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| 1 | Painful intervertebral disc degeneration and inflammation:from laboratory evidence to clinical interventions显示文摘Low back pain(LBP),as a leading cause of disability,is a common musculoskeletal disorder that results in major social and economic burdens.Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration,a significant contributor to LBP.Inflammatory mediators also play an indispensable role in discogenic LBP.The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies.Here,an overview of the advances in inflammation-related pain in disc degeneration is provided,with a discussion on the role of inflammation in IVD degeneration and pain induction.Puncture models,mechanical models,and spontaneous models as the main animal models to study painful disc degeneration are discussed,and the underlying signaling pathways are summarized.Furthermore,potential drug candidates,either under laboratory investigation or undergoing clinical trials,to suppress discogenic LBP by eliminating inflammation are explored.We hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research. | Feng-Juan Lyu Haowen Cui Hehai Pan Kenneth MC Cheung Xu Cao James C.Iatridis Zhaomin Zheng | 2021 | Bone Research2021，9，1： | 24 |
| 2 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 3 | Fundamental Theories of Spatial Similarity Relations in Multi-scale Map Spaces显示文摘Similarity relation is one of the spatial relations in the community of geographic information science and cartography.It is widely used in the retrieval of spatial databases, the recognition of spatial objects from images, and the description of spatial features on maps.However, little achievements have been made for it by far.In this paper, spatial similarity relation was put forward with the introduction of automated map generalization in the construction of multi-scale map databases;then the definition of spatial similarity relations was presented based on set theory, the concept of spatial similarity degree was given, and the characteristics of spatial similarity were discussed in detail, in-cluding reflexivity, symmetry, non-transitivity, self-similarity in multi-scale spaces, and scale-dependence.Finally a classification system for spatial similarity relations in multi-scale map spaces was addressed.This research may be useful to automated map generalization, spatial similarity retrieval and spatial reasoning. | YAN Haowen | 2010 | Chinese Geographical Science2010，20，1： | 17 |
| 4 | Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China显示文摘AIM: To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 andKazakh's esophageal squamous cell cancer in China.METHODS: The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh's patients with esophageal cancer (EC) and 104 non-cancer controls.RESULTS: The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) thanin control subjects (24.0%) (P<0.05; OR, 11.13; 95%CI,5.84-21.22). The difference of GSTM1 null was significantly more frequent in the cancer (34.6%) vsthe control group (3.8%) (P<0.05; OR, 13.24; 95%CI, 4.50-38.89). On the other hand, the combination of GSTM1 presence and CYP2E1 c1/c1 genotypes increased the risk for cancer (P<0.05;OR, 13.42; 95%CI, 6.29-28.3).CONCLUSION: The CYP2E1 c1/c1, GSTM1 deletion genotypes are genetically susceptible biomarkers for ESCC in Kazakh population. Individuals with allele c1 of RsaI polymorphic locus for CYP2E1 may increase the risk of ESCC. Moreover, CYP2E1 wild type (c1/c1) increased thesusceptibility to ESCC risk in Kazakh individuals with GSTM1 presence genotype. | Xiao-MeiLu Yue-MingZhang Ren-YongLin ArziGul XingWang Ya-LouZhang YanZhang YanWang HaoWen | 2005 | World Journal of Gastroenterology2005，11，24： | 15 |
| 5 | p53 polymorphism in human papillomavirus-associated Kazakh's esophageal cancer in Xinjiang,China显示文摘AIM: To investigate the relationship between p53 codon 72 polymorphism and human papillomavirus (HPV) type 16 infection in Kazakh's esophageal cancer (EC) in Xinjiang, China.METHODS: Encoding regions of p53codon 72 and HPV-16 E6 were amplified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction (PCR) methods using pairs of primary esophageal squamous cell carcinoma (SCC) tissue and corresponding normal mucosa, which were collected from 104 patients of Kazakh in Xinjiang, China. RESULTS: Only arginine allele was detected in 70.1% (39/55) of HPV-16-E6-positive cases but only in 40.8% (20/49) of HPV-16-E6-negative cases (P<0.05; OR, 3.53; 95% CI, 1.57-7.98). In contrast, such a significant correlation between p53 polymorphism and HPV infection was not evident in corresponding normal mucosae. The allele frequency of Arg allele in cancer cases (0.68) was higher than that in normal mucosa samples (0.54) (P<0.05; OR, 1.80; 95% CI, 1.21-2.69).CONCLUSION: p53 codon 72 Arg homozygous genotype is one of the high-risk genetic factors for HPV-associated SCC of Kazakh. Individuals carrying Arg allele compared to those with Pro allele have an increased risk for esophageal SCC. | Xiao-MeiLu Yue-MingZhang Ren-YonaLin Xiao-HuiLiang Ya-LouZhang XingWang YanZhang YanWang HaoWen | 2004 | World Journal of Gastroenterology2004，10，19： | 14 |
| 6 | A newly discovered Gigantopithecus fauna from Sanhe Cave, Chongzuo, Guangxi, South China显示文摘Among the most important faunas in the Late Cenozoic, the Gigantopithecus faunas have received a good deal of attention. The Gigantopithecus fauna recently discovered in Sanhe Cave consists of more than 80 mammal species, including cf. Hominidae, Pongo sp., Hylobates sp., Sinomastodon yangzien-sis, Stegodon preorientalis, Cervavitus fenqii, Dicoryphochoerus ultimus and Sus xiaozhu. It is the southernmost Gigantopithecus fauna found so far in China. Its geological age is estimated to be Early Pleistocene based on the fauna and stratigraphic correlation. The significant increase in the estimated body sizes of Ailuropoda, Gigantopithecus and Tapirus shows that the Sanhe fauna is middle Early Pleistocene, later than those from Wushan and Liucheng (early Early Pleistocene). Paleomagnetic dating of the fossil-bearing strata in Sanhe Cave gives an age of approximately 1.2 Ma. The fauna is characterized by tropical-subtropical forest types, including Pongo sp., Tupaia sp., Ia sp., Typhlomys intermedius, etc., and it lacks Palaearctic types. It is a typical tropical forest fauna, suggesting an en-vironment with a lush forest and a warm and humid climate. The discovery of the Sanhe Gigantopith-ecus fauna is significant for establishing the chronological stages of the Gigantopithecus faunas in China, and for discussing their origin, evolution and dynamics. | JIN ChangZhu QIN DaGong PAN WenShi TANG ZhiLu LIU JinYi WANG Yuan DENG ChengLong ZHANG YingQi DONG Wei TONG HaoWen | 2009 | Chinese Science Bulletin2009，54，5： | 14 |
| 7 | Carbon Dioxide Captured from Flue Gas by Modified Ca-based Sorbents in Fixed-bed Reactor at High Temperature显示文摘Four kinds of Ca-based sorbents were prepared by calcination and hydration reactions using different precursors: calcium hydroxide, calcium carbonate, calcium acetate monohydrate and calcium oxide. The CO2 absorption capacity of those sorbents was investigated in a fixed-bed reactor in the temperature range of 350-650℃. It was found that all of those sorbents showed higher capacity for CO2 absorption when the operating temperature higher than 450℃. The CaAc2-CaO sorbent showed the highest CO2 absorption capacity of 299mg·g-1. The morphology of those sorbents was examined by scanning electron microscope (SEM), and the changes of composition before and after carbonation were also determined by X-ray diffraction (XRD). Results indicated that those sorbents have the similar chemical compositions and crystalline phases before carbonation reaction [mainly Ca(OH)2], and CaCO3 is the main component after carbonation reaction. The SEM morphology shows clearly that the sorbent pores were filled with reaction products after carbonation reaction, and became much denser than before. The N2 adsorption-desorption isotherms indicated that the CaAc2-CaO and CaCO3-CaO sorbents have higher specific surface area, larger pore volume and appropriate pore size distribution than that of CaO-CaO and Ca(OH)2-CaO. | YANG Lei YU Hongbing WANG Shengqiang WANG Haowen ZHOU Qibin | 2013 | Chinese Journal of Chemical Engineering2013，21，2： | 8 |
| 8 | Occurrences of warm-adapted mammals in north China over the Quaternary Period and their paleoenvironmental significance显示文摘The north and south China faunas are subdivided along the line of Huaihe River-Qinling Mountains- Hengduan Mountains-Himalayas, to the north is the Palearctic Region, and to the south is the Oriental Region, which is the result of long-time evolution. Hundreds of Quaternary fossil localities have been known up to now, more than 60 of which contain warm-adapted elements which can be referred to 20 species. Among the warm-adapted elements appearing in north China, Hystrix, Macaca, Palaeoloxodon, Dicerorhinus and Bubalus are the most frequently recorded genera. There are three kinds of causal explanation about the frequent appearance of warm-adapted elements in north China: The first hy- pothesis attributed them to the dispersal events of warm-adapted mammals from the south during warm stages or warm seasons; the second scenario thinks that these warm-adapted mammals in north China were once derived there in situ and subsequently emigrated to the south with the cooling down of the global climate; the last hypothesis believes that these warm-adapted elements were not real warm-climate animals at that time. This study shows that almost none of the warm-adapted mammals in north China was recovered in the loess, and also almost all of the fossil localities which bear warm-adapted mammals fall within the warm temperate zone of nowadays. In fossil assemblage, those warm-adapted elements rarely co-exist with the cold-adapted mammals. All these evidences mentioned above indicate that the warm-adapted mammals in north China represent warm climate, but not hot one. Because all these warm-adapted mammals are widely distributed oriental elements, some of them even still exist north of the Huaihe River today. Up to now, no typical oriental elements have ever been re- covered in north China, such as pangolin, primitive primates (e.g. loris and tarsier), big apes (e.g. Gi- gantopithecus, Pongo and Hylobates), etc. The Late Pleistocene lasted a relatively shorter time, but the appearance of warm-adapted mammals during that span were the most frequent and most widespread. It means that the climate of the Late Pleistocene experienced the most frequent fluctuation over the whole period of Quaternary. | TONG HaoWen | 2007 | Science China Earth Sciences2007，50，9： | 8 |
| 9 | Shape anisotropic Fe3O4 nanotubes for efficient microwave absorption显示文摘Although Fe3O4 particles have exhibited excellent microwave absorbing capacity and widely used in practical application due to the synergistic effect of magnetic loss and dielectric loss,their applications are still limited for the required high mass fraction in absorbers.To overcome this problem,the development of Fe3O4 materials with low dimensional structures is necessary.In this study,the shape anisotropic Fe3O4 nanotubes(NTs)with low mass ratios were applied to realize efficient microwave absorption.The NTs with different aspect ratios were prepared through facile electrospinning followed by two-step thermal treatments and mechanical shearing.The cross-linked nanotubular structure enabled the absorbers to have much higher electrical conductivity,multiple scattering,polarization relaxation and better anti-reflection surface,while the shape anisotropic NTs maintained significant multiple resonances with stronger coercivity.These all were beneficial to microwave absorption with enhanced dielectric loss,magnetic loss and sterling impedance matching.Results showed that the absorber with 33.3 wt.%of short Fe3O4 NTs had minimum reflection loss of-58.36 dB at 17.32 GHz with a thickness of 1.27 mm,and had the maximum effective absorbing bandwidth(EAB)of 5.27 GHz when the thickness was 1.53 mm.The absorber with 14.3 wt.%of long Fe3O4 NTs presented the widest EAB in certain radar band with attenuated 80.75%X band and 85%Ku band energy bellow-10 dB at the thickness of 2.65 and 1.53 mm,respectively.This study provided an approach for the development of shape anisotropic magnetic absorbing materials,and broadened their practical applications as magnetic absorbers. | Jialiang Pan Honggui Guo Min Wang Hui Yang Haowen Hu Peng Liu Hongwei Zhu | 2020 | Nano Research2020，13，3： | 8 |
| 10 | Stephanorhinus kirchbergensis (Rhinocerotidae,Mammalia) from the Rhino Cave in Shennongjia,Hubei显示文摘The Rhino Cave,a Paleolithic site in Shennongjia,is the highest altitude locality of rhinoceros in the Middle-South part of China,and it is also the southernmost and the richest locality in Stephanorhinus kirchbergensis fossils which include cranium,mandibles,isolated teeth and postcranials.These materials can be referred to the species Stephanorhinus kirchbergensis according to the following characters:incisorless,mandibular symphysis contracted,occiput high,subaural channel closed,with nasal and frontal horns,nasal septum partially ossified,premolars hypsodont and cheekteeth with smooth enamel surface,etc.;except its relatively shorter limb bones.In China,all the Pleistocene non-Coelodonta tandem-horned rhinoceroses were assigned to the genus Dicerorhinus in the past decades.From today's viewpoint,most of them should be included in the genus Stephanorhinus,because Dicerorhinus is quite different from Stephanorhinus in the following characters:smaller body size,generally unossified nasal septum,subaural channel open and with reduced incisors,etc.This is the first knowledge of Stephanorhinus kirchbergensis associated with Ailuropoda-Stegodon fauna,the typical Pleistocene mammalian fauna in South China. | TONG HaoWen WU XianZhu | 2010 | Chinese Science Bulletin2010，55，12： | 6 |
| 11 | Simultaneous extraction of DNA and RNA from Escherichia coli BL 21 based on silica-coated magnetic nanoparticles显示文摘The extraction of nucleic acid is recognized as one of the most essential steps in molecular biology for initiating other downstream applications such as sequencing, amplification, hybridization, and cloning. Many commercial kits and methods are currently available that allow the extraction of only one type of nucleic acids-DNA or RNA. However, in parallel clinical detection of several diseases, a method for simultaneous extraction of both DNA and RNA from the same source is needed in such cases. In this study, a method for simultaneous extraction of DNA and RNA from bacteria based on magnetic nanoparticles(MNPs) was described. Lysis buffers were prepared to help the nucleic acid released and adsorbed to MNPs. Then, two washing buffers were used to remove the contamination of proteins and carbohydrates. The nucleic acids were finally eluted by Deoxyribonuclease(DNase) and Ribonucleases(RNase) free water. Different factors which might affect the purification of the nucleic acid were investigated, and the quantity and quality parameters of the nucleic acid were also recorded. The DNA and RNA extracted from bacteria were then respectively subjected to polymerase chain reaction(PCR) and reverse transcription PCR(RT-PCR) to further confirm its quality. The results indicated that our method can be successfully used to simultaneously extract DNA and RNA from bacteria. | Jiuhai Wang Zeeshan Ali Nianyue Wang Wenbiao Liang Hongna Liu Fu Li Haowen Yang Lei He Libo Nie Nongyue He Zhiyang Li | 2015 | Science China Chemistry2015，58，11： | 5 |
| 12 | Formula for calculating spatial similarity degrees between point clouds on multi-scale maps taking map scale change as the only independent variable显示文摘The degree of spatial similarity plays an important role in map generalization, yet there has been no quantitative research into it. To fill this gap, this study first defines map scale change and spatial similarity degree/relation in multi-scale map spaces and then proposes a model for calculating the degree of spatial similarity between a point cloud at one scale and its generalized counterpart at another scale. After validation, the new model features 16 points with map scale change as the x coordinate and the degree of spatial similarity as the y coordinate.Finally, using an application for curve fitting, the model achieves an empirical formula that can calculate the degree of spatial similarity using map scale change as the sole independent variable, and vice versa. This formula can be used to automate algorithms for point feature generalization and to determine when to terminate them during the generalization. | Yang Weifang Yan Haowen Li Jonathan | 2015 | Geodesy and Geodynamics2015，6，2： | 5 |
| 13 | Correlation Characteristics of Channels in MIMO Radar显示文摘 | CHEN Haowen LIU Yongxiang YANG Zhaocheng LI Xiang | 2011 | Chinese Journal of Electronics2011，20，1： | 4 |
| 14 | Efficient defect-controlled photocatalytic hydrogen generation based on near-infrared Cu-In-Zn-S quantum dots显示文摘能有效地收获可见的光的光催化剂的发展为在高效率的太阳开车的氢产生的进展是必要的。此处,我们综合了由使用一个壶浇可溶的 CuInS 2(CIS ) 和 Cu-In-Zn-S (CIZS ) 量点(QD ) 水的方法。CIZS QD 被谷胱甘肽 ligands 很好使钝化并且处于水的条件是高度稳定的。我们随后作为为 photocatalytic 氢产生收获材料的一盏灯使用了这些 QD。不同于显示出极其低的效率的很小的乐队差距材料,这些新 QD 在可见、在红外线附近的区域显示显著精力变换效率。在 650 nm 的外部量效率是 1.5% ,就我们的知识而言,它是在在红外线附近的区域完成直到现在的最高的价值。 | Xiao-Yuan Liu Guozhen Zhang Hao Chen Haowen Li Jun Jiang Yi-Tao Long Zhijun Ning | 2018 | Nano Research2018，11，3： | 4 |
| 15 | Panel/full-span free-wake coupled method for unsteady aerodynamics of helicopter rotor blade显示文摘A full-span free-wake method is coupled with an unsteady panel method to accurately predict the unsteady aerodynamics of helicopter rotor blades in hover and forward flight. The unsteady potential-based panel method is used to consider aerodynamics of finite thickness multi-bladed rotors, and the full-span free-wake method is applied to simulating dynamics of rotor wake. These methods are tightly coupled through trailing-edge Kutta condition and by converting doublet-wake panels to full-span vortex filaments. A velocity-field integration technique is also adopted to overcome singularity problem during the interaction between the rotor wake and blades. Helicopter rotors including Caradonna-Tung, UH-60A, and AH-1G rotors, are simulated in hover and forward flight to validate the accuracy of this approach. The predicted aerodynamic loads of rotor blades agree well with available measured data and computational fluid dynamics (CFD) results, and the unsteady dynamics of rotor wake is also well simulated. Compared to CFD, the present method obtains accurate results more efficiently and is suitable to rotorcraft aeroelastic analysis. | Tan Jianfeng Wang Haowen | 2013 | Chinese Journal of Aeronautics2013，26，3： | 4 |
| 16 | Effectiveness of MRA on embolized intracranial aneurysms: a comparison of DSA, CE-MRA, and TOF-MRA显示文摘Purpose: The endovascular treatment of intracranial aneurysms was proven safe and effective compared to the alternative method of surgical clipping, despite the high recurrence rate. Follow-up of embolized intracranial aneurysms is mandatory for the early detection of recurrence and improved outcomes. DSA is used as the reference standard for this assessment. To determine the effectiveness of MRA in follow-up evaluations of intracranial aneurysms after embolization by comparing DSA, CE-MRA, and TOF-MRA. Materials and Methods: Sixty-eight consecutive patients undergoing DSA, TOF-MRA, and CE-MRA during an interval of <1 week were enrolled in this 6-month study. Images were evaluated for occlusion status, patency of the parent vessels, and artifacts. The modified Raymond-Roy occlusion classification and Aneurysm Embolization Grades were used to assess the occlusion status and initial DSA images for detection of recurrence in two filtered study phases with optimized selection criteria. Seventeen observers(phase I: 9, phase II: 8) independently interpreted the double-blinded images. Agreement was expressed with a Fleiss kappa value; p < 0.05 was considered significant. Results: This study included 68 patients with 77 aneurysms; 38(49.35%) were treated with coil alone and 39(50.65%) with stent-assisted coiling. In both phases, DSA was superior to TOF-MRA and CE-MRA using MRRC(Phase I: k = 0.567, p ≤ 0.001; k = 0.287, p ≤ 0.001; k = 0.117, p ≤ 0.001, respectively; Phase II: k = 0.503, p ≤ 0.001; k = 0.303, p ≤ 0.001; k = 0.115, p = 0.038, respectively). TOF-MRA was as effective as DSA(TOF: k = 0.335, p ≤ 0.001; DSA: k = 0.323, p ≤ 0.001) for recurrence detection. Conclusion: We suggest TOF-MRA as a first-line follow-up tool to detect aneurysm recurrence, and DSA to quantify the filling space to make a definite decision on re-embolization. | Ally Mohamed Qassim Sheng Guan Halfan Saidi Ngowo Binghui Liu Haowen Xu | 2018 | Journal of Interventional Medicine2018，1，1： | 4 |
| 17 | A design method for high fabrication tolerance integrated optical mode multiplexer显示文摘The tapered asymmetric directional coupler has the potential to realize high fabrication tolerance and high transmission efficiency on-chip mode multiplexer.However,the geometry parameter selection of tapered structure remains empirical.In this paper,we propose a design method for the tapered structure based on genetic algorithm.Combined with the adjusted coupling equations and interpolation method,lowtime-cost optimization can be realized.Three mode multiplexers(TE0&TE1,TE0&TE2 and TE0&TE5)are designed by our method.According to simulation results,the insertion loss of the designed devices is lower than 1.8 dB and the crosstalk is lower than-15 dB when the fabrication error is within required range(±10 nm for TE0&TE2 and TE0&TE5,and±20 nm for TE0&TE1)in the bandwidth of 1.5–1.6μm.In addition,the entire optimization process takes only 2 h for each device,which is around the time cost of a single 3 D simulation. | Bitao SHEN Haowen SHU Linjie ZHOU Xingjun WANG | 2020 | Science China(Information Sciences)2020，63，6： | 3 |
| 18 | Investigation of rotor control system loads显示文摘This paper concentrates on the aeroelasticity analysis of rotor blade and rotor control systems.A new multi-body dynamics model is established to predict both rotor pitch link loads and swashplate servo loads.Two helicopter rotors of UH-60A and SA349/2,both operating in two critical flight conditions,high-speed flight and high-thrust flight,are studied.The analysis shows good agreements with the flight test data and the calculation results using CAMRAD II.The mechanisms of rotor control loads are then analyzed in details based on the present predictions and the flight test data.In high-speed conditions,the pitch link loads are dominated by the integral of blade pitching moments,which are generated by cyclic pitch control.In high-thrust conditions,the positive pitching loads in the advancing side are caused by high collective pitch angle,and dynamic stall in the retreating side excites high-frequency responses.The swashplate servo loads are predominated by the rotor pitch link loads,and the inertia of the swashplate has signifcant effects on high-frequency harmonics of the servo loads. | Sun Tao Tan Jianfeng Wang Haowen | 2013 | Chinese Journal of Aeronautics2013，26，5： | 3 |
| 19 | Design and application of an Electric Tail Rotor Drive Control(ETRDC) for helicopters with performance tests显示文摘With the development of electric helicopters' motor technology and the widespread use of electric drive rotors, more aircraft use electric rotors to provide thrust and directional control.For a helicopter tail rotor, the wake of the main rotor influences the tail rotor's inflow and wake.In the procedure of controlling, crosswind will also cause changes to the tail disk load. This paper describes requirements and design principles of an electric motor drive and variable pitch tail rotor system. A particular spoke-type architecture of the motor is designed, and the performance of blades is analyzed by the CFD method. The demand for simplicity of moving parts and strict constraints on the weight of a helicopter makes the design of electrical and mechanical components challenging. Different solutions have been investigated to propose an effective alternative to the mechanical actuation system. A test platform is constructed which can collect the dynamic response of the thrust control. The enhancement of the response speed due to an individual motor speed control and variable-pitch system is validated. | Yuwen ZHANG Chen JIANG Yunjie WANG Fan SUN Haowen WANG | 2018 | Chinese Journal of Aeronautics2018，31，9： | 3 |
| 20 | Calcium silicate accelerates cutaneous wound healing with enhanced re-epithelialization through EGF/EGFR/ERK-mediated promotion of epidermal stem cell functions显示文摘Background:Human epidermal stem cells(hESCs)play an important role in re-epithelialization and thereby in facilitating wound healing,while an effective way to activate hESCs remains to be explored.Calcium silicate(CS)is a form of bioceramic that can alter cell behavior and promote tissue regeneration.Here,we have observed the effect of CS on hESCs and investigated its possible mechanism.Methods:Using a mouse full-thickness skin excision model,we explored the therapeutic effect of CS on wound healing and re-epithelialization.In vitro,hESCs were cultured with diluted CS ion extracts(CSIEs),and the proliferation,migration ability and stemness of hESCs were evaluated.The effects of CS on the epidermal growth factor(EGF),epidermal growth factor receptor(EGFR)and extracellular signal-related kinase(ERK)signaling pathway were also explored.Results:In vivo,CS accelerated wound healing and re-epithelialization.Immunohistochemistry demonstrated that CS upregulated cytokeratin 19 and integrinβ1 expression,indicating that CS improved hESCs stemness.In vitro studies confirmed that CS improved the biological function of hESCs.And the possible mechanism could be due to the activation of the EGF/EGFR/ERK signaling pathway.Conclusion:CS can promote re-epithelialization and improve the biological functions of hESCs via activating the EGF/EGFR/ERK signaling pathway. | Bingmin Li Haowen Tang Xiaowei Bian Kui Ma Jiang Chang Xiaobing Fu Cuiping Zhang | 2021 | Burns & Trauma2021，9，1： | 3 |
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