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| 1 | PK-tailored tertiary prophylaxis in patients with severe hemophilia A at beijing Children’s Hospital显示文摘Importance:Tertiary prophylaxis using a low-dose regimen is usually insufficient to prevent recurrent joint bleeding and deterioration in joint diseases in children with severe hemophilia A.Pharmacokinetic(PK)dosing is a useful approach to increase the precision and efficiency of prophylaxis.Objective:To explore the efficacy of PK-tailored tertiary prophylaxis in children with severe hemophilia A.Methods:We implemented a PK-tailored tertiary prophylaxis program for 15 boys with severe hemophilia A aged 5-16 years at Beijing Children’s Hospital.Following PK testing and a 6-month evaluation period(phase I),15 patients were divided in two groups according to individual PK data and actual bleeding:(1)a PK-tailored group[modified prophylaxis regimen according to PK data for the next 6 months(phase II);n=8]and(2)a maintenance group(continued the original regimen for the next 6 months;n=7).We compared the bleeding rate,infusion frequency,and factor VIII(FVIII)consumption between the two groups.results:In the PK-tailored group,the median annual joint bleeding rate was reduced from 7.8 in phase I to 1.4 in phase II,mean annual total factor consumption increased from 1619.0 IU/kg in phase I to 2401.9 IU/kg in phase II,and median infusion frequency for prophylaxis increased from 104 times/year in phase I to 156 times/year in phase II(P<0.05).Although the FVIII consumption increased,it remained at approximately half of the standard method.Interpretation:PK-tailored prophylaxis may represent a more efficient approach to individual prophylaxis in China,but further studies are required to verify this. | Peijing Li Zhenping Chen Xiaoling Cheng Yan Wang Ningning Zhang Yingzi Zhen Xinyi Wu Runhui Wu | 2019 | Pediatric Investigation2019，3，1： | 3 |
| 2 | Towards a Dynamic Controller Scheduling-Timing Problem in Software-Defined Networking显示文摘Controller vulnerabilities allow malicious actors to disrupt or hijack the Software-Defined Networking. Traditionally, it is static mappings between the control plane and data plane. Adversaries have plenty of time to exploit the controller's vulnerabilities and launch attacks wisely. We tend to believe that dynamically altering such static mappings is a promising approach to alleviate this issue, since a moving target is difficult to be compromised even by skilled adversaries. It is critical to determine the right time to conduct scheduling and to balance the overhead afforded and the security levels guaranteed. Little previous work has been done to investigate the economical time in dynamic-scheduling controllers. In this paper, we take the first step to both theoretically and experimentally study the scheduling-timing problem in dynamic control plane. We model this problem as a renewal reward process and propose an optimal algorithm in deciding the right time to schedule with the objective of minimizing the long-term loss rate. In our experiments, simulations based on real network attack datasets are conducted and we demonstrate that our proposed algorithm outperforms given scheduling schemes. | Zhenping Lu Fucai Chen Guozhen Cheng Chao Qi Jianjian Ai | 2017 | China Communications2017，14，10： | 2 |
| 3 | Synthesis of Miktoarm Dumbbell-Like Amphiphilic Triblock Copolymer by Combination of Consecutive RAFT Polymerizations and ATRP显示文摘 | Lifen Zhang Zhenping Cheng Nianchen Zhou Suping Shi Xiaorong Su Xiulin Zhu | 2009 | Polymer Bulletin2009，，1： | 1 |
| 4 | RATRP of MMA in AIBN/FeC13/PPh3 initiation system under microwave irradiation显示文摘 | Zhenping Cheng Xiulin Zhu Lifen Zhang Nianchen Zhou Xinrong Xue | 2003 | Polymer Bulletin2003，，5： | 1 |
| 5 | Brush-type amphiphilic diblock copolymers from 'living' controlled radical polymerizations and their aggregation behavior显示文摘 | Zhu Xiulin Kang E T | 2005 | Langmuir2005，21，3： | 1 |
| 6 | Brush-type amphiphilic diblock copolymers from ' living '/controlled radical polymerizations and their micelle behavior显示文摘 | Cheng ZhenPing Zhu XiuLin Kang E T | 2005 | Langmuir2005，21，16： | 1 |
| 7 | Recent advances in “living”/controlled radical polymerization of phosphorus-containing monomers and their potential applications显示文摘Special research attention has been paid to phosphorus-containing materials and their corresponding applications. This mini review considers recent publications devoted to the 'living'/controlled radical(co)polymerization of phosphorus-containing monomers. In addition, different properties of the polymers involved in the phosphonate group in various chemical environments are demonstrated, and their potential applications are briefly discussed. | Tianchi Xu Lifen Zhang Zhenping Cheng Xiulin Zhu | 2015 | Science China Chemistry2015，58，11： | 1 |
| 8 | Sensitive sandwich ELISA based on a gold nanoparticle layer for cancer detection显示文摘 | Feng Zhou Mengmeng Wang Lin Yuan Zhenping Cheng Zhaoqiang Wu Hong Chen | 2012 | Analyst2012，137，： | 1 |
| 9 | Preparation and characterization of poly(styrene)/metal composites via reversible addition-fragmentation chain transfer (RAFT) polymerization显示文摘 | Di Zhou Xiulin Zhu Jian Zhu Zhenping Cheng | 2008 | Reactive and Functional Polymers2008，，： | 1 |
| 10 | A combination of RAFT and “click” chemistry techniques to synthesizepolymeric europium complexes with selective fluorescence emission 显示文摘 | Li Daoguang Zhu Jian Cheng Zhenping | 2009 | Reactive and Functional Polymers2009，69，4： | 1 |
| 11 | Mechanism study and molecular design in controlled/“living” radical polymerization显示文摘This tutorial review summarizes recent progress in the research field of controlled/'living' radical polymerization (CLRP) from Soochow University.The present paper gives a broad overview of the mechanism study and molecular design in CLRP.The mechanism study in CLRP aided by microwave,initiated by γ-radiation at low temperature,mediated by iron,in reversible addition-fragmentation chain transfer (RAFT) polymerization and the mechanism transfer between different CLRP processes are reviewed and summarized.The molecular design in CLRP,especially in RAFT polymerization for mechanism study,and in achieving tailor-made functional polymers is studied and discussed in the later part. | TU YingFeng,CHENG ZhenPing,ZHANG ZhengBiao,ZHU Jian,ZHANG Wei,ZHOU NianChen,NI PeiHong & ZHU XiuLin College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China | 2010 | Science China Chemistry2010，53，8： | 1 |
| 12 | Extracellular domain of 4-1BBL enhanced the antitumoral efficacy of peripheral blood lymphocytes mediated by anti-CD3<ce:hsp sp='0.25'/>×<ce:hsp sp='0.25'/>anti-Pgp bispecific diabody against human multidrug-resistant leukemia显示文摘 | Hongxing Guo Wenguo Jiang Wenge Liu Yingdai Gao Ming Yang Yuan Zhou Jinhong Wang Jing Qi Xin Cheng Zhenping Zhu Chunzheng Yang Dongsheng Xiong | 2008 | Cellular Immunology2008，，2： | 1 |
| 13 | Case Fatality Rate of Patients with Acute Myocardial Infarction in 253 Chest Pain Centers--China,2019-2020显示文摘Summary What is already known about this topic?Acute myocardial infarction(AMI)is the most serious form of cardiovascular diseases.The case fatality rate(CFR)of AMI patients is an important index to reflect the prognosis of AMI.What is added by this report?During the study period,the overall 30-day,60-day,and 90-day CFR of AMI was 5.9%,6.9%,and 7.6%,respectively.The CFRs in gradeⅢhospitals were lower than in gradeⅡhospitals,and the in-hospital CFR was significantly lower than that in post-discharge out-of-hospital. | Zheng Long Wei Liu Zhenping Zhao Suijun Tong Lijun Wang Maigeng Zhou Dingcheng Xiang Yundai Chen Jianan Wang Xiaoshu Cheng Bao Li Lang Li Wei Li Bei Shi Hong Shi Peng Yin Kai Huang Yong Huo | 2022 | China CDC weekly2022，4，24： | 1 |
| 14 | Influence of the Chemical Structure of Dithiocarbamates with Different R Groups on the Reversible Addition-Fragmentation Chain Transfer Polymerization显示文摘 | Di Zhou Xiulin Zhu Ban Zhu Lihua Hu Zhenping Cheng | 2007 | Applied Polymer Science2007，103，2： | 1 |
| 15 | Prevalence and Patterns of Multimorbidity Among Adults Aged 18 Years and Older—China,2018显示文摘Summary What is already known about this topic?Multimorbidity is becoming more common and poses a major challenge to healthcare systems.However,the prevalence and patterns of multimorbidity among Chinese adults aged≥18 years are largely unknown.What is added by this report?This study found that 46.5% of Chinese adults had multimorbidity in 2018.And the prevalence of multimorbidity prevalence is increased with age.Prevalence of multimorbidity was higher among men,Han Chinese,adults with lower educational level,and those with lower household income.The most common multimorbidity pattern is a combination of three chronic conditions,hypertension,dyslipidemia,and obesity. | Ye Geng Wan Jie Yuan He Xiaolong Zhou Sijia Zhang Wenlan Dong Zhenping Zhao Xiaoguang Cheng Jing Wu | 2023 | China CDC weekly2023，5，2： | 1 |
| 16 | Polymer microspheres with permanent antibacterial surface from surface-initiated atom transfer radical polymerization 显示文摘 | Cheng Zhenping Zhu Xinlin Shi Z L | 2005 | Ind Eng Chem Res2005，44，： | 1 |
| 17 | 显示文摘 | Cheng Zhenping Zhu Xiulin Kang E T | 2006 | Macromolecules2006，39，： | 1 |
| 18 | miR-182-5p attenuates Schistosoma japonicum-induced hepatic fibrosis by targeting tristetraprolin显示文摘Egg granuloma formation in the liver is the main pathological lesion caused by Schistosoma japonicum infection,which generally results in liver fibrosis and may lead to death in advanced patients.MicroRNAs(miRNAs)regulate the process of liver fibrosis,but the putative function of miRNAs in liver fibrosis induced by S.japonicum infection is largely unclear.Here,we detect a new miRNA,miR-182-5p,which shows significantly decreased expression in mouse livers after stimulation by soluble egg antigen(SEA)of S.japonicum or S.japonicum infection.Knockdown or overexpression of miR-182-5p in vitro causes the increased or decreased expression of tristetraprolin(TTP),an important immunosuppressive protein in the process of liver fibrosis.Furthermore,knockdown of miR-182-5p in vivo upregulates TTP expression and significantly alleviates S.japonicum-induced hepatic fibrosis.Our data demonstrate that downregulation of miR-182-5p increases the expression of TTP in mouse livers following schistosome infection,which leads to destabilization of inflammatory factor mRNAs and attenuates liver fibrosis.Our results uncover fine-tuning of liver inflammatory reactions related to liver fibrosis caused by S.japonicum infection and provide new insights into the regulation of schistosomiasis-induced hepatic fibrosis. | Xuejun Zhao Zijie Xia Ziang Wang Mengsi Zhou Xuebing Qiu Cheng Wang Tian Xu Qian Fang Zhenping Ming Huifen Dong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
| 19 | A novel reversible-deactivation radical polymerization strategy via near-infrared light-controlled photothermal conversion dividing wall-type heat exchanger显示文摘As an effective means of utilizing light energy,photothermal conversion has excellent application in the field of polymerization.Herein,a dividing wall-type heat exchanger with the aid of photothermal conversion was designed to conduct polymerization under irradiation with near-infrared(NIR)light by utilizing the ketocyanine-type dye solution as the highly efficient activator(>83.2%photothermal conversion efficiency).Various types of reversible-deactivation radical polymerization(RDRP)methods,including reversible addition-fragmentation chain transfer,atom transfer radical polymerization,and bromine-iodine transformation RDRP,are suitable for this strategy.Well-defined polymers with excellent control over molar mass and molar mass dispersity(D<1.28)were thus synthesized within a few hours under NIR(λ_(max)=810 nm,850 nm)irradiation at room temperature.Importantly,in addition to conventional heating methods(such as electrical heating jackets),the designed dividing wall-type heat exchanger via NIR light activation has another unique advantage:it can enhance the polymerization by the synergistic effect of both heating and NIR light irradiation due to the deeper penetration of NIR light. | Qun Gao Kai Tu Haihui Li Lifen Zhang Zhenping Cheng | 2021 | Science China Chemistry2021，64，7： | 0 |
| 20 | Persistent radical anion of perylene dianhydride:an emerging metal-free photocatalyst for near-infrared photocontrolled RAFT polymerization显示文摘Developing a new type of photocatalyst(PC) and catalytic mechanism for near-infrared(NIR) photocontrolled reversibledeactivation radical polymerization(RDRP) system is charming but challenging.Herein,a novel PC of the persistent radical anion(PRA)(possessing the properties of both radical and anion) was developed for NIR photocontrolled reversible additionfragmentation chain transfer(RAFT) polymerization,enabling successful polymerization while gaining a deep insight into the mechanism of photo-induced electron transfer RAFT(PET-RAFT) polymerization.Different from the conventional and wellaccepted reductive quenching(RQ) pathway,in which the radical anion intermediates of PCs(PCs^(·-)) must be generated in an excited state(ES),here,the PRA(3,4,9,10-perylenetetracarboxylic dianhydride radical anion(PTCDA^(·-))) could generate conveniently in situ in the ground state(GS) and subsequently serve as highly efficient PC in the NIR region(740–850 nm).The successful implementation of this strategy elucidates the peculiar role played by light and the real way of electron transfer behaviors.In fact,the transfer of a single electron from PRA to chain transfer agent(CTA) and cleavage of the C–S bonds is a process from ES to GS,rather than always from GS(PCs^(·-)) to GS(CTA) in the RQ pathway as is well known to all.In addition,the excellent spatial-temporal control and powerful penetration ability of the NIR light were also confirmed by this PRAcatalyzed polymerization system. | Haitao Zhao Guoqing Bian Xiang Xu Weiwei He Lifen Zhang Zhenping Cheng | 2024 | Science China Chemistry2024，67，2： | 0 |
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