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| 1 | Identification of an HLA-A~* 0201-restricted CD8^+ T-cell epitope SSp-1 of SARS-CoV spike protein显示文摘A novel coronavirus, severe acute respiratory syndrome (SA RS)-associated coronavirus (SARS-CoV), has been identified as the causal agent of SARS. Spike (S) protein is a major structural glycoprotein of the SARS virus and a potential target for SARS-specific cell-mediated immune responses. A pa nel of S protein-derived peptides was tested for their binding affinity to HLA -A *0201 molecules. Peptides with high affinity for HLA-A *0201 were then as se ssed for their capacity to elicit specific immune responses mediated by cytotoxi c T lymphocytes (CTLs) both in vivo, in HLA-A2.1/K b transgenic mice, a nd in vitro, from peripheral blood lymphocytes (PBLs) harvested from healthy HLA-A 2.1 + donors. SARS-CoV protein-derived peptide-1 (SSp-1 RLNEVAKNL), induced pepti de-specific CTLs both in vivo (transgenic mice) and in vitro (human PBL s), which specifically released interferon-gamma (IFN-gamma) upon stimulation with SSp-1-pulsed autologous dendritic cells (DCs) or T2 cells. SSp-1-specif ic CTLs also lysed major histocompatibility complex (MHC)-matched tumor cell lines engineered to express S proteins. HLA-A *0201-SSp-1 tetramer staining re vealed the presence of significant populations of SSp-1-specific CTLs in SSp- 1-induced CD8 + T cells. We propose that the newly identified epitope SSp-1 w ill help in the characterization of virus control mechanisms and immunopathology in SARS-CoV infection, and may be relevant to the development of immunotherape utic approaches for SARS. | WangB ChenH JiangX ZhangM WanT LiN ZhouX WuY YangF YuY WangX YangR CaoX | 2004 | 第二军医大学学报2004，25，9： | 21 |
| 2 | A comparison between the 'coil-to-globule' transition of linear chains and the 'volume phase transition' of spherical microgels显示文摘 | Wu C WangX | | 0，，： | 2 |
| 3 | Bundle structure formation on a polymer film at various temperature and scanning velocity 显示文摘 | WangX P Loy M M T Xiao X D | 2002 | Nanotechnology2002，13，： | 1 |
| 4 | Self-hu- midifying composite membrane with self-assembled Pt nanoparticles for polymer electrolyte membrane fuel cells显示文摘 | MUSC WANGXE TANG H L etal | 2006 | J Electrochem Soc2006，153，18： | 1 |
| 5 | Oxidativedesulphurizationof4,6-dimethyldibenzothiophene withhydrogenperoxideoverTi-HMS显示文摘 | WangY LiG WangXS etal | 2007 | Energy& Fuels2007，21，： | 1 |
| 6 | Hydroforming of automotive structural components with rectangular-sections 显示文摘 | YUANSJ HAN C WANGXS | 2006 | International Journal of Machine Tools and Manufacture2006，46，11： | 1 |
| 7 | 调强放射治疗局部晚期鼻咽癌过程中解剖和剂量的变化[J]显示文摘 | Wangx LuJ XiongX 等 | | 医疗放射剂量测定0，，： | 1 |
| 8 | Preparation of UV curable functionalized graphene/polyurethane acrylate nanocomposite with enhanced thermal and mechanical behaviors显示文摘 | WANGX XlNGWY SONGL etal | 2013 | Reactive and Functional Polymers2013，73，6： | 1 |
| 9 | SynthesisandluminesGcenceof Eu3+ doped hydroxyapatitenanocrystallines:effectsofcalcinationsandEuEu3+ content显示文摘 | HanYC WangX Y DaiH L | 2013 | JournalofLuminescence2013，135，： | 1 |
| 10 | Phase Ⅱ study to assess the efficacy of hypofractionated stereotactic radiotherapy in patients with large cavernous sinus hemangiomas显示文摘 | WangX Liu X Mei G | | 0，，： | 1 |
| 11 | Electrochemical investigation on kinetics of potassium intercalating into graphite in KF melt显示文摘 | Liu Dongren Li Wangxing Yang Zhanhong | | 0，，： | 1 |
| 12 | The effect of metal oxide decorated graphene hybrids on Ihe improved thermal stability and tile reduced smoke toxicity in epoxy resins 显示文摘 | WANGX XING W Y FENG X M | 2014 | Chemical Engineering Journal2014，250，1： | 1 |
| 13 | IGF-1R, a target of let-7b, medi- ates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma 显示文摘 | Gao L Wang X WangX | 2014 | Oncotarget2014，5，9： | 1 |
| 14 | 显示文摘 | 董博(DongB) 闰熙博(YanXB) 牛玉洁(NiuYJ) 王欣(WangX) 王连永(WangLY) 王燕铭(WangYM) | | 化学进展0，，： | 1 |
| 15 | Locoregional and distant recurrences after breast conserving therapy in patients with triple-negative breast cancer: A meta-analysis显示文摘 | WangJ XieX WangX | 2013 | Surg Oncol2013，22，4： | 1 |
| 16 | Surface tension and density in the KF-NaF-AlF3-based electrolyte显示文摘 | Yan Hengwei Yang Jianhong Li Wangxing | | 0，，： | 1 |
| 17 | RegulationofMUC5ACmucinsecretionbydepletionofAQP5inSPC-A1cells显示文摘 | ChenZ WangX GaoL etal | 2006 | BiochemBiophysResCommun2006，342，3： | 1 |
| 18 | Fabrication of Fe, Ni, and FeNi coated Al2O3 core-shell microspheres by the heterogeneous precipitation 显示文摘 | SHEN Xiangqian JING Maoxiang LI Wangxing | 2005 | Powder Technol2005，160，3： | 1 |
| 19 | Cathodic behavior of graphite in KF-AlF3-based melts with various cryolite ratios显示文摘 | Liu Dongren Yang Zhanhong Li Wangxing | | 0，，： | 1 |
| 20 | Modification of elec- trode surface with eovalently functionalized ,graphene oxide by 1 - tyrosine for determination of dopamine 显示文摘 | WangX Zhang F Xia J | 2015 | Journal of Eleetroanalytical Chemistry2015，738，： | 1 |
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