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| 1 | Increased frequency and clinical significance of myeloidderived suppressor cells in human colorectal carcinoma显示文摘AIM:To investigate the frequency and clinical significance of the myeloid-derived suppressor cells(MDSC) in human colorectal carcinoma(CRC).METHODS:Samples of peripheral blood and tumor tissue from 49 CRC patients were analyzed.Mononuclear cells were isolated by Ficoll-Hypaque density gradient centrifugation and were subjected to a flow cytometrybased immunophenotypic analysis.RESULTS:A considerable increase in the percentage of CD33+HLA-DR-MDSCs was observed in the peripheral blood(1.89% ± 0.75%) and tumor tissues(2.99% ± 1.29%) of CRC patients as compared with that in theperipheral blood of healthy controls(0.54% ± 0.35%).This expanded CD33+HLA-DR-subset exhibited immature myeloid cell markers,but not lineage markers,and showed up-regulation of CD18/CD11b expression as compared with the MDSCs from healthy donors.Further studies showed that the MDSC proportion in CRC peripheral blood was correlated with nodal metastasis(P = 0.023),whereas that in tumor tissues was correlated with nodal/distant metastasis(P = 0.016/P = 0.047) and tumor stage(P = 0.028),suggesting the involvement of MDSCs in CRC tumor development.CONCLUSION:Characterization of MDSCs in CRC suggests the clinical significance of circulating and tumorinfiltrating MDSCs and may provide new insights into the CRC immunotherapy targeting MDSCs. | Hong-Li Sun, Xin Zhou, Yi-Feng Xue Ke Wang, Yun-Feng ShenI Jing-Jue Mao Hong-Feng Guo Zong-Ning Miao | 2012 | World Journal of Gastroenterology2012，18，25： | 21 |
| 2 | Promoter effect of La2O3 on gold catalyst with different textural structures显示文摘Silica supported gold nanoparticles were synthesized and promoted by lanthanum oxide as dopant. The influences of La_2O_3 and silica textural structure on the gold dispersion, formation of active species, crystalline composition and the reacting role of dopants were studied in detail. The characterization results suggested that the dispersion of gold nanoparticles depended on the textural structure of silica without lanthanum oxide doping where small mesopores are more preferable to disperse gold nanoparticles. The addition of lanthanum oxide largely increased the dispersion of gold nanoparticles and oxygen active sites independent of the textural structure of silica support. The interaction between lanthanum oxide and silica enhanced by the synergy facilitated the release of oxygen vacancies and transition of active oxygen species. In addition, the chemical properties were greatly changed after lanthanum oxide addition which was only inconspicuously impacted by the initial textural structure of silica supports, shedding light on the further design of economic gold catalyst based on simple synthesis method. | Huiyuan Xu Jingjie Luo Shenying Xu Denglei Zhu Wei Chu | 2016 | Journal of Energy Chemistry2016，25，5： | 2 |
| 3 | Resistance Evaluation of Some Chinese Leading Rice Maintainer, Restorer lines and Their Hybrids to Magnaporthe grisea显示文摘Six isolates of Magrtaporthe grisea were selected to inoculate on 10 Chinese leading maintainer lines (B-lines), 14 restorer lines (R-lines) and their F1 hybrid plants. In the tested rice materials, R-lines were proved to be more resistant to blast than B-lines.The resistance frequency of about 25% F1 hybrid plants was less than their parents. In addition, 26 isolates of M. grisea collected from different rice growing areas of China were inoculated on 13 new improved hybrid rice combinations. The resistance frequencies of 5 improved hybrids were better than those of the controls and leadinR varieties in rice production of China. | ZHUXu-dong SHENYing HenriADREIT JulienFROUIN DidierHARREAU | 2004 | Rice science2004，11，3： | 2 |
| 4 | Chemorheology of aqueous-based alumina-poly(rinyl alcohol) gelcasting suspensions显示文摘 | MORISSETTE SHENY L CARISEY T WERTH A L | 1999 | J Am Ceram Soc1999，82，3： | 1 |
| 5 | Roleofaquaporin5inanti-gen-inducedairwayinflammationandmucoushyperproduc-tioninmice显示文摘 | ShenY WangY ChenZ etal | 2011 | JCellMolMed2011，15，6： | 1 |
| 6 | Performance of an Anaerobic Baffled Reactor(ABR)as a hydrolysis-acidogensis unit in treating landfill leachate mixed with municipal sewage 显示文摘 | Wang B ShenY | 2000 | Water Science and Techmology2000，42，12： | 1 |
| 7 | Aquaporin5expressioninhib-itedbyLPSviap38/JNK signalingpathwaysinSPC-A1cells显示文摘 | ShenY ChenZ WangY etal | 2010 | RespirPhysiolNeurobiol2010，171，3： | 1 |
| 8 | Modified Sihler s technique for studying the distribution of intramuscular nerve branches in mammalian skeletal muscle显示文摘 | RumarVP ShenY | 1997 | Anat Rec1997，247，： | 1 |
| 9 | Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression显示文摘 | SteinbergJP TakamiyaK ShenY | 2006 | Neuron2006，49，6： | 1 |
| 10 | CXCLIO and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis 显示文摘 | Laragione T Brenner M Sheny B el al | 2011 | Arthritis Rheum2011，63，11： | 1 |
| 11 | Antimetastatic effect of prodigiosin through inhibition of tumor invasion显示文摘 | Zhang J ShenY Liu J | 2005 | Bioehem Pharmaeol2005，69，3： | 1 |
| 12 | Three new phenolic glyeo sides from Curculigo orchioides G 显示文摘 | Zuo AX ShenY Jiang ZY | 2010 | Fitoterpia2010，81，7： | 1 |
| 13 | Detection and iden-tification of explosives using terahertz pulsed spectroscopicimaging 显示文摘 | SHENY C LO T TADAY P F ei al | 2005 | Applied Physics Letters2005，86，24： | 1 |
| 14 | Ultrahighstrengthandhighelectrical conductivityin copper 显示文摘 | LuL ShenY ChenX etal | 2004 | Science2004，304，5669： | 1 |
| 15 | Tryptase and fatal anaphy- lactic reaction显示文摘 | ShenY W Lu C Zhao Z Q | 2002 | Forensic Med2002，18，3： | 1 |
| 16 | Wing section for hydrofoils-part 2: nonsymmetrical profiles 显示文摘 | SHENY T EPPLER R | 1982 | Journal of Ship Research1982，3945，： | 1 |
| 17 | ImbalanceofcirculatingTlym-phocytesubpopulationinCOPD anditsrelationshipwithCATperformance显示文摘 | ChenC ShenY NiCJ etal | 2012 | JClinLabAnal2012，26，2： | 1 |
| 18 | Angiopoietin-like 4 modifies the interactions between lipoprotein lipase and its endothelial cell transporter GPIHBP1 显示文摘 | Chi X Sheny S K Shows H W | 2015 | J Biol Chem2015，290，11： | 1 |
| 19 | 显示文摘 | ShenY PrasadPN | 2002 | ApplPhysB2002，74，78： | 1 |
| 20 | Nonoperativetreatmentversusposteriorfixationforthoracolumbarjunctionburstfractures withoutneurologicdeficit显示文摘 | ShenW W LiuTJ ShenYS | 2001 | Spine(PhilaPa1976)2001，26，10： | 1 |
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