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| 1 | Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion显示文摘 | Junping Ao Jiao Meng Lei Zhu Huizhen Nie Chenchen Yang Jinjun Li Jianren Gu Qiushi Lin Weiwen Long Xiaoqun Dong Chao Li | 2012 | Molecular Oncology2012，，5： | 1 |
| 2 | Use of NTrap during ureteroscopic Holmium:YAG laser lithotripsy of upper ureteral calculi显示文摘 | Chenchen Feng Qiang Ding Haowen Jiang Peng Gao Hui Wen Bin Gu Zhong Wu | 2012 | Minimally Invasive Therapy & Allied Technologies2012，，2： | 1 |
| 3 | Thalidomide plus chemotherapy exhibit enhanced efficacy in the clinicaltreatment of T-cell non?Hodgkin’s lymphoma: A prospective study of 46 cases显示文摘 | Hongyang Wu Chenchen Zhao Kangsheng Gu Yang Jiao Jiqing Hao Guoping Sun | 2014 | Molecular and Clinical Oncology2014，，： | 1 |
| 4 | Optimization of working parameters for 3MGY-200 axial air-assisted sprayer in kiwifruit orchards显示文摘Axial air-assisted sprayers can distribute pesticides efficiently in kiwifruit orchards.Because of improper parameter settings,most sprayers deliver either too much or too little pesticide.To identify appropriate sprayer parameters for kiwifruit trees,the vertical distribution profiles of the applied liquid spray were examined in this study.The effects of spray fan speed(SFS),spray pressure(SP)and spray distance(SD)on the distributions of the sprayed liquid in the vertical profiles were studied.Combined actions of the above parameters were systematically analysed using the quadratic general rotary design test method.Regression equations for the spray liquid distributions and working factors are presented.Field confirmation experiments were carried out to optimize the parameters.Data analysis showed that the optional sprayer working parameters are those of Group 3,with an SFS equal to 1900 r/min and SP equal to 3.25 MPa.The results of this study provide a reference for future applications of this type of axial air-assisted sprayer in kiwifruit orchards. | Chenchen Gu Zhijie Liu Guanting Pan Yingjun Pu Fuzeng Yang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 1 |
| 5 | NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease显示文摘The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3,connector protein ASC,and effector protein pro-caspase-1.When the NLRP3 inflammasome senses a danger signal from the host or pathogen,activated caspase-1 cleaves the precursors of interleukin(IL)-1βand IL-18 into mature proinflammatory cytokines,simultaneously causing lysis via the pore-forming protein gasdermin D.This induction of cell inflammatory pyroptosis suggests that it is a key process in the innate immune response to pathogens or cellular stress.Recent studies have shown that NLRP3 inflammasome also plays an important role in regulating autoimmune liver diseases,including autoimmune hepatitis,primary biliary cholangitis,and primary sclerosclerotic cholangitis.In this review,we summarize the structure,activation and modulation of the NLRP3 inflammasome,highlight the progress in research on the role of NLRP3 inflammasome in the occurrence and development of autoimmune liver diseases,and discuss potential strategies for targeting the NLRP3 inflammasome in the treatment of autoimmune liver diseases. | Yanling Guan Yiyue Gu Hao Li Bo Liang Chenchen Han Yu Zhang Qian Liu Wei Wei Yang Ma | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 6 | The relationships between maize(Zea mays L.)lodging resistance and yield formation depend on dry matter allocation to ear and stem显示文摘Lodging is a critical constraint to yield increase.There appear to be tradeoffs between yield formation and lodging resistance in maize.Hypothetically,it is feasible to reduce lodging risk as well as increase grain yield by optimizing dry-matter allocation to different organs under different environments.A three-year field experiment was conducted using four maize cultivars with differing lodging resistances and five growing environments in 2018–2020.Lodging-susceptible(LS)cultivars on average yielded more than lodging-resistant(LR)cultivars when lodging was not present.The yield components kernel number per ear(KN)and thousand-kernel weight(TKW)were both negatively correlated with lodging resistance traits(stalk bending strength,rind penetration strength,and dry matter weight per internode length).Before silking,the LR cultivar Lishou 1(LS1)transported more assimilates to the basal stem,resulting in a thicker basal stem,which reduced dry matter allocation to the ear and in turn KN.The lower KN of LS1 was also due partly to the lower plant height(PH),which increased lodging resistance but limited plant dry matter production.In contrast,the LS cultivars Xianyu 335(XY335)and Xundan 20(XD20)produced and allocated more photoassimilates to ears,but limited dry matter allocation to stems.After silking,LS cultivars showed higher TKW than LR cultivars as a function of high photoassimilate productivity and high assimilate allocation to the ear.The higher lodging resistance of LS1 was due mainly to the greater assimilate allocation to stem after silking and lower PH and ear height(EH).High-yielding and high-LR traits of Fumin(FM985)were related to optimized EH and stem anatomical structure,higher leaf productivity,low assimilate demand for kernel formation,and assimilate partitioning to ear.A high presilking temperature accelerated stem extension but reduced stem dry matter accumulation and basal stem strength.Post-silking temperature influences lodging resistance and yield more than other environmental factors.These results will be useful in understanding the tradeoffs between KN,KW,and LR in maize and environmental influences on these tradeoffs. | Ping Zhang Shuangcheng Gu Yuanyuan Wang Chenchen Xu Yating Zhao Xiaoli Liu Pu Wang Shoubing Huang | 2023 | The Crop Journal2023，11，1： | 0 |
| 7 | Corrosion Mechanism of Alumina-magnesia Dry Materials for Smelting Manganese/chromium Steel in Coreless Medium Frequency Induction Furnaces显示文摘Alumina-magnesia dry materials are widely used in induction furnace linings, but they show different kinds of damage when melting different kinds of alloy steel. In this paper, the chemical composition, phase composition, and microstructure of the post-use dry materials for the working liners melting different kinds of steel were evaluated. Furthermore, the corrosion mechanism of the steel on the furnace lining materials was comprehensively analyzed. The findings reveal a significant ability of the Mn element in the molten steel to diffuse and penetrate into the refractories. Mn oxidizes to form MnO at the steel-refractory interface, and then forms a liquid phase with Al_(2)O_(3). The Cr element is dissolved into corundum and spinel of the refractories, resulting in lattice defects and structural damage of the materials. TiO2reacts with Al_(2)O_(3) to form Al_(2)TiO_(5), which plays a crucial role in preventing crack formation and propagation. Part of Ti4+dissolves into magnesia-alumina(MA), densifying the materials. TiO2also slows down the reaction between the Cr element and refractory components, further improving the corrosion resistance of the materials. | LIU Chenchen HUANG Ao NIE Jianhua GU Huazhi QIN Chuanjiang Lidah Mpoli NACHILIMA | 2023 | China's Refractories2023，32，4： | 0 |
| 8 | First-Principles Investigation on Phase Stability,Elastic and Magnetic Properties of Boron Doping in Ni-Mn-Ti Alloy显示文摘The all-d-metal Ni-Mn-Ti Heusler alloy has giant elastocaloric eff ect and excellent mechanical properties,which is diff erent from the conventional Ni-Mn-based Heusler alloys.In this work,the preferred site occupation,phase stability,martensitic transformation,magnetic properties,and electronic structure of the B-doped Ni_(2)Mn_(1.5)Ti_(0.5)alloys are systematically investigated by the fi rst-principles calculations.The results show that B atoms preferentially occupy the octahedral interstitial.The doped B atoms tend to exist in the(Ni_(2)Mn_(1.5)Ti_(0.5))_(1-x)B_(x)(x=0.03,0.06,0.09)alloy in the form of aggregation distribution,and the martensitic transformation temperature decreases with the increase in the B content.For octahedral interstitial doping,the toughness and plasticity of the(Ni_(2)Mn_(1.5)Ti_(0.5))_(1-x)B_(x) alloys decrease,but the strength and rigidity are greatly enhanced.This is because a small part of the d-d hybridization in ternary Ni-Mn-Ti alloy is replaced by the p-d hybridization in Ni-Mn-Ti-B alloy. | Chenchen Xiong Jing Bai Yansong Li Jianglong Gu Xinzeng Liang Ziqi Guan Yudong Zhang Claude Esling Xiang Zhao Liang Zuo | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，7： | 0 |
| 9 | Functional non-homologous end joining patterns triggered by CRISPR/Cas9 in human cells显示文摘CRISPR/Cas9-mediated genome engineering technologies are now widely applied in various organisms,including mouse and human cells(Cong et al.,2013;Mali et al.,2013;Yang et al.,2013;Hsu et al.,2014).The most widely used customized CRISPR/Cas9(Sp Cas9)is derived from Streptococcus pyogenes(Cong et al.,2013).The CRISPR/Cas9 system creates site-specific double- | Fayu Yang Xianglian Ge Xiubin He Xiexie Liu Chenchen Zhou Huihui Sun Junsong Zhang Junzhao Zhao Zongming Song Jia Qu Changbao Liu Feng Gu | 2018 | Journal of Genetics and Genomics2018，45，6： | 0 |
| 10 | Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin显示文摘Induction of osteopontin(OPN),a well-known pro-inflammatory molecule,has been observed in acetaminophen(APAP)-induced hepatotoxicity.However,the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully explored.By employing a hepatotoxic mouse model induced by APAP overdose,we demonstrate that both serum and hepatic OPN levels were significantly elevated in response to APAP treatment.Our in vivo and in vitro studies clearly indicated that the induced expression of hepatic OPN was mainly located in necrosis areas and produced by dying or dead hepatocytes.Functional experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1(CYP2E1).Interestingly,this inhibition of CYP2E1 expression did not occur in unfasted Opn−/−mice,but was significant in fasted Opn−/−mice and maintained for 2hours after APAP challenge in fasted Opn−/−mice.In addition,despite the early protective role of OPN deficiency on APAP-induced hepatotoxicity,OPN deficiency retarded injury resolution by sensitizing hepatocytes to apoptosis and impairing liver regeneration.Finally,we demonstrated that a siRNA-mediated transient hepatic Opn knockdown could sufficiently and significantly protect animals from APAP-induced hepatotoxicity and death.In conclusion,this study clearly defines the cell source of OPN induction in response to APAP treatment,provides a novel insight into the metabolic role of OPN to APAP overdose,and suggests an Opn-targeted therapeutic strategy for the treatment or prevention of APAP-induced hepatotoxicity. | Yankai Wen Chenchen Wang Jinyang Gu Chang Yu Kaixia Wang Xuehua Sun Yun Sun Hailong Wu Ying Tong Qiang Xia Xiaoni Kong | 2019 | Cellular & Molecular Immunology2019，16，5： | 0 |
| 11 | Human-caused increases in reactive nitrogen burial in sediment of global lakes显示文摘Human activities have increased reactive nitrogen(Nr)input to terrestrial ecosystems compared with the pre-industrial era.However,the fate of such Nr input remains uncertain,leading to missing sink of the global nitrogen budget.By synthesizing records of Nr burial in sediments from 303 lakes worldwide,here we show that 9.6±1.1 Tg N year^(-1)(Tg=10^(12) g)accumulated in inland water sediments from 2000 to 2010,accounting for 3%-5% of global Nr input to the land from combined natural and anthropogenic pathways.The recent Nr burial flux doubles pre-industrial estimates,and Nr burial rate significantly increases with global increases in human population and air temperature.Sediment ratios of C:N decrease after 1950 while N:P ratios increase over time due to increasingly elevated Nr burial and other related processes in lakes.These findings imply that Nr burial in lakes is overlooked as an important global sink of Nr input to terrestrial ecosystems. | Mei Wang Benjamin Z.Houlton Sitong Wang Chenchen Ren Hans J.Mvan Grinsven Deli Chen Jianming Xu Baojing Gu | 2021 | The Innovation2021，2，4： | 0 |
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