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| 1 | Defining and predicting deep remission in patients with perianal fistulizing Crohn's disease on anti-tumor necrosis factor therapy显示文摘Perianal fistulas can occur to up to one-third of patients with Crohn's disease(CD) leading to significant disabling disease and morbidity. Fistulising perianal CD treatment often necessitates a combined pharmacological and surgical approach. Anti-tumor necrosis factor(anti-TNF) therapy, particularly infliximab, has been shown to be very effective for both perianal and internal fistulising CD. Nevertheless, current data suggest that sustained remission and long-term complete fistula healing can be achieved in only 30% to 50% of patients. Moreover, these percentages refer mostly to clinical rather than deep remission, defined as endoscopic and radiologic remission, which is quickly emerging as the preferred goal of therapy. Unfortunately, the therapeutic options for perianal fistulising CD are still limited. As such, it would be of great value to be able to predict, and more importantly, prevent treatment failure in these patients by early and continued optimization of antiTNF therapy. Similar to ulcerative colitis and luminal CD, recent data demonstrate that higher infliximab concentrations are associated with better clinical outcomes in patients with perianal fistulising CD. This suggests that therapeutic drug monitoring and a treatto-trough therapeutic approach may emerge as the new standard of care for optimizing anti-TNF therapy in patients with perianal fistulising CD. | konstantinos papamichael adam s cheifetz | 2017 | World Journal of Gastroenterology2017，23，34： | 2 |
| 2 | The incidence and management of infusion reactions to infliximab : a large center experience显示文摘 | Cheifetz A Smedley M Martin S | 2003 | Am J Gastroenterol2003，98，6： | 1 |
| 3 | Human cell surface glycoprotein related to cell proliferation is the receptor for transform显示文摘 | Cheifetz S Hemandez H Laiho M | 1990 | Journal of Biology Chemistry1990，265，20： | 1 |
| 4 | transforming growth factor-beta显示文摘 | Cheifetzs S Laihao M | 1992 | Cabeer Surveyes1992，12，： | 1 |
| 5 | The incidence and management of infusion reactions to infliximab:a large center experience 显示文摘 | Cheifetz A Smedley M Martin S | 2003 | Am J Gastroenterol2003，98，6： | 1 |
| 6 | Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells显示文摘 | Bellon T Cales C | 1992 | Biol Chem1992，267，19： | 1 |
| 7 | The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors显示文摘 | Cheifetz S Weatherbee J A Tsang M L | 1987 | Cell1987，48，3： | 1 |
| 8 | Transforming growth factor-beta receptors and binding proteoglycans显示文摘 | Boyd FT Cheifetz S Andres J | 1990 | J Cell Sci Suppl1990，13，： | 1 |
| 9 | Novel activin receptors:distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors显示文摘 | Wrana JL Cheifetz S | 1992 | Cell1992，68，： | 1 |
| 10 | The role of mucosal healing in the treatment of patients with inflammatory bowel disease显示文摘 | Vaughn BP Shan S Cheifetz AS | 2014 | Curr Treat Options Gastroenterol2014，12，1： | 1 |
| 11 | Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors 显示文摘 | Wrana JL Cheifetz S | 1992 | Cell1992，68，1： | 1 |
| 12 | Influence of osteogenic protein-1 (OP-I, BMP-7)and transforming growth factor-beta 1 on bone formation in vitro显示文摘 | Cheifetz S Li IW McCulloch CA | 1996 | Connect Tissue Res1996，35，14： | 1 |
| 13 | Cyclosporine is safe and effective in patients with severe ulcerative colitis 显示文摘 | Cheifetz AS Stern J Garud S | 2011 | J Clin Gastroenterol2011，45，2： | 1 |
| 14 | Influence of osteogenic protein-1 (OP-1 ;BMP-7) and transforming growth factor-beta 1 on bone formation in vitro显示文摘 | Cheifetz S Li IW McCulloch CA | 1996 | Connect Tissue Res1996，35，14： | 1 |
| 15 | Transforming growth factor-beta显示文摘 | Massague J S Cheifetz S Laiho M | 1992 | Cancer Surveys1992，，12： | 1 |
| 16 | Endoglin is a component of the transforming growth factor - beta receptor system in human endothelial cells显示文摘 | Cheifetz S Bellon T Cales C | 1992 | J Biol Chem1992，267，19： | 1 |
| 17 | Doctor message canalter patients' behavior and attitudes regarding inflammatory bowel disease and colon cancer显示文摘 | Friedman S Cheifetz AS Farraye FA | 2012 | Inflamm Bowel Dis2012，18，8： | 1 |
| 18 | Endoglin is a component of the transforming growth factor-beta receptor system in human endo- thelial ceils 显示文摘 | Cheifetz S Bellon T Cales C | 1992 | J Biol Chem1992，267，19： | 1 |
| 19 | Serum lactates correlate with mortality after operations for complex congenital heart disease显示文摘 | CHEIFETZ I M KERN F H SCHULMAN S R | 1997 | Ann Thorac Surg1997，64，： | 1 |
| 20 | Doctormessage can alter patients, behavior and attitudes regarding inflam-matory bowel disease and colon cancer 显示文摘 | FRIEDMAN S CHEIFETZ A S FARRAYE F A | 2012 | Inflamm Bowel Dis2012，18，8： | 1 |
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