|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-γ显示文摘AIM: To examine the role of Fibrinogen-like protein 2 (fgl2)/fibroleukin in tumor development. Fgl2 has been reported to play a vital role in the pathogenesis in MHV-3 (mouse hepatitis virus) induced fulminant and severe hepatitis,spontaneous abortion,allo-and xeno-graft rejection by mediating 'immune coagulation'. METHODS: Tumor tissues from 133 patients with six types of distinct cancers and the animal tumor tissues from human hepatocellular carcinoma (HCC) model on nude mice (established from high metastasis HCC cell line MHCC97LM6) were obtained. RESULTS: Hfgl2 was detected in tumor tissues from 127 out of 133 patients as well as tumor tissues collected from human HCC nude mice. Hfgl2 was highly expressed both in cancer cells and interstitial inflammatory cells including macrophages,NK cells,and CD8+ T lymphocytes and vascular endothelial cells. Hfgl2 mRNA was localized in cells that expressed hfgl2 protein. Fibrin (nogen) co-localization with hfgl2 expression was determined by dual immunohistochemical staining. In vitro,IL-2 and IFN-γ increased hfgl2 mRNA by 10-100 folds and protein expression in both THP-1 and HUVEC cell lines. One-stage clotting assays demonstrated that THP-1 and HUVEC cells expressing hfgl2 had increased procoagulant activity following cytokines stimulation. CONCLUSION: The hfg12 contributes to the hypercoagulability in cancer and may induce tumor angiogenesis and metastasis via cytokine induction. | Kai Su Fang Chen Wei-Ming Yan Qi-Li Zeng Li Xu Dong Xi Bin Pi Xiao-Ping Luo Qin Ning | 2008 | World Journal of Gastroenterology2008，14，39： | 20 |
| 2 | Climate change, water resources and sustainable development in the arid and semi-arid lands of Central Asia in the past 30 years显示文摘The countries of Central Asia are collectively known as the five '-stans': Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Kazakhstan. In recent times, the Central Asian region has been affected by the shrinkage of the Aral Sea, widespread desertification, soil salinization, biodiversity loss, frequent sand storms, and many other ecological disasters. This paper is a review article based upon the collection, identification and collation of previous studies of environmental changes and regional developments in Central Asia in the past 30 years. Most recent studies have reached a consensus that the temperature rise in Central Asia is occurring faster than the global average. This warming trend will not only result in a higher evaporation in the basin oases, but also to a significant retreat of glaciers in the mountainous areas. Water is the key to sustainable development in the arid and semi-arid regions in Central Asia. The uneven distribution, over consumption, and pollution of water resources in Central Asia have caused severe water supply problems, which have been affecting regional harmony and development for the past 30 years. The widespread and significant land use changes in the 1990 s could be used to improve our understanding of natural variability and human interaction in the region. There has been a positive trend of trans-border cooperation among the Central Asian countries in recent years. International attention has grown and research projects have been initiated to provide water and ecosystem protection in Central Asia. However, the agreements that have been reached might not be able to deliver practical action in time to prevent severe ecological disasters. Water management should be based on hydrographic borders and ministries should be able to make timely decisions without political intervention. Fully integrated management of water resources, land use and industrial development is essential in Central Asia. The ecological crisis should provide sufficient motivation to reach a consensus on unified water management throughout the region. | YU Yang PI Yuanyue YU Xiang TA Zhijie SUN Lingxiao Markus DISSE ZENG Fanjiang LI Yaoming CHEN Xi YU Ruide | 2019 | Journal of Arid Land2019，11，1： | 20 |
| 3 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 4 | Novel immunological and nutritional-based prognostic index for gastric cancer显示文摘AIM: To assess the prognostic significance of immunological and nutritional-based indices, including the prognostic nutritional index(PNI), neutrophillymphocyte ratio(NLR), and platelet-lymphocyte ratio in gastric cancer.METHODS: We retrospectively reviewed 632 gastric cancer patients who underwent gastrectomy between1998 and 2008. Areas under the receiver operating characteristic curve were calculated to compare the predictive ability of the indices, together with estimating the sensitivity, specificity and agreement rate.Univariate and multivariate analyses were performed to identify risk factors for overall survival(OS). Propensity score analysis was performed to adjust variables to control for selection bias.RESULTS: Each index could predict OS in gastric cancer patients in univariate analysis, but only PNI had independent prognostic significance in multivariate analysis before and after adjustment with propensity scoring(hazard ratio, 1.668; 95% confidence interval:1.368-2.035). In subgroup analysis, a low PNI predicted a significantly shorter OS in patients with stage Ⅱ-Ⅲ disease(P = 0.019, P < 0.001), T3-T4 tumors(P <0.001), or lymph node metastasis(P < 0.001). Canton score, a combination of PNI, NLR, and platelet, was a better indicator for OS than PNI, with the largest area under the curve for 12-, 36-, 60-mo OS and overall OS(P = 0.022, P = 0.030, P < 0.001, and P = 0.024,respectively). The maximum sensitivity, specificity, and agreement rate of Canton score for predicting prognosis were 84.6%, 34.9%, and 70.1%, respectively.CONCLUSION: PNI is an independent prognostic factor for OS in gastric cancer. Canton score can be a novel preoperative prognostic index in gastric cancer. | Kai-Yu Sun Jian-Bo Xu Shu-Ling Chen Yu-Jie Yuan Hui Wu Jian-Jun Peng Chuang-Qi Chen Pi Guo Yuan-Tao Hao Yu-Long He | 2015 | World Journal of Gastroenterology2015，21，19： | 18 |
| 5 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 6 | 脑卒中后认知运动干预对步态和平衡影响显示文摘当认知和运动任务同时完成时,会发生认知运动干预(CMI)。该技术已用于运动医学康复来增强疗效。本综述和荟萃分析研究了在脑卒中患者中,CMI用于改善步态和平衡的疗效。本文检索了多个数据库,筛选出了发表于1972年到2014年间的随机对照试验——包括成年脑卒中患者CMI治疗组和对照组。主要评价指标为步态和平衡评定,次要评价指标为日常生活能力以及功能独立性评定。 | Wang XQ Pi YL Chen BL 吴毅 | 2015 | 中国康复2015，30，5： | 13 |
| 7 | Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis显示文摘There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transforming growth factor-β(TGF-β)signalling in the cartilage and subchondral bone of the TMJ using a temporomandibular joint disorder(TMD) rat model, an ageing mouse model and a Camurati–Engelmann disease(CED) mouse model. In the three animal models, the subchondral bone phenotypes in the mandibular condyles were evaluated by μCT, and changes in TMJ condyles were examined by TRAP staining and immunohistochemical analysis of Osterix and p-Smad2/3. Condyle degradation was confirmed by Safranin O staining, the Mankin and OARSI scoring systems and type X collagen(Col X), p-Smad2/3 a and Osterix immunohistochemical analyses. We found apparent histological phenotypes of TMJ-OA in the TMD, ageing and CED animal models, with abnormal activation of TGF-βsignalling in the condylar cartilage and subchondral bone. Moreover, inhibition of TGF-β receptor I attenuated TMJ-OA progression in the TMD models. Therefore, aberrant activation of TGF-β signalling could be a key player in TMJ-OA development. | Liwei Zheng Caixia Pi Jun Zhang Yi Fan Chen Cui Yang Zhou Jianxun Sun Quan Yuan Xin Xu Ling Ye Xu Cao Xuedong Zhou | 2018 | Bone Research2018，6，4： | 13 |
| 8 | Electro-acupuncture at Conception and Governor vessels and transplantation of umbilical cord bloodderived mesenchymal stem cells for treating cerebral ischemia/reperfusion injury显示文摘Mesenchymal stem cell transplantation is a novel means of treating cerebral ischemia/reperfusion,and can promote angiogenesis and neurological functional recovery.Acupuncture at Conception and Governor vessels also has positive effects as a treatment for cerebral ischemia/reperfusion.Therefore,we hypothesized that electro-acupuncture at Conception and Governor vessels plus mesenchymal stem cell transplantation may have better therapeutic effects on the promotion of angiogenesis and recovery of neurological function than either treatment alone.In the present study,human umbilical cord blood-derived mesenchymal stem cells were isolated,cultured,identified and intracranially transplanted into the striatum and subcortex of rats at24 hours following cerebral ischemia/reperfusion.Subsequently,rats were electro-acupunctured at Conception and Governor vessels at 24 hours after transplantation.Modified neurological severity scores and immunohistochemistry findings revealed that the combined interventions of electro-acupuncture and mesenchymal stem cell transplantation clearly improved neurological impairment and up-regulated vascular endothelial growth factor expression around the ischemic focus.The combined intervention provided a better outcome than mesenchymal stem cell transplantation alone.These findings demonstrate that electro-acupuncture at Conception and Governor vessels and mesenchymal stem cell transplantation have synergetic effects on promoting neurological function recovery and angiogenesis in rats after cerebral ischemia/reperfusion. | Haibo Yu Pengdian Chen Zhuoxin Yang Wenshu Luo Min Pi Yonggang Wu Ling Wang | 2014 | Neural Regeneration Research2014，9，1： | 13 |
| 9 | Salt-related structural styles of Kuqa foreland fold belt,northern Tarim basin显示文摘The salt beds of Lower Tertiary developed in the mid-segment of Kuqa foreland fold belt, northern Tarim basin. They considerably controlled structural deformation of the belt. Ac- cording to the field observation, seismic profile interpretation and drilling data, three different structural styles of supra-salt, intra-salt and sub-salt occurred in the Kuqa foreland fold belt. Su- pra-salt structural styles mainly include thrust faults and fault-related sags. Intra-slat structural styles essentially are salt-pillows, intra-salt faults and folds, and salt weld structures. Sub-salt structural styles mainly consist of imbricated thrust faults, duplex structures, pop-up and fault-related folds. It is indicated that great differences exist among supra-salt, intra-salt and sub-salt structures of Kuqa foreland fold belt. The salt-related structures were formed in the same structural stress field. The dynamic mechanism of the salt-related structures is mainly associated with gravitation, compression and plastic flow of salt beds. | TANG Liangjie1,2, JIA Chengzao3, PI Xuejun4, CHEN Suping1,2, WANG Zhiyu5, XIE Huiwen4 1. Key Laboratory for Hydrocarbon Accumulation of Education Ministry, Beijing 102249, China 2. Basin & Reservoir Research Center, University of Petroleum, Beijing 102249, China 3. PetroChina Company Limited, Beijing 100011, China 4. Tarim Oilfield Company, PetroChina Company Ltd., Kurle 841000, China 5. Department of Geology, University of Petroleum, Beijing 102249, China | 2004 | Science China Earth Sciences2004，47，10： | 12 |
| 10 | Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor显示文摘 | Jiu-liang ZHANG Hui WANG Chang CHEN Hui-fang PI Han-li RUAN Peng ZHANG Ji-zhou WU | 2009 | Acta Pharmacologica Sinica2009，30，5： | 7 |
| 11 | Identification and characterization of two morphologically distinct stem cell subpopulations from human urine samples显示文摘Urine-derived stem cells(USCs)have shown potentials for the treatment of skeletal and urological disorders.Based on published literature and our own data,USCs consist of heterogeneous populations of cells.In this paper,we identify and characterize two morphologically distinct subpopulations of USCs from human urine samples,named as spindle-shaped USCs(SS-USCs)and rice-shaped USCs(RS-USCs)respectively.The two subpopulations showed similar clone-forming efficiency,while SS-USCs featured faster proliferation,higher motility,and greater potential for osteogenic and adipogenic differentiation,RS-USCs showed greater potential for chondrogenic differentiation.POU5F1 was strongly expressed in both subpopulations,but MYC was weakly expressed.Both subpopulations showed similar patterns of CD24,CD29,CD34,CD44,CD73,CD90 and CD105 expression,while a higher percentage of RS-USCs were positive for CD133.SS-USCs were positive for VIM,weakly positive for SLC12A1 and UMOD,and negative for KRT18,NPHS1,AQP1 and AQP2,indicating a renal mesenchyme origin;while RSUSCs are positive for VIM,partially positive for KRT18,NPHS1,AQP1,SLC12A1 and UMOD,and negative for AQP2,indicating a nephron tubule origin.The above results can facilitate understanding of the biological characteristics of subpopulations of USCs,and provide a basis for further research and applications of such cells. | An-Jing Chen Jin-Kui Pi Jun-Gen Hu Yi-Zhou Huang Hong-Wei Gao Sheng-Fu Li Jesse Li-Ling Hui-Qi Xie | 2020 | Science China(Life Sciences)2020，63，5： | 7 |
| 12 | Combinatorial effects of conception and governor vessel electroacu-puncture and human umbilical cord blood-derived mesenchymal stem cells on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion显示文摘OBJECTIVE: To investigate the combinatorial effects of conception and governor vessel electroacupuncture(EA) and human umbilical cord blood-derived mesenchymal stem cells(HUCB-MSCs) on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion. METHODS: With the HUCB-MSCs isolated, cultured and identified and the models of cerebral ischemia-reperfusion established, the HUCB-MSCs of passage three were intracranially transplanted and the EA at conception and governor vessels was applied. The pathomorphologic lesion by hematoxylin-eosin staining and the cellular apoptosis by terminal deoxynucleotidyl transferase-mediated nick-end labeling method around the ischemic focus were observed. RESULTS: The cultured adherent HUCB-MSCs exhibited a spindle shape and expressed MSC-specific markers, with the cell purity and proliferation rate significantly increasing after the primary passage. HE staining showed that there were no pathological changes observed in the sham surgery group. However, in the PBS transplantation group, degeneration and necrosis of a great number of nerve cells were seen. In both the HUCB-MSCs transplantation group and the HUCB-MSCs transplantation + EA group, reparative changes of the pathomorphism of the tissue were found. Both combination treatment and simple MSCs treatment were able to improve the pathomorphorlogic lesion following cerebral ischemia and reduce the abnormal TUNEL-positive numbers, with former better than latter. CONCLUSION: HUCB-MSCs improve pathological lesions and inhibit the cellular apoptosis around the cerebral ischemic area. EA at conception and governor vessels also improve pathological lesion and inhibit the cellular apoptosis in rats treated with HUCB-MSCs transplantation, which effects were superior to that of simple HUCB-MSCs transplantation. | Zhuoxin Yang Pengdian Chen Haibo Yu Wenshu Luo Min Pi Yonggang Wu Ling Wang Fuxia Yang Yanhua Gou | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 13 | Green Tea Polyphenols Attenuate High-Fat Diet-Induced Renal Oxidative Stress through SIRT3-Dependent Deacetylation显示文摘Fifty male Wistar rats were fed a standard chow diet or a high-fat(HF)diet,and different concentrations of green tea polyphenols(GTPs)(0.8,1.6,and 3.2 g/L)were administered in the drinking | YANG Hui ZUO Xue Zhi TIAN Chong HE Dong Liang YI Wei Jie CHEN Zhuo ZHANG Pi Wei DING Shi Bin YING Chen Jiang | 2015 | Biomedical and Environmental Sciences2015，28，6： | 4 |
| 14 | Bibliometric profile of neurogenic bladder in the literature:a 20-year bibliometric analysis显示文摘Neurogenic bladder is a dysfunction of the lower urinary tract caused by nervous system disorder.We investigated the trends in publication of articles under the topic 'neurogenic bladder' using bibliometric analysis.Articles on neurogenic bladder,published between 1995 and 2014,were retrieved from the ISI Web of Science citation database.We analyzed the search results for authors,countries,institutions,journals,and top-cited papers.A total of 1,904 articles were retrieved.There was a small increase in the number of articles on neurogenic bladder from 1995(n = 43) to 2014(n = 117).The USA was the leading country in the total number of articles(n = 598).However,the number of publications from China has rapidly increased,and China was ranked second in 2014.Emmanuel Chartier-Kastler(n = 65) was the most productive author,and University of Paris VI(Paris 6)(n = 61) was the most productive institution.The Journal of Urology published the greatest number of articles on this topic(n = 285).Articles on neurogenic bladder were often published in a professional journal under the category Urology & Nephrology,Neurosciences & Neurology,or Rehabilitation.Visualization analysis based on co-citation networks was conducted using Cite Space III.Visualization analysis revealed that the hot spots in neurogenic bladder were botulinum toxin-A,prazosin,bethanechol,and afferent pathways.These findings provide new insight into the publication trends and hot spots in neurogenic bladder. | Yuan Gao Bo Qu Yan Shen Xiao-jing Su Xiao-yan Dong Xue-mei Chen Yu-hong Zhou Hong-ying Pi | 2015 | Neural Regeneration Research2015，10，5： | 4 |
| 15 | Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells显示文摘Bovine aortic endothelial cells(BAECs)were cultured with high glucose(33 mmol/L),4 mg/L green tea polyphenols(GTPs)or 4 mg/L GTPs co-treatment with high glucose for 24 h in the presence or absence of Bafilomycin-A1(BAF).We observed that high glucose increased the accumulation of LC3-II.Treatment with BAF did not further increase the accumulation of LC3-II.Results also showed an increased level of p62 | ZHANG Pi Wei TIAN Chong XU Fang Yi CHEN Zhuo Raynard BURNSIDE YI Wei Jie XIANG Si Yun XIE Xiao WU Nan Nan YANG Hui ZHAO Na Na YE Xiao Lei YING Chen Jiang | 2016 | Biomedical and Environmental Sciences2016，29，7： | 3 |
| 16 | Acute Cerebellar Infarction Complicated with Multiple Intracerebral Hemorrhage Treated by An Integrated Chinese and Western Medicine Approach:A Case Report显示文摘Cerebellar infarction accounts for almost 3%of all ischemic strokes,with 27,400 new cases each year in the USA alone.^(1)Since the computerized tomography(CT)scan is often negative in the early hours after onset,it is difficult to diagnose。 | CHEN Peng SHEN Qin-xuan SHEN Lin-yan WU Zhi-bing PI Li-hong GE Wen-hua QI Wei | 2017 | Chinese Journal of Integrative Medicine2017，23，3： | 3 |
| 17 | Ambient TSP concentration and dustfall variation in Urumqi,China显示文摘Total suspended particulate(TSP, particle diameter≤100 μm) was the dominant air pollutant and significantly influenced local air quality. In this paper, we investigated the interannual and seasonal variations of TSP and dustfall of the atmosphere over Urumqi, the capital city of Xinjiang Uygur autonomous region, northwestern China, basing on environmental monitoring records and meteorological data from 1986–2012. The results showed that during the study period, annual average TSP concentration decreased from 716 to 260 μg/m3, with an average level of 422.9 μg/m3, while dustfall intensity reduced from 350.4 to 166.6 t/(km2?a), with an average level of 259 t/(km2?a). Over 50% of the annual pollution days were induced mainly by TSP. Spring and winter had relatively higher dustfall intensities, and dense traffic and residential areas had the highest dustfall intensities in the Urumqi metropolitan area. With an annual average precipitation of less than 300 mm, atmospheric particulates in Urumqi could be hardly removed through wet deposition. During spring and summertime prevailing winds from northwest and northeast could carry aeolian dust particles from sandy deserts to Urumqi. Aeolian dusts from deserts would remain to be a priority regarding air pollution control in arid oasis cities. | XiaoXiao ZHANG Xi CHEN YuHong GUO ZiFa WANG LianYou LIU Cottle PAUL ShengYu LI HuaWei PI | 2014 | Journal of Arid Land2014，6，6： | 3 |
| 18 | Improved Ag-Si interface performance for Si solar cells using a novel Te-based glass and recrystallization process of Ag显示文摘In order to prove that the Te-based glass frit could be applied to Ag pastes to fabricate Ag electrode and elucidate the reactions among Ag,the frit,and the Si wafer,the Te-based glass and Ag pastes with different contents of glass frit(0 wt%,1 wt%,3 wt%,5 wt%,and 7 wt%)were prepared.The microstructures of Ag electrodes and the phase analysis of interface between Ag electrodes and the Si wafer were investigated using scanning electron microscopy(SEM)coupled with energy-dispersive X-ray spectroscopy(EDX)and X-ray diffraction(XRD).When the content of glass frit is 3 wt%,the Ag electrode has good adhesion with Si wafer.What’s more,Ag crystallites and metallic Te could be found on the Si wafer.These results suggest that the TeO_(2) in the glass frit could react with SiNx anti-reflecting coating(ARC)and Si to serve as a medium for forming Ag crystallites. | Xin-Xin Pi Xiu-Hua Cao Ji-Shi Chen Le Zhang Zhen-Xiao Fu Li-Xi Wang Qi-Tu Zhang | 2021 | Rare Metals2021，40，1： | 3 |
| 19 | Improved insensitive to input parameters trajectory clustering algorithm显示文摘The existing trajectory clustering(TRACLUS) is sensitive to the input parameters ε and MinLns. The parameter value is changed a little, but cluster results are entirely different. Aiming at this vulnerability, a shielding parameters sensitivity trajectory cluster(SPSTC) algorithm is proposed which is insensitive to the input parameters. Firstly, some definitions about the core distance and reachable distance of line segment are presented, and then the algorithm generates cluster sorting according to the core distance and reachable distance. Secondly, the reachable plots of line segment sets are constructed according to the cluster sorting and reachable distance. Thirdly, a parameterized sequence is extracted according to the reachable plot, and then the final trajectory cluster based on the parameterized sequence is acquired. The parameterized sequence represents the inner cluster structure of trajectory data. Experiments on real data sets and test data sets show that the SPSTC algorithm effectively reduces the sensitivity to the input parameters, meanwhile it can obtain the better quality of the trajectory cluster. | Jiashun Chen Dechang Pi | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 3 |
| 20 | Protective effects of lipoic acid-niacin dimers against blue light-induced oxidative damage to retinal pigment epithelium cells显示文摘AIM: To evaluate the protective effects of lipoic acid-niacin(N2 L) dimers against blue light(BL)-induced oxidative damage to human retinal pigment epithelium(hRPE) cells in vitro.METHODS: h RPE cells were divided into a control group(CG), a BL group, an N2 L plus BL irradiation group, an α-lipoic acid(ALA) plus BL group, an ALA-only group, and an N2 L-only group. hRPE cellular viability was detected by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) bromide assays, and apoptosis was evaluated by annexin-V-PE/7-AAD staining followed by flow cytometry. Ultrastructural changes in subcellular organelles were observed by transmission electron microscopy. Reactive oxygen species formation was assayed by flow cytometry. The expression levels of the apoptosis-related proteins BCL-2 associated X protein(BAX), B-cell leukmia/lymphoma 2(BCL-2), and caspase-3 were quantified by Western blot analysis.RESULTS: BL exposure with a light density of 4±0.5 mW/cm2 exceeding 6 h caused hRPE toxicity, whereas treatment with a high dose of N2 L(100 mol/L) or ALA(150 mol/L) maintained cell viability at control levels. BL exposure caused vacuole-like degeneration, mitochondrial swelling, and reduced microvillus formation;however, a high dose of N2 L or ALA maintained the ultrastructure of hRPE cells and their organelles. High doses of N2 L and ALA also protected hRPE cells from BL-induced apoptosis, which was confirmed by Western blot analysis: BCL-2 expression significantly increased, while BAX and caspase-3 expression slightly decreased compared to the CG.CONCLUSION: High-dose N2 L treatment(>100 mol/L) can reduce oxidative damage in degenerating hRPE cells exposed to BL with an efficacy similar to ALA. | Xiu-Lan Zou Yong-Zhen Yu Hong-Hua Yu Guan-Feng Wang Rong-Biao Pi Zhe Xu Chu Zhang Wen-Jie Zhou Dan-Dan Li Xuan-Ge Chen Yu-Ping Zou | 2019 | International Journal of Ophthalmology(English edition)2019，12，8： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员