|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Study of the polymorphism of angiotensinogen,anigiotensin-convening enzyme and angiotensin receptor in type Ⅱ diabetes with end-stage renal disease in Taiwan显示文摘 | Chang HR Cheng CH Shu KH | 2003 | J Chin Med Assoc2003，66，1： | 1 |
| 3 | Extremely rapid extraction of DNA from bacteria and yeasts显示文摘 | Cheng HR Jiang N | 2006 | Biotechnol Lett2006，28，1： | 1 |
| 4 | Cost-utility analysis of the cochlear implant in children显示文摘 | Cheng AK Rubin HR Pow NR Mellon NK Francis HW Niparko JK | 2000 | JAMA2000，，7： | 1 |
| 5 | Extremely rapid extraction of DNA from bacteria and yeasts 显示文摘 | Cheng HR Jiang N | 2006 | Bioteehnology Letters2006，28，1： | 1 |
| 6 | The association between arsenic exposure from drinking water and cerebrovascular disease mortality in Taiwan显示文摘 | Cheng TJ Ke DS Guo HR | 2010 | Water Research2010，44，19： | 1 |
| 7 | The association between arse- nic exposure from drinking water and cerebrovascular dis- ease mortality in Taiwan 显示文摘 | Cheng TJ Ke DS Guo HR | 2010 | Water Res2010，44，19： | 1 |
| 8 | Extremely rapid extraction of DNA from bacteria and yeasts显示文摘 | Cheng HR Jiang N | 2006 | Biotechnology Letters2006，28，1： | 1 |
| 9 | Study of the polymorphism of angiotensinogen, anigiotensin-converting enzyme and angiotensin receptor in type II diabetes with end-stage renal disease in Taiwan显示文摘 | Chang HR Cheng CH Shu KH | 2003 | J Chin Med Assoc2003，66，1： | 1 |
| 10 | Extremely rapid extraction of DNA from bacteria and yeasts显示文摘 | Cheng HR Jiang N | 2006 | Biotechnol Lett2006，28，1： | 1 |
| 11 | Study of the polymorphism of angiotensinogen, angiotensin- converting enzyme and anglotensin receptorin type 2 diabetes with endstage renal disease in Taiwan 显示文摘 | Chang HR Cheng CH Shu KH | 2003 | J Chin Med Assoc2003，66，1： | 1 |
| 12 | Increased expression of 72-KD type IV collagenase(MMP-2) in human aortic atherosclerotic lesions显示文摘 | Li Z Li L Zielke HR Cheng L Xiao R Crow MT | 1996 | Am J Pathol1996，148，1： | 1 |
| 13 | Gestational weight gain and perinatal outcomes of subgroups of Asian-American women,Texas,2009显示文摘 | Cheng HR Walker LO Brown A | 2015 | Womens Health Issues2015，25，3： | 1 |
| 14 | Study of the polymophism of angiotensinogen, angiotensin-converting enzyme and angiotensin receptor in type 2 diabetes with end-stage renal disease in Taiwan 显示文摘 | Chang HR Cheng CH Shu KH | 2003 | Chin Med Assoc2003，66，： | 1 |
| 15 | Gestational weight gain and perinatal outcomes of subgroups of Asian-American women,Texas, 2009 显示文摘 | Cheng HR Walker LO Brown A | 2015 | Womens Health Issues2015，25，3： | 1 |
| 16 | Formaldehyde and volatile organic compounds in Hong Kong homes:concentrations and impact factors显示文摘 | Guo H Kwok NH Cheng HR | 2009 | Indoor Air2009，19，3： | 1 |
| 17 | Infrasonic noise induces axon degeneration of Cultured neurons via calcium pathway 显示文摘 | Cheng HR Wang B Tang C | 2012 | Toxicol Lett2012，212，： | 1 |
| 18 | Extremely rapid extraction of DNA from bacteria and yeasts显示文摘 | Cheng HR | 2006 | Biotechnology Letters2006，28，： | 1 |
| 19 | Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis Bpatients显示文摘 | Cheng HR Liu CJ Tseng TC | 2013 | PLoSOne2013，8，53： | 1 |
| 20 | Study of the polymorphism of angiotensinogen, anigiotensin-converting enzyme and angiotensin receptor in type Ⅱ diabetes with end-stage renal disease in Taiwan 显示文摘 | Chang HR Cheng CH Shu KH | 2003 | J Chin Med Assoc2003，66，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员