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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19显示文摘Coronavirus disease 2019(COVID-19)is a pandemic with no specific drugs and high fatality.The most urgent need is to find effective treatments.We sought to determine whether hydroxychloroquine(HCQ)application may reduce the death risk of critically ill COVID-19 patients.In this retrospective study,we included 550 critically ill COVID-19 patients who need mechanical ventilation in Tongji Hospital,Wuhan,from February 1,2020 to April 4,2020.All 550 patients received comparable basic treatments including antiviral drugs and antibiotics,and 48 of them were treated with oral HCQ treatment(200 mg twice a day for 7–10 days)in addition to the basic treatments.Primary endpoint is fatality of patients,and inflammatory cytokine levels were compared between HCQ and non-hydroxychloroquine(NHCQ)treatments.We found that fatalities are 18.8%(9/48)in HCQ group,which is significantly lower than 47.4%(238/502)in the NHCQ group(P<0.001).The time of hospital stay before patient death is 15(10–21)days and 8(4–14)days for the HCQ and NHCQ groups,respectively(P<0.05).The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2(8.3–118.9)pg mL–1 at the beginning of the treatment to 5.2(3.0–23.4)pg mL–1(P<0.05)at the end of the treatment in the HCQ group but there is no change in the NHCQ group.These data demonstrate that addition of HCQ on top of the basic treatments is highly effective in reducing the fatality of critically ill patients of COVID-19 through attenuation of inflammatory cytokine storm.Therefore,HCQ should be prescribed as a part of treatment for critically ill COVID-19 patients,with possible outcome of saving lives. | Bo Yu Chenze Li Peng Chen Ning Zhou Luyun Wang Jia Li Hualiang Jiang Dao-Wen Wang | 2020 | Science China(Life Sciences)2020，63，10： | 7 |
| 3 | Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases显示文摘Coronavirus disease 2019(COVID-19) is a global pandemic which has caused numerous deaths worldwide. The present study investigated the roles of hypoproteinemia in the clinical outcome and liver dysfunction of COVID-19 patients. In this retrospective study, we extracted data from 2,623 clinically confirmed adult COVID-19 patients(≥18 years old) between January 29,2020 and March 6, 2020 in Tongji Hospital, Wuhan, China. The patients were divided into three groups—non-critically ill,critically ill, and death groups—in accordance with the Chinese Clinical Guideline for COVID-19. Serum albumin, low-density lipoproteins cholesterol(LDL-C), and high-density lipoproteins cholesterol(HDL-C) concentrations and inflammatory cytokines levels were measured and compared among these three groups. The median age of these 2,623 patients was 64 years old(interquartile range(IQR), 52–71). Among the patients enrolled in the study, 2,008(76.6%) were diagnosed as non-critically ill and 615(23.4%) were critically ill patients, including 383(14.6%) critically ill survivors and 232(8.8%) critically ill deaths in the hospital. Marked hypoalbuminemia occurred in 38.2%, 71.2%, and 82.4% patients in non-critically ill, critically ill, and death groups, respectively, on admission and 45.9%, 77.7%, and 95.6% of these three groups, respectively, during hospitalization. We also discovered that serum low-density lipoprotein(LDL) and HDL levels were significantly lower in critically ill and death groups compared to non-critically ill group. Meanwhile, the patients displayed dramatically elevated levels of serum inflammatory factors, while a markedly prolonged activated partial thromboplastin time(APTT) in critically ill patients reflected coagulopathy. This study suggests that COVID-19-induced cytokine storm causes hepatotoxicity and subsequently critical hypoalbuminemia, which are associated with exacerbation of disease-associated inflammatory responses and progression of the disease and ultimately leads to death for some critically ill patients. | Wei Huang Chenze Li Zhiquan Wang Hong Wang Ning Zhou Jiangang Jiang Li Ni Xin A.Zhang Dao-Wen Wang | 2020 | Science China(Life Sciences)2020，63，11： | 7 |
| 4 | Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection显示文摘Aortic dissection(AD) is a devastating,heterogeneous condition of aorta.The homeostasis between collagens and matrix metalloproteases(MMPs)/tissue inhibitors of MMPs(TIMPs) system in the extracellular matrix plays an important role for structure and functions of aorta.However,our knowledge on association between variants of genes in this system and pathogenesis of AD is very limited.We analyzed all yet known coding human genes of collagens(45 genes),MMPs/TIMPs(27genes) in 702 sporadic AD patients and in 163 matched healthy controls,by using massively targeted next-generation and Sanger sequencing.To define the pathogenesis of potential disease-causing candidate genes,we performed transcriptome sequencing and pedigree co-segregation analysis in some genes and generated Col5a2 knockout rats.We identified 257 pathogenic or likely pathogenic variants which involved 88.89%(64/72) genes in collagens-MMPs/TIMPs system and accounted for 31.05%(218/702) sporadic AD patients.In them,84.86%patients(185/218) carried one variant,12.84%two variants and 2.30%more than two variants.Importantly,we identified 52 novel probably pathogenic loss-of-function(LOF) variants(20 nonsense,16 frameshift,14 splice sites,one stop-loss,one initiation codon) in 11.06%(50/452) AD patients,which were absent in 163controls(P=2.5×10^(-5)).Transcriptome sequencing revealed that identified variants induced dyshomeostasis in expression of collagens-TIMPs/MMPs systems.The Col5α2^(-/-) rats manifested growth retardation and aortic dysplasia.Our study provides a first comprehensive map of genetic alterations in collagens-MMPs/TIMPs system in sporadic AD patients and suggests that variants of these genes contribute largely to AD pathogenesis. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Chenze Li Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2017 | Science China(Life Sciences)2017，60，1： | 4 |
| 5 | Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs显示文摘Dear Editor.The coronavirus disease 2019(COVID-19)pandemic caused by widespread infection with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)(Chen et al.,2020;Guan et al.,2020)has led to a global health crisis.More than 3.5 million infections and 246,838 deaths have occurred as of May 4,2020(Saqrane and El Mhammedi,2020),with a rapid upward trend.Many CO VID-19 patients suffer from complicated systemic injuries such as cardiac(Chen et al.,2020)and hepatic(Huang et al.,2020)damages. | Bo Yu Chenze Li Peng Chen Jia Li Hualiang Jiang Dao-Wen Wang | 2021 | Science China(Life Sciences)2021，64，2： | 2 |
| 6 | Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients显示文摘到在急性冠的症候群(交流) 以后的病人的第二等的预防药(ATM ) 的低坚持与差的临床的结果被联系。然而,文学在对与交流在中国病人与穷人联系的 ATM 和风险的评价以后提供有限数据。在当前的工作, ATM 在 Tongji 与交流在连续地招募的病人被估计从 2013 年 11 月 5 日的医院到 2014 年 12 月 31 日。2126 个病人的一个总数在低坚持下面被分类(盖住的天(PDC ) 分配 C <50%) 并且高坚持(PDC >50%) 在分泌物以后基于他们的表演组织。所有病人被跟随在上面在第一,第 6,和第 12 月当记录 ATM 和主要不利心脏的事件(向) 时,排出。Bivariate 逻辑回归被用来识别与 ATM 联系的因素。考克斯回归被用来在分泌物以后在一年以内分析在 ATM 和向之间的协会。结果证明冠的动脉独自绕过 grafting (CABG ) 到 P2Y12 对手的高坚持的有的显著地更低的比例(83.0% 对 90.7% , P < 0.01 ) 比仅仅与经皮的冠的干预(一种总线标准) 对待的病人。而且在经历一种总线标准的病人,到 P2Y12 对手的高坚持减少了向的风险(危险比率 = 0.172, 95% 信心间隔:0.039-0.763;P = 0.021 ) 。在结论,对待一种总线标准的病人是对比对待 CABG 的病人仍然是支持者到药敏感的更多。到 P2Y12 对手的高坚持与向的更低的风险被联系。 | Yang Sun Chenze Li Lina Zhang Dong Hu Xudong Zhang Ting Yu Min Tao Dao Wen Wang Xiaoqing Shen | 2017 | Frontiers of Medicine2017，11，1： | 2 |
| 7 | Reversal of MDR1/P-Glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo显示文摘 | ShiZ Liang Y J ChenZ S etal | 2006 | Cancer Biology Therapy2006，5，1： | 1 |
| 8 | Roleofaquaporin5inanti-gen-inducedairwayinflammationandmucoushyperproduc-tioninmice显示文摘 | ShenY WangY ChenZ etal | 2011 | JCellMolMed2011，15，6： | 1 |
| 9 | RegulationofMUC5ACmucinsecretionbydepletionofAQP5inSPC-A1cells显示文摘 | ChenZ WangX GaoL etal | 2006 | BiochemBiophysResCommun2006，342，3： | 1 |
| 10 | Aquaporin5expressioninhib-itedbyLPSviap38/JNK signalingpathwaysinSPC-A1cells显示文摘 | ShenY ChenZ WangY etal | 2010 | RespirPhysiolNeurobiol2010，171，3： | 1 |
| 11 | A New Two-Parameter Lifetime Distribution With BathtubShape or Increasing Failure Rate Function显示文摘 | ChenZ | 2000 | Statistics & ProbailityLetters2000，，49： | 1 |
| 12 | Effects of plant polyphenols on ovarian follicular reserve in aging mrs 显示文摘 | CHENZ G LUO L L XU J J | 2010 | Biochem Cell Biol2010，88，4： | 1 |
| 13 | TheexperimentalstudyonHotBiXiaotreatingacutegoutyarthritis显示文摘 | ZhuXX(朱萱萱) ChenZ(陈震) JiW(纪伟) eta1 | | 中国药品标准0，，： | 1 |
| 14 | Acute promyelocytic leukemia: from highly fatal to highly curable 显示文摘 | WangZY ChenZ | 2008 | Blood2008，111，5： | 1 |
| 15 | A Vertical Subsurface FlowConstructed Wetland in Beijing 显示文摘 | ChenZ M Chen B Zhou J B | 2007 | Communications in NonlinearScience and Numerical Simulation2007，1016，10： | 1 |
| 16 | Health-related quality of Life measured by the Short Form 36 in immune thrombocytopenic purpura:a cross-sectional survey in China显示文摘 | ZhouZ YangL ChenZ | 2007 | Eur J Haematol2007，78，6： | 1 |
| 17 | Automatic detection and tracking of human heads using an active stereo vision system显示文摘 | TANGC-Y CHENZ HUANGY-P | 2000 | International Journal of Pattem Recognition and Artificial Intelligence2000，14，2： | 1 |
| 18 | Preparation by differential gradient centrifugation is better than swim pin selecting sperm with normal morphology (Strictcriteria)显示文摘 | Prakash P Leykin L ChenZ | 1998 | Fertil Steril1998，69，4： | 1 |
| 19 | Geochronology and isotopeanalysis of the Late Paleozoic to Mesozoic granitoids from North-eastern Vietnam and implications for the evolution of the SouthChina block显示文摘 | ChenZ C Lin W Faure M | 2014 | Journal of Asian Earth Sciences2014，86，： | 1 |
| 20 | Rheinprotectspancreaticβcellsfromdynaminrelatedprotein1mediatedmitochondrialfissionandcellapoptosisunderhyperglycemia显示文摘 | LiuJ ChenZ ZhangY etal | 2013 | Diabetes2013，62，11： | 1 |
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