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| 1 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 2 | Effectiveness and time-course adaptation of resistance training vs. plyometric training in prepubertal soccer players显示文摘Purpose:This study aimed to assess the effectiveness and time course for improvements in explosive actions through resistance training(RT)vs.plyometric training(PT)in prepubertal soccer players.Methods:Thirty-four male subjects were assigned to:a control group(n=11);an RT group(5 regular soccer training sessions per week,n=12);a PT group(3 soccer training sessions and 2 RT sessions per week,n=11).The outcome measures included tests for the assessment of muscle strength(e.g.,1 repetition maximum half-squat test),jump ability(e.g.,countermovement jump,squat jump,standing long jump,and multiple 5 bounds test),linear speed(e.g.,20m sprint test),and change of direction(e.g.,Illinois change of direction test).Results:The RTG showed an improvement in the half-squat(△=13.2%;d=1.3,p<0.001)and countermovement jump(△=9.4%;d=2.4,p<0.001)at Week 4,whereas improvements in the 20-m sprint(△=4.2%;d=1.1,p<0.01);change of direction(CoD)(△=3.8%;d=2.1,p<0.01);multiple 5 bounds(△=5.1%;d=1.5,p<0.05);standing long jump(△=7.2%;d=1.2,p<0.01);squat jump(△=19.6%;d=1.5,p<0.01);were evident at Week 8.The PTG showed improvements in CoD(△=2.1%;d=1.3,p<0.05);standing long jump(△=9.3%;d=1.1,p<0.01);countermovement jump(△=16.1%;d=1.2,p<0.01);and squat jump(△=16.7%;d=1.4,p<0.01);at Week 8 whereas improvements in the 20-m sprint(△=4.1%;d=1.3,p<0.01);and multiple 5 bounds(△=7.4%;d=2.4,p<0.001);were evident only after Week.The RT and PT groups showed improvements in all sprint,CoD,and jump tests(p<0.05)and in half-squat performance,for which improvement was only shown within the RTG(p<0.001).Conclusion:RT and PT conducted in combination with regular soccer training are safe and feasible interventions for prepubertal soccer players.In addition,these interventions were shown to be effective training tools to improve explosive actions with different time courses of improvements,which manifested earlier in the RTG than in the PTG.These outcomes may help coaches and fitness trainers set out clear and concise goals of training according to the specific time course of improvement difference between RT and PT on proxies of athletic performance of prepubertal soccer players. | Yassine Negra Helmi Chaabene Thomas Stöggl Mehréz Hammami Mohamed Souhaiel Chelly Younés Hachana | 2020 | Journal of Sport and Health Science2020，9，6： | 3 |
| 3 | Multiple pyogenic liver abscess显示文摘多重生脓肝脓肿很少被描述了。我们报导影响要求外科的排水的一个 38 岁的女人的多重生脓肝脓肿的一个致命的案例。进化被出现标记一腐败有多器官的吃惊系统失败。病人死了在外科以后的 48 h。疾病的原因,治疗学和结果被讨论。 | Mabrouk Bahloul Anis Chaari Nadia Bouaziz-Khlaf Hatem Kallel Leila Herguefi Hedi Chelly Chokri Ben Hamida Mounir Bouaziz | 2006 | World Journal of Gastroenterology2006，12，18： | 2 |
| 4 | Uterine malformation and pregnancy显示文摘 | Chelli H Attaoui H Lebbi I | 1994 | Gyneco Obstet Biol Reprod1994，23，5： | 1 |
| 5 | Dimensinal stability and detail reproduction of irreversible hydrocolloid and elastomeric impressions disinfected by immersion显示文摘 | Johoson G H Chellis K D Gordon G E | 1998 | J Prosthet Dent1998，79，4： | 1 |
| 6 | A2A adenosine receptor ligands and proinflammatory cytokines induce PC12 cell death through apoptosis显示文摘 | Trincavelli M L Falleni A Chelli B | 2003 | Biochem Pharmacol2003，66，10： | 1 |
| 7 | Genetics and pathophysiology of mental retardation显示文摘 | Chelly J Khelfaoui M Francis F | 2006 | Eur J Hum C enet2006，14，6： | 1 |
| 8 | Impact of peripheral nerve block with low dose local anesthetics on analgesia and functional outcomes following total knee arthroplasty:a ret- rospective study 显示文摘 | Liu Q Chelly JE Williams JP | 2015 | Pain Med2015，16，5： | 1 |
| 9 | The role of surgery in postoperative nerve injuries following total hip replacement 显示文摘 | Uskova A A Plakseychuk A Chelly J E | 2010 | J Clin Anesth2010，22，4： | 1 |
| 10 | Platelet 18 kDa Translocator Protein density is reduced in depressed patients with adult separation anxiety显示文摘 | Chelli B Pini S Abelli M | 2008 | Eur Neuropsychopharmacol2008，18，4： | 1 |
| 11 | The value of laparoscopy in management of abdominal trauma显示文摘 | Chelly MR Major K Spivak J | 2003 | Am Surg2003，69，11： | 1 |
| 12 | The onset time of roeuronium is slowed by esmolol and accelerated by ephedrine显示文摘 | Ezri T Chelly JE | 2000 | Anesth Analg2000，90，5： | 1 |
| 13 | Analytical methods for solid phase peptide synthesis 显示文摘 | Sabatino G Chelli M Brandi A | 2004 | Cur Org Chem2004，8，： | 1 |
| 14 | Nursing time study for the administration of a PRN oral analgesic on an orthopedic postoperative unit显示文摘 | Pizzi L J Chelly J E Marlin V | 2013 | Pain Management Nursing2013，25，123： | 1 |
| 15 | Hemangiopericytoma in the central nervous system显示文摘 | A. Mekni J. Kourda I. Chelly L. Ferchichi K. Bellil K.B. Hammouda N. Kchir M. Zitouna M. Khaldi S. Haouet | 2008 | Neurochirurgie2008，，1： | 1 |
| 16 | Effect of dystrophin gene deletions on mRNA levels and processing in Duchenne and Becker muscular dystrophies 显示文摘 | Chelly J Gilgenkrantz H Lambert M | 1990 | Cell1990，63，6： | 1 |
| 17 | Mild vitamin A deficiency delays fetal lung maturation in the rat显示文摘 | Chailley-Heu B Chelly N Lelievre-Pegorier M | 1999 | Am J Respir Cell Mol Biol1999，21，1： | 1 |
| 18 | Molecular genetics of Rett syndrome : When DNA methylation goes unrecognized 显示文摘 | Bienvenu T Chelly J | 2006 | Nat Rev Genet2006，7，6： | 1 |
| 19 | Continuous femoral blocks improve recovery and outcome of patients undergoing total knee arthroplasty显示文摘 | Chelly JE Greger J Gebhard R | | 0，，04： | 1 |
| 20 | Analgesia after total knee arthroplasty:is continuous sciatic blockade显示文摘 | Ben-David B Schmalenberger K Chelly JE | | 0，，3： | 1 |
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