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| 1 | Mechanical behavior of coal under different mining rates:A case study from laboratory experiments to field testing显示文摘During the development of hot dry rock,the research on thermal fatigue damage caused by thermal shock of cold and heat cycles is the basis that ensures the long-term utilization of geothermal resources,but there are not enough relevant studies at present.Based on this,the thermal damage tests of granite at different temperatures(250,350,450°C)and quenching cycles(1,5,10,15 cycles)were carried out.Preliminary reveals the damage mechanism and heat transfer law of the quenching cycle effect on hot dry rock.The results show that with the increase of temperature and cycles,the uneven thermal expansion of minerals and the thermal shock caused by quenching promote the crack development of granite,resulting in the decrease of P-wave velocity,thermal conductivity and uniaxial compressive strength of granite.Meanwhile,the COMSOL was used to simulate the heat transfer of hot dry rock under different heat treatment conditions.It concluded that the increase in the number of quenching cycles reduced the heat transfer capacity of the granite,especially more than 10 quenching cycles,which also reflects that the thermal fatigue damage leads to a longer time for the temperature recovery of the hot dry rock mass.In addition,the three-dimensional nonlinear fitting relationship among thermal conductivity,temperature and cycle number was established for the first time,which can better reveal the change rule of thermal conductivity after quenching thermal fatigue effect of hot dry rock.The research results provide theoretical support for hot dry rock reservoir reconstruction and production efficiency evaluation. | Mingzhong Gao Jing Xie Yanan Gao Wenyong Wang Cong Li Bengao Yang Junjun Liu Heping Xie | 2021 | International Journal of Mining Science and Technology2021，31，5： | 39 |
| 2 | BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair显示文摘Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair. | Yuxing Guo Yuan Yuan Ling Wu Thach-Vu Ho Junjun Jing Hideki Sugii Jingyuan Li Xia Han Jifan Feng Chuanbin Guo Yang Chai | 2018 | Bone Research2018，6，4： | 12 |
| 3 | PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4显示文摘 | Wenyong Long Wei Zhao Bo Ning Jing Huang Junjun Chu Linfeng Li Qianquan Ma Changsheng Xing Helen Y. Wang Qing Liu Rong-Fu Wang | 2018 | Journal of Molecular Cell Biology2018，10，2： | 5 |
| 4 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 2 |
| 5 | Effect of curing agent polarity on water absorption and free vol- ume in epoxy resin studied by PALS显示文摘 | Wang Junjun Gong Jing Gong Zhenli | 2010 | Nuclear In- struments and Methods in Physics Research B2010，268，： | 1 |
| 6 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 1 |
| 7 | ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy in metastatic colorectal cancer显示文摘Cetuximab is one of the most valuable targeted therapy monoclonal antibodies in the treatment of metastatic colorectal cancer(CRC).However,the mechanisms affecting cetuximab resistance in CRC treatment remain unclear.Metabolism,especially fatty acid metabolism,has been reported to play an important role in tumor treatment.The correlation between cetuximab resistance and metabolism and whether it can be a new biomarker to evaluate the sensitivity of cetuximab in CRC treatment still need to be further explored.In this study,we perform a comprehensive analysis to confirm the relationship between fatty acid metabolism and cetuximab resistance,and the differentially expressed genes(DEGs)related to cetuximab drug resistance in CRC are screened by bioinformatics technology.We find that acetyl-CoA carboxylase beta(ACACB),ADH1C,CES1,MGLL,FMO5,and GPT are the hub DEGs,and ACACB is the most important biomarker among them.In addition,we systematically analyze the role of ACACB in the tumorigenesis of CRC,including tissue expression,CRC cell growth,cetuximab sensitivity,and potential downstream pathways,by using bioinformatics techniques,in vitro experiments and clinical cohort validation.Our results confirm that cetuximab resistance is correlated with metabolism.ACACB can lead to decreased sensitivity to cetuximab in CRC,and its mechanism may be related to EGFR phosphorylation,which could affect the activation of the mTOR/Akt signaling pathway and regulation of CDT1-,cyclin D1-,and p21-related cell cycle modulation. | Hi-Ju Hong Yanfei Shao Sen Zhang Guang Yang Hongtao Jia Xiao Yang Ling Huang Shuchun Li Batuer Aikemu Luyang Zhang Junjun Ma Lu Zang Jing Sun Minhua Zheng | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 8 | Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies显示文摘The past decade has seen significant advances in our understanding of Hedgehog(HH)signaling pathway in various biological events.HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium.HH signaling pathway has important functions in embryonic development and tissue homeostasis.It plays a central role in the regulation of the proliferation and differentiation of adult stem cells.Importantly,it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence,malignant progression,poor prognosis and even increased mortality.Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer.A variety of drugs have been developed,including small molecule inhibitors,natural compounds,and long non-coding RNA(LncRNA),some of which are approved for clinical use.This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer.Furthermore,we address status quo and limitations of targeted therapies of HH signaling pathway.Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer,as well as opportunities and challenges of therapeutic targets for cancer. | Junjun Jing Zhuoxuan Wu Jiahe Wang Guowen Luo Hengyi Lin Yi Fan Chenchen Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 9 | Physiological and molecular bases of the boron deficiency response in tomatoes显示文摘Boron is an essential microelement for plant growth.Tomato is one of the most cultivated fruits and vegetables in the world,and boron deficiency severely inhibits its yield and quality.However,the mechanism of tomato in response to boron deficiency remains largely unclear.Here,we investigated the physiological and molecular bases of the boron deficiency response in hydroponically grown tomato seedlings.Boron deficiency repressed the expression of genes associated with nitrogen metabolism,while it induced the expression of genes related to the pentose phosphate pathway,thereby altering carbon flow to provide energy for plants to cope with stress.Boron deficiency increased the accumulation of copper,manganese and iron,thereby maintaining chlorophyll content and photosynthetic efficiency at the early stage of stress.In addition,boron deficiency downregulated the expression of genes involved in cell wall organization and reduced the contents of pectin and cellulose in roots,ultimately retarding root growth.Furthermore,boron deficiency markedly altered phytohormone levels and signaling pathways in roots.The contents of jasmonic acid,jasmonoy1-L-isoleucine,trans-zeatin riboside,abscisic acid,salicylic acid,and SA glucoside were decreased;in contrast,the contents of isopentenyladenine riboside and ethylene precursor 1-aminocyclopropane-1-carboxylic acid were increased in the roots of boron-deficient tomato plants.These results collectively indicate that tomato roots reprogram carbon/nitrogen metabolism,alter cell wall components and modulate phytohormone pathways to survive boron deficiency.This study provides a theoretical basis for further elucidating the adaptive mechanism of tomato in response to boron deficiency. | Junjun Li Huihui Fan Qianqian Song Lili Jing Hao Yu Ruishan Li Ping Zhang Fei Liu Weimin Li Liangliang Sun Jin Xu | 2023 | Horticulture Research2023，10，12： | 0 |
| 10 | Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny显示文摘Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation.The initiation of Hertwig’s epithelial root sheath(HERS)induces odontoblast differentiation and the subsequent radicular dentin deposition.Precisely controlled signaling pathways modulate the behaviors of HERS and the fates of dental mesenchymal stem cells(DMSCs).Disruptions in these pathways lead to defects in root development,such as shortened roots and furcation abnormalities.Advances in dental stem cells,biomaterials,and bioprinting show immense promise for bioengineered tooth root regeneration.However,replicating the developmental intricacies of odontogenesis has not been resolved in clinical treatment and remains a major challenge in this field.Ongoing research focusing on the mechanisms of root development,advanced biomaterials,and manufacturing techniques will enable next-generation biological root regeneration that restores the physiological structure and function of the tooth root.This review summarizes recent discoveries in the underlying mechanisms governing root ontogeny and discusses some recent key findings in developing of new biologically based dental therapies. | Pengcheng Rao Junjun jing Yi Fan Chenchen Zhou | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 11 | Rapid Path Extraction and Three-Dimensional Roaming of the Virtual Endonasal Endoscope显示文摘Compared with traditional endonasal endoscope,Virtual endonasal endoscope(VEE)is a computerized alternative solution with the advantages of being non-invasive,affordable,no perforation,low risk of infection,and high degree of sensitivity.A Central path extraction algorithm based on Pre-planning of the roaming area(CPE-PRA)is proposed to extract the central path of the nasal cavity model efficiently.And a B-spline curve fitting algorithm based on Relative center deviation(RCD)is introduced to fit a smooth curve to the extracted path,so that the virtual camera could have both a steady turning speed and a broad vision.A series of comparison tests were conducted to evaluate the effectiveness and efficiency of the proposed algorithms. | WANG Yudong HAN Jing PAN Junjun WANG Jing CAO Yi ZHU Li LUO Yanlin | 2021 | Chinese Journal of Electronics2021，30，3： | 0 |
| 12 | Emerging roles of exosomes in oral diseases progression显示文摘Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine. | Jiayi Wang Junjun Jing Chenchen Zhou Yi Fan | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 13 | Mechanism of ball milled activated carbon in improving the desalination performance of flow-and fixed-electrode in capacitive deionization desalination显示文摘Capacitive deionization(CDI)is a novel electrochemical water-treatment technology.The electrode material is an important factor in determining the ion separation efficiency.Activated carbon(AC)is extensively used as an electrode material;however,there are still many deficiencies in commercial AC.We adopted a simple processing method,ball milling,to produce ball milled AC(BAC)to improve the physical and electrochemical properties of the original AC and desalination efficiency.The BAC was characterized in detail and used for membrane capacitive deionization(MCDI)and flow-electrode capacitive deionization(FCDI)electrode materials.After ball milling,the BAC obtained excellent pore structures and favorable surfaces for ion adsorption,which reduced electron transfer resistance and ion migration resistance in the electrodes.The optimal ball-milling time was 10 h.However,the improved effects of BAC as fixed electrodes and flow electrodes are different and the related mechanisms are discussed in detail.The average salt adsorption rates(ASAR)of FCDI and MCDI were improved by 134%and 17%,respectively,and the energy-normalized removal salt(ENRS)were enhanced by 21%and 53%,respectively.We believe that simple,low-cost,and environmentally friendly BAC has great potential for practical engineering applications of FCDI and MCDI. | Ge Shen Junjun Ma Jianrui Niu Ruina Zhang Jing Zhang Xiaoju Wang Jie Liu Jiarong Gu Ruicheng Chen Xiqing Li Chun Liu | 2023 | Frontiers of Environmental Science & Engineering2023，17，5： | 0 |
| 14 | CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation显示文摘Chromatin is spatially organized into three-dimensional structures at different levels including A/B compartments, topologically associating domains and loops. The canonical CTCF-mediated loop extrusion model can explain the formation of loops. However, the organization mechanisms underlying long-range chromatin interactions such as interactions between A–A compartments are still poorly understood. Here we show that different from the canonical loop extrusion model, RYBP-mediated phase separation of CTCF organizes inter-A compartment interactions. Based on this model, we designed and verified an induced CTCF phase separation system in embryonic stem cells (ESCs), which facilitated inter-A compartment interactions, improved self-renewal of ESCs and inhibited their differentiation toward neural progenitor cells. These findings support a novel and non-canonical role of CTCF in organizing long-range chromatin interactions via phase separation. | Chao Wei Lumeng Jia Xiaona Huang Jin Tan Mulan Wang Jing Niu Yingping Hou Jun Sun Pengguihang Zeng Jia Wang Li Qing Lin Ma Xinyi Liu Xiuxiao Tang Fenjie Li Shaoshuai Jiang Jingxin Liu Tingting Li Lili Fan Yujie Sun Juntao Gao Cheng Li Junjun Ding | 2022 | Cell Research2022，32，8： | 0 |
| 15 | Progresses on Personalized Nutritional Evaluation and Recommendation显示文摘Health is maintained by a state of dynamic homeostasis in which nutrient intake and expenditure are of good balance.Therefore,it is important to know exactly the nutritional value of food sources,as well as the nutritional requirements of individuals,in order to achieve optimal nutrition.Considering the interaction between diet and individual background,nutritional evaluation and recommendation has become a complicate issue needing further investigations.While traditional nutrition research has made significant progress in population nutrition,modern nutrition research is now becoming possible to focus on personalized nutrition in health promotion,disease prevention,performance improvement,and risk assessment of individual with the development of emerging omics technologies.This review tried to summarize the methods used in nutritional evaluation and recommendation as well as their applications.Though personal nutrition evaluation and recommendation are still not well-established,utilization of these advanced technologies may expand our knowledge in bioavailability and bioefficacy of diet ingredients,pathophysiological changes in response to dietary intervention,as well as nutrition-associated disease biomarkers discovery,and thus contributing to personalized nutrition. | Gang Lin Chuang Liu Huaijun Zhou Shuo Feng Yiqiang Chen Luoyun Fang Guoyao Wu Jing Zhang Shiyan Qiao Junjun Wang | 2010 | Journal of Animal Science and Biotechnology2010，1，3： | 0 |
| 16 | Dihydropyrimidinase like 3 as a novel target of wild type p53 suppresses MAPK pathway in response to hypoxia显示文摘Endometrial cancer remains to be a major type of malignancy in threatening female life.Molecular insights in advancing our understanding of endometrial tumorigenesis are much needed.We here report that a less-studied protein Dihydropyrimidinase like 3(DPYSL3)is a potent tumor suppressor.DPYSL3 is uniquely regulated by wild type p53(wtp53),and its expression is at the highest level when cells carry wtp53 and are exposed to hypoxia.We reveal that wtp53 can bind DPYSL3 promoter to enhance DPYSL3 expression and in turn,the elevated DPYSL3 can restrain cancer cell proliferation and invasion in vitro and in vivo.Importantly,we observe that DPYSL3 can interfere with MAP kinase pathway,supported by a substantially reduced level of phosphorylated ERK in cells with high expression of DPYSL3.Furthermore,we identify the specific region of DPYSL3 that is responsible for its interaction with MEK and a subsequently reduced activity of ERK.In combination of molecular docking and mutagenesis analysis,we validated that the therapeutic implication of 17 A.A.s of DPYSL3,which can reduce the activity of the MAPK pathway and inhibit endometrial tumor cell growth in vitro and in vivo.Therefore,our study not only demonstrates in-depth understanding of human tumorigenesis,especially endometrial tumor,but also only provides a therapeutic potential to develop an effective tool to fight against human malignancy. | YUANNA DU WENWEN GONG JING LIANG RUKUN ZANG JUNJUN MOU | 2022 | BIOCELL2022，46，5： | 0 |
| 17 | Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice显示文摘Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma. | Yin Yang Zhaoxi Yang Maoxia Lv Ang Jia Junjun Li Baitao Liao Jing’an Chen Zhengzheng Wu Yi Shi Yang Xia Dezhong Yao Ke Chen | 2024 | Neural Regeneration Research2024，19，1： | 0 |
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