings is mainly attributed to aluminum content in them.In comparison with the Ti_(1-x)Al_xN single layer coating,the TiN layer inserting into the Ti_(1-x)Al_xN in a multilayer coating increases the tendency of Ti diffusion toward the surface and forms a Ti-enriched top surface oxide layer,thus degrades the oxidation resistance.As far as the oxidation resistance is concerned in this study,Ti_(0.33)Al_(0.67)N single layer coating performs the best among all coatings.The kinetic of oxidation behavior of all coatings presents two definite stages.One is a slow oxidation growth which conforms to parabolic law,and the other presents severe mass gain with oxidation duration.The annealing time for severe oxidation initiation is responsible to Fe_2O_3formation in the oxide scale. | Jihua Peng Dongyi Su Chengxi Wang | 2014 | Journal of Materials Science & Technology2014，30，8： | 1 |
| 13 | Invasion of pine wood nematode population formation and expansion mechanism (in Chinese) 显示文摘 | XieBY ChengXY ShiJ | 2009 | 生命科学2009，39，4： | 1 |
| 14 | Application of Ag/AgBr/GdVO_4 composite photocatalyst in wastewater treatment显示文摘Ag/AgBr/GdVO_4 composite photocatalysts were designed and synthesized in this paper.The physical and chemical structures, as well as optical properties of the synthesized composite were investigated via XRD, XPS, TEM, and UV–vis. It is found that the composite showed a ternary heterojunction structure of Ag, Ag Br and GdVO_4. Meanwhile, it has a high intensity of light current, indicating its high separation efficiency of electron and hole.Photocatalytic oxidation of rhodamine B(RhB) under visible light irradiation was performed to investigate the activity of the Ag/Ag Br/GdVO_4 composite. Result indicates that it shows excellent photocatalytic activity. Under visible light irradiation for 12 min, about 80% of Rh B(30 μmol/L) was degraded. The degradation rate is estimated to be 0.253 min1, which is three times higher than that of pure AgBr. The high photoactivity can be ascribed to the synergetic effect of Ag Br, GdVO_4, and Ag nanoparticle in separation of electron–hole pairs. | Xin Zhang Chenghao Wang Chengxi Yu Botao Teng Yiming He Leihong Zhao Maohong Fan | 2018 | Journal of Environmental Sciences2018，30，1： | 1 |
| 15 | Effect of transplantation with autologous bone marrow stem cells on acute myocardial infarction显示文摘 | Chaoquan Peng Ke Yang Peng Xiang Chengxi Zhang Liyuan Zou Xiao Wu Ya Gao Zhuang Kang Keke He Jinlai Liu Muhua Cheng Jingfeng Wang Lin Chen | 2011 | International Journal of Cardiology2011，，： | 1 |
| 16 | A user-friendly alternative to formaldehyde-based DNA silver-staining method on polyacrylamide gels显示文摘 | He Hongzhang Cong Weitao Jiang Chengxi | 2010 | Elee- trophoresis2010，14，31： | 1 |
| 17 | Cracking mechanism and simplified design method for bottom flange in prestressed concrete box girder bridge 显示文摘 | XIANG Yiqiang TANG Guobin LIU Chengxi | 2011 | Journal of Bridge Engineering2011，16，2： | 1 |
| 18 | Predictions of the Mechanical Properties and Microstructure Evolution of High Strength Steel in Hot Stamping显示文摘 | Junjia Cui Chengxi Lei Zhongwen Xing Chunfeng Li Shumei Ma | 2012 | Journal of Materials Engineering and Performance2012，，11： | 1 |
| 19 | Sorption enhanced steam reforming of ethanol on Ni-CaO-A12 03 muhifunctional catalysts derived from hydrotalcite- like compounds 显示文摘 | Wu Gaowei Zhang Chengxi Li Shiqi | 2012 | Energy & Environmental Science2012，5，10： | 1 |
| 20 | Microstructure distribution and mechanical properties prediction of boron alloy during hot forming using FE simulation显示文摘 | Junjia Cui Chengxi Lei Zhongwen Xing Chunfeng Li | 2011 | Materials Science & Engineering A2011，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员